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Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control

Temporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-m... Full description

Journal Title: Sci Rep 2016, Vol.6(1), pp.28909-28909
Main Author: Li, Weifeng
Other Authors: Chen, Ziyi , Yan, Nan , Jones, Jeffery A. , Guo, Zhiqiang , Huang, Xiyan , Chen, Shaozhen , Liu, Peng , Liu, Hanjun
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 2045-2322 ; DOI: 10.1038/srep28909
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recordid: palgrave_j10.1038/srep28909
title: Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control
format: Article
creator:
  • Li, Weifeng
  • Chen, Ziyi
  • Yan, Nan
  • Jones, Jeffery A.
  • Guo, Zhiqiang
  • Huang, Xiyan
  • Chen, Shaozhen
  • Liu, Peng
  • Liu, Hanjun
subjects:
  • Article
ispartof: Sci Rep, 2016, Vol.6(1), pp.28909-28909
description: Temporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-motor integration for voice control, however, remains largely unknown. To address this question, event-related potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation and that the functional networks that support the auditory-motor processing of pitch feedback errors differ between patients with TLE and healthy controls.
language: eng
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identifier: ISSN: 2045-2322 ; DOI: 10.1038/srep28909
fulltext: fulltext
issn:
  • 2045-2322
  • 20452322
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titleTemporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control
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identifierISSN: 2045-2322 ; DOI: 10.1038/srep28909
descriptionTemporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-motor integration for voice control, however, remains largely unknown. To address this question, event-related potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation and that the functional networks that support the auditory-motor processing of pitch feedback errors differ between patients with TLE and healthy controls.
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titleTemporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control
descriptionTemporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-motor integration for voice control, however, remains largely unknown. To address this question, event-related potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation and that the functional networks that support the auditory-motor processing of pitch feedback errors differ between patients with TLE and healthy controls.
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abstractTemporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-motor integration for voice control, however, remains largely unknown. To address this question, event-related potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation and that the functional networks that support the auditory-motor processing of pitch feedback errors differ between patients with TLE and healthy controls.
pubNature Publishing Group UK
doi10.1038/srep28909
pages28909