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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (Age-and Sex-Specific Genetic Effects on Body Size and Shape)

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR adjBMI ), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially be... Full description

Journal Title: 2015 Vol.11(10), p.e1005378
Main Author: Winkler, Thomas W
Other Authors: Justice, Anne E , Graff, Mariaelisa , Barata, Llilda , Feitosa, Mary F , Chu, Su , Czajkowski, Jacek , Esko, Tõnu , Fall, Tove , Kilpeläinen, Tuomas O , Lu, Yingchang , Mägi, Reedik , Mihailov, Evelin , Pers, Tune H , Rüeger, Sina , Teumer, Alexander , Ehret, Georg B , Ferreira, Teresa , Heard-Costa, Nancy L , Karjalainen, Juha , Lagou, Vasiliki , Mahajan, Anubha , Neinast, Michael D , Prokopenko, Inga , Simino, Jeannette , Teslovich, Tanya M , Jansen, Rick , Westra, Harm-Jan , White, Charles C , Absher, Devin , Ahluwalia, Tarunveer S , Ahmad, Shafqat , Albrecht, Eva , Alves, Alexessander Couto , Bragg-Gresham, Jennifer L , de Craen, Anton J. M , Bis, Joshua C , Bonnefond, Amélie , Boucher, Gabrielle , Cadby, Gemma , Cheng, Yu-Ching , Chiang, Charleston W. K , Delgado, Graciela , Demirkan, Ayse , Dueker, Nicole , Eklund, Niina , Eiriksdottir, Gudny , Eriksson, Joel , Feenstra, Bjarke , Fischer, Krista , Frau, Francesca , Galesloot, Tessel E , Geller, Frank , Goel, Anuj , Gorski, Mathias , Grammer, Tanja B , Gustafsson, Stefan , Haitjema, Saskia , Hottenga, Jouke-Jan , Huffman, Jennifer E , Jackson, Anne U , Jacobs, Kevin B , Johansson, Åsa , Kaakinen, Marika , Kleber, Marcus E , Lahti, Jari , Leach, Irene Mateo , Lehne, Benjamin , Liu, Youfang , Lo, Ken Sin , Lorentzon, Mattias , Luan, Jian'an , Madden, Pamela A. F , Mangino, Massimo , McKnight, Barbara , Medina-Gomez, Carolina , Monda, Keri L , Montasser, May E , Müller, Gabriele , Müller-Nurasyid, Martina , Nolte, Ilja M , Panoutsopoulou, Kalliope , Pascoe, Laura , Paternoster, Lavinia , Rayner, Nigel W , Renström, Frida , Rizzi, Federica , Rose, Lynda M , Ryan, Kathy A , Salo, Perttu , Sanna, Serena , Scharnagl, Hubert , Shi, Jianxin , Smith, Albert Vernon , Southam, Lorraine , Stančáková, Alena , Steinthorsdottir, Valgerdur , Strawbridge, Rona J , Sung, Yun Ju , Tachmazidou, Ioanna , Tanaka, Toshiko , Thorleifsson, Gudmar , Trompet, Stella , Pervjakova, Natalia , Tyrer, Jonathan P , Vandenput, Liesbeth , van der Laan, Sander W , van der Velde, Nathalie , van Setten, Jessica , van Vliet-Ostaptchouk, Jana V , Verweij, Niek , Vlachopoulou, Efthymia , Waite, Lindsay L , Wang, Sophie R , Wang, Zhaoming , Wild, Sarah H , Willenborg, Christina , Wilson, James F , Wong, Andrew , Yang, Jian , Yengo, Loïc , Yerges-Armstrong, Laura M , Yu, Lei , Zhang, Weihua , Zhao, Jing Hua , Andersson, Ehm A , Bakker, Stephan J. L , Baldassarre, Damiano , Banasik, Karina , Barcella, Matteo , Barlassina, Cristina , Bellis, Claire , Benaglio, Paola , Blangero, John , Blüher, Matthias , Bonnet, Fabrice , Bonnycastle, Lori L , Boyd, Heather A , Bruinenberg, Marcel , Buchman, Aron S , Campbell, Harry , Chen, Yii-Der Ida , Chines, Peter S , Claudi-Boehm, Simone , Cole, John , Collins, Francis S , de Geus, Eco J. C , de Groot, Lisette C. P. G. M , Dimitriou, Maria , Duan, Jubao , Enroth, Stefan , Eury, Elodie , Farmaki, Aliki-Eleni , Forouhi, Nita G , Friedrich, Nele , Gejman, Pablo V , Gigante, Bruna , Glorioso, Nicola , Go, Alan S , Gottesman, Omri , Gräßler, Jürgen , Grallert, Harald , Grarup, Niels , Gu, Yu-Mei , Broer, Linda , Ham, Annelies C , Hansen, Torben , Harris, Tamara B , Hartman, Catharina A , Hassinen, Maija , Hastie, Nicholas , Hattersley, Andrew T , Heath, Andrew C , Henders, Anjali K , Hernandez, Dena , Hillege, Hans , Holmen, Oddgeir , Hovingh, Kees G , Hui, Jennie , Husemoen, Lise L , Hutri-Kähönen, Nina , Hysi, Pirro G , Illig, Thomas , De Jager, Philip L , Jalilzadeh, Shapour , Jørgensen, Torben , Jukema, J. Wouter , Juonala, Markus , Kanoni, Stavroula , Karaleftheri, Maria , Khaw, Kay Tee , Kinnunen, Leena , Kittner, Steven J , Koenig, Wolfgang , Kolcic, Ivana , Kovacs, Peter , Krarup, Nikolaj T , Kratzer, Wolfgang , Krüger, Janine , Kuh, Diana , Kumari, Meena , Kyriakou, Theodosios , Langenberg, Claudia , Lannfelt, Lars , Lanzani, Chiara , Lotay, Vaneet , Launer, Lenore J , Leander, Karin , Lindström, Jaana , Linneberg, Allan , Liu, Yan-Ping , Lobbens, Stéphane , Luben, Robert , Lyssenko, Valeriya , Männistö, Satu , Magnusson, Patrik K , McArdle, Wendy L , Menni, Cristina , Merger, Sigrun , Milani, Lili , Montgomery, Grant W , Morris, Andrew P , Narisu, Narisu , Nelis, Mari , Ong, Ken K , Palotie, Aarno , Pérusse, Louis , Pichler, Irene , Pilia, Maria G , Pouta, Anneli , Rheinberger, Myriam , Ribel-Madsen, Rasmus , Richards, Marcus , Rice, Kenneth M , Rice, Treva K , Rivolta, Carlo , Salomaa, Veikko , Sanders, Alan R , Sarzynski, Mark A , Scholtens, Salome , Scott, Robert A , Scott, William R , Sebert, Sylvain , Sengupta, Sebanti , Sennblad, Bengt , Seufferlein, Thomas , Silveira, Angela , Slagboom, P. Eline , Smit, Jan H , Sparsø, Thomas H , Stirrups, Kathleen , Stolk, Ronald P , Stringham, Heather M , Swertz, Morris A , Swift, Amy J , Syvänen, Ann-Christine , Tan, Sian-Tsung , Thorand, Barbara , Tönjes, Anke , Tremblay, Angelo , Tsafantakis, Emmanouil , van der Most, Peter J , Völker, Uwe , Vohl, Marie-Claude , Vonk, Judith M , Waldenberger, Melanie , Walker, Ryan W , Wennauer, Roman , Widén, Elisabeth , Willemsen, Gonneke , Wilsgaard, Tom , Wright, Alan F , Zillikens, M. Carola , van Dijk, Suzanne C , van Schoor, Natasja M , Asselbergs, Folkert W , de Bakker, Paul I. W , Beckmann, Jacques S , Beilby, John , Bennett, David A , Bergman, Richard N , Bergmann, Sven , Böger, Carsten A , Boehm, Bernhard O , Boerwinkle, Eric , Boomsma, Dorret I , Bornstein, Stefan R , Bottinger, Erwin P , Bouchard, Claude , Chambers, John C , Chanock, Stephen J , Chasman, Daniel I , Cucca, Francesco , Cusi, Daniele , Dedoussis, George , Erdmann, Jeanette , Eriksson, Johan G , Evans, Denis A , de Faire, Ulf , Farrall, Martin , Ferrucci, Luigi , Ford, Ian , Franke, Lude , Franks, Paul W , Froguel, Philippe , Gansevoort, Ron T , Gieger, Christian , Grönberg, Henrik , Gudnason, Vilmundur , Gyllensten, Ulf , Hall, Per , Hamsten, Anders , van der Harst, Pim , Hayward, Caroline , Heliövaara, Markku , Hengstenberg, Christian , Hicks, Andrew A , Hingorani, Aroon , Hofman, Albert , Hu, Frank , Huikuri, Heikki V , Hveem, Kristian , James, Alan L , Jordan, Joanne M , Jula, Antti , Kähönen, Mika , Kajantie, Eero , Kathiresan, Sekar , Kiemeney, Lambertus A. L. M , Kivimaki, Mika , Knekt, Paul B , Koistinen, Heikki A , Kooner, Jaspal S , Koskinen, Seppo , Kuusisto, Johanna , Maerz, Winfried , Martin, Nicholas G , Laakso, Markku , Lakka, Timo A , Lehtimäki, Terho , Lettre, Guillaume , Levinson, Douglas F , Lind, Lars , Lokki, Marja-Liisa , Mäntyselkä, Pekka , Melbye, Mads , Metspalu, Andres , Mitchell, Braxton D , Moll, Frans L , Murray, Jeffrey C , Musk, Arthur W , Nieminen, Markku S , Njølstad, Inger , Ohlsson, Claes , Oldehinkel, Albertine J , Oostra, Ben A , Palmer, Lyle J , Pankow, James S , Pasterkamp, Gerard , Pedersen, Nancy L , Pedersen, Oluf , Penninx, Brenda W , Perola, Markus , Peters, Annette , Polašek, Ozren , Pramstaller, Peter P , Psaty, Bruce M , Qi, Lu , Quertermous, Thomas , Raitakari, Olli T , Rankinen, Tuomo , Rauramaa, Rainer , Ridker, Paul M , Rioux, John D , Rivadeneira, Fernando , Rotter, Jerome I , Rudan, Igor , den Ruijter, Hester M , Saltevo, Juha , Sattar, Naveed , Schunkert, Heribert , Schwarz, Peter E. H , Shuldiner, Alan R , Sinisalo, Juha , Snieder, Harold , Sørensen, Thorkild I. A , Spector, Tim D , Staessen, Jan A , Stefania, Bandinelli , Thorsteinsdottir, Unnur , Stumvoll, Michael , Tardif, Jean-Claude , Tremoli, Elena , Tuomilehto, Jaakko , Uitterlinden, André G , Uusitupa, Matti , Verbeek, André L. M , Vermeulen, Sita H , Viikari, Jorma S , Vitart, Veronique , Völzke, Henry , Vollenweider, Peter , Waeber, Gérard , Walker, Mark , Wallaschofski, Henri , Wareham, Nicholas J , Watkins, Hugh , Zeggini, Eleftheria , Chakravarti, Aravinda , Clegg, Deborah J , Cupples, L. Adrienne , Gordon-Larsen, Penny , Jaquish, Cashell E , Rao, D. C , Abecasis, Goncalo R , Assimes, Themistocles L , Barroso, Inês , Berndt, Sonja I , Boehnke, Michael , Deloukas, Panos , Fox, Caroline S , Groop, Leif C , Hunter, David J , Ingelsson, Erik , Kaplan, Robert C , McCarthy, Mark I , Mohlke, Karen L , O'Connell, Jeffrey R , Schlessinger, David , Strachan, David P , Stefansson, Kari , van Duijn, Cornelia M , Hirschhorn, Joel N , Lindgren, Cecilia M , Heid, Iris M , North, Kari E , Borecki, Ingrid B , Kutalik, Zoltán , Loos, Ruth J. F
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1553-7390 ; E-ISSN: 1553-7404 ; DOI: 10.1371/journal.pgen.1005378
Zum Text:
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recordid: plos10.1371/journal.pgen.1005378
title: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (Age-and Sex-Specific Genetic Effects on Body Size and Shape)
format: Article
creator:
  • Winkler, Thomas W
  • Justice, Anne E
  • Graff, Mariaelisa
  • Barata, Llilda
  • Feitosa, Mary F
  • Chu, Su
  • Czajkowski, Jacek
  • Esko, Tõnu
  • Fall, Tove
  • Kilpeläinen, Tuomas O
  • Lu, Yingchang
  • Mägi, Reedik
  • Mihailov, Evelin
  • Pers, Tune H
  • Rüeger, Sina
  • Teumer, Alexander
  • Ehret, Georg B
  • Ferreira, Teresa
  • Heard-Costa, Nancy L
  • Karjalainen, Juha
  • Lagou, Vasiliki
  • Mahajan, Anubha
  • Neinast, Michael D
  • Prokopenko, Inga
  • Simino, Jeannette
  • Teslovich, Tanya M
  • Jansen, Rick
  • Westra, Harm-Jan
  • White, Charles C
  • Absher, Devin
  • Ahluwalia, Tarunveer S
  • Ahmad, Shafqat
  • Albrecht, Eva
  • Alves, Alexessander Couto
  • Bragg-Gresham, Jennifer L
  • de Craen, Anton J. M
  • Bis, Joshua C
  • Bonnefond, Amélie
  • Boucher, Gabrielle
  • Cadby, Gemma
  • Cheng, Yu-Ching
  • Chiang, Charleston W. K
  • Delgado, Graciela
  • Demirkan, Ayse
  • Dueker, Nicole
  • Eklund, Niina
  • Eiriksdottir, Gudny
  • Eriksson, Joel
  • Feenstra, Bjarke
  • Fischer, Krista
  • Frau, Francesca
  • Galesloot, Tessel E
  • Geller, Frank
  • Goel, Anuj
  • Gorski, Mathias
  • Grammer, Tanja B
  • Gustafsson, Stefan
  • Haitjema, Saskia
  • Hottenga, Jouke-Jan
  • Huffman, Jennifer E
  • Jackson, Anne U
  • Jacobs, Kevin B
  • Johansson, Åsa
  • Kaakinen, Marika
  • Kleber, Marcus E
  • Lahti, Jari
  • Leach, Irene Mateo
  • Lehne, Benjamin
  • Liu, Youfang
  • Lo, Ken Sin
  • Lorentzon, Mattias
  • Luan, Jian'an
  • Madden, Pamela A. F
  • Mangino, Massimo
  • McKnight, Barbara
  • Medina-Gomez, Carolina
  • Monda, Keri L
  • Montasser, May E
  • Müller, Gabriele
  • Müller-Nurasyid, Martina
  • Nolte, Ilja M
  • Panoutsopoulou, Kalliope
  • Pascoe, Laura
  • Paternoster, Lavinia
  • Rayner, Nigel W
  • Renström, Frida
  • Rizzi, Federica
  • Rose, Lynda M
  • Ryan, Kathy A
  • Salo, Perttu
  • Sanna, Serena
  • Scharnagl, Hubert
  • Shi, Jianxin
  • Smith, Albert Vernon
  • Southam, Lorraine
  • Stančáková, Alena
  • Steinthorsdottir, Valgerdur
  • Strawbridge, Rona J
  • Sung, Yun Ju
  • Tachmazidou, Ioanna
  • Tanaka, Toshiko
  • Thorleifsson, Gudmar
  • Trompet, Stella
  • Pervjakova, Natalia
  • Tyrer, Jonathan P
  • Vandenput, Liesbeth
  • van der Laan, Sander W
  • van der Velde, Nathalie
  • van Setten, Jessica
  • van Vliet-Ostaptchouk, Jana V
  • Verweij, Niek
  • Vlachopoulou, Efthymia
  • Waite, Lindsay L
  • Wang, Sophie R
  • Wang, Zhaoming
  • Wild, Sarah H
  • Willenborg, Christina
  • Wilson, James F
  • Wong, Andrew
  • Yang, Jian
  • Yengo, Loïc
  • Yerges-Armstrong, Laura M
  • Yu, Lei
  • Zhang, Weihua
  • Zhao, Jing Hua
  • Andersson, Ehm A
  • Bakker, Stephan J. L
  • Baldassarre, Damiano
  • Banasik, Karina
  • Barcella, Matteo
  • Barlassina, Cristina
  • Bellis, Claire
  • Benaglio, Paola
  • Blangero, John
  • Blüher, Matthias
  • Bonnet, Fabrice
  • Bonnycastle, Lori L
  • Boyd, Heather A
  • Bruinenberg, Marcel
  • Buchman, Aron S
  • Campbell, Harry
  • Chen, Yii-Der Ida
  • Chines, Peter S
  • Claudi-Boehm, Simone
  • Cole, John
  • Collins, Francis S
  • de Geus, Eco J. C
  • de Groot, Lisette C. P. G. M
  • Dimitriou, Maria
  • Duan, Jubao
  • Enroth, Stefan
  • Eury, Elodie
  • Farmaki, Aliki-Eleni
  • Forouhi, Nita G
  • Friedrich, Nele
  • Gejman, Pablo V
  • Gigante, Bruna
  • Glorioso, Nicola
  • Go, Alan S
  • Gottesman, Omri
  • Gräßler, Jürgen
  • Grallert, Harald
  • Grarup, Niels
  • Gu, Yu-Mei
  • Broer, Linda
  • Ham, Annelies C
  • Hansen, Torben
  • Harris, Tamara B
  • Hartman, Catharina A
  • Hassinen, Maija
  • Hastie, Nicholas
  • Hattersley, Andrew T
  • Heath, Andrew C
  • Henders, Anjali K
  • Hernandez, Dena
  • Hillege, Hans
  • Holmen, Oddgeir
  • Hovingh, Kees G
  • Hui, Jennie
  • Husemoen, Lise L
  • Hutri-Kähönen, Nina
  • Hysi, Pirro G
  • Illig, Thomas
  • De Jager, Philip L
  • Jalilzadeh, Shapour
  • Jørgensen, Torben
  • Jukema, J. Wouter
  • Juonala, Markus
  • Kanoni, Stavroula
  • Karaleftheri, Maria
  • Khaw, Kay Tee
  • Kinnunen, Leena
  • Kittner, Steven J
  • Koenig, Wolfgang
  • Kolcic, Ivana
  • Kovacs, Peter
  • Krarup, Nikolaj T
  • Kratzer, Wolfgang
  • Krüger, Janine
  • Kuh, Diana
  • Kumari, Meena
  • Kyriakou, Theodosios
  • Langenberg, Claudia
  • Lannfelt, Lars
  • Lanzani, Chiara
  • Lotay, Vaneet
  • Launer, Lenore J
  • Leander, Karin
  • Lindström, Jaana
  • Linneberg, Allan
  • Liu, Yan-Ping
  • Lobbens, Stéphane
  • Luben, Robert
  • Lyssenko, Valeriya
  • Männistö, Satu
  • Magnusson, Patrik K
  • McArdle, Wendy L
  • Menni, Cristina
  • Merger, Sigrun
  • Milani, Lili
  • Montgomery, Grant W
  • Morris, Andrew P
  • Narisu, Narisu
  • Nelis, Mari
  • Ong, Ken K
  • Palotie, Aarno
  • Pérusse, Louis
  • Pichler, Irene
  • Pilia, Maria G
  • Pouta, Anneli
  • Rheinberger, Myriam
  • Ribel-Madsen, Rasmus
  • Richards, Marcus
  • Rice, Kenneth M
  • Rice, Treva K
  • Rivolta, Carlo
  • Salomaa, Veikko
  • Sanders, Alan R
  • Sarzynski, Mark A
  • Scholtens, Salome
  • Scott, Robert A
  • Scott, William R
  • Sebert, Sylvain
  • Sengupta, Sebanti
  • Sennblad, Bengt
  • Seufferlein, Thomas
  • Silveira, Angela
  • Slagboom, P. Eline
  • Smit, Jan H
  • Sparsø, Thomas H
  • Stirrups, Kathleen
  • Stolk, Ronald P
  • Stringham, Heather M
  • Swertz, Morris A
  • Swift, Amy J
  • Syvänen, Ann-Christine
  • Tan, Sian-Tsung
  • Thorand, Barbara
  • Tönjes, Anke
  • Tremblay, Angelo
  • Tsafantakis, Emmanouil
  • van der Most, Peter J
  • Völker, Uwe
  • Vohl, Marie-Claude
  • Vonk, Judith M
  • Waldenberger, Melanie
  • Walker, Ryan W
  • Wennauer, Roman
  • Widén, Elisabeth
  • Willemsen, Gonneke
  • Wilsgaard, Tom
  • Wright, Alan F
  • Zillikens, M. Carola
  • van Dijk, Suzanne C
  • van Schoor, Natasja M
  • Asselbergs, Folkert W
  • de Bakker, Paul I. W
  • Beckmann, Jacques S
  • Beilby, John
  • Bennett, David A
  • Bergman, Richard N
  • Bergmann, Sven
  • Böger, Carsten A
  • Boehm, Bernhard O
  • Boerwinkle, Eric
  • Boomsma, Dorret I
  • Bornstein, Stefan R
  • Bottinger, Erwin P
  • Bouchard, Claude
  • Chambers, John C
  • Chanock, Stephen J
  • Chasman, Daniel I
  • Cucca, Francesco
  • Cusi, Daniele
  • Dedoussis, George
  • Erdmann, Jeanette
  • Eriksson, Johan G
  • Evans, Denis A
  • de Faire, Ulf
  • Farrall, Martin
  • Ferrucci, Luigi
  • Ford, Ian
  • Franke, Lude
  • Franks, Paul W
  • Froguel, Philippe
  • Gansevoort, Ron T
  • Gieger, Christian
  • Grönberg, Henrik
  • Gudnason, Vilmundur
  • Gyllensten, Ulf
  • Hall, Per
  • Hamsten, Anders
  • van der Harst, Pim
  • Hayward, Caroline
  • Heliövaara, Markku
  • Hengstenberg, Christian
  • Hicks, Andrew A
  • Hingorani, Aroon
  • Hofman, Albert
  • Hu, Frank
  • Huikuri, Heikki V
  • Hveem, Kristian
  • James, Alan L
  • Jordan, Joanne M
  • Jula, Antti
  • Kähönen, Mika
  • Kajantie, Eero
  • Kathiresan, Sekar
  • Kiemeney, Lambertus A. L. M
  • Kivimaki, Mika
  • Knekt, Paul B
  • Koistinen, Heikki A
  • Kooner, Jaspal S
  • Koskinen, Seppo
  • Kuusisto, Johanna
  • Maerz, Winfried
  • Martin, Nicholas G
  • Laakso, Markku
  • Lakka, Timo A
  • Lehtimäki, Terho
  • Lettre, Guillaume
  • Levinson, Douglas F
  • Lind, Lars
  • Lokki, Marja-Liisa
  • Mäntyselkä, Pekka
  • Melbye, Mads
  • Metspalu, Andres
  • Mitchell, Braxton D
  • Moll, Frans L
  • Murray, Jeffrey C
  • Musk, Arthur W
  • Nieminen, Markku S
  • Njølstad, Inger
  • Ohlsson, Claes
  • Oldehinkel, Albertine J
  • Oostra, Ben A
  • Palmer, Lyle J
  • Pankow, James S
  • Pasterkamp, Gerard
  • Pedersen, Nancy L
  • Pedersen, Oluf
  • Penninx, Brenda W
  • Perola, Markus
  • Peters, Annette
  • Polašek, Ozren
  • Pramstaller, Peter P
  • Psaty, Bruce M
  • Qi, Lu
  • Quertermous, Thomas
  • Raitakari, Olli T
  • Rankinen, Tuomo
  • Rauramaa, Rainer
  • Ridker, Paul M
  • Rioux, John D
  • Rivadeneira, Fernando
  • Rotter, Jerome I
  • Rudan, Igor
  • den Ruijter, Hester M
  • Saltevo, Juha
  • Sattar, Naveed
  • Schunkert, Heribert
  • Schwarz, Peter E. H
  • Shuldiner, Alan R
  • Sinisalo, Juha
  • Snieder, Harold
  • Sørensen, Thorkild I. A
  • Spector, Tim D
  • Staessen, Jan A
  • Stefania, Bandinelli
  • Thorsteinsdottir, Unnur
  • Stumvoll, Michael
  • Tardif, Jean-Claude
  • Tremoli, Elena
  • Tuomilehto, Jaakko
  • Uitterlinden, André G
  • Uusitupa, Matti
  • Verbeek, André L. M
  • Vermeulen, Sita H
  • Viikari, Jorma S
  • Vitart, Veronique
  • Völzke, Henry
  • Vollenweider, Peter
  • Waeber, Gérard
  • Walker, Mark
  • Wallaschofski, Henri
  • Wareham, Nicholas J
  • Watkins, Hugh
  • Zeggini, Eleftheria
  • Chakravarti, Aravinda
  • Clegg, Deborah J
  • Cupples, L. Adrienne
  • Gordon-Larsen, Penny
  • Jaquish, Cashell E
  • Rao, D. C
  • Abecasis, Goncalo R
  • Assimes, Themistocles L
  • Barroso, Inês
  • Berndt, Sonja I
  • Boehnke, Michael
  • Deloukas, Panos
  • Fox, Caroline S
  • Groop, Leif C
  • Hunter, David J
  • Ingelsson, Erik
  • Kaplan, Robert C
  • McCarthy, Mark I
  • Mohlke, Karen L
  • O'Connell, Jeffrey R
  • Schlessinger, David
  • Strachan, David P
  • Stefansson, Kari
  • van Duijn, Cornelia M
  • Hirschhorn, Joel N
  • Lindgren, Cecilia M
  • Heid, Iris M
  • North, Kari E
  • Borecki, Ingrid B
  • Kutalik, Zoltán
  • Loos, Ruth J. F
subjects:
  • Research Article
ispartof: 2015, Vol.11(10), p.e1005378
description: Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR adjBMI ), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHR adjBMI , we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHR adjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR
language: eng
source:
identifier: ISSN: 1553-7390 ; E-ISSN: 1553-7404 ; DOI: 10.1371/journal.pgen.1005378
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  • 1553-7404
  • 15537390
  • 15537404
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titleThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (Age-and Sex-Specific Genetic Effects on Body Size and Shape)
creatorWinkler, Thomas W ; Justice, Anne E ; Graff, Mariaelisa ; Barata, Llilda ; Feitosa, Mary F ; Chu, Su ; Czajkowski, Jacek ; Esko, Tõnu ; Fall, Tove ; Kilpeläinen, Tuomas O ; Lu, Yingchang ; Mägi, Reedik ; Mihailov, Evelin ; Pers, Tune H ; Rüeger, Sina ; Teumer, Alexander ; Ehret, Georg B ; Ferreira, Teresa ; Heard-Costa, Nancy L ; Karjalainen, Juha ; Lagou, Vasiliki ; Mahajan, Anubha ; Neinast, Michael D ; Prokopenko, Inga ; Simino, Jeannette ; Teslovich, Tanya M ; Jansen, Rick ; Westra, Harm-Jan ; White, Charles C ; Absher, Devin ; Ahluwalia, Tarunveer S ; Ahmad, Shafqat ; Albrecht, Eva ; Alves, Alexessander Couto ; Bragg-Gresham, Jennifer L ; de Craen, Anton J. M ; Bis, Joshua C ; Bonnefond, Amélie ; Boucher, Gabrielle ; Cadby, Gemma ; Cheng, Yu-Ching ; Chiang, Charleston W. K ; Delgado, Graciela ; Demirkan, Ayse ; Dueker, Nicole ; Eklund, Niina ; Eiriksdottir, Gudny ; Eriksson, Joel ; Feenstra, Bjarke ; Fischer, Krista ; Frau, Francesca ; Galesloot, Tessel E ; Geller, Frank ; Goel, Anuj ; Gorski, Mathias ; Grammer, Tanja B ; Gustafsson, Stefan ; Haitjema, Saskia ; Hottenga, Jouke-Jan ; Huffman, Jennifer E ; Jackson, Anne U ; Jacobs, Kevin B ; Johansson, Åsa ; Kaakinen, Marika ; Kleber, Marcus E ; Lahti, Jari ; Leach, Irene Mateo ; Lehne, Benjamin ; Liu, Youfang ; Lo, Ken Sin ; Lorentzon, Mattias ; Luan, Jian'an ; Madden, Pamela A. F ; Mangino, Massimo ; McKnight, Barbara ; Medina-Gomez, Carolina ; Monda, Keri L ; Montasser, May E ; Müller, Gabriele ; Müller-Nurasyid, Martina ; Nolte, Ilja M ; Panoutsopoulou, Kalliope ; Pascoe, Laura ; Paternoster, Lavinia ; Rayner, Nigel W ; Renström, Frida ; Rizzi, Federica ; Rose, Lynda M ; Ryan, Kathy A ; Salo, Perttu ; Sanna, Serena ; Scharnagl, Hubert ; Shi, Jianxin ; Smith, Albert Vernon ; Southam, Lorraine ; Stančáková, Alena ; Steinthorsdottir, Valgerdur ; Strawbridge, Rona J ; Sung, Yun Ju ; Tachmazidou, Ioanna ; Tanaka, Toshiko ; Thorleifsson, Gudmar ; Trompet, Stella ; Pervjakova, Natalia ; Tyrer, Jonathan P ; Vandenput, Liesbeth ; van der Laan, Sander W ; van der Velde, Nathalie ; van Setten, Jessica ; van Vliet-Ostaptchouk, Jana V ; Verweij, Niek ; Vlachopoulou, Efthymia ; Waite, Lindsay L ; Wang, Sophie R ; Wang, Zhaoming ; Wild, Sarah H ; Willenborg, Christina ; Wilson, James F ; Wong, Andrew ; Yang, Jian ; Yengo, Loïc ; Yerges-Armstrong, Laura M ; Yu, Lei ; Zhang, Weihua ; Zhao, Jing Hua ; Andersson, Ehm A ; Bakker, Stephan J. L ; Baldassarre, Damiano ; Banasik, Karina ; Barcella, Matteo ; Barlassina, Cristina ; Bellis, Claire ; Benaglio, Paola ; Blangero, John ; Blüher, Matthias ; Bonnet, Fabrice ; Bonnycastle, Lori L ; Boyd, Heather A ; Bruinenberg, Marcel ; Buchman, Aron S ; Campbell, Harry ; Chen, Yii-Der Ida ; Chines, Peter S ; Claudi-Boehm, Simone ; Cole, John ; Collins, Francis S ; de Geus, Eco J. C ; de Groot, Lisette C. P. G. M ; Dimitriou, Maria ; Duan, Jubao ; Enroth, Stefan ; Eury, Elodie ; Farmaki, Aliki-Eleni ; Forouhi, Nita G ; Friedrich, Nele ; Gejman, Pablo V ; Gigante, Bruna ; Glorioso, Nicola ; Go, Alan S ; Gottesman, Omri ; Gräßler, Jürgen ; Grallert, Harald ; Grarup, Niels ; Gu, Yu-Mei ; Broer, Linda ; Ham, Annelies C ; Hansen, Torben ; Harris, Tamara B ; Hartman, Catharina A ; Hassinen, Maija ; Hastie, Nicholas ; Hattersley, Andrew T ; Heath, Andrew C ; Henders, Anjali K ; Hernandez, Dena ; Hillege, Hans ; Holmen, Oddgeir ; Hovingh, Kees G ; Hui, Jennie ; Husemoen, Lise L ; Hutri-Kähönen, Nina ; Hysi, Pirro G ; Illig, Thomas ; De Jager, Philip L ; Jalilzadeh, Shapour ; Jørgensen, Torben ; Jukema, J. Wouter ; Juonala, Markus ; Kanoni, Stavroula ; Karaleftheri, Maria ; Khaw, Kay Tee ; Kinnunen, Leena ; Kittner, Steven J ; Koenig, Wolfgang ; Kolcic, Ivana ; Kovacs, Peter ; Krarup, Nikolaj T ; Kratzer, Wolfgang ; Krüger, Janine ; Kuh, Diana ; Kumari, Meena ; Kyriakou, Theodosios ; Langenberg, Claudia ; Lannfelt, Lars ; Lanzani, Chiara ; Lotay, Vaneet ; Launer, Lenore J ; Leander, Karin ; Lindström, Jaana ; Linneberg, Allan ; Liu, Yan-Ping ; Lobbens, Stéphane ; Luben, Robert ; Lyssenko, Valeriya ; Männistö, Satu ; Magnusson, Patrik K ; McArdle, Wendy L ; Menni, Cristina ; Merger, Sigrun ; Milani, Lili ; Montgomery, Grant W ; Morris, Andrew P ; Narisu, Narisu ; Nelis, Mari ; Ong, Ken K ; Palotie, Aarno ; Pérusse, Louis ; Pichler, Irene ; Pilia, Maria G ; Pouta, Anneli ; Rheinberger, Myriam ; Ribel-Madsen, Rasmus ; Richards, Marcus ; Rice, Kenneth M ; Rice, Treva K ; Rivolta, Carlo ; Salomaa, Veikko ; Sanders, Alan R ; Sarzynski, Mark A ; Scholtens, Salome ; Scott, Robert A ; Scott, William R ; Sebert, Sylvain ; Sengupta, Sebanti ; Sennblad, Bengt ; Seufferlein, Thomas ; Silveira, Angela ; Slagboom, P. Eline ; Smit, Jan H ; Sparsø, Thomas H ; Stirrups, Kathleen ; Stolk, Ronald P ; Stringham, Heather M ; Swertz, Morris A ; Swift, Amy J ; Syvänen, Ann-Christine ; Tan, Sian-Tsung ; Thorand, Barbara ; Tönjes, Anke ; Tremblay, Angelo ; Tsafantakis, Emmanouil ; van der Most, Peter J ; Völker, Uwe ; Vohl, Marie-Claude ; Vonk, Judith M ; Waldenberger, Melanie ; Walker, Ryan W ; Wennauer, Roman ; Widén, Elisabeth ; Willemsen, Gonneke ; Wilsgaard, Tom ; Wright, Alan F ; Zillikens, M. Carola ; van Dijk, Suzanne C ; van Schoor, Natasja M ; Asselbergs, Folkert W ; de Bakker, Paul I. 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M ; Kivimaki, Mika ; Knekt, Paul B ; Koistinen, Heikki A ; Kooner, Jaspal S ; Koskinen, Seppo ; Kuusisto, Johanna ; Maerz, Winfried ; Martin, Nicholas G ; Laakso, Markku ; Lakka, Timo A ; Lehtimäki, Terho ; Lettre, Guillaume ; Levinson, Douglas F ; Lind, Lars ; Lokki, Marja-Liisa ; Mäntyselkä, Pekka ; Melbye, Mads ; Metspalu, Andres ; Mitchell, Braxton D ; Moll, Frans L ; Murray, Jeffrey C ; Musk, Arthur W ; Nieminen, Markku S ; Njølstad, Inger ; Ohlsson, Claes ; Oldehinkel, Albertine J ; Oostra, Ben A ; Palmer, Lyle J ; Pankow, James S ; Pasterkamp, Gerard ; Pedersen, Nancy L ; Pedersen, Oluf ; Penninx, Brenda W ; Perola, Markus ; Peters, Annette ; Polašek, Ozren ; Pramstaller, Peter P ; Psaty, Bruce M ; Qi, Lu ; Quertermous, Thomas ; Raitakari, Olli T ; Rankinen, Tuomo ; Rauramaa, Rainer ; Ridker, Paul M ; Rioux, John D ; Rivadeneira, Fernando ; Rotter, Jerome I ; Rudan, Igor ; den Ruijter, Hester M ; Saltevo, Juha ; Sattar, Naveed ; Schunkert, Heribert ; Schwarz, Peter E. 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ispartof2015, Vol.11(10), p.e1005378
identifier
subjectResearch Article
descriptionGenome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR adjBMI ), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHR adjBMI , we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHR adjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHR adjBMI , we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHR adjBMI . This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHR adjBMI . These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. ; Adult body size and body shape differ substantially between men and women and change over time. More than 100 genetic variants that influence body mass index (measure of body size) or waist-to-hip ratio (measure of body shape) have been identified. While there is evidence that some genetic loci affect body shape differently in men than in women, little is known about whether genetic effects differ in older compared to younger adults, and whether such changes differ between men and women. Therefore, we conducted a systematic genome-wide search, including 114 studies (>320,000 individuals), to specifically identify genetic loci with age- and or sex-dependent effects on body size and shape. We identified 15 loci of which the effect on BMI was different in older compared to younger adults, whereas we found no evidence for loci with different effects in men compared to women. The opposite was seen for body shape as we identified 44 loci of which the effect on waist-to-hip ratio differed between men and women, but no difference between younger and older adults were observed. Our observations may provide new insights into the biology that underlies weight change with age or the sexual dimorphism of body shape.
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0Winkler, Thomas W
1Justice, Anne E
2Graff, Mariaelisa
3Barata, Llilda
4Feitosa, Mary F
5Chu, Su
6Czajkowski, Jacek
7Esko, Tõnu
8Fall, Tove
9Kilpeläinen, Tuomas O
10Lu, Yingchang
11Mägi, Reedik
12Mihailov, Evelin
13Pers, Tune H
14Rüeger, Sina
15Teumer, Alexander
16Ehret, Georg B
17Ferreira, Teresa
18Heard-Costa, Nancy L
19Karjalainen, Juha
20Lagou, Vasiliki
21Mahajan, Anubha
22Neinast, Michael D
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25Teslovich, Tanya M
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29Absher, Devin
30Ahluwalia, Tarunveer S
31Ahmad, Shafqat
32Albrecht, Eva
33Alves, Alexessander Couto
34Bragg-Gresham, Jennifer L
35de Craen, Anton J. M
36Bis, Joshua C
37Bonnefond, Amélie
38Boucher, Gabrielle
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42Delgado, Graciela
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46Eiriksdottir, Gudny
47Eriksson, Joel
48Feenstra, Bjarke
49Fischer, Krista
50Frau, Francesca
51Galesloot, Tessel E
52Geller, Frank
53Goel, Anuj
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55Grammer, Tanja B
56Gustafsson, Stefan
57Haitjema, Saskia
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59Huffman, Jennifer E
60Jackson, Anne U
61Jacobs, Kevin B
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63Kaakinen, Marika
64Kleber, Marcus E
65Lahti, Jari
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68Liu, Youfang
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70Lorentzon, Mattias
71Luan, Jian'an
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73Mangino, Massimo
74McKnight, Barbara
75Medina-Gomez, Carolina
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86Rizzi, Federica
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88Ryan, Kathy A
89Salo, Perttu
90Sanna, Serena
91Scharnagl, Hubert
92Shi, Jianxin
93Smith, Albert Vernon
94Southam, Lorraine
95Stančáková, Alena
96Steinthorsdottir, Valgerdur
97Strawbridge, Rona J
98Sung, Yun Ju
99Tachmazidou, Ioanna
100...
titleThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (Age-and Sex-Specific Genetic Effects on Body Size and Shape)
descriptionGenome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR adjBMI ), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHR adjBMI , we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHR adjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHR adjBMI , we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHR adjBMI . This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHR adjBMI . These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. ; Adult body size and body shape differ substantially between men and women and change over time. More than 100 genetic variants that influence body mass index (measure of body size) or waist-to-hip ratio (measure of body shape) have been identified. While there is evidence that some genetic loci affect body shape differently in men than in women, little is known about whether genetic effects differ in older compared to younger adults, and whether such changes differ between men and women. Therefore, we conducted a systematic genome-wide search, including 114 studies (>320,000 individuals), to specifically identify genetic loci with age- and or sex-dependent effects on body size and shape. We identified 15 loci of which the effect on BMI was different in older compared to younger adults, whereas we found no evidence for loci with different effects in men compared to women. The opposite was seen for body shape as we identified 44 loci of which the effect on waist-to-hip ratio differed between men and women, but no difference between younger and older adults were observed. Our observations may provide new insights into the biology that underlies weight change with age or the sexual dimorphism of body shape.
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titleThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (Age-and Sex-Specific Genetic Effects on Body Size and Shape)
authorWinkler, Thomas W ; Justice, Anne E ; Graff, Mariaelisa ; Barata, Llilda ; Feitosa, Mary F ; Chu, Su ; Czajkowski, Jacek ; Esko, Tõnu ; Fall, Tove ; Kilpeläinen, Tuomas O ; Lu, Yingchang ; Mägi, Reedik ; Mihailov, Evelin ; Pers, Tune H ; Rüeger, Sina ; Teumer, Alexander ; Ehret, Georg B ; Ferreira, Teresa ; Heard-Costa, Nancy L ; Karjalainen, Juha ; Lagou, Vasiliki ; Mahajan, Anubha ; Neinast, Michael D ; Prokopenko, Inga ; Simino, Jeannette ; Teslovich, Tanya M ; Jansen, Rick ; Westra, Harm-Jan ; White, Charles C ; Absher, Devin ; Ahluwalia, Tarunveer S ; Ahmad, Shafqat ; Albrecht, Eva ; Alves, Alexessander Couto ; Bragg-Gresham, Jennifer L ; de Craen, Anton J. M ; Bis, Joshua C ; Bonnefond, Amélie ; Boucher, Gabrielle ; Cadby, Gemma ; Cheng, Yu-Ching ; Chiang, Charleston W. K ; Delgado, Graciela ; Demirkan, Ayse ; Dueker, Nicole ; Eklund, Niina ; Eiriksdottir, Gudny ; Eriksson, Joel ; Feenstra, Bjarke ; Fischer, Krista ; Frau, Francesca ; Galesloot, Tessel E ; Geller, Frank ; Goel, Anuj ; Gorski, Mathias ; Grammer, Tanja B ; Gustafsson, Stefan ; Haitjema, Saskia ; Hottenga, Jouke-Jan ; Huffman, Jennifer E ; Jackson, Anne U ; Jacobs, Kevin B ; Johansson, Åsa ; Kaakinen, Marika ; Kleber, Marcus E ; Lahti, Jari ; Leach, Irene Mateo ; Lehne, Benjamin ; Liu, Youfang ; Lo, Ken Sin ; Lorentzon, Mattias ; Luan, Jian'an ; Madden, Pamela A. F ; Mangino, Massimo ; McKnight, Barbara ; Medina-Gomez, Carolina ; Monda, Keri L ; Montasser, May E ; Müller, Gabriele ; Müller-Nurasyid, Martina ; Nolte, Ilja M ; Panoutsopoulou, Kalliope ; Pascoe, Laura ; Paternoster, Lavinia ; Rayner, Nigel W ; Renström, Frida ; Rizzi, Federica ; Rose, Lynda M ; Ryan, Kathy A ; Salo, Perttu ; Sanna, Serena ; Scharnagl, Hubert ; Shi, Jianxin ; Smith, Albert Vernon ; Southam, Lorraine ; Stančáková, Alena ; Steinthorsdottir, Valgerdur ; Strawbridge, Rona J ; Sung, Yun Ju ; Tachmazidou, Ioanna ; Tanaka, Toshiko ; Thorleifsson, Gudmar ; Trompet, Stella ; Pervjakova, Natalia ; Tyrer, Jonathan P ; Vandenput, Liesbeth ; van der Laan, Sander W ; van der Velde, Nathalie ; van Setten, Jessica ; van Vliet-Ostaptchouk, Jana V ; Verweij, Niek ; Vlachopoulou, Efthymia ; Waite, Lindsay L ; Wang, Sophie R ; Wang, Zhaoming ; Wild, Sarah H ; Willenborg, Christina ; Wilson, James F ; Wong, Andrew ; Yang, Jian ; Yengo, Loïc ; Yerges-Armstrong, Laura M ; Yu, Lei ; Zhang, Weihua ; Zhao, Jing Hua ; Andersson, Ehm A ; Bakker, Stephan J. L ; Baldassarre, Damiano ; Banasik, Karina ; Barcella, Matteo ; Barlassina, Cristina ; Bellis, Claire ; Benaglio, Paola ; Blangero, John ; Blüher, Matthias ; Bonnet, Fabrice ; Bonnycastle, Lori L ; Boyd, Heather A ; Bruinenberg, Marcel ; Buchman, Aron S ; Campbell, Harry ; Chen, Yii-Der Ida ; Chines, Peter S ; Claudi-Boehm, Simone ; Cole, John ; Collins, Francis S ; de Geus, Eco J. C ; de Groot, Lisette C. P. G. M ; Dimitriou, Maria ; Duan, Jubao ; Enroth, Stefan ; Eury, Elodie ; Farmaki, Aliki-Eleni ; Forouhi, Nita G ; Friedrich, Nele ; Gejman, Pablo V ; Gigante, Bruna ; Glorioso, Nicola ; Go, Alan S ; Gottesman, Omri ; Gräßler, Jürgen ; Grallert, Harald ; Grarup, Niels ; Gu, Yu-Mei ; Broer, Linda ; Ham, Annelies C ; Hansen, Torben ; Harris, Tamara B ; Hartman, Catharina A ; Hassinen, Maija ; Hastie, Nicholas ; Hattersley, Andrew T ; Heath, Andrew C ; Henders, Anjali K ; Hernandez, Dena ; Hillege, Hans ; Holmen, Oddgeir ; Hovingh, Kees G ; Hui, Jennie ; Husemoen, Lise L ; Hutri-Kähönen, Nina ; Hysi, Pirro G ; Illig, Thomas ; De Jager, Philip L ; Jalilzadeh, Shapour ; Jørgensen, Torben ; Jukema, J. Wouter ; Juonala, Markus ; Kanoni, Stavroula ; Karaleftheri, Maria ; Khaw, Kay Tee ; Kinnunen, Leena ; Kittner, Steven J ; Koenig, Wolfgang ; Kolcic, Ivana ; Kovacs, Peter ; Krarup, Nikolaj T ; Kratzer, Wolfgang ; Krüger, Janine ; Kuh, Diana ; Kumari, Meena ; Kyriakou, Theodosios ; Langenberg, Claudia ; Lannfelt, Lars ; Lanzani, Chiara ; Lotay, Vaneet ; Launer, Lenore J ; Leander, Karin ; Lindström, Jaana ; Linneberg, Allan ; Liu, Yan-Ping ; Lobbens, Stéphane ; Luben, Robert ; Lyssenko, Valeriya ; Männistö, Satu ; Magnusson, Patrik K ; McArdle, Wendy L ; Menni, Cristina ; Merger, Sigrun ; Milani, Lili ; Montgomery, Grant W ; Morris, Andrew P ; Narisu, Narisu ; Nelis, Mari ; Ong, Ken K ; Palotie, Aarno ; Pérusse, Louis ; Pichler, Irene ; Pilia, Maria G ; Pouta, Anneli ; Rheinberger, Myriam ; Ribel-Madsen, Rasmus ; Richards, Marcus ; Rice, Kenneth M ; Rice, Treva K ; Rivolta, Carlo ; Salomaa, Veikko ; Sanders, Alan R ; Sarzynski, Mark A ; Scholtens, Salome ; Scott, Robert A ; Scott, William R ; Sebert, Sylvain ; Sengupta, Sebanti ; Sennblad, Bengt ; Seufferlein, Thomas ; Silveira, Angela ; Slagboom, P. Eline ; Smit, Jan H ; Sparsø, Thomas H ; Stirrups, Kathleen ; Stolk, Ronald P ; Stringham, Heather M ; Swertz, Morris A ; Swift, Amy J ; Syvänen, Ann-Christine ; Tan, Sian-Tsung ; Thorand, Barbara ; Tönjes, Anke ; Tremblay, Angelo ; Tsafantakis, Emmanouil ; van der Most, Peter J ; Völker, Uwe ; Vohl, Marie-Claude ; Vonk, Judith M ; Waldenberger, Melanie ; Walker, Ryan W ; Wennauer, Roman ; Widén, Elisabeth ; Willemsen, Gonneke ; Wilsgaard, Tom ; Wright, Alan F ; Zillikens, M. Carola ; van Dijk, Suzanne C ; van Schoor, Natasja M ; Asselbergs, Folkert W ; de Bakker, Paul I. 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M ; Kivimaki, Mika ; Knekt, Paul B ; Koistinen, Heikki A ; Kooner, Jaspal S ; Koskinen, Seppo ; Kuusisto, Johanna ; Maerz, Winfried ; Martin, Nicholas G ; Laakso, Markku ; Lakka, Timo A ; Lehtimäki, Terho ; Lettre, Guillaume ; Levinson, Douglas F ; Lind, Lars ; Lokki, Marja-Liisa ; Mäntyselkä, Pekka ; Melbye, Mads ; Metspalu, Andres ; Mitchell, Braxton D ; Moll, Frans L ; Murray, Jeffrey C ; Musk, Arthur W ; Nieminen, Markku S ; Njølstad, Inger ; Ohlsson, Claes ; Oldehinkel, Albertine J ; Oostra, Ben A ; Palmer, Lyle J ; Pankow, James S ; Pasterkamp, Gerard ; Pedersen, Nancy L ; Pedersen, Oluf ; Penninx, Brenda W ; Perola, Markus ; Peters, Annette ; Polašek, Ozren ; Pramstaller, Peter P ; Psaty, Bruce M ; Qi, Lu ; Quertermous, Thomas ; Raitakari, Olli T ; Rankinen, Tuomo ; Rauramaa, Rainer ; Ridker, Paul M ; Rioux, John D ; Rivadeneira, Fernando ; Rotter, Jerome I ; Rudan, Igor ; den Ruijter, Hester M ; Saltevo, Juha ; Sattar, Naveed ; Schunkert, Heribert ; Schwarz, Peter E. H ; Shuldiner, Alan R ; Sinisalo, Juha ; Snieder, Harold ; Sørensen, Thorkild I. A ; Spector, Tim D ; Staessen, Jan A ; Stefania, Bandinelli ; Thorsteinsdottir, Unnur ; Stumvoll, Michael ; Tardif, Jean-Claude ; Tremoli, Elena ; Tuomilehto, Jaakko ; Uitterlinden, André G ; Uusitupa, Matti ; Verbeek, André L. M ; Vermeulen, Sita H ; Viikari, Jorma S ; Vitart, Veronique ; Völzke, Henry ; Vollenweider, Peter ; Waeber, Gérard ; Walker, Mark ; Wallaschofski, Henri ; Wareham, Nicholas J ; Watkins, Hugh ; Zeggini, Eleftheria ; Chakravarti, Aravinda ; Clegg, Deborah J ; Cupples, L. Adrienne ; Gordon-Larsen, Penny ; Jaquish, Cashell E ; Rao, D. C ; Abecasis, Goncalo R ; Assimes, Themistocles L ; Barroso, Inês ; Berndt, Sonja I ; Boehnke, Michael ; Deloukas, Panos ; Fox, Caroline S ; Groop, Leif C ; Hunter, David J ; Ingelsson, Erik ; Kaplan, Robert C ; McCarthy, Mark I ; Mohlke, Karen L ; O'Connell, Jeffrey R ; Schlessinger, David ; Strachan, David P ; Stefansson, Kari ; van Duijn, Cornelia M ; Hirschhorn, Joel N ; Lindgren, Cecilia M ; Heid, Iris M ; North, Kari E ; Borecki, Ingrid B ; Kutalik, Zoltán ; Loos, Ruth J. F
creationdate20151001
facets
frbrgroupid8918683239657643013
frbrtype5
languageeng
creationdate2015
topicResearch Article
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Winkler, Thomas W
1Justice, Anne E
2Graff, Mariaelisa
3Barata, Llilda
4Feitosa, Mary F
5Chu, Su
6Czajkowski, Jacek
7Esko, Tõnu
8Fall, Tove
9Kilpeläinen, Tuomas O
10Lu, Yingchang
11Mägi, Reedik
12Mihailov, Evelin
13Pers, Tune H
14Rüeger, Sina
15Teumer, Alexander
16Ehret, Georg B
17Ferreira, Teresa
18Heard-Costa, Nancy L
19Karjalainen, Juha
20Lagou, Vasiliki
21Mahajan, Anubha
22Neinast, Michael D
23Prokopenko, Inga
24Simino, Jeannette
25Teslovich, Tanya M
26Jansen, Rick
27Westra, Harm-Jan
28White, Charles C
29Absher, Devin
30Ahluwalia, Tarunveer S
31Ahmad, Shafqat
32Albrecht, Eva
33Alves, Alexessander Couto
34Bragg-Gresham, Jennifer L
35de Craen, Anton J. M
36Bis, Joshua C
37Bonnefond, Amélie
38Boucher, Gabrielle
39Cadby, Gemma
40Cheng, Yu-Ching
41Chiang, Charleston W. K
42Delgado, Graciela
43Demirkan, Ayse
44Dueker, Nicole
45Eklund, Niina
46Eiriksdottir, Gudny
47Eriksson, Joel
48Feenstra, Bjarke
49Fischer, Krista
50Frau, Francesca
51Galesloot, Tessel E
52Geller, Frank
53Goel, Anuj
54Gorski, Mathias
55Grammer, Tanja B
56Gustafsson, Stefan
57Haitjema, Saskia
58Hottenga, Jouke-Jan
59Huffman, Jennifer E
60Jackson, Anne U
61Jacobs, Kevin B
62Johansson, Åsa
63Kaakinen, Marika
64Kleber, Marcus E
65Lahti, Jari
66Leach, Irene Mateo
67Lehne, Benjamin
68Liu, Youfang
69Lo, Ken Sin
70Lorentzon, Mattias
71Luan, Jian'an
72Madden, Pamela A. F
73Mangino, Massimo
74McKnight, Barbara
75Medina-Gomez, Carolina
76Monda, Keri L
77Montasser, May E
78Müller, Gabriele
79Müller-Nurasyid, Martina
80Nolte, Ilja M
81Panoutsopoulou, Kalliope
82Pascoe, Laura
83Paternoster, Lavinia
84Rayner, Nigel W
85Renström, Frida
86Rizzi, Federica
87Rose, Lynda M
88Ryan, Kathy A
89Salo, Perttu
90Sanna, Serena
91Scharnagl, Hubert
92Shi, Jianxin
93Smith, Albert Vernon
94Southam, Lorraine
95Stančáková, Alena
96Steinthorsdottir, Valgerdur
97Strawbridge, Rona J
98Sung, Yun Ju
99Tachmazidou, Ioanna
100...
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fulltextfulltext
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aulast
0Winkler
1Justice
2Graff
3Barata
4Feitosa
5Chu
6Czajkowski
7Esko
8Fall
9Kilpeläinen
10Lu
11Mägi
12Mihailov
13Pers
14Rüeger
15Teumer
16Ehret
17Ferreira
18Heard-Costa
19Karjalainen
20Lagou
21Mahajan
22Neinast
23Prokopenko
24Simino
25Teslovich
26Jansen
27Westra
28White
29Absher
30Ahluwalia
31Ahmad
32Albrecht
33Alves
34Bragg-Gresham
35de Craen
36Bis
37Bonnefond
38Boucher
39Cadby
40Cheng
41Chiang
42Delgado
43Demirkan
44Dueker
45Eklund
46Eiriksdottir
47Eriksson
48Feenstra
49Fischer
50Frau
51Galesloot
52Geller
53Goel
54Gorski
55Grammer
56Gustafsson
57Haitjema
58Hottenga
59Huffman
60Jackson
61Jacobs
62Johansson
63Kaakinen
64Kleber
65Lahti
66Leach
67Lehne
68Liu
69Lo
70Lorentzon
71Luan
72Madden
73Mangino
74McKnight
75Medina-Gomez
76Monda
77Montasser
78Müller
79Müller-Nurasyid
80Nolte
81Panoutsopoulou
82Pascoe
83Paternoster
84Rayner
85Renström
86Rizzi
87Rose
88Ryan
89Salo
90Sanna
91Scharnagl
92Shi
93Smith
94Southam
95Stančáková
96Steinthorsdottir
97Strawbridge
98Sung
99Tachmazidou
100...
aufirst
0Thomas W.
1Anne E.
2Mariaelisa
3Llilda
4Mary F.
5Su
6Jacek
7Tõnu
8Tove
9Tuomas O.
10Yingchang
11Reedik
12Evelin
13Tune H.
14Sina
15Alexander
16Georg B.
17Teresa
18Nancy L.
19Juha
20Vasiliki
21Anubha
22Michael D.
23Inga
24Jeannette
25Tanya M.
26Rick
27Harm-Jan
28Charles C.
29Devin
30Tarunveer S.
31Shafqat
32Eva
33Alexessander Couto
34Jennifer L.
35Anton J. M.
36Joshua C.
37Amélie
38Gabrielle
39Gemma
40Yu-Ching
41Charleston W. K.
42Graciela
43Ayse
44Nicole
45Niina
46Gudny
47Joel
48Bjarke
49Krista
50Francesca
51Tessel E.
52Frank
53Anuj
54Mathias
55Tanja B.
56Stefan
57Saskia
58Jouke-Jan
59Jennifer E.
60Anne U.
61Kevin B.
62Åsa
63Marika
64Marcus E.
65Jari
66Irene Mateo
67Benjamin
68Youfang
69Ken Sin
70Mattias
71Jian'an
72Pamela A. F.
73Massimo
74Barbara
75Carolina
76Keri L.
77May E.
78Gabriele
79Martina
80Ilja M.
81Kalliope
82Laura
83Lavinia
84Nigel W.
85Frida
86Federica
87Lynda M.
88Kathy A.
89Perttu
90Serena
91Hubert
92Jianxin
93Albert Vernon
94Lorraine
95Alena
96Valgerdur
97Rona J.
98Yun Ju
99Ioanna
100...
au
0Winkler, Thomas W
1Justice, Anne E
2Graff, Mariaelisa
3Barata, Llilda
4Feitosa, Mary F
5Chu, Su
6Czajkowski, Jacek
7Esko, Tõnu
8Fall, Tove
9Kilpeläinen, Tuomas O
10Lu, Yingchang
11Mägi, Reedik
12Mihailov, Evelin
13Pers, Tune H
14Rüeger, Sina
15Teumer, Alexander
16Ehret, Georg B
17Ferreira, Teresa
18Heard-Costa, Nancy L
19Karjalainen, Juha
20Lagou, Vasiliki
21Mahajan, Anubha
22Neinast, Michael D
23Prokopenko, Inga
24Simino, Jeannette
25Teslovich, Tanya M
26Jansen, Rick
27Westra, Harm-Jan
28White, Charles C
29Absher, Devin
30Ahluwalia, Tarunveer S
31Ahmad, Shafqat
32Albrecht, Eva
33Alves, Alexessander Couto
34Bragg-Gresham, Jennifer L
35de Craen, Anton J. M
36Bis, Joshua C
37Bonnefond, Amélie
38Boucher, Gabrielle
39Cadby, Gemma
40Cheng, Yu-Ching
41Chiang, Charleston W. K
42Delgado, Graciela
43Demirkan, Ayse
44Dueker, Nicole
45Eklund, Niina
46Eiriksdottir, Gudny
47Eriksson, Joel
48Feenstra, Bjarke
49Fischer, Krista
50Frau, Francesca
51Galesloot, Tessel E
52Geller, Frank
53Goel, Anuj
54Gorski, Mathias
55Grammer, Tanja B
56Gustafsson, Stefan
57Haitjema, Saskia
58Hottenga, Jouke-Jan
59Huffman, Jennifer E
60Jackson, Anne U
61Jacobs, Kevin B
62Johansson, Åsa
63Kaakinen, Marika
64Kleber, Marcus E
65Lahti, Jari
66Leach, Irene Mateo
67Lehne, Benjamin
68Liu, Youfang
69Lo, Ken Sin
70Lorentzon, Mattias
71Luan, Jian'an
72Madden, Pamela A. F
73Mangino, Massimo
74McKnight, Barbara
75Medina-Gomez, Carolina
76Monda, Keri L
77Montasser, May E
78Müller, Gabriele
79Müller-Nurasyid, Martina
80Nolte, Ilja M
81Panoutsopoulou, Kalliope
82Pascoe, Laura
83Paternoster, Lavinia
84Rayner, Nigel W
85Renström, Frida
86Rizzi, Federica
87Rose, Lynda M
88Ryan, Kathy A
89Salo, Perttu
90Sanna, Serena
91Scharnagl, Hubert
92Shi, Jianxin
93Smith, Albert Vernon
94Southam, Lorraine
95Stančáková, Alena
96Steinthorsdottir, Valgerdur
97Strawbridge, Rona J
98Sung, Yun Ju
99Tachmazidou, Ioanna
100...
atitleThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (Age-and Sex-Specific Genetic Effects on Body Size and Shape)
risdate20151001
volume11
issue10
spagee1005378
pagese1005378
issn1553-7390
eissn1553-7404
genrearticle
ristypeJOUR
abstractGenome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR adjBMI ), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHR adjBMI , we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHR adjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHR adjBMI , we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHR adjBMI . This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHR adjBMI . These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. ; Adult body size and body shape differ substantially between men and women and change over time. More than 100 genetic variants that influence body mass index (measure of body size) or waist-to-hip ratio (measure of body shape) have been identified. While there is evidence that some genetic loci affect body shape differently in men than in women, little is known about whether genetic effects differ in older compared to younger adults, and whether such changes differ between men and women. Therefore, we conducted a systematic genome-wide search, including 114 studies (>320,000 individuals), to specifically identify genetic loci with age- and or sex-dependent effects on body size and shape. We identified 15 loci of which the effect on BMI was different in older compared to younger adults, whereas we found no evidence for loci with different effects in men compared to women. The opposite was seen for body shape as we identified 44 loci of which the effect on waist-to-hip ratio differed between men and women, but no difference between younger and older adults were observed. Our observations may provide new insights into the biology that underlies weight change with age or the sexual dimorphism of body shape.
copSan Francisco, CA USA
pubPublic Library of Science
doi10.1371/journal.pgen.1005378
orcidid0000-0003-2071-5866
isbn0003644016000
oafree_for_read
date2015-10-01