schliessen

Filtern

 

Bibliotheken

Δ-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2

Δ 9 -tetrahydrocannabinol (Δ 9 -THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB 1 ) and 2 (CB 2 ). Most recently, dendritic cells (DC) were identified for their potential t... Full description

Journal Title: Toxicological Sciences 2013, Vol. 131(2), pp.419-433
Main Author: Karmaus, Peer W. F
Other Authors: Chen, Weimin , Crawford, Robert , Kaplan, Barbara L. F , Kaminski, Norbert E
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 1096-6080 ; E-ISSN: 1096-0929 ; DOI: 10.1093/toxsci/kfs315
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: oxford10.1093/toxsci/kfs315
title: Δ-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2
format: Article
creator:
  • Karmaus, Peer W. F
  • Chen, Weimin
  • Crawford, Robert
  • Kaplan, Barbara L. F
  • Kaminski, Norbert E
subjects:
  • Δ - Tetrahydrocannabinol
  • Cannabinoid Receptors
  • Immune Modulation
  • Antigen - Presenting Cells
  • Influenza.
ispartof: Toxicological Sciences, 2013, Vol. 131(2), pp.419-433
description: Δ 9 -tetrahydrocannabinol (Δ 9 -THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB 1 ) and 2 (CB 2 ). Most recently, dendritic cells (DC) were identified for their potential to enhance influenza-induced immunopathology in mice lacking CB 1 and CB 2 (CB 1 −/− CB 2 −/− ). This study focused on the modulation of the inflammatory immune response to influenza by Δ 9 -THC and the role of CB 1 and/or CB 2 as receptor targets for Δ 9 -THC. C57Bl/6 (wild type) and CB 1 −/− CB 2 −/− mice were administered Δ 9 -THC (75mg/kg) surrounding the intranasal instillation of A/PR/8/34 influenza virus. Three days post infection (dpi), Δ 9 -THC broadly decreased expression levels of mRNA induced by the innate immune response to influenza, suppressed the percentage of interferon-gamma (IFN-γ)–producing CD4 + and interleukin-17–producing NK1.1 + cells, and reduced the influx of antigen-presenting cells (APC), including inflammatory myeloid cells and monocytes/macrophages, into the lung in a CB 1 - and/or CB 2 -dependent manner. Δ 9 -THC had little effect on the expression of CD86, major histocompatibility complex I (MHC I), and MHC II by APC isolated from the lung. In vitro studies demonstrated that lipopolysaccharide (LPS)–induced maturation was suppressed by Δ 9 -THC in bone marrow–derived DC (bmDC). Furthermore, antigen-specific IFN-γ production by CD8 + T cells after coculture was reduced by Δ 9 -THC treatment of bmDC in a CB 1 - and/or CB 2 -dependent manner. Collectively, these studies suggest that Δ 9 -THC potently suppresses myeloid cell immune function, in a manner involving CB 1 and/or CB 2 , thereby impairing immune responses to influenza infection.
language:
source:
identifier: ISSN: 1096-6080 ; E-ISSN: 1096-0929 ; DOI: 10.1093/toxsci/kfs315
fulltext: fulltext
issn:
  • 1096-6080
  • 10966080
  • 1096-0929
  • 10960929
url: Link


@attributes
ID1108038817
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1093/toxsci/kfs315
sourceidoxford
recordidTN_oxford10.1093/toxsci/kfs315
sourceformatXML
sourcesystemPC
pqid1273817971
display
typearticle
titleΔ-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2
creatorKarmaus, Peer W. F ; Chen, Weimin ; Crawford, Robert ; Kaplan, Barbara L. F ; Kaminski, Norbert E
ispartofToxicological Sciences, 2013, Vol. 131(2), pp.419-433
identifier
subjectΔ - Tetrahydrocannabinol ; Cannabinoid Receptors ; Immune Modulation ; Antigen - Presenting Cells ; Influenza.
descriptionΔ 9 -tetrahydrocannabinol (Δ 9 -THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB 1 ) and 2 (CB 2 ). Most recently, dendritic cells (DC) were identified for their potential to enhance influenza-induced immunopathology in mice lacking CB 1 and CB 2 (CB 1 −/− CB 2 −/− ). This study focused on the modulation of the inflammatory immune response to influenza by Δ 9 -THC and the role of CB 1 and/or CB 2 as receptor targets for Δ 9 -THC. C57Bl/6 (wild type) and CB 1 −/− CB 2 −/− mice were administered Δ 9 -THC (75mg/kg) surrounding the intranasal instillation of A/PR/8/34 influenza virus. Three days post infection (dpi), Δ 9 -THC broadly decreased expression levels of mRNA induced by the innate immune response to influenza, suppressed the percentage of interferon-gamma (IFN-γ)–producing CD4 + and interleukin-17–producing NK1.1 + cells, and reduced the influx of antigen-presenting cells (APC), including inflammatory myeloid cells and monocytes/macrophages, into the lung in a CB 1 - and/or CB 2 -dependent manner. Δ 9 -THC had little effect on the expression of CD86, major histocompatibility complex I (MHC I), and MHC II by APC isolated from the lung. In vitro studies demonstrated that lipopolysaccharide (LPS)–induced maturation was suppressed by Δ 9 -THC in bone marrow–derived DC (bmDC). Furthermore, antigen-specific IFN-γ production by CD8 + T cells after coculture was reduced by Δ 9 -THC treatment of bmDC in a CB 1 - and/or CB 2 -dependent manner. Collectively, these studies suggest that Δ 9 -THC potently suppresses myeloid cell immune function, in a manner involving CB 1 and/or CB 2 , thereby impairing immune responses to influenza infection.
source
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Karmaus, Peer W. F
1Chen, Weimin
2Crawford, Robert
3Kaplan, Barbara L. F
4Kaminski, Norbert E
titleΔ-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2
descriptionΔ 9 -tetrahydrocannabinol (Δ 9 -THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB 1 ) and 2 (CB 2 ). Most recently, dendritic cells (DC) were identified for their potential to enhance influenza-induced immunopathology in mice lacking CB 1 and CB 2 (CB 1 −/− CB 2 −/− ). This study focused on the modulation of the inflammatory immune response to influenza by Δ 9 -THC and the role of CB 1 and/or CB 2 as receptor targets for Δ 9 -THC. C57Bl/6 (wild type) and CB 1 −/− CB 2 −/− mice were administered Δ 9 -THC (75mg/kg) surrounding the intranasal instillation of A/PR/8/34 influenza virus. Three days post infection (dpi), Δ 9 -THC broadly decreased expression levels of mRNA induced by the innate immune response to influenza, suppressed the percentage of interferon-gamma (IFN-γ)–producing CD4 + and interleukin-17–producing NK1.1 + cells, and reduced the influx of antigen-presenting cells (APC), including inflammatory myeloid cells and monocytes/macrophages, into the lung in a CB 1 - and/or CB 2 -dependent manner. Δ 9 -THC had little effect on the expression of CD86, major histocompatibility complex I (MHC I), and MHC II by APC isolated from the lung. In vitro studies demonstrated that lipopolysaccharide (LPS)–induced maturation was suppressed by Δ 9 -THC in bone marrow–derived DC (bmDC). Furthermore, antigen-specific IFN-γ production by CD8 + T cells after coculture was reduced by Δ 9 -THC treatment of bmDC in a CB 1 - and/or CB 2 -dependent manner. Collectively, these studies suggest that Δ 9 -THC potently suppresses myeloid cell immune function, in a manner involving CB 1 and/or CB 2 , thereby impairing immune responses to influenza infection.
subject
0Δ-tetrahydrocannabinol
1cannabinoid receptors
2immune modulation
3antigen-presenting cells
4influenza.
general
010.1093/toxsci/kfs315
1Oxford Journals
sourceidoxford
recordidoxford10.1093/toxsci/kfs315
issn
01096-6080
110966080
21096-0929
310960929
rsrctypearticle
creationdate2013
addtitleToxicological Sciences
searchscopeoxford
scopeoxford
lsr40201302
lsr4120121114
lsr30VSR-Enriched:[pqid]
sort
titleΔ-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2
authorKarmaus, Peer W. F ; Chen, Weimin ; Crawford, Robert ; Kaplan, Barbara L. F ; Kaminski, Norbert E
creationdate20130200
facets
frbrgroupid6686875370388808646
frbrtype5
creationdate2013
topic
0Δ - Tetrahydrocannabinol
1Cannabinoid Receptors
2Immune Modulation
3Antigen - Presenting Cells
4Influenza.
collectionOxford Journals (Oxford University Press)
prefilterarticles
rsrctypearticles
creatorcontrib
0Karmaus, Peer W. F
1Chen, Weimin
2Crawford, Robert
3Kaplan, Barbara L. F
4Kaminski, Norbert E
jtitleToxicological Sciences
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Karmaus
1Chen
2Crawford
3Kaplan
4Kaminski
aufirst
0Peer W. F.
1Weimin
2Robert
3Barbara L. F.
4Norbert E.
au
0Karmaus, Peer W. F.
1Chen, Weimin
2Crawford, Robert
3Kaplan, Barbara L. F.
4Kaminski, Norbert E.
atitleΔ-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2
jtitleToxicological Sciences
risdate201302
volume131
issue2
spage419
epage433
pages419-433
issn1096-6080
eissn1096-0929
formatjournal
genrearticle
ristypeJOUR
abstractΔ 9 -tetrahydrocannabinol (Δ 9 -THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB 1 ) and 2 (CB 2 ). Most recently, dendritic cells (DC) were identified for their potential to enhance influenza-induced immunopathology in mice lacking CB 1 and CB 2 (CB 1 −/− CB 2 −/− ). This study focused on the modulation of the inflammatory immune response to influenza by Δ 9 -THC and the role of CB 1 and/or CB 2 as receptor targets for Δ 9 -THC. C57Bl/6 (wild type) and CB 1 −/− CB 2 −/− mice were administered Δ 9 -THC (75mg/kg) surrounding the intranasal instillation of A/PR/8/34 influenza virus. Three days post infection (dpi), Δ 9 -THC broadly decreased expression levels of mRNA induced by the innate immune response to influenza, suppressed the percentage of interferon-gamma (IFN-γ)–producing CD4 + and interleukin-17–producing NK1.1 + cells, and reduced the influx of antigen-presenting cells (APC), including inflammatory myeloid cells and monocytes/macrophages, into the lung in a CB 1 - and/or CB 2 -dependent manner. Δ 9 -THC had little effect on the expression of CD86, major histocompatibility complex I (MHC I), and MHC II by APC isolated from the lung. In vitro studies demonstrated that lipopolysaccharide (LPS)–induced maturation was suppressed by Δ 9 -THC in bone marrow–derived DC (bmDC). Furthermore, antigen-specific IFN-γ production by CD8 + T cells after coculture was reduced by Δ 9 -THC treatment of bmDC in a CB 1 - and/or CB 2 -dependent manner. Collectively, these studies suggest that Δ 9 -THC potently suppresses myeloid cell immune function, in a manner involving CB 1 and/or CB 2 , thereby impairing immune responses to influenza infection.
pubOxford University Press
doi10.1093/toxsci/kfs315
date2013-02