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Therapeutic Plasma Exchange and Its Impact on Drug Levels

Abstract Objectives To examine and summarize the current literature on the effects of therapeutic plasma exchange on medication levels. Methods Literature review was performed via searches of the Cochrane Database and PubMed-MEDLINE (1996 to August 2016) looking for all case reports, case series, an... Full description

Journal Title: American Journal of Clinical Pathology 2017, Vol. 148(3), pp.190-198
Main Author: Cheng, Caleb W
Other Authors: Hendrickson, Jeanne E , Tormey, Christopher A , Sidhu, Davinder
Format: Electronic Article Electronic Article
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ID: ISSN: 0002-9173 ; E-ISSN: 1943-7722 ; DOI: 10.1093/ajcp/aqx056
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recordid: oxford10.1093/ajcp/aqx056
title: Therapeutic Plasma Exchange and Its Impact on Drug Levels
format: Article
creator:
  • Cheng, Caleb W
  • Hendrickson, Jeanne E
  • Tormey, Christopher A
  • Sidhu, Davinder
subjects:
  • Pathology Consultation
  • Therapeutic Plasma Exchange
  • Pharmacokinetics
ispartof: American Journal of Clinical Pathology, 2017, Vol. 148(3), pp.190-198
description: Abstract Objectives To examine and summarize the current literature on the effects of therapeutic plasma exchange on medication levels. Methods Literature review was performed via searches of the Cochrane Database and PubMed-MEDLINE (1996 to August 2016) looking for all case reports, case series, and human randomized controlled trials involving therapeutic plasma exchange (TPE)–associated drug removal. Results Approximately 60 peer-reviewed articles were identified with the majority being case reports; no randomized controlled trials were identified. These reports and the authors’ own experiences were used to derive practical guidance regarding the effect of TPE on circulating drug levels. Conclusions There were several limitations with existing studies, many of which relate to procedural and/or clinical properties of patients undergoing TPE. As such, additional studies are needed before definitive guidelines can be established. There is clear need for development of consensus and additional investigations in this domain.
language:
source:
identifier: ISSN: 0002-9173 ; E-ISSN: 1943-7722 ; DOI: 10.1093/ajcp/aqx056
fulltext: fulltext
issn:
  • 0002-9173
  • 00029173
  • 1943-7722
  • 19437722
url: Link


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descriptionAbstract Objectives To examine and summarize the current literature on the effects of therapeutic plasma exchange on medication levels. Methods Literature review was performed via searches of the Cochrane Database and PubMed-MEDLINE (1996 to August 2016) looking for all case reports, case series, and human randomized controlled trials involving therapeutic plasma exchange (TPE)–associated drug removal. Results Approximately 60 peer-reviewed articles were identified with the majority being case reports; no randomized controlled trials were identified. These reports and the authors’ own experiences were used to derive practical guidance regarding the effect of TPE on circulating drug levels. Conclusions There were several limitations with existing studies, many of which relate to procedural and/or clinical properties of patients undergoing TPE. As such, additional studies are needed before definitive guidelines can be established. There is clear need for development of consensus and additional investigations in this domain.
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