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Two-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database

BACKGROUND: In response to the increasing concern with the safety of the drug-eluting stent (DES), the present study aimed to evaluate the long-term safety and efficacy of DES used for a Chinese patient population. METHODS: All patients, who underwent an index elective percutaneous coronary interven... Full description

Journal Title: Chinese Medical Journal 2009, Vol.122(19), pp.2261-2267
Main Author: Gao, Run-Lin
Other Authors: Xu, Bo , Chen, Ji-Lin , Yang, Yue-Jin , Qiao, Shu-Bin , Wang, Yang , Dou, Ke-Fei , Qin, Xue-Wen , Yao, Min , Liu, Hai-Bo , Wu, Yong-Jian , Yuan, Jin-Qing , Chen, Jue , You, Shi-Jie , Dai, Jun , Ma, Wei-Hua , Li, Wei
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ID: ISSN: 0366-6999 ; DOI: 10.3760/cma.j.issn.0366-6999.2009.19.015
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00029330-200910010-00014
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title: Two-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database
format: Article
creator:
  • Gao, Run-Lin
  • Xu, Bo
  • Chen, Ji-Lin
  • Yang, Yue-Jin
  • Qiao, Shu-Bin
  • Wang, Yang
  • Dou, Ke-Fei
  • Qin, Xue-Wen
  • Yao, Min
  • Liu, Hai-Bo
  • Wu, Yong-Jian
  • Yuan, Jin-Qing
  • Chen, Jue
  • You, Shi-Jie
  • Dai, Jun
  • Ma, Wei-Hua
  • Li, Wei
subjects:
  • 中心数据库
  • 金属支架
  • 临床
  • 洗脱
  • 植入
  • 毒品
  • Stent
  • Drug Eluting
  • Bare Metal
  • Registry
  • Propensity Score
ispartof: Chinese Medical Journal, 2009, Vol.122(19), pp.2261-2267
description: BACKGROUND: In response to the increasing concern with the safety of the drug-eluting stent (DES), the present study aimed to evaluate the long-term safety and efficacy of DES used for a Chinese patient population. METHODS: All patients, who underwent an index elective percutaneous coronary intervention with an implantation of either DES or bare-metal stent (BMS) in a single institution from April 2004 to December 2006, were included in the analysis. A propensity-score matching technique was applied to adjust and to minimize the impact of confounding factors. RESULTS: Overall, there were 1465 patients (20.2%) who had undergone an implantation of only BMS, and 5769 patients (79.8%) of only DES. The propensity-score matching technique set up 1321 pairs of patients for analysis. There were no significant differences between the rates of stent thrombosis (definite and probable) of the two groups (1.06% vs 1.21%, P=0.8580). Although rates of mortality and myocardial infarction (MI) during the 2-year follow-up period had not differed significantly, rates of death/MI (3.0% vs 4.5%, P=0.0263), target-lesion revascularization (TLR, 3.2% vs 8.5, P=0.0001), target-vessel revascularization (TVR, 5.8% vs 9.5%, P
language:
source:
identifier: ISSN: 0366-6999 ; DOI: 10.3760/cma.j.issn.0366-6999.2009.19.015
fulltext: fulltext
issn:
  • 0366-6999
  • 03666999
url: Link


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titleTwo-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database
creatorGao, Run-Lin ; Xu, Bo ; Chen, Ji-Lin ; Yang, Yue-Jin ; Qiao, Shu-Bin ; Wang, Yang ; Dou, Ke-Fei ; Qin, Xue-Wen ; Yao, Min ; Liu, Hai-Bo ; Wu, Yong-Jian ; Yuan, Jin-Qing ; Chen, Jue ; You, Shi-Jie ; Dai, Jun ; Ma, Wei-Hua ; Li, Wei
ispartofChinese Medical Journal, 2009, Vol.122(19), pp.2261-2267
identifierISSN: 0366-6999 ; DOI: 10.3760/cma.j.issn.0366-6999.2009.19.015
descriptionBACKGROUND: In response to the increasing concern with the safety of the drug-eluting stent (DES), the present study aimed to evaluate the long-term safety and efficacy of DES used for a Chinese patient population. METHODS: All patients, who underwent an index elective percutaneous coronary intervention with an implantation of either DES or bare-metal stent (BMS) in a single institution from April 2004 to December 2006, were included in the analysis. A propensity-score matching technique was applied to adjust and to minimize the impact of confounding factors. RESULTS: Overall, there were 1465 patients (20.2%) who had undergone an implantation of only BMS, and 5769 patients (79.8%) of only DES. The propensity-score matching technique set up 1321 pairs of patients for analysis. There were no significant differences between the rates of stent thrombosis (definite and probable) of the two groups (1.06% vs 1.21%, P=0.8580). Although rates of mortality and myocardial infarction (MI) during the 2-year follow-up period had not differed significantly, rates of death/MI (3.0% vs 4.5%, P=0.0263), target-lesion revascularization (TLR, 3.2% vs 8.5, P=0.0001), target-vessel revascularization (TVR, 5.8% vs 9.5%, P <0.0001) and any revascularization (10.0% vs 13.3%, P=0.0066) were significantly lower for the DES group than for the BMS group. Among the patients in whom devices were implanted for off-label indications, the propensity-score matched rates of stent thrombosis, mortality, MI, and death/MI were not significantly different, while rates of TLR, TVR and any revascularization were significantly lower for the DES group than for the BMS group. CONCLUSIONS: During the 2 years of follow-up post stenting, DES use is associated with lower rates of death/MI, TLR, TVR and any revascularization, compared with BMS, in propensity-score matched Chinese patient populations. In the setting of off-label usage, DES use is also associated with similar advantages.
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subject中心数据库 ; 金属支架 ; 临床 ; 洗脱 ; 植入 ; 毒品 ; Stent; Drug Eluting; Bare Metal; Registry; Propensity Score;
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15MA, Wei-hua
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titleTwo-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database
descriptionBACKGROUND: In response to the increasing concern with the safety of the drug-eluting stent (DES), the present study aimed to evaluate the long-term safety and efficacy of DES used for a Chinese patient population. METHODS: All patients, who underwent an index elective percutaneous coronary intervention with an implantation of either DES or bare-metal stent (BMS) in a single institution from April 2004 to December 2006, were included in the analysis. A propensity-score matching technique was applied to adjust and to minimize the impact of confounding factors. RESULTS: Overall, there were 1465 patients (20.2%) who had undergone an implantation of only BMS, and 5769 patients (79.8%) of only DES. The propensity-score matching technique set up 1321 pairs of patients for analysis. There were no significant differences between the rates of stent thrombosis (definite and probable) of the two groups (1.06% vs 1.21%, P=0.8580). Although rates of mortality and myocardial infarction (MI) during the 2-year follow-up period had not differed significantly, rates of death/MI (3.0% vs 4.5%, P=0.0263), target-lesion revascularization (TLR, 3.2% vs 8.5, P=0.0001), target-vessel revascularization (TVR, 5.8% vs 9.5%, P <0.0001) and any revascularization (10.0% vs 13.3%, P=0.0066) were significantly lower for the DES group than for the BMS group. Among the patients in whom devices were implanted for off-label indications, the propensity-score matched rates of stent thrombosis, mortality, MI, and death/MI were not significantly different, while rates of TLR, TVR and any revascularization were significantly lower for the DES group than for the BMS group. CONCLUSIONS: During the 2 years of follow-up post stenting, DES use is associated with lower rates of death/MI, TLR, TVR and any revascularization, compared with BMS, in propensity-score matched Chinese patient populations. In the setting of off-label usage, DES use is also associated with similar advantages.
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1© 2009 Chinese Medical Association
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authorGao, Run-Lin ; Xu, Bo ; Chen, Ji-Lin ; Yang, Yue-Jin ; Qiao, Shu-Bin ; Wang, Yang ; Dou, Ke-Fei ; Qin, Xue-Wen ; Yao, Min ; Liu, Hai-Bo ; Wu, Yong-Jian ; Yuan, Jin-Qing ; Chen, Jue ; You, Shi-Jie ; Dai, Jun ; Ma, Wei-Hua ; Li, Wei
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abstractBACKGROUND: In response to the increasing concern with the safety of the drug-eluting stent (DES), the present study aimed to evaluate the long-term safety and efficacy of DES used for a Chinese patient population. METHODS: All patients, who underwent an index elective percutaneous coronary intervention with an implantation of either DES or bare-metal stent (BMS) in a single institution from April 2004 to December 2006, were included in the analysis. A propensity-score matching technique was applied to adjust and to minimize the impact of confounding factors. RESULTS: Overall, there were 1465 patients (20.2%) who had undergone an implantation of only BMS, and 5769 patients (79.8%) of only DES. The propensity-score matching technique set up 1321 pairs of patients for analysis. There were no significant differences between the rates of stent thrombosis (definite and probable) of the two groups (1.06% vs 1.21%, P=0.8580). Although rates of mortality and myocardial infarction (MI) during the 2-year follow-up period had not differed significantly, rates of death/MI (3.0% vs 4.5%, P=0.0263), target-lesion revascularization (TLR, 3.2% vs 8.5, P=0.0001), target-vessel revascularization (TVR, 5.8% vs 9.5%, P <0.0001) and any revascularization (10.0% vs 13.3%, P=0.0066) were significantly lower for the DES group than for the BMS group. Among the patients in whom devices were implanted for off-label indications, the propensity-score matched rates of stent thrombosis, mortality, MI, and death/MI were not significantly different, while rates of TLR, TVR and any revascularization were significantly lower for the DES group than for the BMS group. CONCLUSIONS: During the 2 years of follow-up post stenting, DES use is associated with lower rates of death/MI, TLR, TVR and any revascularization, compared with BMS, in propensity-score matched Chinese patient populations. In the setting of off-label usage, DES use is also associated with similar advantages.
pub© 2009 Chinese Medical Association
doi10.3760/cma.j.issn.0366-6999.2009.19.015
date2009-10