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New Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging (Nanoparticle Agent for MRI)

Liposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated... Full description

Journal Title: PLoS ONE 2009, Vol.4(10), p.e7628
Main Author: Ghaghada, Ketan B
Other Authors: Ravoori, Murali , Sabapathy, Divya , Bankson, James , Kundra, Vikas , Annapragada, Ananth
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0007628
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recordid: plos10.1371/journal.pone.0007628
title: New Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging (Nanoparticle Agent for MRI)
format: Article
creator:
  • Ghaghada, Ketan B
  • Ravoori, Murali
  • Sabapathy, Divya
  • Bankson, James
  • Kundra, Vikas
  • Annapragada, Ananth
subjects:
  • Research Article
  • Radiology And Medical Imaging
  • Cardiovascular Disorders -- Cardiovascular Imaging
  • Radiology And Medical Imaging -- Magnetic Resonance Imaging
ispartof: PLoS ONE, 2009, Vol.4(10), p.e7628
description: Liposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated gadolinium liposomes) or presented on the surface of liposomes (surface-conjugated gadolinium liposomes). We hypothesized that a liposomal agent that contained both core-encapsulated gadolinium and surface-conjugated gadolinium, defined herein as dual-mode gadolinium (Dual-Gd) liposomes, would result in a significant improvement in nanoparticle-based T1 relaxivity over the previous generations of liposomal agents. In this study, we have developed and tested, both in vitro and in vivo , such a dual-mode liposomal-based gadolinium contrast agent. ; Three types of liposomal agents were fabricated: core-encapsulated, surface-conjugated and dual-mode gadolinium liposomes. physico-chemical characterizations of the agents were performed to determine particle size and elemental composition. Gadolinium-based and nanoparticle-based T1 relaxivities of various agents were determined in bovine plasma. Subsequently, the agents were tested for contrast-enhanced magnetic resonance angiography (CE-MRA) studies. Characterization of the agents demonstrated the highest gadolinium atoms per nanoparticle for Dual-Gd liposomes. , surface-conjugated gadolinium liposomes demonstrated the highest T1 relaxivity on a gadolinium-basis. However, Dual-Gd liposomes demonstrated the highest T1 relaxivity on a nanoparticle-basis. , Dual-Gd liposomes resulted in the highest signal-to-noise ratio (SNR) and contrast-to-noise ratio in CE-MRA studies. ; The dual-mode gadolinium liposomal contrast agent demonstrated higher particle-based T1 relaxivity, both and , compared to either the core-encapsulated or the surface-conjugated liposomal agent. The dual-mode gadolinium liposomes could enable reduced particle dose for use in CE-MRA and increased contrast sensitivity for use in molecular imaging.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0007628
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleNew Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging (Nanoparticle Agent for MRI)
creatorGhaghada, Ketan B ; Ravoori, Murali ; Sabapathy, Divya ; Bankson, James ; Kundra, Vikas ; Annapragada, Ananth
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subjectResearch Article ; Radiology And Medical Imaging ; Cardiovascular Disorders -- Cardiovascular Imaging ; Radiology And Medical Imaging -- Magnetic Resonance Imaging
descriptionLiposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated gadolinium liposomes) or presented on the surface of liposomes (surface-conjugated gadolinium liposomes). We hypothesized that a liposomal agent that contained both core-encapsulated gadolinium and surface-conjugated gadolinium, defined herein as dual-mode gadolinium (Dual-Gd) liposomes, would result in a significant improvement in nanoparticle-based T1 relaxivity over the previous generations of liposomal agents. In this study, we have developed and tested, both in vitro and in vivo , such a dual-mode liposomal-based gadolinium contrast agent. ; Three types of liposomal agents were fabricated: core-encapsulated, surface-conjugated and dual-mode gadolinium liposomes. physico-chemical characterizations of the agents were performed to determine particle size and elemental composition. Gadolinium-based and nanoparticle-based T1 relaxivities of various agents were determined in bovine plasma. Subsequently, the agents were tested for contrast-enhanced magnetic resonance angiography (CE-MRA) studies. Characterization of the agents demonstrated the highest gadolinium atoms per nanoparticle for Dual-Gd liposomes. , surface-conjugated gadolinium liposomes demonstrated the highest T1 relaxivity on a gadolinium-basis. However, Dual-Gd liposomes demonstrated the highest T1 relaxivity on a nanoparticle-basis. , Dual-Gd liposomes resulted in the highest signal-to-noise ratio (SNR) and contrast-to-noise ratio in CE-MRA studies. ; The dual-mode gadolinium liposomal contrast agent demonstrated higher particle-based T1 relaxivity, both and , compared to either the core-encapsulated or the surface-conjugated liposomal agent. The dual-mode gadolinium liposomes could enable reduced particle dose for use in CE-MRA and increased contrast sensitivity for use in molecular imaging.
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titleNew Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging (Nanoparticle Agent for MRI)
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abstractLiposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated gadolinium liposomes) or presented on the surface of liposomes (surface-conjugated gadolinium liposomes). We hypothesized that a liposomal agent that contained both core-encapsulated gadolinium and surface-conjugated gadolinium, defined herein as dual-mode gadolinium (Dual-Gd) liposomes, would result in a significant improvement in nanoparticle-based T1 relaxivity over the previous generations of liposomal agents. In this study, we have developed and tested, both in vitro and in vivo , such a dual-mode liposomal-based gadolinium contrast agent. ; Three types of liposomal agents were fabricated: core-encapsulated, surface-conjugated and dual-mode gadolinium liposomes. physico-chemical characterizations of the agents were performed to determine particle size and elemental composition. Gadolinium-based and nanoparticle-based T1 relaxivities of various agents were determined in bovine plasma. Subsequently, the agents were tested for contrast-enhanced magnetic resonance angiography (CE-MRA) studies. Characterization of the agents demonstrated the highest gadolinium atoms per nanoparticle for Dual-Gd liposomes. , surface-conjugated gadolinium liposomes demonstrated the highest T1 relaxivity on a gadolinium-basis. However, Dual-Gd liposomes demonstrated the highest T1 relaxivity on a nanoparticle-basis. , Dual-Gd liposomes resulted in the highest signal-to-noise ratio (SNR) and contrast-to-noise ratio in CE-MRA studies. ; The dual-mode gadolinium liposomal contrast agent demonstrated higher particle-based T1 relaxivity, both and , compared to either the core-encapsulated or the surface-conjugated liposomal agent. The dual-mode gadolinium liposomes could enable reduced particle dose for use in CE-MRA and increased contrast sensitivity for use in molecular imaging.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0007628
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date2009-10-29