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Protective effect of epicardial adiponectin on atrial fibrillation following cardiac surgery

Objective: Inflammation has been implicated in the pathogenesis of postoperative atrial fibrillation (AF). Adipose tissue secretes both pro-inflammatory cytokines such as interleukin-6 (IL-6) and anti-inflammatory mediators such as adiponectin. We set out to examine the association of adiponectin an... Full description

Journal Title: European Journal of Cardio-Thoracic Surgery 2011, Vol. 39(2), pp.228-232
Main Author: Kourliouros, Antonios
Other Authors: Karastergiou, Kalypso , Nowell, Justin , Gukop, Philemon , Tavakkoli Hosseini, Morteza , Valencia, Oswaldo , Mohamed Ali, Vidya , Jahangiri, Marjan
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ID: ISSN: 1010-7940 ; E-ISSN: 1873-734X ; DOI: 10.1016/j.ejcts.2010.05.006
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recordid: oxford10.1016/j.ejcts.2010.05.006
title: Protective effect of epicardial adiponectin on atrial fibrillation following cardiac surgery
format: Article
creator:
  • Kourliouros, Antonios
  • Karastergiou, Kalypso
  • Nowell, Justin
  • Gukop, Philemon
  • Tavakkoli Hosseini, Morteza
  • Valencia, Oswaldo
  • Mohamed Ali, Vidya
  • Jahangiri, Marjan
subjects:
  • Atrial Fibrillation
  • Inflammation
  • Epicardial Adipose Tissue
  • Adiponectin
ispartof: European Journal of Cardio-Thoracic Surgery, 2011, Vol. 39(2), pp.228-232
description: Objective: Inflammation has been implicated in the pathogenesis of postoperative atrial fibrillation (AF). Adipose tissue secretes both pro-inflammatory cytokines such as interleukin-6 (IL-6) and anti-inflammatory mediators such as adiponectin. We set out to examine the association of adiponectin and IL-6, both circulating and locally produced by the epicardial adipose tissue, with AF development after cardiac surgery. Methods: A total of 90 consecutive patients undergoing cardiac surgery were evaluated. Blood samples were collected before induction of anaesthesia. Epicardial fat was obtained upon commencement of cardiopulmonary bypass. IL-6 and adiponectin levels were determined in serum and supernatant of epicardial adipose tissue organ cultures with two-site enzyme-linked immunosorbent assay (ELISA). Heart rhythm was assessed with continuous tele-monitoring for 72 h postoperatively, and with 6-hourly clinical examinations and daily electrocardiograms (ECGs) thereafter. Results: A total of 36 patients developed postoperative AF (40%). Baseline-serum IL-6 and adiponectin were not associated with AF ( p  = 0.86 and 0.95, respectively). Epicardial adipose tissue IL-6 levels did not correlate with the development of the arrhythmia either ( p  = 0.37). However, epicardial adiponectin release was lower in patients who developed AF than in those who remained in sinus rhythm (76 (interquartile range (IQR) 35–98) vs 53 ((IQR) 35–69) ng h −1  g −1 of tissue cultured, p  = 0.066). Following linear regression, the association of epicardial adiponectin with AF almost reached statistical significance ( p  = 0.066). Multivariate logistic regression analysis of identified risk factors for AF, with the inclusion of epicardial adiponectin as an independent variable, revealed increased age (odds ratio (OR) 1.09, 95% confidence interval (CI) 1.02–1.17, p  = 0.013) and epicardial adiponectin levels (OR 0.98, 95% CI 0.97–1.00, p  = 0.054) as independent predictors of postoperative AF. Conclusions: Increased epicardial adiponectin is associated with maintenance of sinus rhythm following cardiac surgery. This reinforces the inflammatory hypothesis in the pathogenesis of postoperative AF and may represent a novel therapeutic target for its effective prevention.
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identifier: ISSN: 1010-7940 ; E-ISSN: 1873-734X ; DOI: 10.1016/j.ejcts.2010.05.006
fulltext: fulltext
issn:
  • 1010-7940
  • 10107940
  • 1873-734X
  • 1873734X
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titleProtective effect of epicardial adiponectin on atrial fibrillation following cardiac surgery
creatorKourliouros, Antonios ; Karastergiou, Kalypso ; Nowell, Justin ; Gukop, Philemon ; Tavakkoli Hosseini, Morteza ; Valencia, Oswaldo ; Mohamed Ali, Vidya ; Jahangiri, Marjan
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subjectAtrial Fibrillation ; Inflammation ; Epicardial Adipose Tissue ; Adiponectin
descriptionObjective: Inflammation has been implicated in the pathogenesis of postoperative atrial fibrillation (AF). Adipose tissue secretes both pro-inflammatory cytokines such as interleukin-6 (IL-6) and anti-inflammatory mediators such as adiponectin. We set out to examine the association of adiponectin and IL-6, both circulating and locally produced by the epicardial adipose tissue, with AF development after cardiac surgery. Methods: A total of 90 consecutive patients undergoing cardiac surgery were evaluated. Blood samples were collected before induction of anaesthesia. Epicardial fat was obtained upon commencement of cardiopulmonary bypass. IL-6 and adiponectin levels were determined in serum and supernatant of epicardial adipose tissue organ cultures with two-site enzyme-linked immunosorbent assay (ELISA). Heart rhythm was assessed with continuous tele-monitoring for 72 h postoperatively, and with 6-hourly clinical examinations and daily electrocardiograms (ECGs) thereafter. Results: A total of 36 patients developed postoperative AF (40%). Baseline-serum IL-6 and adiponectin were not associated with AF ( p  = 0.86 and 0.95, respectively). Epicardial adipose tissue IL-6 levels did not correlate with the development of the arrhythmia either ( p  = 0.37). However, epicardial adiponectin release was lower in patients who developed AF than in those who remained in sinus rhythm (76 (interquartile range (IQR) 35–98) vs 53 ((IQR) 35–69) ng h −1  g −1 of tissue cultured, p  = 0.066). Following linear regression, the association of epicardial adiponectin with AF almost reached statistical significance ( p  = 0.066). Multivariate logistic regression analysis of identified risk factors for AF, with the inclusion of epicardial adiponectin as an independent variable, revealed increased age (odds ratio (OR) 1.09, 95% confidence interval (CI) 1.02–1.17, p  = 0.013) and epicardial adiponectin levels (OR 0.98, 95% CI 0.97–1.00, p  = 0.054) as independent predictors of postoperative AF. Conclusions: Increased epicardial adiponectin is associated with maintenance of sinus rhythm following cardiac surgery. This reinforces the inflammatory hypothesis in the pathogenesis of postoperative AF and may represent a novel therapeutic target for its effective prevention.
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titleProtective effect of epicardial adiponectin on atrial fibrillation following cardiac surgery
descriptionObjective: Inflammation has been implicated in the pathogenesis of postoperative atrial fibrillation (AF). Adipose tissue secretes both pro-inflammatory cytokines such as interleukin-6 (IL-6) and anti-inflammatory mediators such as adiponectin. We set out to examine the association of adiponectin and IL-6, both circulating and locally produced by the epicardial adipose tissue, with AF development after cardiac surgery. Methods: A total of 90 consecutive patients undergoing cardiac surgery were evaluated. Blood samples were collected before induction of anaesthesia. Epicardial fat was obtained upon commencement of cardiopulmonary bypass. IL-6 and adiponectin levels were determined in serum and supernatant of epicardial adipose tissue organ cultures with two-site enzyme-linked immunosorbent assay (ELISA). Heart rhythm was assessed with continuous tele-monitoring for 72 h postoperatively, and with 6-hourly clinical examinations and daily electrocardiograms (ECGs) thereafter. Results: A total of 36 patients developed postoperative AF (40%). Baseline-serum IL-6 and adiponectin were not associated with AF ( p  = 0.86 and 0.95, respectively). Epicardial adipose tissue IL-6 levels did not correlate with the development of the arrhythmia either ( p  = 0.37). However, epicardial adiponectin release was lower in patients who developed AF than in those who remained in sinus rhythm (76 (interquartile range (IQR) 35–98) vs 53 ((IQR) 35–69) ng h −1  g −1 of tissue cultured, p  = 0.066). Following linear regression, the association of epicardial adiponectin with AF almost reached statistical significance ( p  = 0.066). Multivariate logistic regression analysis of identified risk factors for AF, with the inclusion of epicardial adiponectin as an independent variable, revealed increased age (odds ratio (OR) 1.09, 95% confidence interval (CI) 1.02–1.17, p  = 0.013) and epicardial adiponectin levels (OR 0.98, 95% CI 0.97–1.00, p  = 0.054) as independent predictors of postoperative AF. Conclusions: Increased epicardial adiponectin is associated with maintenance of sinus rhythm following cardiac surgery. This reinforces the inflammatory hypothesis in the pathogenesis of postoperative AF and may represent a novel therapeutic target for its effective prevention.
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abstractObjective: Inflammation has been implicated in the pathogenesis of postoperative atrial fibrillation (AF). Adipose tissue secretes both pro-inflammatory cytokines such as interleukin-6 (IL-6) and anti-inflammatory mediators such as adiponectin. We set out to examine the association of adiponectin and IL-6, both circulating and locally produced by the epicardial adipose tissue, with AF development after cardiac surgery. Methods: A total of 90 consecutive patients undergoing cardiac surgery were evaluated. Blood samples were collected before induction of anaesthesia. Epicardial fat was obtained upon commencement of cardiopulmonary bypass. IL-6 and adiponectin levels were determined in serum and supernatant of epicardial adipose tissue organ cultures with two-site enzyme-linked immunosorbent assay (ELISA). Heart rhythm was assessed with continuous tele-monitoring for 72 h postoperatively, and with 6-hourly clinical examinations and daily electrocardiograms (ECGs) thereafter. Results: A total of 36 patients developed postoperative AF (40%). Baseline-serum IL-6 and adiponectin were not associated with AF ( p  = 0.86 and 0.95, respectively). Epicardial adipose tissue IL-6 levels did not correlate with the development of the arrhythmia either ( p  = 0.37). However, epicardial adiponectin release was lower in patients who developed AF than in those who remained in sinus rhythm (76 (interquartile range (IQR) 35–98) vs 53 ((IQR) 35–69) ng h −1  g −1 of tissue cultured, p  = 0.066). Following linear regression, the association of epicardial adiponectin with AF almost reached statistical significance ( p  = 0.066). Multivariate logistic regression analysis of identified risk factors for AF, with the inclusion of epicardial adiponectin as an independent variable, revealed increased age (odds ratio (OR) 1.09, 95% confidence interval (CI) 1.02–1.17, p  = 0.013) and epicardial adiponectin levels (OR 0.98, 95% CI 0.97–1.00, p  = 0.054) as independent predictors of postoperative AF. Conclusions: Increased epicardial adiponectin is associated with maintenance of sinus rhythm following cardiac surgery. This reinforces the inflammatory hypothesis in the pathogenesis of postoperative AF and may represent a novel therapeutic target for its effective prevention.
pubElsevier Science B.V.
doi10.1016/j.ejcts.2010.05.006
date2011-02