schliessen

Filtern

 

Bibliotheken

Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups

Background Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor EpsteinBarr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. Methods We conducted a genome-wide association study of 1200... Full description

Journal Title: Journal of the National Cancer Institute 2012, Vol. 104(3), pp.240-253
Main Author: Urayama, Kevin Y
Other Authors: Jarrett, Ruth F , Hjalgrim, Henrik , Diepstra, Arjan , Kamatani, Yoichiro , Chabrier, Amelie , Gaborieau, Valerie , Boland, Anne , Nieters, Alexandra , Becker, Nikolaus , Foretova, Lenka , Benavente, Yolanda , Maynadié, Marc , Staines, Anthony , Shield, Lesley , Lake, Annette , Montgomery, Dorothy , Taylor, Malcolm , Smedby, Karin Ekström , Amini, Rose - Marie , Adami, Hans - Olov , Glimelius, Bengt , Feenstra, Bjarke , Nolte, Ilja M , Visser, Lydia , Van Imhoff, Gustaaf W , Lightfoot, Tracy , Cocco, Pierluigi , Kiemeney, Lambertus , Vermeulen, Sita H , Holcatova, Ivana , Vatten, Lars , Macfarlane, Gary J , Thomson, Peter , Conway, David I , Benhamou, Simone , Agudo, Antonio , Healy, Claire M , Overvad, Kim , Tjønneland, Anne , Melin, Beatrice , Canzian, Federico , Khaw, Kay - Tee , Travis, Ruth C , Peeters, Petra H. M , González, Carlos A , Quirós, José Ramón , Sánchez, María - José , Huerta, José María , Ardanaz, Eva , Dorronsoro, Miren , Clavel - Chapelon, Françoise , Bueno - De - Mesquita, H. Bas , Riboli, Elio , Roman, Eve , Boffetta, Paolo , De Sanjosé, Silvia , Zelenika, Diana , Melbye, Mads , Van Den Berg, Anke , Lathrop, Mark , Brennan, Paul , Mckay, James D
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0027-8874 ; E-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djr516
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: oxford10.1093/jnci/djr516
title: Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups
format: Article
creator:
  • Urayama, Kevin Y
  • Jarrett, Ruth F
  • Hjalgrim, Henrik
  • Diepstra, Arjan
  • Kamatani, Yoichiro
  • Chabrier, Amelie
  • Gaborieau, Valerie
  • Boland, Anne
  • Nieters, Alexandra
  • Becker, Nikolaus
  • Foretova, Lenka
  • Benavente, Yolanda
  • Maynadié, Marc
  • Staines, Anthony
  • Shield, Lesley
  • Lake, Annette
  • Montgomery, Dorothy
  • Taylor, Malcolm
  • Smedby, Karin Ekström
  • Amini, Rose - Marie
  • Adami, Hans - Olov
  • Glimelius, Bengt
  • Feenstra, Bjarke
  • Nolte, Ilja M
  • Visser, Lydia
  • Van Imhoff, Gustaaf W
  • Lightfoot, Tracy
  • Cocco, Pierluigi
  • Kiemeney, Lambertus
  • Vermeulen, Sita H
  • Holcatova, Ivana
  • Vatten, Lars
  • Macfarlane, Gary J
  • Thomson, Peter
  • Conway, David I
  • Benhamou, Simone
  • Agudo, Antonio
  • Healy, Claire M
  • Overvad, Kim
  • Tjønneland, Anne
  • Melin, Beatrice
  • Canzian, Federico
  • Khaw, Kay - Tee
  • Travis, Ruth C
  • Peeters, Petra H. M
  • González, Carlos A
  • Quirós, José Ramón
  • Sánchez, María - José
  • Huerta, José María
  • Ardanaz, Eva
  • Dorronsoro, Miren
  • Clavel - Chapelon, Françoise
  • Bueno - De - Mesquita, H. Bas
  • Riboli, Elio
  • Roman, Eve
  • Boffetta, Paolo
  • De Sanjosé, Silvia
  • Zelenika, Diana
  • Melbye, Mads
  • Van Den Berg, Anke
  • Lathrop, Mark
  • Brennan, Paul
  • Mckay, James D
subjects:
  • Genomics -- Analysis
  • Virus Diseases -- Risk Factors
  • Virus Diseases -- Analysis
  • Tumors -- Risk Factors
  • Tumors -- Analysis
  • Hla Antigens -- Analysis
  • Epstein-barr Virus -- Analysis
  • Psoriasis -- Risk Factors
  • Psoriasis -- Analysis
  • Lymphomas -- Risk Factors
  • Lymphomas -- Analysis
ispartof: Journal of the National Cancer Institute, 2012, Vol. 104(3), pp.240-253
description: Background Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor EpsteinBarr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. Methods We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple Iogistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cis) assuming a Iog-additive genetic model for the variants. AII statistical tests were two-sided. Results Two novel Ioci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P= 1.3 x [10.sup.-13]) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to 0.62, P = 8.3 x [10.sup.-25]) with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-positive cHL and genetic variants within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00 to 3.00, P = 1.2 x [10.sup.-15] is; rs6904029, HCG9: OR = 0.46, 95% CI = 0.36 to 0.59, P = 5.5 x [10.sup.-10]) and between EBV-negative cHL and rs6903608 within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI = 1.84 to 2.35, P = 6.1 x [10.sup.-31]). The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x [10.sup.-9]), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear. Notably, one additional psoriasis-associated variant, rs27524 (5q15, ERAP1), showed evidence of an association with cHL in the genome-wide association study (OR = 1.21, 95% CI = 1.10 to 1.33, P= 1.5 x [10.sup.-4]) and replication series (P= .03). Conclusion Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. J Natl Cancer Inst 2012;104:240-253 DOI: 10.1093/jnci/djr516
language:
source:
identifier: ISSN: 0027-8874 ; E-ISSN: 1460-2105 ; DOI: 10.1093/jnci/djr516
fulltext: fulltext
issn:
  • 0027-8874
  • 00278874
  • 1460-2105
  • 14602105
url: Link


@attributes
ID622062341
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1093/jnci/djr516
sourceidoxford
recordidTN_oxford10.1093/jnci/djr516
sourceformatXML
sourcesystemPC
pqid926559243
galeid282580944
display
typearticle
titleGenome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups
creatorUrayama, Kevin Y ; Jarrett, Ruth F ; Hjalgrim, Henrik ; Diepstra, Arjan ; Kamatani, Yoichiro ; Chabrier, Amelie ; Gaborieau, Valerie ; Boland, Anne ; Nieters, Alexandra ; Becker, Nikolaus ; Foretova, Lenka ; Benavente, Yolanda ; Maynadié, Marc ; Staines, Anthony ; Shield, Lesley ; Lake, Annette ; Montgomery, Dorothy ; Taylor, Malcolm ; Smedby, Karin Ekström ; Amini, Rose - Marie ; Adami, Hans - Olov ; Glimelius, Bengt ; Feenstra, Bjarke ; Nolte, Ilja M ; Visser, Lydia ; Van Imhoff, Gustaaf W ; Lightfoot, Tracy ; Cocco, Pierluigi ; Kiemeney, Lambertus ; Vermeulen, Sita H ; Holcatova, Ivana ; Vatten, Lars ; Macfarlane, Gary J ; Thomson, Peter ; Conway, David I ; Benhamou, Simone ; Agudo, Antonio ; Healy, Claire M ; Overvad, Kim ; Tjønneland, Anne ; Melin, Beatrice ; Canzian, Federico ; Khaw, Kay - Tee ; Travis, Ruth C ; Peeters, Petra H. M ; González, Carlos A ; Quirós, José Ramón ; Sánchez, María - José ; Huerta, José María ; Ardanaz, Eva ; Dorronsoro, Miren ; Clavel - Chapelon, Françoise ; Bueno - De - Mesquita, H. Bas ; Riboli, Elio ; Roman, Eve ; Boffetta, Paolo ; De Sanjosé, Silvia ; Zelenika, Diana ; Melbye, Mads ; Van Den Berg, Anke ; Lathrop, Mark ; Brennan, Paul ; Mckay, James D
ispartofJournal of the National Cancer Institute, 2012, Vol. 104(3), pp.240-253
identifier
source
subjectGenomics -- Analysis ; Virus Diseases -- Risk Factors ; Virus Diseases -- Analysis ; Tumors -- Risk Factors ; Tumors -- Analysis ; Hla Antigens -- Analysis ; Epstein-barr Virus -- Analysis ; Psoriasis -- Risk Factors ; Psoriasis -- Analysis ; Lymphomas -- Risk Factors ; Lymphomas -- Analysis;
descriptionBackground Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor EpsteinBarr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. Methods We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple Iogistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cis) assuming a Iog-additive genetic model for the variants. AII statistical tests were two-sided. Results Two novel Ioci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P= 1.3 x [10.sup.-13]) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to 0.62, P = 8.3 x [10.sup.-25]) with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-positive cHL and genetic variants within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00 to 3.00, P = 1.2 x [10.sup.-15] is; rs6904029, HCG9: OR = 0.46, 95% CI = 0.36 to 0.59, P = 5.5 x [10.sup.-10]) and between EBV-negative cHL and rs6903608 within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI = 1.84 to 2.35, P = 6.1 x [10.sup.-31]). The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x [10.sup.-9]), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear. Notably, one additional psoriasis-associated variant, rs27524 (5q15, ERAP1), showed evidence of an association with cHL in the genome-wide association study (OR = 1.21, 95% CI = 1.10 to 1.33, P= 1.5 x [10.sup.-4]) and replication series (P= .03). Conclusion Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. J Natl Cancer Inst 2012;104:240-253 DOI: 10.1093/jnci/djr516
version12
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Urayama, Kevin Y
1Jarrett, Ruth F
2Hjalgrim, Henrik
3Diepstra, Arjan
4Kamatani, Yoichiro
5Chabrier, Amelie
6Gaborieau, Valerie
7Boland, Anne
8Nieters, Alexandra
9Becker, Nikolaus
10Foretova, Lenka
11Benavente, Yolanda
12Maynadié, Marc
13Staines, Anthony
14Shield, Lesley
15Lake, Annette
16Montgomery, Dorothy
17Taylor, Malcolm
18Smedby, Karin Ekström
19Amini, Rose-Marie
20Adami, Hans-Olov
21Glimelius, Bengt
22Feenstra, Bjarke
23Nolte, Ilja M
24Visser, Lydia
25van Imhoff, Gustaaf W
26Lightfoot, Tracy
27Cocco, Pierluigi
28Kiemeney, Lambertus
29Vermeulen, Sita H
30Holcatova, Ivana
31Vatten, Lars
32Macfarlane, Gary J
33Thomson, Peter
34Conway, David I
35Benhamou, Simone
36Agudo, Antonio
37Healy, Claire M
38Overvad, Kim
39Tjønneland, Anne
40Melin, Beatrice
41Canzian, Federico
42Khaw, Kay-Tee
43Travis, Ruth C
44Peeters, Petra H. M
45González, Carlos A
46Quirós, José Ramón
47Sánchez, María-José
48Huerta, José María
49Ardanaz, Eva
50Dorronsoro, Miren
51Clavel-Chapelon, Françoise
52Bueno-de-Mesquita, H. Bas
53Riboli, Elio
54Roman, Eve
55Boffetta, Paolo
56de Sanjosé, Silvia
57Zelenika, Diana
58Melbye, Mads
59van den Berg, Anke
60Lathrop, Mark
61Brennan, Paul
62McKay, James D
titleGenome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups
general
010.1093/jnci/djr516
1Oxford Journals
sourceidoxford
recordidoxford10.1093/jnci/djr516
issn
00027-8874
100278874
21460-2105
314602105
rsrctypearticle
creationdate2012
addtitleJournal of the National Cancer Institute
searchscopeoxford
scopeoxford
lsr40201208
lsr4120120127
lsr30VSR-Enriched:[subject, description, pqid, galeid]
sort
titleGenome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups
authorUrayama, Kevin Y ; Jarrett, Ruth F ; Hjalgrim, Henrik ; Diepstra, Arjan ; Kamatani, Yoichiro ; Chabrier, Amelie ; Gaborieau, Valerie ; Boland, Anne ; Nieters, Alexandra ; Becker, Nikolaus ; Foretova, Lenka ; Benavente, Yolanda ; Maynadié, Marc ; Staines, Anthony ; Shield, Lesley ; Lake, Annette ; Montgomery, Dorothy ; Taylor, Malcolm ; Smedby, Karin Ekström ; Amini, Rose - Marie ; Adami, Hans - Olov ; Glimelius, Bengt ; Feenstra, Bjarke ; Nolte, Ilja M ; Visser, Lydia ; Van Imhoff, Gustaaf W ; Lightfoot, Tracy ; Cocco, Pierluigi ; Kiemeney, Lambertus ; Vermeulen, Sita H ; Holcatova, Ivana ; Vatten, Lars ; Macfarlane, Gary J ; Thomson, Peter ; Conway, David I ; Benhamou, Simone ; Agudo, Antonio ; Healy, Claire M ; Overvad, Kim ; Tjønneland, Anne ; Melin, Beatrice ; Canzian, Federico ; Khaw, Kay - Tee ; Travis, Ruth C ; Peeters, Petra H. M ; González, Carlos A ; Quirós, José Ramón ; Sánchez, María - José ; Huerta, José María ; Ardanaz, Eva ; Dorronsoro, Miren ; Clavel - Chapelon, Françoise ; Bueno - De - Mesquita, H. Bas ; Riboli, Elio ; Roman, Eve ; Boffetta, Paolo ; De Sanjosé, Silvia ; Zelenika, Diana ; Melbye, Mads ; Van Den Berg, Anke ; Lathrop, Mark ; Brennan, Paul ; Mckay, James D
creationdate20120000
facets
frbrgroupid6745037999851469332
frbrtype5
creationdate2012
collectionOxford Journals (Oxford University Press)
prefilterarticles
rsrctypearticles
creatorcontrib
0Urayama, Kevin Y
1Jarrett, Ruth F
2Hjalgrim, Henrik
3Diepstra, Arjan
4Kamatani, Yoichiro
5Chabrier, Amelie
6Gaborieau, Valerie
7Boland, Anne
8Nieters, Alexandra
9Becker, Nikolaus
10Foretova, Lenka
11Benavente, Yolanda
12Maynadié, Marc
13Staines, Anthony
14Shield, Lesley
15Lake, Annette
16Montgomery, Dorothy
17Taylor, Malcolm
18Smedby, Karin Ekström
19Amini, Rose - Marie
20Adami, Hans - Olov
21Glimelius, Bengt
22Feenstra, Bjarke
23Nolte, Ilja M
24Visser, Lydia
25Van Imhoff, Gustaaf W
26Lightfoot, Tracy
27Cocco, Pierluigi
28Kiemeney, Lambertus
29Vermeulen, Sita H
30Holcatova, Ivana
31Vatten, Lars
32Macfarlane, Gary J
33Thomson, Peter
34Conway, David I
35Benhamou, Simone
36Agudo, Antonio
37Healy, Claire M
38Overvad, Kim
39Tjønneland, Anne
40Melin, Beatrice
41Canzian, Federico
42Khaw, Kay - Tee
43Travis, Ruth C
44Peeters, Petra H. M
45González, Carlos A
46Quirós, José Ramón
47Sánchez, María - José
48Huerta, José María
49Ardanaz, Eva
50Dorronsoro, Miren
51Clavel - Chapelon, Françoise
52Bueno - De - Mesquita, H. Bas
53Riboli, Elio
54Roman, Eve
55Boffetta, Paolo
56De Sanjosé, Silvia
57Zelenika, Diana
58Melbye, Mads
59Van Den Berg, Anke
60Lathrop, Mark
61Brennan, Paul
62Mckay, James D
jtitleJournal Of The National Cancer Institute
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Urayama
1Jarrett
2Hjalgrim
3Diepstra
4Kamatani
5Chabrier
6Gaborieau
7Boland
8Nieters
9Becker
10Foretova
11Benavente
12Maynadié
13Staines
14Shield
15Lake
16Montgomery
17Taylor
18Smedby
19Amini
20Adami
21Glimelius
22Feenstra
23Nolte
24Visser
25van Imhoff
26Lightfoot
27Cocco
28Kiemeney
29Vermeulen
30Holcatova
31Vatten
32Macfarlane
33Thomson
34Conway
35Benhamou
36Agudo
37Healy
38Overvad
39Tjønneland
40Melin
41Canzian
42Khaw
43Travis
44Peeters
45González
46Quirós
47Sánchez
48Huerta
49Ardanaz
50Dorronsoro
51Clavel-Chapelon
52Bueno-de-Mesquita
53Riboli
54Roman
55Boffetta
56de Sanjosé
57Zelenika
58Melbye
59van den Berg
60Lathrop
61Brennan
62McKay
aufirst
0Kevin Y.
1Ruth F.
2Henrik
3Arjan
4Yoichiro
5Amelie
6Valerie
7Anne
8Alexandra
9Nikolaus
10Lenka
11Yolanda
12Marc
13Anthony
14Lesley
15Annette
16Dorothy
17Malcolm
18Karin Ekström
19Rose-Marie
20Hans-Olov
21Bengt
22Bjarke
23Ilja M.
24Lydia
25Gustaaf W.
26Tracy
27Pierluigi
28Lambertus
29Sita H.
30Ivana
31Lars
32Gary J.
33Peter
34David I.
35Simone
36Antonio
37Claire M.
38Kim
39Beatrice
40Federico
41Kay-Tee
42Ruth C.
43Petra H. M.
44Carlos A.
45José Ramón
46María-José
47José María
48Eva
49Miren
50Françoise
51H. Bas
52Elio
53Eve
54Paolo
55Silvia
56Diana
57Mads
58Anke
59Mark
60Paul
61James D.
au
0Urayama, Kevin Y.
1Jarrett, Ruth F.
2Hjalgrim, Henrik
3Diepstra, Arjan
4Kamatani, Yoichiro
5Chabrier, Amelie
6Gaborieau, Valerie
7Boland, Anne
8Nieters, Alexandra
9Becker, Nikolaus
10Foretova, Lenka
11Benavente, Yolanda
12Maynadié, Marc
13Staines, Anthony
14Shield, Lesley
15Lake, Annette
16Montgomery, Dorothy
17Taylor, Malcolm
18Smedby, Karin Ekström
19Amini, Rose-Marie
20Adami, Hans-Olov
21Glimelius, Bengt
22Feenstra, Bjarke
23Nolte, Ilja M.
24Visser, Lydia
25van Imhoff, Gustaaf W.
26Lightfoot, Tracy
27Cocco, Pierluigi
28Kiemeney, Lambertus
29Vermeulen, Sita H.
30Holcatova, Ivana
31Vatten, Lars
32Macfarlane, Gary J.
33Thomson, Peter
34Conway, David I.
35Benhamou, Simone
36Agudo, Antonio
37Healy, Claire M.
38Overvad, Kim
39Tjønneland, Anne
40Melin, Beatrice
41Canzian, Federico
42Khaw, Kay-Tee
43Travis, Ruth C.
44Peeters, Petra H. M.
45González, Carlos A.
46Quirós, José Ramón
47Sánchez, María-José
48Huerta, José María
49Ardanaz, Eva
50Dorronsoro, Miren
51Clavel-Chapelon, Françoise
52Bueno-de-Mesquita, H. Bas
53Riboli, Elio
54Roman, Eve
55Boffetta, Paolo
56de Sanjosé, Silvia
57Zelenika, Diana
58Melbye, Mads
59van den Berg, Anke
60Lathrop, Mark
61Brennan, Paul
62McKay, James D.
atitleGenome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups
jtitleJournal of the National Cancer Institute
date2012
risdate2012
volume104
issue3
spage240
epage253
pages240-253
issn0027-8874
eissn1460-2105
formatjournal
genrearticle
ristypeJOUR
pubOxford University Press
doi10.1093/jnci/djr516