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Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women

Background: Higher-protein meals (>25 g protein/meal) have been associated with enhanced satiety but the role of amino acids is unclear. Leucine has been proposed to stimulate satiety in rodents but has not been assessed in humans. Objective: We assessed the acute effects of lower-protein nutrition... Full description

Journal Title: The Journal of Nutrition 2018, Vol. 148(5), pp.693-701
Main Author: Bolster, Douglas R
Other Authors: Rahn, Maike , Kamil, Alison G , Bristol, Lindsey T , Goltz, Shellen R , Leidy, Heather J , Blaze Mt, Melvin , Nunez, Michael A , Guo, Elizabeth , Wang, Jianquan , Harkness, Laura S
Format: Electronic Article Electronic Article
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Pyy
ID: ISSN: 0022-3166 ; E-ISSN: 1541-6100 ; DOI: 10.1093/jn/nxy023
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recordid: oxford10.1093/jn/nxy023
title: Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women
format: Article
creator:
  • Bolster, Douglas R
  • Rahn, Maike
  • Kamil, Alison G
  • Bristol, Lindsey T
  • Goltz, Shellen R
  • Leidy, Heather J
  • Blaze Mt, Melvin
  • Nunez, Michael A
  • Guo, Elizabeth
  • Wang, Jianquan
  • Harkness, Laura S
subjects:
  • Hunger
  • Fullness
  • Appetite Sensations
  • Plasma Leucine
  • Appetite
  • Women
  • Leucine
  • Protein - Nutrition Bars
  • Pyy
ispartof: The Journal of Nutrition, 2018, Vol. 148(5), pp.693-701
description: Background: Higher-protein meals (>25 g protein/meal) have been associated with enhanced satiety but the role of amino acids is unclear. Leucine has been proposed to stimulate satiety in rodents but has not been assessed in humans. Objective: We assessed the acute effects of lower-protein nutrition bars, enhanced with a leucine peptide (LP), on postprandial appetite sensations in combination with plasma leucine and peptide YY (PYY) in healthy women. Methods: Utilizing a double-blind randomized crossover design, 40 healthy women [28 [+ or -] 7.5 y; body mass index (BMI, In kg/[m.sup.2]): 23.5 [+ or -] 2.4] consumed the following isocaloric (180 kcal) pre-loads on 3 separate visits: control bar [9 g protein with 0 g added LP (0-g LP)] or treatment bars (11 g protein with 2 g added LP (2-g LP) or 13 g protein with 3 g added LP (3-g LP)]. Pre- and postprandial hunger, desire to eat, prospective food consumption (PFC), fullness, and plasma leucine were assessed every 30 min for 240 min. Plasma PYY was assessed hourly for 240 min (n = 24). Results: Main effects of time (P < 0.0001) and treatment (P < 0.03) were detected for postprandial hunger, desire to eat, PFC, and fullness. Post hoc analyses revealed that the 2-g and 3-g LP bars elicited greater increases in fullness and greater decreases in PFC compared with 0-g LP (all, P < 0.05) with no differences between the 2-g and 3-g LP bars. The 2-g bar elicited greater decreases in hunger and desire to eat compared with the 0-g LP bar (both, P [less than or equal to] 0.01), whereas 3-g LP did not. Appetite Incremental areas under the curves (iAUCs) and PYY outcomes were not different between bars. A treatment x time interaction was detected for plasma leucine with increases occurring in a leucine-dose-dependent manner (P
language:
source:
identifier: ISSN: 0022-3166 ; E-ISSN: 1541-6100 ; DOI: 10.1093/jn/nxy023
fulltext: fulltext
issn:
  • 0022-3166
  • 00223166
  • 1541-6100
  • 15416100
url: Link


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titleConsuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women
creatorBolster, Douglas R ; Rahn, Maike ; Kamil, Alison G ; Bristol, Lindsey T ; Goltz, Shellen R ; Leidy, Heather J ; Blaze Mt, Melvin ; Nunez, Michael A ; Guo, Elizabeth ; Wang, Jianquan ; Harkness, Laura S
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subjectHunger ; Fullness ; Appetite Sensations ; Plasma Leucine ; Appetite ; Women ; Leucine ; Protein - Nutrition Bars ; Pyy
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descriptionBackground: Higher-protein meals (>25 g protein/meal) have been associated with enhanced satiety but the role of amino acids is unclear. Leucine has been proposed to stimulate satiety in rodents but has not been assessed in humans. Objective: We assessed the acute effects of lower-protein nutrition bars, enhanced with a leucine peptide (LP), on postprandial appetite sensations in combination with plasma leucine and peptide YY (PYY) in healthy women. Methods: Utilizing a double-blind randomized crossover design, 40 healthy women [28 [+ or -] 7.5 y; body mass index (BMI, In kg/[m.sup.2]): 23.5 [+ or -] 2.4] consumed the following isocaloric (180 kcal) pre-loads on 3 separate visits: control bar [9 g protein with 0 g added LP (0-g LP)] or treatment bars (11 g protein with 2 g added LP (2-g LP) or 13 g protein with 3 g added LP (3-g LP)]. Pre- and postprandial hunger, desire to eat, prospective food consumption (PFC), fullness, and plasma leucine were assessed every 30 min for 240 min. Plasma PYY was assessed hourly for 240 min (n = 24). Results: Main effects of time (P < 0.0001) and treatment (P < 0.03) were detected for postprandial hunger, desire to eat, PFC, and fullness. Post hoc analyses revealed that the 2-g and 3-g LP bars elicited greater increases in fullness and greater decreases in PFC compared with 0-g LP (all, P < 0.05) with no differences between the 2-g and 3-g LP bars. The 2-g bar elicited greater decreases in hunger and desire to eat compared with the 0-g LP bar (both, P [less than or equal to] 0.01), whereas 3-g LP did not. Appetite Incremental areas under the curves (iAUCs) and PYY outcomes were not different between bars. A treatment x time interaction was detected for plasma leucine with increases occurring in a leucine-dose-dependent manner (P <= 0.0001). Conclusion: Despite the dose-dependent increases in plasma leucine following the consumption of lower-protein bars enhanced with LP only the 2-g LP bar elicited consistent postprandial changes in select appetite sensations compared with the 0-g LP bar. This study was registered on clinicaltrials.gov as NCT02091570. Keywords: hunger, fullness, appetite sensations, plasma leucine, appetite, women, leucine, protein-nutrition bars, PYY doi: https://doi.org/10.1093/jn/nxy023.
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titleConsuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women
authorBolster, Douglas R ; Rahn, Maike ; Kamil, Alison G ; Bristol, Lindsey T ; Goltz, Shellen R ; Leidy, Heather J ; Blaze Mt, Melvin ; Nunez, Michael A ; Guo, Elizabeth ; Wang, Jianquan ; Harkness, Laura S
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