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Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals

Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes—particularly, among individuals with a similar body mass index—could be related to concentrations of persistent organic pollutants (POPs). To our knowle... Full description

Journal Title: American Journal of Epidemiology 2018, Vol. 187(3), pp.494-506
Main Author: Gasull, Magda
Other Authors: Castell, Conxa , Pallarès, Natàlia , Miret, Carme , Pumarega, José , Téllez - Plaza, María , López, Tomàs , Salas - Salvadó, Jordi , Lee, Duk - Hee , Goday, Albert , Porta, Miquel
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ID: ISSN: 0002-9262 ; E-ISSN: 1476-6256 ; DOI: 10.1093/aje/kwx267
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recordid: oxford10.1093/aje/kwx267
title: Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals
format: Article
creator:
  • Gasull, Magda
  • Castell, Conxa
  • Pallarès, Natàlia
  • Miret, Carme
  • Pumarega, José
  • Téllez - Plaza, María
  • López, Tomàs
  • Salas - Salvadó, Jordi
  • Lee, Duk - Hee
  • Goday, Albert
  • Porta, Miquel
subjects:
  • Environmental Exposure/Adverse Effects
  • Environmental Pollutants/Toxicity
  • Health Survey
  • Human Biomonitoring
  • Metabolic Phenotype
  • Metabolic Syndrome
  • Metabolically Healthy Obese
  • Persistent Organic Pollutants
ispartof: American Journal of Epidemiology, 2018, Vol. 187(3), pp.494-506
description: Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes—particularly, among individuals with a similar body mass index—could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, β-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.
language:
source:
identifier: ISSN: 0002-9262 ; E-ISSN: 1476-6256 ; DOI: 10.1093/aje/kwx267
fulltext: fulltext
issn:
  • 0002-9262
  • 00029262
  • 1476-6256
  • 14766256
url: Link


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titleBlood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals
creatorGasull, Magda ; Castell, Conxa ; Pallarès, Natàlia ; Miret, Carme ; Pumarega, José ; Téllez - Plaza, María ; López, Tomàs ; Salas - Salvadó, Jordi ; Lee, Duk - Hee ; Goday, Albert ; Porta, Miquel
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subjectEnvironmental Exposure/Adverse Effects ; Environmental Pollutants/Toxicity ; Health Survey ; Human Biomonitoring ; Metabolic Phenotype ; Metabolic Syndrome ; Metabolically Healthy Obese ; Persistent Organic Pollutants
descriptionFactors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes—particularly, among individuals with a similar body mass index—could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, β-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.
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titleBlood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals
descriptionFactors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes—particularly, among individuals with a similar body mass index—could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, β-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.
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authorGasull, Magda ; Castell, Conxa ; Pallarès, Natàlia ; Miret, Carme ; Pumarega, José ; Téllez - Plaza, María ; López, Tomàs ; Salas - Salvadó, Jordi ; Lee, Duk - Hee ; Goday, Albert ; Porta, Miquel
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abstractFactors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes—particularly, among individuals with a similar body mass index—could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, β-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.
pubOxford University Press
doi10.1093/aje/kwx267
date2018-03-01