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Pharmacological Strategies to Retard Cardiovascular Aging

Aging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia... Full description

Journal Title: Circulation Research 2016, Vol.118(10), pp.1626-1642
Main Author: Alfaras, G., Irene
Other Authors: Di Germanio, G., Clara , Bernier, G., Michel , Csiszar, G., Anna , Ungvari, G., Zoltan , Lakatta, G., Edward , De Cabo, G., Rafael
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ID: ISSN: 0009-7330 ; DOI: 10.1161/CIRCRESAHA.116.307475
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00003012-201605130-00019
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recordid: ovid00003012-201605130-00019
title: Pharmacological Strategies to Retard Cardiovascular Aging
format: Article
creator:
  • Alfaras, G., Irene
  • Di Germanio, G., Clara
  • Bernier, G., Michel
  • Csiszar, G., Anna
  • Ungvari, G., Zoltan
  • Lakatta, G., Edward
  • De Cabo, G., Rafael
subjects:
  • Medicine
ispartof: Circulation Research, 2016, Vol.118(10), pp.1626-1642
description: Aging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat cardiovascular disease. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the prolongevity benefits of various therapeutic strategies that support cardiovascular health.
language:
source:
identifier: ISSN: 0009-7330 ; DOI: 10.1161/CIRCRESAHA.116.307475
fulltext: fulltext
issn:
  • 0009-7330
  • 00097330
url: Link


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identifierISSN: 0009-7330 ; DOI: 10.1161/CIRCRESAHA.116.307475
descriptionAging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat cardiovascular disease. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the prolongevity benefits of various therapeutic strategies that support cardiovascular health.
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titlePharmacological Strategies to Retard Cardiovascular Aging
descriptionAging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat cardiovascular disease. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the prolongevity benefits of various therapeutic strategies that support cardiovascular health.
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abstractAging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat cardiovascular disease. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the prolongevity benefits of various therapeutic strategies that support cardiovascular health.
pub© 2016 American Heart Association, Inc.
doi10.1161/CIRCRESAHA.116.307475
eissn15244571
date2016-05-13