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Diet quality and genetic association with body mass index: results from 3 observational studies

ABSTRACT Background It is unknown whether dietary quality modifies genetic association with body mass index (BMI). Objective This study examined whether dietary quality modifies genetic association with BMI. Design We calculated 3 diet quality scores including the Alternative Healthy Eating Index 20... Full description

Journal Title: The American Journal of Clinical Nutrition 2018, Vol. 108(6), pp.1291-1300
Main Author: Ding, Ming
Other Authors: Ellervik, Christina , Huang, Tao , Jensen, Majken K , Curhan, Gary C , Pasquale, Louis R , Kang, Jae H , Wiggs, Janey L , Hunter, David J , Willett, Walter C , Rimm, Eric B , Kraft, Peter , Chasman, Daniel I , Qi, Lu , Hu, Frank B , Qi, Qibin
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ID: ISSN: 0002-9165 ; E-ISSN: 1938-3207 ; DOI: 10.1093/ajcn/nqy203
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recordid: oxford10.1093/ajcn/nqy203
title: Diet quality and genetic association with body mass index: results from 3 observational studies
format: Article
creator:
  • Ding, Ming
  • Ellervik, Christina
  • Huang, Tao
  • Jensen, Majken K
  • Curhan, Gary C
  • Pasquale, Louis R
  • Kang, Jae H
  • Wiggs, Janey L
  • Hunter, David J
  • Willett, Walter C
  • Rimm, Eric B
  • Kraft, Peter
  • Chasman, Daniel I
  • Qi, Lu
  • Hu, Frank B
  • Qi, Qibin
subjects:
  • Body Mass Index
  • Genetic Risk Score
  • Diet Scores
ispartof: The American Journal of Clinical Nutrition, 2018, Vol. 108(6), pp.1291-1300
description: ABSTRACT Background It is unknown whether dietary quality modifies genetic association with body mass index (BMI). Objective This study examined whether dietary quality modifies genetic association with BMI. Design We calculated 3 diet quality scores including the Alternative Healthy Eating Index 2010 (AHEI-2010), the Alternative Mediterranean Diet score (AMED), and the Dietary Approach to Stop Hypertension (DASH) diet score. We examined the interactions of a genetic risk score (GRS) based on 97 BMI-associated variants with the 3 diet quality scores on BMI in 30,904 participants from 3 large cohorts. Results We found significant interactions between total GRS and all 3 diet scores on BMI assessed after 2–3 y, with an attenuated genetic effect observed in individuals with healthier diets (AHEI: P-interaction = 0.003; AMED: P = 0.001; DASH: P = 0.004). For example, the difference in BMI (kg/m2) per 10-unit increment of the GRS was smaller among participants in the highest tertile of AHEI score compared with those in the lowest tertile (0.84; 95% CI: 0.72, 0.96 compared with 1.14; 95% CI: 0.99, 1.29). Results were consistent across the 3 cohorts with no significant heterogeneity. The interactions with diet scores on BMI appeared more significant for central nervous system GRSs (P  0.05 for 3 diet scores). Conclusions A higher diet quality attenuated genetic predisposition to obesity. These findings underscore the importance of maintaining a healthful diet for the prevention of obesity, particularly for those individuals with a strong genetic predisposition to obesity. This trial was registered with the Clinical Trial Registry as NCT03577639.
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identifier: ISSN: 0002-9165 ; E-ISSN: 1938-3207 ; DOI: 10.1093/ajcn/nqy203
fulltext: fulltext
issn:
  • 0002-9165
  • 00029165
  • 1938-3207
  • 19383207
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titleDiet quality and genetic association with body mass index: results from 3 observational studies
creatorDing, Ming ; Ellervik, Christina ; Huang, Tao ; Jensen, Majken K ; Curhan, Gary C ; Pasquale, Louis R ; Kang, Jae H ; Wiggs, Janey L ; Hunter, David J ; Willett, Walter C ; Rimm, Eric B ; Kraft, Peter ; Chasman, Daniel I ; Qi, Lu ; Hu, Frank B ; Qi, Qibin
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descriptionABSTRACT Background It is unknown whether dietary quality modifies genetic association with body mass index (BMI). Objective This study examined whether dietary quality modifies genetic association with BMI. Design We calculated 3 diet quality scores including the Alternative Healthy Eating Index 2010 (AHEI-2010), the Alternative Mediterranean Diet score (AMED), and the Dietary Approach to Stop Hypertension (DASH) diet score. We examined the interactions of a genetic risk score (GRS) based on 97 BMI-associated variants with the 3 diet quality scores on BMI in 30,904 participants from 3 large cohorts. Results We found significant interactions between total GRS and all 3 diet scores on BMI assessed after 2–3 y, with an attenuated genetic effect observed in individuals with healthier diets (AHEI: P-interaction = 0.003; AMED: P = 0.001; DASH: P = 0.004). For example, the difference in BMI (kg/m2) per 10-unit increment of the GRS was smaller among participants in the highest tertile of AHEI score compared with those in the lowest tertile (0.84; 95% CI: 0.72, 0.96 compared with 1.14; 95% CI: 0.99, 1.29). Results were consistent across the 3 cohorts with no significant heterogeneity. The interactions with diet scores on BMI appeared more significant for central nervous system GRSs (P < 0.01 for 3 diet scores) than for non–central nervous system GRSs (P > 0.05 for 3 diet scores). Conclusions A higher diet quality attenuated genetic predisposition to obesity. These findings underscore the importance of maintaining a healthful diet for the prevention of obesity, particularly for those individuals with a strong genetic predisposition to obesity. This trial was registered with the Clinical Trial Registry as NCT03577639.
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authorDing, Ming ; Ellervik, Christina ; Huang, Tao ; Jensen, Majken K ; Curhan, Gary C ; Pasquale, Louis R ; Kang, Jae H ; Wiggs, Janey L ; Hunter, David J ; Willett, Walter C ; Rimm, Eric B ; Kraft, Peter ; Chasman, Daniel I ; Qi, Lu ; Hu, Frank B ; Qi, Qibin
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