schliessen

Filtern

 

Bibliotheken

Physical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease

PURPOSE: Both physical activity and physical fitness are associated with decreased coronary heart disease (CHD) risk. Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD. METHODS: We conducted a prospective cohort stu... Full description

Journal Title: Medicine & Science in Sports & Exercise 2013, Vol.45(4), pp.691-697
Main Author: Chomistek, K., Andrea
Other Authors: Chasman, I., Daniel , Cook, R., Nancy , Rimm, B., Eric , Lee, B., I-Min
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0195-9131 ; DOI: 10.1249/MSS.0b013e3182784e9f
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005768-201304000-00011
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: ovid00005768-201304000-00011
title: Physical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease
format: Article
creator:
  • Chomistek, K., Andrea
  • Chasman, I., Daniel
  • Cook, R., Nancy
  • Rimm, B., Eric
  • Lee, B., I-Min
subjects:
  • Medicine
  • Physical Therapy
ispartof: Medicine & Science in Sports & Exercise, 2013, Vol.45(4), pp.691-697
description: PURPOSE: Both physical activity and physical fitness are associated with decreased coronary heart disease (CHD) risk. Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD. METHODS: We conducted a prospective cohort study among 23,016 initially healthy women in the Women’s Genome Health Study. Leisure time physical activity was reported at entry and during follow-up. A total of 58 single nucleotide polymorphisms associated with physical fitness were identified from published literature and summed to create four separate genetic scores related to phenotypes of endurance, muscle strength, V˙O2max, and overall fitness. RESULTS: During a median of 14.4 yr, 320 incident CHD events occurred. Increased physical activity was associated with lower CHD risk in multivariable-adjusted models (P = 0.0008). Independent of physical activity, only muscle strength genetic score was inversely associated with CHD risk (P = 0.05). There was no evidence that the inverse relation between physical activity and CHD was modified by any of the genetic scores for physical fitness. For overall fitness genetic score, the hazard ratio (HR) per 500 kcal·wk of physical activity was 0.85 (95% confidence interval [CI] = 0.72–1.00) in the highest quartile of genetic score and 0.79 (95% CI = 0.67–0.92) in the lowest quartile (P, interaction = 0.50). For V˙O2max genetic score, the HR was 0.86 (95% CI = 0.72–1.02) and 0.84 (95% CI = 0.72–0.98), respectively (P, interaction = 0.59). CONCLUSIONS: In this large prospective cohort of women, genes associated with physical fitness did not modify the inverse association between physical activity and CHD risk.
language:
source:
identifier: ISSN: 0195-9131 ; DOI: 10.1249/MSS.0b013e3182784e9f
fulltext: fulltext
issn:
  • 0195-9131
  • 01959131
url: Link


@attributes
ID1027070497
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid00005768-201304000-00011
sourceidovid
recordidTN_ovid00005768-201304000-00011
sourceformatXML
sourcesystemPC
pqid1318691024
galeid385569538
display
typearticle
titlePhysical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease
creatorChomistek, K., Andrea ; Chasman, I., Daniel ; Cook, R., Nancy ; Rimm, B., Eric ; Lee, B., I-Min
ispartofMedicine & Science in Sports & Exercise, 2013, Vol.45(4), pp.691-697
identifierISSN: 0195-9131 ; DOI: 10.1249/MSS.0b013e3182784e9f
descriptionPURPOSE: Both physical activity and physical fitness are associated with decreased coronary heart disease (CHD) risk. Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD. METHODS: We conducted a prospective cohort study among 23,016 initially healthy women in the Women’s Genome Health Study. Leisure time physical activity was reported at entry and during follow-up. A total of 58 single nucleotide polymorphisms associated with physical fitness were identified from published literature and summed to create four separate genetic scores related to phenotypes of endurance, muscle strength, V˙O2max, and overall fitness. RESULTS: During a median of 14.4 yr, 320 incident CHD events occurred. Increased physical activity was associated with lower CHD risk in multivariable-adjusted models (P = 0.0008). Independent of physical activity, only muscle strength genetic score was inversely associated with CHD risk (P = 0.05). There was no evidence that the inverse relation between physical activity and CHD was modified by any of the genetic scores for physical fitness. For overall fitness genetic score, the hazard ratio (HR) per 500 kcal·wk of physical activity was 0.85 (95% confidence interval [CI] = 0.72–1.00) in the highest quartile of genetic score and 0.79 (95% CI = 0.67–0.92) in the lowest quartile (P, interaction = 0.50). For V˙O2max genetic score, the HR was 0.86 (95% CI = 0.72–1.02) and 0.84 (95% CI = 0.72–0.98), respectively (P, interaction = 0.59). CONCLUSIONS: In this large prospective cohort of women, genes associated with physical fitness did not modify the inverse association between physical activity and CHD risk.
source
subjectMedicine ; Physical Therapy;
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005768-201304000-00011$$EView_record_at_Wolters_Kluwer_Health_Ovid_Technologies
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutOvid.html$$EView_Wolters_Kluwer_Health,_Lippincott,_Williams_&_Wilkins_Copyright_Statement
search
creatorcontrib
0CHOMISTEK, K, ANDREA
1CHASMAN, I, DANIEL
2COOK, R, NANCY
3RIMM, B, ERIC
4LEE, B, I-MIN
titlePhysical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease
descriptionPURPOSE: Both physical activity and physical fitness are associated with decreased coronary heart disease (CHD) risk. Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD. METHODS: We conducted a prospective cohort study among 23,016 initially healthy women in the Women’s Genome Health Study. Leisure time physical activity was reported at entry and during follow-up. A total of 58 single nucleotide polymorphisms associated with physical fitness were identified from published literature and summed to create four separate genetic scores related to phenotypes of endurance, muscle strength, V˙O2max, and overall fitness. RESULTS: During a median of 14.4 yr, 320 incident CHD events occurred. Increased physical activity was associated with lower CHD risk in multivariable-adjusted models (P = 0.0008). Independent of physical activity, only muscle strength genetic score was inversely associated with CHD risk (P = 0.05). There was no evidence that the inverse relation between physical activity and CHD was modified by any of the genetic scores for physical fitness. For overall fitness genetic score, the hazard ratio (HR) per 500 kcal·wk of physical activity was 0.85 (95% confidence interval [CI] = 0.72–1.00) in the highest quartile of genetic score and 0.79 (95% CI = 0.67–0.92) in the lowest quartile (P, interaction = 0.50). For V˙O2max genetic score, the HR was 0.86 (95% CI = 0.72–1.02) and 0.84 (95% CI = 0.72–0.98), respectively (P, interaction = 0.59). CONCLUSIONS: In this large prospective cohort of women, genes associated with physical fitness did not modify the inverse association between physical activity and CHD risk.
general
010.1249/MSS.0b013e3182784e9f
1©2013The American College of Sports Medicine
2Lippincott Williams & Wilkins - Journals
sourceidovid
recordidovid00005768-201304000-00011
issn
00195-9131
101959131
rsrctypearticle
creationdate2013
addtitleMedicine & Science in Sports & Exercise
searchscopeovid
scopeovid
lsr30VSR-Enriched:[eissn, subject, pqid, galeid]
sort
titlePhysical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease
authorChomistek, K., Andrea ; Chasman, I., Daniel ; Cook, R., Nancy ; Rimm, B., Eric ; Lee, B., I-Min
creationdate20130400
facets
frbrgroupid5885197088015028581
frbrtype5
newrecords20170725
creationdate2013
collectionLippincott Williams & Wilkins Journals (Wolters Kluwer Health)
prefilterarticles
rsrctypearticles
creatorcontrib
0Chomistek, K., Andrea
1Chasman, I., Daniel
2Cook, R., Nancy
3Rimm, B., Eric
4Lee, B., I-Min
jtitleMedicine & Science in Sports & Exercise
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0CHOMISTEK
1CHASMAN
2COOK
3RIMM
4LEE
aufirst
0ANDREA
1DANIEL
2NANCY
3ERIC
4I-MIN
auinitm
0K.
1I.
2R.
3B.
au
0Chomistek, K., Andrea
1Chasman, I., Daniel
2Cook, R., Nancy
3Rimm, B., Eric
4Lee, B., I-Min
atitlePhysical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease
jtitleMedicine & Science in Sports & Exercise
risdate201304
volume45
issue4
spage691
epage697
pages691-697
issn0195-9131
formatjournal
genrearticle
ristypeJOUR
abstractPURPOSE: Both physical activity and physical fitness are associated with decreased coronary heart disease (CHD) risk. Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD. METHODS: We conducted a prospective cohort study among 23,016 initially healthy women in the Women’s Genome Health Study. Leisure time physical activity was reported at entry and during follow-up. A total of 58 single nucleotide polymorphisms associated with physical fitness were identified from published literature and summed to create four separate genetic scores related to phenotypes of endurance, muscle strength, V˙O2max, and overall fitness. RESULTS: During a median of 14.4 yr, 320 incident CHD events occurred. Increased physical activity was associated with lower CHD risk in multivariable-adjusted models (P = 0.0008). Independent of physical activity, only muscle strength genetic score was inversely associated with CHD risk (P = 0.05). There was no evidence that the inverse relation between physical activity and CHD was modified by any of the genetic scores for physical fitness. For overall fitness genetic score, the hazard ratio (HR) per 500 kcal·wk of physical activity was 0.85 (95% confidence interval [CI] = 0.72–1.00) in the highest quartile of genetic score and 0.79 (95% CI = 0.67–0.92) in the lowest quartile (P, interaction = 0.50). For V˙O2max genetic score, the HR was 0.86 (95% CI = 0.72–1.02) and 0.84 (95% CI = 0.72–0.98), respectively (P, interaction = 0.59). CONCLUSIONS: In this large prospective cohort of women, genes associated with physical fitness did not modify the inverse association between physical activity and CHD risk.
pub©2013The American College of Sports Medicine
doi10.1249/MSS.0b013e3182784e9f
eissn15300315
date2013-04