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Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet

Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD). Objective: We evaluated the associations between 1 ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2 )... Full description

Journal Title: The American Journal of Clinical Nutrition 2017, Vol. 106(4), pp.973-983
Main Author: Toledo, Estefanía
Other Authors: Wang, Dong D , Ruiz - Canela, Miguel , Clish, Clary B , Razquin, Cristina , Zheng, Yan , Guasch - Ferré, Marta , Hruby, Adela , Corella, Dolores , Gómez - Gracia, Enrique , Fiol, Miquel , Estruch, Ramón , Ros, Emilio , Lapetra, José , Fito, Montserrat , Aros, Fernando , Serra - Majem, Luis , Liang, Liming , Salas - Salvadó, Jordi , Hu, Frank B , Martínez - González, Miguel A
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ID: ISSN: 0002-9165 ; E-ISSN: 1938-3207 ; DOI: 10.3945/ajcn.116.151159
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recordid: oxford10.3945/ajcn.116.151159
title: Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
format: Article
creator:
  • Toledo, Estefanía
  • Wang, Dong D
  • Ruiz - Canela, Miguel
  • Clish, Clary B
  • Razquin, Cristina
  • Zheng, Yan
  • Guasch - Ferré, Marta
  • Hruby, Adela
  • Corella, Dolores
  • Gómez - Gracia, Enrique
  • Fiol, Miquel
  • Estruch, Ramón
  • Ros, Emilio
  • Lapetra, José
  • Fito, Montserrat
  • Aros, Fernando
  • Serra - Majem, Luis
  • Liang, Liming
  • Salas - Salvadó, Jordi
  • Hu, Frank B
  • Martínez - González, Miguel A
subjects:
  • Mediterranean Diet
  • Predimed
  • Lipids
  • Metabolomics
  • Randomized Trial
  • Cardiovascular Disease
ispartof: The American Journal of Clinical Nutrition, 2017, Vol. 106(4), pp.973-983
description: Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD). Objective: We evaluated the associations between 1 ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2 ) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3 ) 1-y changes in lipid species and subsequent CVD. Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]. Results: Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles ( P -trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant ( P < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons. Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
language:
source:
identifier: ISSN: 0002-9165 ; E-ISSN: 1938-3207 ; DOI: 10.3945/ajcn.116.151159
fulltext: fulltext
issn:
  • 0002-9165
  • 00029165
  • 1938-3207
  • 19383207
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titlePlasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
creatorToledo, Estefanía ; Wang, Dong D ; Ruiz - Canela, Miguel ; Clish, Clary B ; Razquin, Cristina ; Zheng, Yan ; Guasch - Ferré, Marta ; Hruby, Adela ; Corella, Dolores ; Gómez - Gracia, Enrique ; Fiol, Miquel ; Estruch, Ramón ; Ros, Emilio ; Lapetra, José ; Fito, Montserrat ; Aros, Fernando ; Serra - Majem, Luis ; Liang, Liming ; Salas - Salvadó, Jordi ; Hu, Frank B ; Martínez - González, Miguel A
ispartofThe American Journal of Clinical Nutrition, 2017, Vol. 106(4), pp.973-983
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subjectMediterranean Diet ; Predimed ; Lipids ; Metabolomics ; Randomized Trial ; Cardiovascular Disease
descriptionBackground: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD). Objective: We evaluated the associations between 1 ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2 ) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3 ) 1-y changes in lipid species and subsequent CVD. Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]. Results: Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles ( P -trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant ( P < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons. Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
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1Wang, Dong D
2Ruiz-Canela, Miguel
3Clish, Clary B
4Razquin, Cristina
5Zheng, Yan
6Guasch-Ferré, Marta
7Hruby, Adela
8Corella, Dolores
9Gómez-Gracia, Enrique
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12Ros, Emilio
13Lapetra, José
14Fito, Montserrat
15Aros, Fernando
16Serra-Majem, Luis
17Liang, Liming
18Salas-Salvadó, Jordi
19Hu, Frank B
20Martínez-González, Miguel A
titlePlasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
description
0Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).
1Objective: We evaluated the associations between 1 ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2 ) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3 ) 1-y changes in lipid species and subsequent CVD.
2Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)].
3Results: Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles ( P -trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant ( P < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons.
4Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
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titlePlasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
authorToledo, Estefanía ; Wang, Dong D ; Ruiz - Canela, Miguel ; Clish, Clary B ; Razquin, Cristina ; Zheng, Yan ; Guasch - Ferré, Marta ; Hruby, Adela ; Corella, Dolores ; Gómez - Gracia, Enrique ; Fiol, Miquel ; Estruch, Ramón ; Ros, Emilio ; Lapetra, José ; Fito, Montserrat ; Aros, Fernando ; Serra - Majem, Luis ; Liang, Liming ; Salas - Salvadó, Jordi ; Hu, Frank B ; Martínez - González, Miguel A
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7Hruby, Adela
8Corella, Dolores
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abstractBackground: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD). Objective: We evaluated the associations between 1 ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2 ) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3 ) 1-y changes in lipid species and subsequent CVD. Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]. Results: Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles ( P -trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant ( P < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons. Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
pubOxford University Press
doi10.3945/ajcn.116.151159
orcididhttp://orcid.org/0000-0002-6263-4434
date2017-10-01