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Oral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome

Background. We investigated the efficacy of oral mizoribine pulse therapy (mizoribine-pulse) for cyclosporin (CyA)-dependent, steroid-resistant nephrotic syndrome (SRNS) and frequently relapsing, steroid-dependent nephrotic syndrome (FR-SDNS). Methods. One child with CyA-dependent SRNS and eight chi... Full description

Journal Title: Nephrology Dialysis Transplantation 2005, Vol.20(10), pp.2243-2247
Main Author: Kawasaki, Yukihiko
Other Authors: Hosoya, Mitsuaki , Kobayashi, Schogo , Ohara, Shinichirou , Onishi, Noriko , Takahashi, Ai , Isome, Masato , Suzuki, Hitoshi
Format: Electronic Article Electronic Article
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ID: ISSN: 0931-0509 ; E-ISSN: 1460-2385 ; DOI: 10.1093/ndt/gfh996
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recordid: oxford_sgml10.1093/ndt/gfh996
title: Oral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome
format: Article
creator:
  • Kawasaki, Yukihiko
  • Hosoya, Mitsuaki
  • Kobayashi, Schogo
  • Ohara, Shinichirou
  • Onishi, Noriko
  • Takahashi, Ai
  • Isome, Masato
  • Suzuki, Hitoshi
subjects:
  • Children
  • Clinical
  • Mizoribine Oral Pulse Therapy
  • Nephrotic Syndrome
  • Steroid-resistant Nephrotic Syndrome
ispartof: Nephrology Dialysis Transplantation, 2005, Vol.20(10), pp.2243-2247
description: Background. We investigated the efficacy of oral mizoribine pulse therapy (mizoribine-pulse) for cyclosporin (CyA)-dependent, steroid-resistant nephrotic syndrome (SRNS) and frequently relapsing, steroid-dependent nephrotic syndrome (FR-SDNS). Methods. One child with CyA-dependent SRNS and eight children with CyA-dependent FR-SDNS were treated with mizoribine-pulse (daily dose: 10mgkg; maximum total dose 500mg). We compared clinical manifestations before and after mizoribine-pulse, and studied the changes in serum mizoribine concentration in each patient on days when mizoribine was administered. Results. Four patients had no subsequent relapses (responders). Two of the four responders discontinued prednisolone and CyA, the other two discontinued CyA. Although each of the five other patients (non-responders) experienced single subsequent relapses, the dosages of prednisolone and CyA after mizoribine-pulse were decreased significantly compared with before mizoribine-pulse. The peak blood concentration of mizoribine in the responders was higher than in the non-responders (3.60.9 vs 1.80.4gml). Conclusions. Mizoribine-pulse may be effective for some patients with CyA-dependent SRNS and FR-SDNS.
language:
source:
identifier: ISSN: 0931-0509 ; E-ISSN: 1460-2385 ; DOI: 10.1093/ndt/gfh996
fulltext: fulltext
issn:
  • 0931-0509
  • 09310509
  • 1460-2385
  • 14602385
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titleOral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome
creatorKawasaki, Yukihiko ; Hosoya, Mitsuaki ; Kobayashi, Schogo ; Ohara, Shinichirou ; Onishi, Noriko ; Takahashi, Ai ; Isome, Masato ; Suzuki, Hitoshi
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subjectChildren; Clinical; Mizoribine Oral Pulse Therapy; Nephrotic Syndrome; Steroid-resistant Nephrotic Syndrome
descriptionBackground. We investigated the efficacy of oral mizoribine pulse therapy (mizoribine-pulse) for cyclosporin (CyA)-dependent, steroid-resistant nephrotic syndrome (SRNS) and frequently relapsing, steroid-dependent nephrotic syndrome (FR-SDNS). Methods. One child with CyA-dependent SRNS and eight children with CyA-dependent FR-SDNS were treated with mizoribine-pulse (daily dose: 10mgkg; maximum total dose 500mg). We compared clinical manifestations before and after mizoribine-pulse, and studied the changes in serum mizoribine concentration in each patient on days when mizoribine was administered. Results. Four patients had no subsequent relapses (responders). Two of the four responders discontinued prednisolone and CyA, the other two discontinued CyA. Although each of the five other patients (non-responders) experienced single subsequent relapses, the dosages of prednisolone and CyA after mizoribine-pulse were decreased significantly compared with before mizoribine-pulse. The peak blood concentration of mizoribine in the responders was higher than in the non-responders (3.60.9 vs 1.80.4gml). Conclusions. Mizoribine-pulse may be effective for some patients with CyA-dependent SRNS and FR-SDNS.
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titleOral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome
descriptionBackground. We investigated the efficacy of oral mizoribine pulse therapy (mizoribine-pulse) for cyclosporin (CyA)-dependent, steroid-resistant nephrotic syndrome (SRNS) and frequently relapsing, steroid-dependent nephrotic syndrome (FR-SDNS). Methods. One child with CyA-dependent SRNS and eight children with CyA-dependent FR-SDNS were treated with mizoribine-pulse (daily dose: 10mgkg; maximum total dose 500mg). We compared clinical manifestations before and after mizoribine-pulse, and studied the changes in serum mizoribine concentration in each patient on days when mizoribine was administered. Results. Four patients had no subsequent relapses (responders). Two of the four responders discontinued prednisolone and CyA, the other two discontinued CyA. Although each of the five other patients (non-responders) experienced single subsequent relapses, the dosages of prednisolone and CyA after mizoribine-pulse were decreased significantly compared with before mizoribine-pulse. The peak blood concentration of mizoribine in the responders was higher than in the non-responders (3.60.9 vs 1.80.4gml). Conclusions. Mizoribine-pulse may be effective for some patients with CyA-dependent SRNS and FR-SDNS.
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abstractBackground. We investigated the efficacy of oral mizoribine pulse therapy (mizoribine-pulse) for cyclosporin (CyA)-dependent, steroid-resistant nephrotic syndrome (SRNS) and frequently relapsing, steroid-dependent nephrotic syndrome (FR-SDNS). Methods. One child with CyA-dependent SRNS and eight children with CyA-dependent FR-SDNS were treated with mizoribine-pulse (daily dose: 10mgkg; maximum total dose 500mg). We compared clinical manifestations before and after mizoribine-pulse, and studied the changes in serum mizoribine concentration in each patient on days when mizoribine was administered. Results. Four patients had no subsequent relapses (responders). Two of the four responders discontinued prednisolone and CyA, the other two discontinued CyA. Although each of the five other patients (non-responders) experienced single subsequent relapses, the dosages of prednisolone and CyA after mizoribine-pulse were decreased significantly compared with before mizoribine-pulse. The peak blood concentration of mizoribine in the responders was higher than in the non-responders (3.60.9 vs 1.80.4gml). Conclusions. Mizoribine-pulse may be effective for some patients with CyA-dependent SRNS and FR-SDNS.
pubOxford University Press
doi10.1093/ndt/gfh996
pages2243-227
date2005-10