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Blood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study

BACKGROUND AND PURPOSE—: High blood pressure is a major cause of cardiovascular events, and carotid flow pulsatility may be associated with cardiovascular events. However, the combined effect of blood pressure and flow pulsatility on the development of stroke remains unclear. Therefore, we investiga... Full description

Journal Title: Stroke 2016, Vol.47(9), pp.2262-2268
Main Author: Chuang, Shao-Yuan
Other Authors: Cheng, Hao-Min , Bai, Chyi-Huey , Yeh, Wen-Ting , Chen, Jiunn-Rong , Pan, Wen-Harn
Format: Electronic Article Electronic Article
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ID: ISSN: 0039-2499 ; DOI: 10.1161/STROKEAHA.116.013207
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00007670-201609000-00018
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title: Blood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study
format: Article
creator:
  • Chuang, Shao-Yuan
  • Cheng, Hao-Min
  • Bai, Chyi-Huey
  • Yeh, Wen-Ting
  • Chen, Jiunn-Rong
  • Pan, Wen-Harn
subjects:
  • Medicine
ispartof: Stroke, 2016, Vol.47(9), pp.2262-2268
description: BACKGROUND AND PURPOSE—: High blood pressure is a major cause of cardiovascular events, and carotid flow pulsatility may be associated with cardiovascular events. However, the combined effect of blood pressure and flow pulsatility on the development of stroke remains unclear. Therefore, we investigated the combined influence of central blood pressure and pulsatility index (PI) on the incidence of stroke. METHODS—: Baseline data from 2033 adults (≥30 years) without stroke history in the Cardiovascular Disease Risk Factor Two-Township Study were linked to incident stroke. Common carotid flow PI was calculated by peak systolic velocity, end-diastolic velocity, and mean vessel velocity, which were measured in the common carotid artery. Hazard ratios for the risk of total stroke resulting from high central systolic blood pressure (CSBP) and high PI were calculated with Cox proportional hazard models. RESULTS—: Over a median follow-up of 9.81 years, 132 people incurred stroke events. The incidence rates of stroke were 1.3, 6.4, and 13.2 per 1000 person-years for tertile groups of CSBP (P for trend
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identifier: ISSN: 0039-2499 ; DOI: 10.1161/STROKEAHA.116.013207
fulltext: fulltext
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  • 0039-2499
  • 00392499
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titleBlood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study
creatorChuang, Shao-Yuan ; Cheng, Hao-Min ; Bai, Chyi-Huey ; Yeh, Wen-Ting ; Chen, Jiunn-Rong ; Pan, Wen-Harn
ispartofStroke, 2016, Vol.47(9), pp.2262-2268
identifierISSN: 0039-2499 ; DOI: 10.1161/STROKEAHA.116.013207
descriptionBACKGROUND AND PURPOSE—: High blood pressure is a major cause of cardiovascular events, and carotid flow pulsatility may be associated with cardiovascular events. However, the combined effect of blood pressure and flow pulsatility on the development of stroke remains unclear. Therefore, we investigated the combined influence of central blood pressure and pulsatility index (PI) on the incidence of stroke. METHODS—: Baseline data from 2033 adults (≥30 years) without stroke history in the Cardiovascular Disease Risk Factor Two-Township Study were linked to incident stroke. Common carotid flow PI was calculated by peak systolic velocity, end-diastolic velocity, and mean vessel velocity, which were measured in the common carotid artery. Hazard ratios for the risk of total stroke resulting from high central systolic blood pressure (CSBP) and high PI were calculated with Cox proportional hazard models. RESULTS—: Over a median follow-up of 9.81 years, 132 people incurred stroke events. The incidence rates of stroke were 1.3, 6.4, and 13.2 per 1000 person-years for tertile groups of CSBP (P for trend<0.05) and 4.3, 7.0, and 9.4 per 1000 person-years for tertile groups of PI (P for trend<0.05). Compared with the first tertile of CSBP, hazard ratios were 4.88 (95% confidence interval, 2.29–10.43) for the second tertile and 10.42 (5.05–21.53) for the third tertile. Hazard ratios of PI were 2.18 (1.39–3.42; third tertile) and 1.64 (1.02–2.63; second tertile) compared with the first tertile. The individuals with a high CSBP and high PI had a 13-fold higher stroke risk compared with those with low CSBP and low PI (13.2; 1.75–99.71) after adjusting for age, sex, and traditional cardiovascular risk. CONCLUSIONS—: CSBP and common carotid PI jointly and independently predicted future stroke. Carotid flow pulsatility may play an important role in the development of stroke.
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titleBlood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study
descriptionBACKGROUND AND PURPOSE—: High blood pressure is a major cause of cardiovascular events, and carotid flow pulsatility may be associated with cardiovascular events. However, the combined effect of blood pressure and flow pulsatility on the development of stroke remains unclear. Therefore, we investigated the combined influence of central blood pressure and pulsatility index (PI) on the incidence of stroke. METHODS—: Baseline data from 2033 adults (≥30 years) without stroke history in the Cardiovascular Disease Risk Factor Two-Township Study were linked to incident stroke. Common carotid flow PI was calculated by peak systolic velocity, end-diastolic velocity, and mean vessel velocity, which were measured in the common carotid artery. Hazard ratios for the risk of total stroke resulting from high central systolic blood pressure (CSBP) and high PI were calculated with Cox proportional hazard models. RESULTS—: Over a median follow-up of 9.81 years, 132 people incurred stroke events. The incidence rates of stroke were 1.3, 6.4, and 13.2 per 1000 person-years for tertile groups of CSBP (P for trend<0.05) and 4.3, 7.0, and 9.4 per 1000 person-years for tertile groups of PI (P for trend<0.05). Compared with the first tertile of CSBP, hazard ratios were 4.88 (95% confidence interval, 2.29–10.43) for the second tertile and 10.42 (5.05–21.53) for the third tertile. Hazard ratios of PI were 2.18 (1.39–3.42; third tertile) and 1.64 (1.02–2.63; second tertile) compared with the first tertile. The individuals with a high CSBP and high PI had a 13-fold higher stroke risk compared with those with low CSBP and low PI (13.2; 1.75–99.71) after adjusting for age, sex, and traditional cardiovascular risk. CONCLUSIONS—: CSBP and common carotid PI jointly and independently predicted future stroke. Carotid flow pulsatility may play an important role in the development of stroke.
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010.1161/STROKEAHA.116.013207
1© 2016 American Heart Association, Inc.
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abstractBACKGROUND AND PURPOSE—: High blood pressure is a major cause of cardiovascular events, and carotid flow pulsatility may be associated with cardiovascular events. However, the combined effect of blood pressure and flow pulsatility on the development of stroke remains unclear. Therefore, we investigated the combined influence of central blood pressure and pulsatility index (PI) on the incidence of stroke. METHODS—: Baseline data from 2033 adults (≥30 years) without stroke history in the Cardiovascular Disease Risk Factor Two-Township Study were linked to incident stroke. Common carotid flow PI was calculated by peak systolic velocity, end-diastolic velocity, and mean vessel velocity, which were measured in the common carotid artery. Hazard ratios for the risk of total stroke resulting from high central systolic blood pressure (CSBP) and high PI were calculated with Cox proportional hazard models. RESULTS—: Over a median follow-up of 9.81 years, 132 people incurred stroke events. The incidence rates of stroke were 1.3, 6.4, and 13.2 per 1000 person-years for tertile groups of CSBP (P for trend<0.05) and 4.3, 7.0, and 9.4 per 1000 person-years for tertile groups of PI (P for trend<0.05). Compared with the first tertile of CSBP, hazard ratios were 4.88 (95% confidence interval, 2.29–10.43) for the second tertile and 10.42 (5.05–21.53) for the third tertile. Hazard ratios of PI were 2.18 (1.39–3.42; third tertile) and 1.64 (1.02–2.63; second tertile) compared with the first tertile. The individuals with a high CSBP and high PI had a 13-fold higher stroke risk compared with those with low CSBP and low PI (13.2; 1.75–99.71) after adjusting for age, sex, and traditional cardiovascular risk. CONCLUSIONS—: CSBP and common carotid PI jointly and independently predicted future stroke. Carotid flow pulsatility may play an important role in the development of stroke.
pub© 2016 American Heart Association, Inc.
doi10.1161/STROKEAHA.116.013207
eissn15244628
date2016-09