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Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women

BACKGROUND—: Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. METHODS AND RESULTS—: We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary hea... Full description

Journal Title: Circulation 2015, Vol.132(4), pp.260-268
Main Author: Malik, S., Vasanti
Other Authors: Chiuve, E., Stephanie , Campos, B., Hannia , Rimm, B., Eric , Mozaffarian, B., Dariush , Hu, B., Frank , Sun, B., Qi
Format: Electronic Article Electronic Article
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ID: ISSN: 0009-7322 ; DOI: 10.1161/CIRCULATIONAHA.114.014911
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recordid: ovid10.1161/CIRCULATIONAHA.114.014911
title: Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women
format: Article
creator:
  • Malik, S., Vasanti
  • Chiuve, E., Stephanie
  • Campos, B., Hannia
  • Rimm, B., Eric
  • Mozaffarian, B., Dariush
  • Hu, B., Frank
  • Sun, B., Qi
subjects:
  • Medicine
  • Anatomy & Physiology
ispartof: Circulation, 2015, Vol.132(4), pp.260-268
description: BACKGROUND—: Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. METHODS AND RESULTS—: We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases who were prospectively identified and confirmed among women in the Nurses’ Health Study (NHS; 1990–2006) and among men in the Health Professionals Follow-Up Study (HPFS; 1994–2008). A total of 1233 CHD-free controls were randomly selected and matched to cases in these 2 cohorts. Conditional logistic regression was used to estimate hazard ratios and 95% confidence intervals. Plasma VLCSFAs were correlated with favorable profiles of blood lipids, C-reactive protein, and adiponectin in the NHS and HPFS and with fasting insulin and C-peptide levels in a nationally representative US comparison population. After multivariate adjustment for lifestyle factors, body mass index, diet, and long-chain n-3 and trans fatty acids, total VLCSFAs in plasma were associated with a 52% decreased risk of CHD (pooled hazard ratio, 0.48; 95% confidence interval, 0.32–0.72, comparing extreme quintiles; Ptrend
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identifier: ISSN: 0009-7322 ; DOI: 10.1161/CIRCULATIONAHA.114.014911
fulltext: fulltext
issn:
  • 0009-7322
  • 00097322
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titleCirculating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women
creatorMalik, S., Vasanti ; Chiuve, E., Stephanie ; Campos, B., Hannia ; Rimm, B., Eric ; Mozaffarian, B., Dariush ; Hu, B., Frank ; Sun, B., Qi
ispartofCirculation, 2015, Vol.132(4), pp.260-268
identifierISSN: 0009-7322 ; DOI: 10.1161/CIRCULATIONAHA.114.014911
descriptionBACKGROUND—: Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. METHODS AND RESULTS—: We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases who were prospectively identified and confirmed among women in the Nurses’ Health Study (NHS; 1990–2006) and among men in the Health Professionals Follow-Up Study (HPFS; 1994–2008). A total of 1233 CHD-free controls were randomly selected and matched to cases in these 2 cohorts. Conditional logistic regression was used to estimate hazard ratios and 95% confidence intervals. Plasma VLCSFAs were correlated with favorable profiles of blood lipids, C-reactive protein, and adiponectin in the NHS and HPFS and with fasting insulin and C-peptide levels in a nationally representative US comparison population. After multivariate adjustment for lifestyle factors, body mass index, diet, and long-chain n-3 and trans fatty acids, total VLCSFAs in plasma were associated with a 52% decreased risk of CHD (pooled hazard ratio, 0.48; 95% confidence interval, 0.32–0.72, comparing extreme quintiles; Ptrend<0.0001). For VLCSFAs in erythrocytes, a nonsignificant inverse trend with CHD risk was observed (pooled hazard ratio, 0.66; 95% confidence interval, 0.41–1.06, comparing extreme quintiles; Ptrend=0.16). CONCLUSIONS—: In US men and women, plasma VLCSFAs were independently associated with favorable profiles of blood lipids and other cardiovascular disease risk markers and a lower risk of CHD. Erythrocyte VLCSFAs were associated with nonsignificant trends of lower CHD risk. Future studies are warranted to elucidate the underlying biological mechanisms.
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titleCirculating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women
descriptionBACKGROUND—: Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. METHODS AND RESULTS—: We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases who were prospectively identified and confirmed among women in the Nurses’ Health Study (NHS; 1990–2006) and among men in the Health Professionals Follow-Up Study (HPFS; 1994–2008). A total of 1233 CHD-free controls were randomly selected and matched to cases in these 2 cohorts. Conditional logistic regression was used to estimate hazard ratios and 95% confidence intervals. Plasma VLCSFAs were correlated with favorable profiles of blood lipids, C-reactive protein, and adiponectin in the NHS and HPFS and with fasting insulin and C-peptide levels in a nationally representative US comparison population. After multivariate adjustment for lifestyle factors, body mass index, diet, and long-chain n-3 and trans fatty acids, total VLCSFAs in plasma were associated with a 52% decreased risk of CHD (pooled hazard ratio, 0.48; 95% confidence interval, 0.32–0.72, comparing extreme quintiles; Ptrend<0.0001). For VLCSFAs in erythrocytes, a nonsignificant inverse trend with CHD risk was observed (pooled hazard ratio, 0.66; 95% confidence interval, 0.41–1.06, comparing extreme quintiles; Ptrend=0.16). CONCLUSIONS—: In US men and women, plasma VLCSFAs were independently associated with favorable profiles of blood lipids and other cardiovascular disease risk markers and a lower risk of CHD. Erythrocyte VLCSFAs were associated with nonsignificant trends of lower CHD risk. Future studies are warranted to elucidate the underlying biological mechanisms.
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abstractBACKGROUND—: Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. METHODS AND RESULTS—: We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases who were prospectively identified and confirmed among women in the Nurses’ Health Study (NHS; 1990–2006) and among men in the Health Professionals Follow-Up Study (HPFS; 1994–2008). A total of 1233 CHD-free controls were randomly selected and matched to cases in these 2 cohorts. Conditional logistic regression was used to estimate hazard ratios and 95% confidence intervals. Plasma VLCSFAs were correlated with favorable profiles of blood lipids, C-reactive protein, and adiponectin in the NHS and HPFS and with fasting insulin and C-peptide levels in a nationally representative US comparison population. After multivariate adjustment for lifestyle factors, body mass index, diet, and long-chain n-3 and trans fatty acids, total VLCSFAs in plasma were associated with a 52% decreased risk of CHD (pooled hazard ratio, 0.48; 95% confidence interval, 0.32–0.72, comparing extreme quintiles; Ptrend<0.0001). For VLCSFAs in erythrocytes, a nonsignificant inverse trend with CHD risk was observed (pooled hazard ratio, 0.66; 95% confidence interval, 0.41–1.06, comparing extreme quintiles; Ptrend=0.16). CONCLUSIONS—: In US men and women, plasma VLCSFAs were independently associated with favorable profiles of blood lipids and other cardiovascular disease risk markers and a lower risk of CHD. Erythrocyte VLCSFAs were associated with nonsignificant trends of lower CHD risk. Future studies are warranted to elucidate the underlying biological mechanisms.
pub© 2015 by the American College of Cardiology Foundation and the American Heart Association, Inc.
doi10.1161/CIRCULATIONAHA.114.014911
eissn15244539
date2015-07-28