schliessen

Filtern

 

Bibliotheken

Identify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study

This study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depres... Full description

Journal Title: NeuroReport 2018, Vol.29(11), pp.907-916
Main Author: Yang, X., Chunxia
Other Authors: Zhang, X., Aixia , Jia, X., Aixiang , Ma, X., Jack , Sun, X., Ning , Wang, X., Yanfang , Li, X., Xinrong , Liu, X., Zhifen , Liu, X., Sha , Xu, X., Yong , Zhang, X., Kerang
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0959-4965 ; DOI: 10.1097/WNR.0000000000001054
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: ovid10.1097/WNR.0000000000001054
title: Identify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
format: Article
creator:
  • Yang, X., Chunxia
  • Zhang, X., Aixia
  • Jia, X., Aixiang
  • Ma, X., Jack
  • Sun, X., Ning
  • Wang, X., Yanfang
  • Li, X., Xinrong
  • Liu, X., Zhifen
  • Liu, X., Sha
  • Xu, X., Yong
  • Zhang, X., Kerang
subjects:
  • Biological Markers -- Research
  • Brain -- Health Aspects
  • Brain -- Physiological Aspects
  • Magnetic Resonance Imaging -- Usage
  • Major Depressive Disorder -- Control
ispartof: NeuroReport, 2018, Vol.29(11), pp.907-916
description: This study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD. Overall, 13 of the 43 patients who had at least 3 years of follow-up care and the 17-item Hamilton Depression rating scale less than 7 took no antidepressants for more than half a year at the end of the 3-year follow-up. We further chose a group of 14 healthy controls matched for age, sex and education level with patients with rMDD. Multiple comparison analysis was performed for ALFF and ReHo. The statistical significance level was set at P value of less than 0.05. We examined whether there were differences among the three groups in the whole-brain ALFF and ReHo during resting state. Compared with healthy controls, patients with fMDD showed significant decrease of ReHo in the right anterior lobe of cerebellum and significant increase of ReHo in the right inferior temporal gyrus, and significant decrease of ALFF in the left inferior parietal lobule and right caudate nucleus. Compared with patients with rMDD, those with fMDD showed significant increase of ReHo in the right fusiform gyrus and the left middle temporal gyrus, and significant increase of ALFF in the right superior temporal gyrus. Compared with healthy controls, patients with rMDD showed significant increase of ReHo in the right supramarginal and significant decrease of ReHo in the right precuneus, and significant decrease of ALFF in the right lingual gyrus and in the left superior frontal lobe. Only patients with fMDD showed the relatively robust increase in intrinsic activity of temporal gyrus. The temporal gyrus may play a critical role in depressive symptomatology. Abnormal right fusiform gyrus, left middle temporal gyrus, and right superior temporal gyrus alterations were present only in patients with rMDD but not in patients with fMDD, indicating that these alterations may be a therapeutic target for MDD. Abnormal right supramarginal, right precuneus, right lingual gyrus and left superior frontal lobe alterations were present only in patients with rMDD and not in healthy con
language:
source:
identifier: ISSN: 0959-4965 ; DOI: 10.1097/WNR.0000000000001054
fulltext: fulltext
issn:
  • 0959-4965
  • 09594965
url: Link


@attributes
ID1528248185
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1097/WNR.0000000000001054
sourceidovid
recordidTN_ovid10.1097/WNR.0000000000001054
sourceformatXML
sourcesystemPC
pqid2057124590
galeid544854070
display
typearticle
titleIdentify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
creatorYang, X., Chunxia ; Zhang, X., Aixia ; Jia, X., Aixiang ; Ma, X., Jack ; Sun, X., Ning ; Wang, X., Yanfang ; Li, X., Xinrong ; Liu, X., Zhifen ; Liu, X., Sha ; Xu, X., Yong ; Zhang, X., Kerang
ispartofNeuroReport, 2018, Vol.29(11), pp.907-916
identifierISSN: 0959-4965 ; DOI: 10.1097/WNR.0000000000001054
descriptionThis study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD. Overall, 13 of the 43 patients who had at least 3 years of follow-up care and the 17-item Hamilton Depression rating scale less than 7 took no antidepressants for more than half a year at the end of the 3-year follow-up. We further chose a group of 14 healthy controls matched for age, sex and education level with patients with rMDD. Multiple comparison analysis was performed for ALFF and ReHo. The statistical significance level was set at P value of less than 0.05. We examined whether there were differences among the three groups in the whole-brain ALFF and ReHo during resting state. Compared with healthy controls, patients with fMDD showed significant decrease of ReHo in the right anterior lobe of cerebellum and significant increase of ReHo in the right inferior temporal gyrus, and significant decrease of ALFF in the left inferior parietal lobule and right caudate nucleus. Compared with patients with rMDD, those with fMDD showed significant increase of ReHo in the right fusiform gyrus and the left middle temporal gyrus, and significant increase of ALFF in the right superior temporal gyrus. Compared with healthy controls, patients with rMDD showed significant increase of ReHo in the right supramarginal and significant decrease of ReHo in the right precuneus, and significant decrease of ALFF in the right lingual gyrus and in the left superior frontal lobe. Only patients with fMDD showed the relatively robust increase in intrinsic activity of temporal gyrus. The temporal gyrus may play a critical role in depressive symptomatology. Abnormal right fusiform gyrus, left middle temporal gyrus, and right superior temporal gyrus alterations were present only in patients with rMDD but not in patients with fMDD, indicating that these alterations may be a therapeutic target for MDD. Abnormal right supramarginal, right precuneus, right lingual gyrus and left superior frontal lobe alterations were present only in patients with rMDD and not in healthy control, and thus may be used as a state marker of MDD.
source
subjectBiological Markers -- Research ; Brain -- Health Aspects ; Brain -- Physiological Aspects ; Magnetic Resonance Imaging -- Usage ; Major Depressive Disorder -- Control;
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutOvid.html$$EView_Wolters_Kluwer_Health,_Lippincott,_Williams_&_Wilkins_Copyright_Statement
search
creatorcontrib
0Yang, X, Chunxia
1Zhang, X, Aixia
2Jia, X, Aixiang
3Ma, X, Jack
4Sun, X, Ning
5Wang, X, Yanfang
6Li, X, Xinrong
7Liu, X, Zhifen
8Liu, X, Sha
9Xu, X, Yong
10Zhang, X, Kerang
titleIdentify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
descriptionThis study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD. Overall, 13 of the 43 patients who had at least 3 years of follow-up care and the 17-item Hamilton Depression rating scale less than 7 took no antidepressants for more than half a year at the end of the 3-year follow-up. We further chose a group of 14 healthy controls matched for age, sex and education level with patients with rMDD. Multiple comparison analysis was performed for ALFF and ReHo. The statistical significance level was set at P value of less than 0.05. We examined whether there were differences among the three groups in the whole-brain ALFF and ReHo during resting state. Compared with healthy controls, patients with fMDD showed significant decrease of ReHo in the right anterior lobe of cerebellum and significant increase of ReHo in the right inferior temporal gyrus, and significant decrease of ALFF in the left inferior parietal lobule and right caudate nucleus. Compared with patients with rMDD, those with fMDD showed significant increase of ReHo in the right fusiform gyrus and the left middle temporal gyrus, and significant increase of ALFF in the right superior temporal gyrus. Compared with healthy controls, patients with rMDD showed significant increase of ReHo in the right supramarginal and significant decrease of ReHo in the right precuneus, and significant decrease of ALFF in the right lingual gyrus and in the left superior frontal lobe. Only patients with fMDD showed the relatively robust increase in intrinsic activity of temporal gyrus. The temporal gyrus may play a critical role in depressive symptomatology. Abnormal right fusiform gyrus, left middle temporal gyrus, and right superior temporal gyrus alterations were present only in patients with rMDD but not in patients with fMDD, indicating that these alterations may be a therapeutic target for MDD. Abnormal right supramarginal, right precuneus, right lingual gyrus and left superior frontal lobe alterations were present only in patients with rMDD and not in healthy control, and thus may be used as a state marker of MDD.
general
010.1097/WNR.0000000000001054
1© 2018 Wolters Kluwer Health | Lippincott Williams & Wilkins
2Lippincott Williams & Wilkins - Journals
sourceidovid
recordidovid10.1097/WNR.0000000000001054
issn
00959-4965
109594965
rsrctypearticle
creationdate2018
addtitleNeuroReport
searchscopeovid
scopeovid
lsr30VSR-Enriched:[subject, date, galeid, pqid, eissn]
sort
titleIdentify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
authorYang, X., Chunxia ; Zhang, X., Aixia ; Jia, X., Aixiang ; Ma, X., Jack ; Sun, X., Ning ; Wang, X., Yanfang ; Li, X., Xinrong ; Liu, X., Zhifen ; Liu, X., Sha ; Xu, X., Yong ; Zhang, X., Kerang
creationdate20180800
facets
frbrgroupid7005198423863399471
frbrtype5
newrecords20180620
creationdate2018
collectionLippincott Williams & Wilkins Journals (Wolters Kluwer Health)
prefilterarticles
rsrctypearticles
creatorcontrib
0Yang, X., Chunxia
1Zhang, X., Aixia
2Jia, X., Aixiang
3Ma, X., Jack
4Sun, X., Ning
5Wang, X., Yanfang
6Li, X., Xinrong
7Liu, X., Zhifen
8Liu, X., Sha
9Xu, X., Yong
10Zhang, X., Kerang
jtitleNeuroReport
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Yang
1Zhang
2Jia
3Ma
4Sun
5Wang
6Li
7Liu
8Xu
aufirst
0Chunxia
1Aixia
2Aixiang
3Jack
4Ning
5Yanfang
6Xinrong
7Zhifen
8Sha
9Yong
10Kerang
auinitmX.
au
0Yang, X., Chunxia
1Zhang, X., Aixia
2Jia, X., Aixiang
3Ma, X., Jack
4Sun, X., Ning
5Wang, X., Yanfang
6Li, X., Xinrong
7Liu, X., Zhifen
8Liu, X., Sha
9Xu, X., Yong
10Zhang, X., Kerang
atitleIdentify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
jtitleNeuroReport
risdate201808
volume29
issue11
spage907
epage916
pages907-916
issn0959-4965
formatjournal
genrearticle
ristypeJOUR
abstractThis study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD. Overall, 13 of the 43 patients who had at least 3 years of follow-up care and the 17-item Hamilton Depression rating scale less than 7 took no antidepressants for more than half a year at the end of the 3-year follow-up. We further chose a group of 14 healthy controls matched for age, sex and education level with patients with rMDD. Multiple comparison analysis was performed for ALFF and ReHo. The statistical significance level was set at P value of less than 0.05. We examined whether there were differences among the three groups in the whole-brain ALFF and ReHo during resting state. Compared with healthy controls, patients with fMDD showed significant decrease of ReHo in the right anterior lobe of cerebellum and significant increase of ReHo in the right inferior temporal gyrus, and significant decrease of ALFF in the left inferior parietal lobule and right caudate nucleus. Compared with patients with rMDD, those with fMDD showed significant increase of ReHo in the right fusiform gyrus and the left middle temporal gyrus, and significant increase of ALFF in the right superior temporal gyrus. Compared with healthy controls, patients with rMDD showed significant increase of ReHo in the right supramarginal and significant decrease of ReHo in the right precuneus, and significant decrease of ALFF in the right lingual gyrus and in the left superior frontal lobe. Only patients with fMDD showed the relatively robust increase in intrinsic activity of temporal gyrus. The temporal gyrus may play a critical role in depressive symptomatology. Abnormal right fusiform gyrus, left middle temporal gyrus, and right superior temporal gyrus alterations were present only in patients with rMDD but not in patients with fMDD, indicating that these alterations may be a therapeutic target for MDD. Abnormal right supramarginal, right precuneus, right lingual gyrus and left superior frontal lobe alterations were present only in patients with rMDD and not in healthy control, and thus may be used as a state marker of MDD.
pub© 2018 Wolters Kluwer Health | Lippincott Williams & Wilkins
doi10.1097/WNR.0000000000001054
eissn1473558X
date2018-08-01