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Total Adiponectin and Risk of Symptomatic Lower Extremity Peripheral Artery Disease in Men

OBJECTIVE—: Lower concentrations of adiponectin have been linked to subsequent risk of coronary heart disease in healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral artery disease (PAD), is uncertain. We investigated the associ... Full description

Journal Title: Arteriosclerosis Thrombosis, and Vascular Biology, 2013, Vol.33(5), pp.1092-1097
Main Author: Joosten, M., Michel
Other Authors: Joshipura, J., Kaumudi , Pai, K., Jennifer , Bertoia, L., Monica , Rimm, B., Eric , Mittleman, A., Murray , Mukamal, J., Kenneth
Format: Electronic Article Electronic Article
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ID: ISSN: 1079-5642 ; DOI: 10.1161/ATVBAHA.112.301089
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00043605-201305000-00029
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title: Total Adiponectin and Risk of Symptomatic Lower Extremity Peripheral Artery Disease in Men
format: Article
creator:
  • Joosten, M., Michel
  • Joshipura, J., Kaumudi
  • Pai, K., Jennifer
  • Bertoia, L., Monica
  • Rimm, B., Eric
  • Mittleman, A., Murray
  • Mukamal, J., Kenneth
subjects:
  • Medicine
ispartof: Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, Vol.33(5), pp.1092-1097
description: OBJECTIVE—: Lower concentrations of adiponectin have been linked to subsequent risk of coronary heart disease in healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral artery disease (PAD), is uncertain. We investigated the association between total adiponectin and risk of lower extremity PAD. APPROACH AND RESULTS—: We performed a prospective, nested case–control study among 18 225 male participants of the Health Professionals Follow-up Study who were free of diagnosed cardiovascular disease at the time of blood draw (1993–1995). During 14 years of follow-up, 143 men developed PAD. Using risk set sampling, controls were selected in a 3:1 ratio and matched on age, smoking status, fasting status, and date of blood draw (n=429). Median (interquartile range) adiponectin concentrations at baseline were lower among cases compared with controls (4.1 [3.2–5.5] versus 5.4 [3.8–7.5] µg/mL; P
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identifier: ISSN: 1079-5642 ; DOI: 10.1161/ATVBAHA.112.301089
fulltext: fulltext
issn:
  • 1079-5642
  • 10795642
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titleTotal Adiponectin and Risk of Symptomatic Lower Extremity Peripheral Artery Disease in Men
creatorJoosten, M., Michel ; Joshipura, J., Kaumudi ; Pai, K., Jennifer ; Bertoia, L., Monica ; Rimm, B., Eric ; Mittleman, A., Murray ; Mukamal, J., Kenneth
ispartofArteriosclerosis, Thrombosis, and Vascular Biology, 2013, Vol.33(5), pp.1092-1097
identifierISSN: 1079-5642 ; DOI: 10.1161/ATVBAHA.112.301089
descriptionOBJECTIVE—: Lower concentrations of adiponectin have been linked to subsequent risk of coronary heart disease in healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral artery disease (PAD), is uncertain. We investigated the association between total adiponectin and risk of lower extremity PAD. APPROACH AND RESULTS—: We performed a prospective, nested case–control study among 18 225 male participants of the Health Professionals Follow-up Study who were free of diagnosed cardiovascular disease at the time of blood draw (1993–1995). During 14 years of follow-up, 143 men developed PAD. Using risk set sampling, controls were selected in a 3:1 ratio and matched on age, smoking status, fasting status, and date of blood draw (n=429). Median (interquartile range) adiponectin concentrations at baseline were lower among cases compared with controls (4.1 [3.2–5.5] versus 5.4 [3.8–7.5] µg/mL; P<0.001). A log-linear inverse association was evident over the full spectrum of adiponectin concentrations with PAD risk after controlling for baseline cardiovascular risk factors using restricted spline conditional logistic regression. Adiponectin was associated with a 42% lower risk of PAD per SD increase in natural log-transformed adiponectin (relative risk, 0.58; 95% confidence interval, 0.45–0.74) after adjustment for cardiovascular risk factors. The relative risk was attenuated (relative risk, 0.68; 95% confidence interval, 0.51–0.92) after further accounting for high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, and cystatin C. Additional adjustment for hemoglobin A1c, triglycerides, and γ-glutamyltransferase had little impact on this association (relative risk, 0.68; 95% confidence interval, 0.50–0.92). CONCLUSIONS—: Total adiponectin is inversely associated with risk of symptomatic lower extremity PAD in men.
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titleTotal Adiponectin and Risk of Symptomatic Lower Extremity Peripheral Artery Disease in Men
descriptionOBJECTIVE—: Lower concentrations of adiponectin have been linked to subsequent risk of coronary heart disease in healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral artery disease (PAD), is uncertain. We investigated the association between total adiponectin and risk of lower extremity PAD. APPROACH AND RESULTS—: We performed a prospective, nested case–control study among 18 225 male participants of the Health Professionals Follow-up Study who were free of diagnosed cardiovascular disease at the time of blood draw (1993–1995). During 14 years of follow-up, 143 men developed PAD. Using risk set sampling, controls were selected in a 3:1 ratio and matched on age, smoking status, fasting status, and date of blood draw (n=429). Median (interquartile range) adiponectin concentrations at baseline were lower among cases compared with controls (4.1 [3.2–5.5] versus 5.4 [3.8–7.5] µg/mL; P<0.001). A log-linear inverse association was evident over the full spectrum of adiponectin concentrations with PAD risk after controlling for baseline cardiovascular risk factors using restricted spline conditional logistic regression. Adiponectin was associated with a 42% lower risk of PAD per SD increase in natural log-transformed adiponectin (relative risk, 0.58; 95% confidence interval, 0.45–0.74) after adjustment for cardiovascular risk factors. The relative risk was attenuated (relative risk, 0.68; 95% confidence interval, 0.51–0.92) after further accounting for high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, and cystatin C. Additional adjustment for hemoglobin A1c, triglycerides, and γ-glutamyltransferase had little impact on this association (relative risk, 0.68; 95% confidence interval, 0.50–0.92). CONCLUSIONS—: Total adiponectin is inversely associated with risk of symptomatic lower extremity PAD in men.
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1© 2013 American Heart Association, Inc.
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abstractOBJECTIVE—: Lower concentrations of adiponectin have been linked to subsequent risk of coronary heart disease in healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral artery disease (PAD), is uncertain. We investigated the association between total adiponectin and risk of lower extremity PAD. APPROACH AND RESULTS—: We performed a prospective, nested case–control study among 18 225 male participants of the Health Professionals Follow-up Study who were free of diagnosed cardiovascular disease at the time of blood draw (1993–1995). During 14 years of follow-up, 143 men developed PAD. Using risk set sampling, controls were selected in a 3:1 ratio and matched on age, smoking status, fasting status, and date of blood draw (n=429). Median (interquartile range) adiponectin concentrations at baseline were lower among cases compared with controls (4.1 [3.2–5.5] versus 5.4 [3.8–7.5] µg/mL; P<0.001). A log-linear inverse association was evident over the full spectrum of adiponectin concentrations with PAD risk after controlling for baseline cardiovascular risk factors using restricted spline conditional logistic regression. Adiponectin was associated with a 42% lower risk of PAD per SD increase in natural log-transformed adiponectin (relative risk, 0.58; 95% confidence interval, 0.45–0.74) after adjustment for cardiovascular risk factors. The relative risk was attenuated (relative risk, 0.68; 95% confidence interval, 0.51–0.92) after further accounting for high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, and cystatin C. Additional adjustment for hemoglobin A1c, triglycerides, and γ-glutamyltransferase had little impact on this association (relative risk, 0.68; 95% confidence interval, 0.50–0.92). CONCLUSIONS—: Total adiponectin is inversely associated with risk of symptomatic lower extremity PAD in men.
pub© 2013 American Heart Association, Inc.
doi10.1161/ATVBAHA.112.301089
eissn15244636
date2013-05