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Influence of sibutramine in addition to diet and exercise on the relationship between weight loss and blood glucose changes

Abstract Aims Weight loss is expected to improve glycaemic control in patients with diabetes or at high risk hereof. Sibutramine causes weight loss and is associated with an increased risk of myocardial infarction and stroke in high-risk patients. We examined the impact of sibutramine-induced weight... Full description

Journal Title: European Heart Journal – Cardiovascular Pharmacotherapy 2017, Vol. 3(3), pp.134-139
Main Author: Kamil, Sadaf
Other Authors: Finer, Nicholas , James, William Philip T , Caterson, Ian D , Andersson, Charlotte , Torp - Pedersen, Christian
Format: Electronic Article Electronic Article
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ID: ISSN: 2055-6837 ; E-ISSN: 2055-6845 ; DOI: 10.1093/ehjcvp/pvw029
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recordid: oxford10.1093/ehjcvp/pvw029
title: Influence of sibutramine in addition to diet and exercise on the relationship between weight loss and blood glucose changes
format: Article
creator:
  • Kamil, Sadaf
  • Finer, Nicholas
  • James, William Philip T
  • Caterson, Ian D
  • Andersson, Charlotte
  • Torp - Pedersen, Christian
subjects:
  • Type 2 Diabetes Mellitus
  • Haemoglobin A
  • Blood Glucose
  • Weight Loss
  • Sibutramine
  • Cardiovascular Heart Disease
ispartof: European Heart Journal – Cardiovascular Pharmacotherapy, 2017, Vol. 3(3), pp.134-139
description: Abstract Aims Weight loss is expected to improve glycaemic control in patients with diabetes or at high risk hereof. Sibutramine causes weight loss and is associated with an increased risk of myocardial infarction and stroke in high-risk patients. We examined the impact of sibutramine-induced weight loss on glycaemic control. Methods and results In total, 8192 obese patients with diabetes were randomized to sibutramine or placebo plus diet and exercise after a preliminary 6 weeks in which all patients received sibutramine. Patients were classified into four groups of weight change. A total of 1582 patients had a weight loss >5.7 kg; 2047 patients lost 3.7–5.7 kg; 2432 patients lost 
language:
source:
identifier: ISSN: 2055-6837 ; E-ISSN: 2055-6845 ; DOI: 10.1093/ehjcvp/pvw029
fulltext: fulltext
issn:
  • 2055-6837
  • 20556837
  • 2055-6845
  • 20556845
url: Link


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titleInfluence of sibutramine in addition to diet and exercise on the relationship between weight loss and blood glucose changes
creatorKamil, Sadaf ; Finer, Nicholas ; James, William Philip T ; Caterson, Ian D ; Andersson, Charlotte ; Torp - Pedersen, Christian
ispartofEuropean Heart Journal – Cardiovascular Pharmacotherapy, 2017, Vol. 3(3), pp.134-139
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subjectType 2 Diabetes Mellitus ; Haemoglobin A ; Blood Glucose ; Weight Loss ; Sibutramine ; Cardiovascular Heart Disease
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descriptionAbstract Aims Weight loss is expected to improve glycaemic control in patients with diabetes or at high risk hereof. Sibutramine causes weight loss and is associated with an increased risk of myocardial infarction and stroke in high-risk patients. We examined the impact of sibutramine-induced weight loss on glycaemic control. Methods and results In total, 8192 obese patients with diabetes were randomized to sibutramine or placebo plus diet and exercise after a preliminary 6 weeks in which all patients received sibutramine. Patients were classified into four groups of weight change. A total of 1582 patients had a weight loss >5.7 kg; 2047 patients lost 3.7–5.7 kg; 2432 patients lost <3.7 kg, and 1875 patients gained weight. Patients on sibutramine lost slightly more weight than those on placebo (−0.2 kg on average, P < 0.0001). Mean blood glucose changes in the placebo group were −0.6 mmol/L (±3.1, P = 0.0002), −0.2  mmol/L (±2.7, P = 0.04), and −0.1  mmol/L (±3.0, P = 0.01) in the moderate, modest, and mild weight loss groups, respectively; in the weight gain group blood glucose levels increased by +0.2 mmol/L (±3.1, P = 0.003). Corresponding mean blood glucose changes in the sibutramine-treated patients were −0.4 mmol/L (±3.2, P = 0.0002), +0.1 mmol/L (±3.0, P = 0.04), +0.4 mmol/L (±2.8, P = 0.01), and +0.2 mmol/L (±3.4, P = 0.003). Mean values of HbA1c followed the same pattern though the HbA1c changes were smaller with weight loss and greater with weight gain in the sibutramine group. All results were statistically significant (P < 0.0001). Conclusion Weight loss induced by sibutramine, diet, and exercise attenuates falls in blood glucose levels and HbA1c compared with similar weight loss with placebo, diet, and exercise.
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