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Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent... Full description

Journal Title: Human Molecular Genetics 2015, Vol. 24(6), pp.1791-1800
Main Author: He, Meian
Other Authors: Xu, Min , Zhang, Ben , Liang, Jun , Chen, Peng , Lee, Jong - Young , Johnson, Todd A , Li, Huaixing , Yang, Xiaobo , Dai, Juncheng , Liang, Liming , Gui, Lixuan , Qi, Qibin , Huang, Jinyan , Li, Yanping , Adair, Linda S , Aung, Tin , Cai, Qiuyin , Cheng, Ching - Yu , Cho, Myeong - Chan , Cho, Yoon Shin , Chu, Minjie , Cui, Bin , Gao, Yu - Tang , Go, Min Jin , Gu, Dongfeng , Gu, Weiqiong , Guo, Huan , Hao, Yongchen , Hong, Jie , Hu, Zhibin , Hu, Yanling , Huang, Jianfeng , Hwang, Joo - Yeon , Ikram, Mohammad Kamran , Jin, Guangfu , Kang, Dae - Hee , Khor, Chiea Chuen , Kim, Bong - Jo , Kim, Hung Tae , Kubo, Michiaki , Lee, Jeannette , Lee, Juyoung , Lee, Nanette R , Li, Ruoying , Li, Jun , Liu, Jianjun , Longe, Jirong , Lu, Wei , Lu, Xiangfeng , Miao, Xiaoping , Okada, Yukinori , Ong, Rick Twee - Hee , Qiu, Gaokun , Seielstad, Mark , Sim, Xueling , Song, Huaidong , Takeuchi, Fumihiko , Tanaka, Toshihiro , Taylor, Phil R , Wang, Laiyuan , Wang, Weiqing , Wang, Yiqin , Wu, Chen , Wu, Ying , Xiang, Yong - Bing , Yamamoto, Ken , Yang, Handong , Liao, Ming , Yokota, Mitsuhiro , Young, Terri , Zhang, Xiaomin , Kato, Norihiro , Wang, Qing K , Zheng, Wei , Hu, Frank B , Lin, Dongxin , Shen, Hongbing , Teo, Yik Ying , Mo, Zengnan , Wong, Tien Yin , Lin, Xu , Mohlke, Karen L , Ning, Guang , Tsunoda, Tatsuhiko , Han, Bok - Ghee , Shu, Xiao - Ou , Tai, E. Shyong , Wu, Tangchun , Qi, Lu
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ID: ISSN: 0964-6906 ; E-ISSN: 1460-2083 ; DOI: 10.1093/hmg/ddu583
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recordid: oxford10.1093/hmg/ddu583
title: Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
format: Article
creator:
  • He, Meian
  • Xu, Min
  • Zhang, Ben
  • Liang, Jun
  • Chen, Peng
  • Lee, Jong - Young
  • Johnson, Todd A
  • Li, Huaixing
  • Yang, Xiaobo
  • Dai, Juncheng
  • Liang, Liming
  • Gui, Lixuan
  • Qi, Qibin
  • Huang, Jinyan
  • Li, Yanping
  • Adair, Linda S
  • Aung, Tin
  • Cai, Qiuyin
  • Cheng, Ching - Yu
  • Cho, Myeong - Chan
  • Cho, Yoon Shin
  • Chu, Minjie
  • Cui, Bin
  • Gao, Yu - Tang
  • Go, Min Jin
  • Gu, Dongfeng
  • Gu, Weiqiong
  • Guo, Huan
  • Hao, Yongchen
  • Hong, Jie
  • Hu, Zhibin
  • Hu, Yanling
  • Huang, Jianfeng
  • Hwang, Joo - Yeon
  • Ikram, Mohammad Kamran
  • Jin, Guangfu
  • Kang, Dae - Hee
  • Khor, Chiea Chuen
  • Kim, Bong - Jo
  • Kim, Hung Tae
  • Kubo, Michiaki
  • Lee, Jeannette
  • Lee, Juyoung
  • Lee, Nanette R
  • Li, Ruoying
  • Li, Jun
  • Liu, Jianjun
  • Longe, Jirong
  • Lu, Wei
  • Lu, Xiangfeng
  • Miao, Xiaoping
  • Okada, Yukinori
  • Ong, Rick Twee - Hee
  • Qiu, Gaokun
  • Seielstad, Mark
  • Sim, Xueling
  • Song, Huaidong
  • Takeuchi, Fumihiko
  • Tanaka, Toshihiro
  • Taylor, Phil R
  • Wang, Laiyuan
  • Wang, Weiqing
  • Wang, Yiqin
  • Wu, Chen
  • Wu, Ying
  • Xiang, Yong - Bing
  • Yamamoto, Ken
  • Yang, Handong
  • Liao, Ming
  • Yokota, Mitsuhiro
  • Young, Terri
  • Zhang, Xiaomin
  • Kato, Norihiro
  • Wang, Qing K
  • Zheng, Wei
  • Hu, Frank B
  • Lin, Dongxin
  • Shen, Hongbing
  • Teo, Yik Ying
  • Mo, Zengnan
  • Wong, Tien Yin
  • Lin, Xu
  • Mohlke, Karen L
  • Ning, Guang
  • Tsunoda, Tatsuhiko
  • Han, Bok - Ghee
  • Shu, Xiao - Ou
  • Tai, E. Shyong
  • Wu, Tangchun
  • Qi, Lu
subjects:
  • Medicine
  • Biology
ispartof: Human Molecular Genetics, 2015, Vol. 24(6), pp.1791-1800
description: Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10 −8 , together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
language:
source:
identifier: ISSN: 0964-6906 ; E-ISSN: 1460-2083 ; DOI: 10.1093/hmg/ddu583
fulltext: fulltext
issn:
  • 0964-6906
  • 09646906
  • 1460-2083
  • 14602083
url: Link


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titleMeta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
creatorHe, Meian ; Xu, Min ; Zhang, Ben ; Liang, Jun ; Chen, Peng ; Lee, Jong - Young ; Johnson, Todd A ; Li, Huaixing ; Yang, Xiaobo ; Dai, Juncheng ; Liang, Liming ; Gui, Lixuan ; Qi, Qibin ; Huang, Jinyan ; Li, Yanping ; Adair, Linda S ; Aung, Tin ; Cai, Qiuyin ; Cheng, Ching - Yu ; Cho, Myeong - Chan ; Cho, Yoon Shin ; Chu, Minjie ; Cui, Bin ; Gao, Yu - Tang ; Go, Min Jin ; Gu, Dongfeng ; Gu, Weiqiong ; Guo, Huan ; Hao, Yongchen ; Hong, Jie ; Hu, Zhibin ; Hu, Yanling ; Huang, Jianfeng ; Hwang, Joo - Yeon ; Ikram, Mohammad Kamran ; Jin, Guangfu ; Kang, Dae - Hee ; Khor, Chiea Chuen ; Kim, Bong - Jo ; Kim, Hung Tae ; Kubo, Michiaki ; Lee, Jeannette ; Lee, Juyoung ; Lee, Nanette R ; Li, Ruoying ; Li, Jun ; Liu, Jianjun ; Longe, Jirong ; Lu, Wei ; Lu, Xiangfeng ; Miao, Xiaoping ; Okada, Yukinori ; Ong, Rick Twee - Hee ; Qiu, Gaokun ; Seielstad, Mark ; Sim, Xueling ; Song, Huaidong ; Takeuchi, Fumihiko ; Tanaka, Toshihiro ; Taylor, Phil R ; Wang, Laiyuan ; Wang, Weiqing ; Wang, Yiqin ; Wu, Chen ; Wu, Ying ; Xiang, Yong - Bing ; Yamamoto, Ken ; Yang, Handong ; Liao, Ming ; Yokota, Mitsuhiro ; Young, Terri ; Zhang, Xiaomin ; Kato, Norihiro ; Wang, Qing K ; Zheng, Wei ; Hu, Frank B ; Lin, Dongxin ; Shen, Hongbing ; Teo, Yik Ying ; Mo, Zengnan ; Wong, Tien Yin ; Lin, Xu ; Mohlke, Karen L ; Ning, Guang ; Tsunoda, Tatsuhiko ; Han, Bok - Ghee ; Shu, Xiao - Ou ; Tai, E. Shyong ; Wu, Tangchun ; Qi, Lu
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identifier
descriptionHuman height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10 −8 , together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
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titleMeta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
descriptionHuman height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10 −8 , together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
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titleMeta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
authorHe, Meian ; Xu, Min ; Zhang, Ben ; Liang, Jun ; Chen, Peng ; Lee, Jong - Young ; Johnson, Todd A ; Li, Huaixing ; Yang, Xiaobo ; Dai, Juncheng ; Liang, Liming ; Gui, Lixuan ; Qi, Qibin ; Huang, Jinyan ; Li, Yanping ; Adair, Linda S ; Aung, Tin ; Cai, Qiuyin ; Cheng, Ching - Yu ; Cho, Myeong - Chan ; Cho, Yoon Shin ; Chu, Minjie ; Cui, Bin ; Gao, Yu - Tang ; Go, Min Jin ; Gu, Dongfeng ; Gu, Weiqiong ; Guo, Huan ; Hao, Yongchen ; Hong, Jie ; Hu, Zhibin ; Hu, Yanling ; Huang, Jianfeng ; Hwang, Joo - Yeon ; Ikram, Mohammad Kamran ; Jin, Guangfu ; Kang, Dae - Hee ; Khor, Chiea Chuen ; Kim, Bong - Jo ; Kim, Hung Tae ; Kubo, Michiaki ; Lee, Jeannette ; Lee, Juyoung ; Lee, Nanette R ; Li, Ruoying ; Li, Jun ; Liu, Jianjun ; Longe, Jirong ; Lu, Wei ; Lu, Xiangfeng ; Miao, Xiaoping ; Okada, Yukinori ; Ong, Rick Twee - Hee ; Qiu, Gaokun ; Seielstad, Mark ; Sim, Xueling ; Song, Huaidong ; Takeuchi, Fumihiko ; Tanaka, Toshihiro ; Taylor, Phil R ; Wang, Laiyuan ; Wang, Weiqing ; Wang, Yiqin ; Wu, Chen ; Wu, Ying ; Xiang, Yong - Bing ; Yamamoto, Ken ; Yang, Handong ; Liao, Ming ; Yokota, Mitsuhiro ; Young, Terri ; Zhang, Xiaomin ; Kato, Norihiro ; Wang, Qing K ; Zheng, Wei ; Hu, Frank B ; Lin, Dongxin ; Shen, Hongbing ; Teo, Yik Ying ; Mo, Zengnan ; Wong, Tien Yin ; Lin, Xu ; Mohlke, Karen L ; Ning, Guang ; Tsunoda, Tatsuhiko ; Han, Bok - Ghee ; Shu, Xiao - Ou ; Tai, E. Shyong ; Wu, Tangchun ; Qi, Lu
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8Yang, Xiaobo
9Dai, Juncheng
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16Aung, Tin
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25Gu, Dongfeng
26Gu, Weiqiong
27Guo, Huan
28Hao, Yongchen
29Hong, Jie
30Hu, Zhibin
31Hu, Yanling
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0He, Meian
1Xu, Min
2Zhang, Ben
3Liang, Jun
4Chen, Peng
5Lee, Jong-Young
6Johnson, Todd A.
7Li, Huaixing
8Yang, Xiaobo
9Dai, Juncheng
10Liang, Liming
11Gui, Lixuan
12Qi, Qibin
13Huang, Jinyan
14Li, Yanping
15Adair, Linda S.
16Aung, Tin
17Cai, Qiuyin
18Cheng, Ching-Yu
19Cho, Myeong-Chan
20Cho, Yoon Shin
21Chu, Minjie
22Cui, Bin
23Gao, Yu-Tang
24Go, Min Jin
25Gu, Dongfeng
26Gu, Weiqiong
27Guo, Huan
28Hao, Yongchen
29Hong, Jie
30Hu, Zhibin
31Hu, Yanling
32Huang, Jianfeng
33Hwang, Joo-Yeon
34Ikram, Mohammad Kamran
35Jin, Guangfu
36Kang, Dae-Hee
37Khor, Chiea Chuen
38Kim, Bong-Jo
39Kim, Hung Tae
40Kubo, Michiaki
41Lee, Jeannette
42Lee, Juyoung
43Lee, Nanette R.
44Li, Ruoying
45Li, Jun
46Liu, JianJun
47Longe, Jirong
48Lu, Wei
49Lu, Xiangfeng
50Miao, Xiaoping
51Okada, Yukinori
52Ong, Rick Twee-Hee
53Qiu, Gaokun
54Seielstad, Mark
55Sim, Xueling
56Song, Huaidong
57Takeuchi, Fumihiko
58Tanaka, Toshihiro
59Taylor, Phil R.
60Wang, Laiyuan
61Wang, Weiqing
62Wang, Yiqin
63Wu, Chen
64Wu, Ying
65Xiang, Yong-Bing
66Yamamoto, Ken
67Yang, Handong
68Liao, Ming
69Yokota, Mitsuhiro
70Young, Terri
71Zhang, Xiaomin
72Kato, Norihiro
73Wang, Qing K.
74Zheng, Wei
75Hu, Frank B.
76Lin, Dongxin
77Shen, Hongbing
78Teo, Yik Ying
79Mo, Zengnan
80Wong, Tien Yin
81Lin, Xu
82Mohlke, Karen L.
83Ning, Guang
84Tsunoda, Tatsuhiko
85Han, Bok-Ghee
86Shu, Xiao-Ou
87Tai, E. Shyong
88Wu, Tangchun
89Qi, Lu
atitleMeta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
jtitleHuman Molecular Genetics
risdate201503
volume24
issue6
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abstractHuman height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10 −8 , together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.
pubOxford University Press
doi10.1093/hmg/ddu583
date2015-03