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Hemodynamic and Metabolic Effects of Sodium Nitroprusside on the Performance and Metabolism of Regional Ischemic Myocardium

To assess the effects of sodium nitroprusside (5-10 μg/min) on total and regional cardiac performance, energetics, and lactate metabolism during acute ischemia, studies were performed in 21 open-chest dogs. For studies of regional function and metabolism, length gauges were sutured to the epicardial... Full description

Journal Title: Circulation 1975, Vol.52(3), pp.400-407
Main Author: Da Luz, L., Protasio
Other Authors: Forrester, S., James , Wyatt, L., H. , Tyberg, V., John , Chagrasulis, W., Robert , Parmley, J. C., William , Swan, J. C., H.
Format: Electronic Article Electronic Article
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ID: ISSN: 0009-7322
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00003017-197509000-00006
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title: Hemodynamic and Metabolic Effects of Sodium Nitroprusside on the Performance and Metabolism of Regional Ischemic Myocardium
format: Article
creator:
  • Da Luz, L., Protasio
  • Forrester, S., James
  • Wyatt, L., H.
  • Tyberg, V., John
  • Chagrasulis, W., Robert
  • Parmley, J. C., William
  • Swan, J. C., H.
subjects:
  • Coronary Disease -- Physiopathology
  • Coronary Vessels -- Drug Effects
  • Ferricyanides -- Pharmacology
  • Heart -- Drug Effects
  • Hemodynamics -- Drug Effects
  • Myocardium -- Metabolism
  • Nitroprusside -- Pharmacology
ispartof: Circulation, 1975, Vol.52(3), pp.400-407
description: To assess the effects of sodium nitroprusside (5-10 μg/min) on total and regional cardiac performance, energetics, and lactate metabolism during acute ischemia, studies were performed in 21 open-chest dogs. For studies of regional function and metabolism, length gauges were sutured to the epicardial surface and an epicardial vein adjacent to the artery to be occluded was cannulated.Following occlusion of the left anterior descending coronary artery, cardiac output, mean arterial pressure, epicardial vein blood flow, and systolic shortening of the ischemic segment decreased significantly. In the blood samples from the ischemic zone, but not in those from the coronary sinus, lactate extraction shifted to production. In seven control dogs these alterations persisted throughout the experiment. In 14 animals treated with nitroprusside, cardiac output increased while peripheral resistance and mean arterial pressure decreased. Systolic shortening in the ischemic segment increased from 1.10 ± 0.24 (sem) to 1.77 ± 0.30 mm (P < 0.005). In eight dogs, regional venous outflow increased from 1.9 ± 0.1 to 3.0 ± 0.4 ml/min despite a slight reduction in mean arterial pressure. Concomitantly, regional negative lactate balance was reduced from −61.0 ± 20.0 to −23.2 ± 5.7% (P < 0.05).These results indicate that nitroprusside significantly improves both total cardiac performance and the mechanical performance of regional ischemic myocardium. Moreover, this improvement in mechanical function occurred concomitantly with apparent increase in regional perfusion and reduction in lactate production, suggesting that nitroprusside simultaneously alleviates ischemia.
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source:
identifier: ISSN: 0009-7322
fulltext: fulltext
issn:
  • 0009-7322
  • 00097322
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titleHemodynamic and Metabolic Effects of Sodium Nitroprusside on the Performance and Metabolism of Regional Ischemic Myocardium
creatorDa Luz, L., Protasio ; Forrester, S., James ; Wyatt, L., H. ; Tyberg, V., John ; Chagrasulis, W., Robert ; Parmley, J. C., William ; Swan, J. C., H.
ispartofCirculation, 1975, Vol.52(3), pp.400-407
identifierISSN: 0009-7322
descriptionTo assess the effects of sodium nitroprusside (5-10 μg/min) on total and regional cardiac performance, energetics, and lactate metabolism during acute ischemia, studies were performed in 21 open-chest dogs. For studies of regional function and metabolism, length gauges were sutured to the epicardial surface and an epicardial vein adjacent to the artery to be occluded was cannulated.Following occlusion of the left anterior descending coronary artery, cardiac output, mean arterial pressure, epicardial vein blood flow, and systolic shortening of the ischemic segment decreased significantly. In the blood samples from the ischemic zone, but not in those from the coronary sinus, lactate extraction shifted to production. In seven control dogs these alterations persisted throughout the experiment. In 14 animals treated with nitroprusside, cardiac output increased while peripheral resistance and mean arterial pressure decreased. Systolic shortening in the ischemic segment increased from 1.10 ± 0.24 (sem) to 1.77 ± 0.30 mm (P < 0.005). In eight dogs, regional venous outflow increased from 1.9 ± 0.1 to 3.0 ± 0.4 ml/min despite a slight reduction in mean arterial pressure. Concomitantly, regional negative lactate balance was reduced from −61.0 ± 20.0 to −23.2 ± 5.7% (P < 0.05).These results indicate that nitroprusside significantly improves both total cardiac performance and the mechanical performance of regional ischemic myocardium. Moreover, this improvement in mechanical function occurred concomitantly with apparent increase in regional perfusion and reduction in lactate production, suggesting that nitroprusside simultaneously alleviates ischemia.
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subjectCoronary Disease -- Physiopathology ; Coronary Vessels -- Drug Effects ; Ferricyanides -- Pharmacology ; Heart -- Drug Effects ; Hemodynamics -- Drug Effects ; Myocardium -- Metabolism ; Nitroprusside -- Pharmacology;
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titleHemodynamic and Metabolic Effects of Sodium Nitroprusside on the Performance and Metabolism of Regional Ischemic Myocardium
descriptionTo assess the effects of sodium nitroprusside (5-10 μg/min) on total and regional cardiac performance, energetics, and lactate metabolism during acute ischemia, studies were performed in 21 open-chest dogs. For studies of regional function and metabolism, length gauges were sutured to the epicardial surface and an epicardial vein adjacent to the artery to be occluded was cannulated.Following occlusion of the left anterior descending coronary artery, cardiac output, mean arterial pressure, epicardial vein blood flow, and systolic shortening of the ischemic segment decreased significantly. In the blood samples from the ischemic zone, but not in those from the coronary sinus, lactate extraction shifted to production. In seven control dogs these alterations persisted throughout the experiment. In 14 animals treated with nitroprusside, cardiac output increased while peripheral resistance and mean arterial pressure decreased. Systolic shortening in the ischemic segment increased from 1.10 ± 0.24 (sem) to 1.77 ± 0.30 mm (P < 0.005). In eight dogs, regional venous outflow increased from 1.9 ± 0.1 to 3.0 ± 0.4 ml/min despite a slight reduction in mean arterial pressure. Concomitantly, regional negative lactate balance was reduced from −61.0 ± 20.0 to −23.2 ± 5.7% (P < 0.05).These results indicate that nitroprusside significantly improves both total cardiac performance and the mechanical performance of regional ischemic myocardium. Moreover, this improvement in mechanical function occurred concomitantly with apparent increase in regional perfusion and reduction in lactate production, suggesting that nitroprusside simultaneously alleviates ischemia.
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abstractTo assess the effects of sodium nitroprusside (5-10 μg/min) on total and regional cardiac performance, energetics, and lactate metabolism during acute ischemia, studies were performed in 21 open-chest dogs. For studies of regional function and metabolism, length gauges were sutured to the epicardial surface and an epicardial vein adjacent to the artery to be occluded was cannulated.Following occlusion of the left anterior descending coronary artery, cardiac output, mean arterial pressure, epicardial vein blood flow, and systolic shortening of the ischemic segment decreased significantly. In the blood samples from the ischemic zone, but not in those from the coronary sinus, lactate extraction shifted to production. In seven control dogs these alterations persisted throughout the experiment. In 14 animals treated with nitroprusside, cardiac output increased while peripheral resistance and mean arterial pressure decreased. Systolic shortening in the ischemic segment increased from 1.10 ± 0.24 (sem) to 1.77 ± 0.30 mm (P < 0.005). In eight dogs, regional venous outflow increased from 1.9 ± 0.1 to 3.0 ± 0.4 ml/min despite a slight reduction in mean arterial pressure. Concomitantly, regional negative lactate balance was reduced from −61.0 ± 20.0 to −23.2 ± 5.7% (P < 0.05).These results indicate that nitroprusside significantly improves both total cardiac performance and the mechanical performance of regional ischemic myocardium. Moreover, this improvement in mechanical function occurred concomitantly with apparent increase in regional perfusion and reduction in lactate production, suggesting that nitroprusside simultaneously alleviates ischemia.
pub© 1975 American Heart Association, Inc.
doi10.1161/01.CIR.52.3.400
eissn15244539
date1975-09