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The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode (Genome Sequence and Evolution of Wolbachia)

Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related R... Full description

Journal Title: PLoS Biology 2005, Vol.3(4), p.e121
Main Author: Foster, Jeremy
Other Authors: Ganatra, Mehul , Kamal, Ibrahim , Ware, Jennifer , Makarova, Kira , Ivanova, Natalia , Bhattacharyya, Anamitra , Kapatral, Vinayak , Kumar, Sanjay , Posfai, Janos , Vincze, Tamas , Ingram, Jessica , Moran, Laurie , Lapidus, Alla , Omelchenko, Marina , Kyrpides, Nikos , Ghedin, Elodie , Wang, Shiliang , Goltsman, Eugene , Joukov, Victor , Ostrovskaya, Olga , Tsukerman, Kiryl , Mazur, Mikhail , Comb, Donald , Koonin, Eugene , Slatko, Barton
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1544-9173 ; E-ISSN: 1545-7885 ; DOI: 10.1371/journal.pbio.0030121
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recordid: plos10.1371/journal.pbio.0030121
title: The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode (Genome Sequence and Evolution of Wolbachia)
format: Article
creator:
  • Foster, Jeremy
  • Ganatra, Mehul
  • Kamal, Ibrahim
  • Ware, Jennifer
  • Makarova, Kira
  • Ivanova, Natalia
  • Bhattacharyya, Anamitra
  • Kapatral, Vinayak
  • Kumar, Sanjay
  • Posfai, Janos
  • Vincze, Tamas
  • Ingram, Jessica
  • Moran, Laurie
  • Lapidus, Alla
  • Omelchenko, Marina
  • Kyrpides, Nikos
  • Ghedin, Elodie
  • Wang, Shiliang
  • Goltsman, Eugene
  • Joukov, Victor
  • Ostrovskaya, Olga
  • Tsukerman, Kiryl
  • Mazur, Mikhail
  • Comb, Donald
  • Koonin, Eugene
  • Slatko, Barton
subjects:
  • Research Article
  • Computational Biology
  • Evolutionary Biology
  • Genetics And Genomics
  • Infectious Diseases
  • Microbiology
  • Eubacteria
  • Nematodes
  • Homo (human)
ispartof: PLoS Biology, 2005, Vol.3(4), p.e121
description: Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia 's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi ( w Bm) with the Wolbachia endosymbiont of Drosophila melanogaster ( w Mel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to w Mel, w Bm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of w Bm in contrast to the parasitic lifestyle of w Mel. The smaller genome size of w Bm, relative to w Mel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease. ; Analysis of this genome, which resides within filarial parasites, offers insight into endosymbiont evolution and the promise of new strategies for the elimination of human filarial disease.
language: eng
source:
identifier: ISSN: 1544-9173 ; E-ISSN: 1545-7885 ; DOI: 10.1371/journal.pbio.0030121
fulltext: fulltext
issn:
  • 1544-9173
  • 1545-7885
  • 15449173
  • 15457885
url: Link


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titleThe Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode (Genome Sequence and Evolution of Wolbachia)
creatorFoster, Jeremy ; Ganatra, Mehul ; Kamal, Ibrahim ; Ware, Jennifer ; Makarova, Kira ; Ivanova, Natalia ; Bhattacharyya, Anamitra ; Kapatral, Vinayak ; Kumar, Sanjay ; Posfai, Janos ; Vincze, Tamas ; Ingram, Jessica ; Moran, Laurie ; Lapidus, Alla ; Omelchenko, Marina ; Kyrpides, Nikos ; Ghedin, Elodie ; Wang, Shiliang ; Goltsman, Eugene ; Joukov, Victor ; Ostrovskaya, Olga ; Tsukerman, Kiryl ; Mazur, Mikhail ; Comb, Donald ; Koonin, Eugene ; Slatko, Barton
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subjectResearch Article ; Computational Biology ; Evolutionary Biology ; Genetics And Genomics ; Infectious Diseases ; Microbiology ; Eubacteria ; Nematodes ; Homo (human)
descriptionComplete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia 's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi ( w Bm) with the Wolbachia endosymbiont of Drosophila melanogaster ( w Mel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to w Mel, w Bm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of w Bm in contrast to the parasitic lifestyle of w Mel. The smaller genome size of w Bm, relative to w Mel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease. ; Analysis of this genome, which resides within filarial parasites, offers insight into endosymbiont evolution and the promise of new strategies for the elimination of human filarial disease.
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titleThe Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode (Genome Sequence and Evolution of Wolbachia)
descriptionComplete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia 's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi ( w Bm) with the Wolbachia endosymbiont of Drosophila melanogaster ( w Mel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to w Mel, w Bm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of w Bm in contrast to the parasitic lifestyle of w Mel. The smaller genome size of w Bm, relative to w Mel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease. ; Analysis of this genome, which resides within filarial parasites, offers insight into endosymbiont evolution and the promise of new strategies for the elimination of human filarial disease.
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abstractComplete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia 's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi ( w Bm) with the Wolbachia endosymbiont of Drosophila melanogaster ( w Mel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to w Mel, w Bm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of w Bm in contrast to the parasitic lifestyle of w Mel. The smaller genome size of w Bm, relative to w Mel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease. ; Analysis of this genome, which resides within filarial parasites, offers insight into endosymbiont evolution and the promise of new strategies for the elimination of human filarial disease.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pbio.0030121
oafree_for_read
date2005-04-29