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Alloimmunization and Erythrocyte Autoimmunization in Transfusion-dependent Egyptian Thalassemic Patients

BACKGROUND: Alloimmunization to red blood cellsʼ (RBCs) antigens and formation of autoantibodies against RBCs is a frequent complication among immunocompetent transfusion-dependent patients. Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. The objective of this... Full description

Journal Title: Journal of Pediatric Hematology/Oncology 2011, Vol.33(6), pp.409-414
Main Author: Saied, A., Dalia
Other Authors: Kaddah, M., Ahmed , Badr Eldin, M., Reem , Mohaseb, S., Safaa
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ID: ISSN: 1077-4114 ; DOI: 10.1097/MPH.0b013e3182208154
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00043426-201108000-00003
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title: Alloimmunization and Erythrocyte Autoimmunization in Transfusion-dependent Egyptian Thalassemic Patients
format: Article
creator:
  • Saied, A., Dalia
  • Kaddah, M., Ahmed
  • Badr Eldin, M., Reem
  • Mohaseb, S., Safaa
subjects:
  • Blood Transfusion
  • Autoantibodies -- Immunology
  • Erythrocytes -- Immunology
  • Isoantibodies -- Immunology
  • Beta-Thalassemia -- Immunology
ispartof: Journal of Pediatric Hematology/Oncology, 2011, Vol.33(6), pp.409-414
description: BACKGROUND: Alloimmunization to red blood cellsʼ (RBCs) antigens and formation of autoantibodies against RBCs is a frequent complication among immunocompetent transfusion-dependent patients. Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. The objective of this study was to evaluate the presence of alloantibodies and autoantibodies in regularly transfused β-thalassemic patients and the factors influencing the development of alloantibodies. MATERIALS AND METHODS: The clinical and transfusion records of 95 Egyptian β-thalassemic patients, with a mean age of 17.07 years, presenting to the National Blood Transfusion Centre for regular blood transfusion were evaluated for alloimmunization and antibody formation. RESULTS: Alloantibodies were encountered in 27 patients (28.4%). The most frequent alloantibodies encountered were anti-Kell (23.6%) and anti-E (23.6%). Patients with blood group O were the highest in developing antibodies (37.9%). Patients with blood phenotypes R2r Kell negative developed more alloantibodies. Autoantibodies were encountered in only 1 patient. CONCLUSIONS: Alloimmunization to RBCsʼ antigens is a frequent finding among Egyptian transfusion-dependent thalassemic patients, with the majority of patients being transfused with blood matched for ABO and D antigens only. Absence of phenotypically matched donors, except for a limited number of patients, may have contributed to this problem.
language:
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identifier: ISSN: 1077-4114 ; DOI: 10.1097/MPH.0b013e3182208154
fulltext: fulltext
issn:
  • 1077-4114
  • 10774114
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titleAlloimmunization and Erythrocyte Autoimmunization in Transfusion-dependent Egyptian Thalassemic Patients
creatorSaied, A., Dalia ; Kaddah, M., Ahmed ; Badr Eldin, M., Reem ; Mohaseb, S., Safaa
ispartofJournal of Pediatric Hematology/Oncology, 2011, Vol.33(6), pp.409-414
identifierISSN: 1077-4114 ; DOI: 10.1097/MPH.0b013e3182208154
descriptionBACKGROUND: Alloimmunization to red blood cellsʼ (RBCs) antigens and formation of autoantibodies against RBCs is a frequent complication among immunocompetent transfusion-dependent patients. Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. The objective of this study was to evaluate the presence of alloantibodies and autoantibodies in regularly transfused β-thalassemic patients and the factors influencing the development of alloantibodies. MATERIALS AND METHODS: The clinical and transfusion records of 95 Egyptian β-thalassemic patients, with a mean age of 17.07 years, presenting to the National Blood Transfusion Centre for regular blood transfusion were evaluated for alloimmunization and antibody formation. RESULTS: Alloantibodies were encountered in 27 patients (28.4%). The most frequent alloantibodies encountered were anti-Kell (23.6%) and anti-E (23.6%). Patients with blood group O were the highest in developing antibodies (37.9%). Patients with blood phenotypes R2r Kell negative developed more alloantibodies. Autoantibodies were encountered in only 1 patient. CONCLUSIONS: Alloimmunization to RBCsʼ antigens is a frequent finding among Egyptian transfusion-dependent thalassemic patients, with the majority of patients being transfused with blood matched for ABO and D antigens only. Absence of phenotypically matched donors, except for a limited number of patients, may have contributed to this problem.
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subjectBlood Transfusion ; Autoantibodies -- Immunology ; Erythrocytes -- Immunology ; Isoantibodies -- Immunology ; Beta-Thalassemia -- Immunology;
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titleAlloimmunization and Erythrocyte Autoimmunization in Transfusion-dependent Egyptian Thalassemic Patients
descriptionBACKGROUND: Alloimmunization to red blood cellsʼ (RBCs) antigens and formation of autoantibodies against RBCs is a frequent complication among immunocompetent transfusion-dependent patients. Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. The objective of this study was to evaluate the presence of alloantibodies and autoantibodies in regularly transfused β-thalassemic patients and the factors influencing the development of alloantibodies. MATERIALS AND METHODS: The clinical and transfusion records of 95 Egyptian β-thalassemic patients, with a mean age of 17.07 years, presenting to the National Blood Transfusion Centre for regular blood transfusion were evaluated for alloimmunization and antibody formation. RESULTS: Alloantibodies were encountered in 27 patients (28.4%). The most frequent alloantibodies encountered were anti-Kell (23.6%) and anti-E (23.6%). Patients with blood group O were the highest in developing antibodies (37.9%). Patients with blood phenotypes R2r Kell negative developed more alloantibodies. Autoantibodies were encountered in only 1 patient. CONCLUSIONS: Alloimmunization to RBCsʼ antigens is a frequent finding among Egyptian transfusion-dependent thalassemic patients, with the majority of patients being transfused with blood matched for ABO and D antigens only. Absence of phenotypically matched donors, except for a limited number of patients, may have contributed to this problem.
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abstractBACKGROUND: Alloimmunization to red blood cellsʼ (RBCs) antigens and formation of autoantibodies against RBCs is a frequent complication among immunocompetent transfusion-dependent patients. Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. The objective of this study was to evaluate the presence of alloantibodies and autoantibodies in regularly transfused β-thalassemic patients and the factors influencing the development of alloantibodies. MATERIALS AND METHODS: The clinical and transfusion records of 95 Egyptian β-thalassemic patients, with a mean age of 17.07 years, presenting to the National Blood Transfusion Centre for regular blood transfusion were evaluated for alloimmunization and antibody formation. RESULTS: Alloantibodies were encountered in 27 patients (28.4%). The most frequent alloantibodies encountered were anti-Kell (23.6%) and anti-E (23.6%). Patients with blood group O were the highest in developing antibodies (37.9%). Patients with blood phenotypes R2r Kell negative developed more alloantibodies. Autoantibodies were encountered in only 1 patient. CONCLUSIONS: Alloimmunization to RBCsʼ antigens is a frequent finding among Egyptian transfusion-dependent thalassemic patients, with the majority of patients being transfused with blood matched for ABO and D antigens only. Absence of phenotypically matched donors, except for a limited number of patients, may have contributed to this problem.
pub© 2011 Lippincott Williams & Wilkins, Inc.
doi10.1097/MPH.0b013e3182208154
eissn15363678
date2011-08