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Alternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development (Sept9 in Zebrafish Development)

Septins are involved in a number of cellular processes including cytokinesis and organization of the cytoskeleton. Alterations in human septin-9 ( SEPT9 ) levels have been linked to multiple cancers, whereas mutations in SEPT9 cause the episodic neuropathy, hereditary neuralgic amyotrophy (HNA). Des... Full description

Journal Title: PLoS ONE 2010, Vol.5(5), p.e10712
Main Author: Landsverk, Megan L
Other Authors: Weiser, Douglas C , Hannibal, Mark C , Kimelman, David
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0010712
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recordid: plos10.1371/journal.pone.0010712
title: Alternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development (Sept9 in Zebrafish Development)
format: Article
creator:
  • Landsverk, Megan L
  • Weiser, Douglas C
  • Hannibal, Mark C
  • Kimelman, David
subjects:
  • Research Article
  • Developmental Biology
  • Developmental Biology -- Molecular Development
  • Developmental Biology -- Morphogenesis And Cell Biology
  • Genetics And Genomics -- Gene Expression
  • Genetics And Genomics -- Gene Function
ispartof: PLoS ONE, 2010, Vol.5(5), p.e10712
description: Septins are involved in a number of cellular processes including cytokinesis and organization of the cytoskeleton. Alterations in human septin-9 ( SEPT9 ) levels have been linked to multiple cancers, whereas mutations in SEPT9 cause the episodic neuropathy, hereditary neuralgic amyotrophy (HNA). Despite its important function in human health, the in vivo role of SEPT9 is unknown. ; Here we utilize zebrafish to study the role of in early development. We show that zebrafish possess two genes, and that, like humans, express multiple transcripts. Knockdown or overexpression of transcripts results in specific developmental alterations including circulation defects and aberrant epidermal development. ; Our work demonstrates that plays an important role in zebrafish development, and establishes zebrafish as a valuable model organism for the study of .
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0010712
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleAlternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development (Sept9 in Zebrafish Development)
creatorLandsverk, Megan L ; Weiser, Douglas C ; Hannibal, Mark C ; Kimelman, David
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subjectResearch Article ; Developmental Biology ; Developmental Biology -- Molecular Development ; Developmental Biology -- Morphogenesis And Cell Biology ; Genetics And Genomics -- Gene Expression ; Genetics And Genomics -- Gene Function
descriptionSeptins are involved in a number of cellular processes including cytokinesis and organization of the cytoskeleton. Alterations in human septin-9 ( SEPT9 ) levels have been linked to multiple cancers, whereas mutations in SEPT9 cause the episodic neuropathy, hereditary neuralgic amyotrophy (HNA). Despite its important function in human health, the in vivo role of SEPT9 is unknown. ; Here we utilize zebrafish to study the role of in early development. We show that zebrafish possess two genes, and that, like humans, express multiple transcripts. Knockdown or overexpression of transcripts results in specific developmental alterations including circulation defects and aberrant epidermal development. ; Our work demonstrates that plays an important role in zebrafish development, and establishes zebrafish as a valuable model organism for the study of .
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titleAlternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development (Sept9 in Zebrafish Development)
descriptionSeptins are involved in a number of cellular processes including cytokinesis and organization of the cytoskeleton. Alterations in human septin-9 ( SEPT9 ) levels have been linked to multiple cancers, whereas mutations in SEPT9 cause the episodic neuropathy, hereditary neuralgic amyotrophy (HNA). Despite its important function in human health, the in vivo role of SEPT9 is unknown. ; Here we utilize zebrafish to study the role of in early development. We show that zebrafish possess two genes, and that, like humans, express multiple transcripts. Knockdown or overexpression of transcripts results in specific developmental alterations including circulation defects and aberrant epidermal development. ; Our work demonstrates that plays an important role in zebrafish development, and establishes zebrafish as a valuable model organism for the study of .
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abstractSeptins are involved in a number of cellular processes including cytokinesis and organization of the cytoskeleton. Alterations in human septin-9 ( SEPT9 ) levels have been linked to multiple cancers, whereas mutations in SEPT9 cause the episodic neuropathy, hereditary neuralgic amyotrophy (HNA). Despite its important function in human health, the in vivo role of SEPT9 is unknown. ; Here we utilize zebrafish to study the role of in early development. We show that zebrafish possess two genes, and that, like humans, express multiple transcripts. Knockdown or overexpression of transcripts results in specific developmental alterations including circulation defects and aberrant epidermal development. ; Our work demonstrates that plays an important role in zebrafish development, and establishes zebrafish as a valuable model organism for the study of .
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doi10.1371/journal.pone.0010712
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date2010-05-19