schliessen

Filtern

 

Bibliotheken

Evaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM) (COME/ROM Candidate Gene Analyses)

DNA sequence variants in genes involved in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). We evaluated single nucleotide polymorphisms (SNPs) in 15 functional candidate genes. A... Full description

Journal Title: PLoS ONE 2011, Vol.6(8), p.e22297
Main Author: Sale, Michèle M
Other Authors: Chen, Wei-Min , Weeks, Daniel E , Mychaleckyj, Josyf C , Hou, Xuanlin , Marion, Miranda , Segade, Fernando , Casselbrant, Margaretha L , Mandel, Ellen M , Ferrell, Robert E , Rich, Stephen S , Daly, Kathleen A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0022297
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0022297
title: Evaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM) (COME/ROM Candidate Gene Analyses)
format: Article
creator:
  • Sale, Michèle M
  • Chen, Wei-Min
  • Weeks, Daniel E
  • Mychaleckyj, Josyf C
  • Hou, Xuanlin
  • Marion, Miranda
  • Segade, Fernando
  • Casselbrant, Margaretha L
  • Mandel, Ellen M
  • Ferrell, Robert E
  • Rich, Stephen S
  • Daly, Kathleen A
subjects:
  • Research Article
  • Biology
  • Medicine
  • Genetics And Genomics
  • Infectious Diseases
  • Computational Biology
  • Evolutionary Biology
  • Otolaryngology
ispartof: PLoS ONE, 2011, Vol.6(8), p.e22297
description: DNA sequence variants in genes involved in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). We evaluated single nucleotide polymorphisms (SNPs) in 15 functional candidate genes. A total of 99 SNPs were successfully genotyped on the Sequenom platform in 142 families (618 subjects) from the Minnesota COME/ROM Family Study. Data were analyzed for association with COME/ROM using the Generalized Disequilibrium Test (GDT). Sex and age at exam were adjusted as covariates, relatedness was accounted for, and genotype differences from all phenotypically discordant relative pairs were utilized to measure the evidence of association between COME/ROM and each SNP. SNP rs2735733 in the region of the mucin 5, subtypes A/C gene ( MUC5AC ) exhibited nominal evidence for association with COME/ROM (P = 0.002). Two additional SNPs from this region had P values
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0022297
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID1090234371
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0022297
sourceidplos
recordidTN_plos10.1371/journal.pone.0022297
sourcesystemPC
pqid884844775
galeid476882361
display
typearticle
titleEvaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM) (COME/ROM Candidate Gene Analyses)
creatorSale, Michèle M ; Chen, Wei-Min ; Weeks, Daniel E ; Mychaleckyj, Josyf C ; Hou, Xuanlin ; Marion, Miranda ; Segade, Fernando ; Casselbrant, Margaretha L ; Mandel, Ellen M ; Ferrell, Robert E ; Rich, Stephen S ; Daly, Kathleen A
contributorToland, Amanda Ewart (Editor)
ispartofPLoS ONE, 2011, Vol.6(8), p.e22297
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0022297
subjectResearch Article ; Biology ; Medicine ; Genetics And Genomics ; Infectious Diseases ; Computational Biology ; Evolutionary Biology ; Otolaryngology
descriptionDNA sequence variants in genes involved in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). We evaluated single nucleotide polymorphisms (SNPs) in 15 functional candidate genes. A total of 99 SNPs were successfully genotyped on the Sequenom platform in 142 families (618 subjects) from the Minnesota COME/ROM Family Study. Data were analyzed for association with COME/ROM using the Generalized Disequilibrium Test (GDT). Sex and age at exam were adjusted as covariates, relatedness was accounted for, and genotype differences from all phenotypically discordant relative pairs were utilized to measure the evidence of association between COME/ROM and each SNP. SNP rs2735733 in the region of the mucin 5, subtypes A/C gene ( MUC5AC ) exhibited nominal evidence for association with COME/ROM (P = 0.002). Two additional SNPs from this region had P values<0.05. Other variants exhibiting associations with COME/ROM at P<0.05 included the SCN1B SNP rs8100085 (P = 0.013), SFTPD SNP rs1051246 (P = 0.039) and TLR4 SNP rs2770146 (P = 0.038). However, none of these associations replicated in an independent sample of COME/ROM families. The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Sale, Michèle M
1Chen, Wei-Min
2Weeks, Daniel E
3Mychaleckyj, Josyf C
4Hou, Xuanlin
5Marion, Miranda
6Segade, Fernando
7Casselbrant, Margaretha L
8Mandel, Ellen M
9Ferrell, Robert E
10Rich, Stephen S
11Daly, Kathleen A
12Toland, Amanda Ewart (Editor)
titleEvaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM) (COME/ROM Candidate Gene Analyses)
descriptionDNA sequence variants in genes involved in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). We evaluated single nucleotide polymorphisms (SNPs) in 15 functional candidate genes. A total of 99 SNPs were successfully genotyped on the Sequenom platform in 142 families (618 subjects) from the Minnesota COME/ROM Family Study. Data were analyzed for association with COME/ROM using the Generalized Disequilibrium Test (GDT). Sex and age at exam were adjusted as covariates, relatedness was accounted for, and genotype differences from all phenotypically discordant relative pairs were utilized to measure the evidence of association between COME/ROM and each SNP. SNP rs2735733 in the region of the mucin 5, subtypes A/C gene ( MUC5AC ) exhibited nominal evidence for association with COME/ROM (P = 0.002). Two additional SNPs from this region had P values<0.05. Other variants exhibiting associations with COME/ROM at P<0.05 included the SCN1B SNP rs8100085 (P = 0.013), SFTPD SNP rs1051246 (P = 0.039) and TLR4 SNP rs2770146 (P = 0.038). However, none of these associations replicated in an independent sample of COME/ROM families. The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology.
subject
0Research Article
1Biology
2Medicine
3Genetics And Genomics
4Infectious Diseases
5Computational Biology
6Evolutionary Biology
7Otolaryngology
general
010.1371/journal.pone.0022297
1English
sourceidplos
recordidplos10.1371/journal.pone.0022297
issn
01932-6203
119326203
rsrctypearticle
creationdate2011
recordtypearticle
addtitle
0PLoS ONE
1COME/ROM Candidate Gene Analyses
searchscopeplos
scopeplos
lsr30VSR-Enriched:[galeid, pqid]
sort
titleEvaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM) (COME/ROM Candidate Gene Analyses)
authorSale, Michèle M ; Chen, Wei-Min ; Weeks, Daniel E ; Mychaleckyj, Josyf C ; Hou, Xuanlin ; Marion, Miranda ; Segade, Fernando ; Casselbrant, Margaretha L ; Mandel, Ellen M ; Ferrell, Robert E ; Rich, Stephen S ; Daly, Kathleen A
creationdate20110816
facets
frbrgroupid3164730585615905617
frbrtype5
languageeng
creationdate2011
topic
0Research Article
1Biology
2Medicine
3Genetics And Genomics
4Infectious Diseases
5Computational Biology
6Evolutionary Biology
7Otolaryngology
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Sale, Michèle M
1Chen, Wei-Min
2Weeks, Daniel E
3Mychaleckyj, Josyf C
4Hou, Xuanlin
5Marion, Miranda
6Segade, Fernando
7Casselbrant, Margaretha L
8Mandel, Ellen M
9Ferrell, Robert E
10Rich, Stephen S
11Daly, Kathleen A
12Toland, Amanda Ewart
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12011
k219326203
k310.1371/journal.pone.0022297
k46
k58
k622297
k7plos one
k8evaluation of 15 functional candidate genes for association with chronic otitis media with effusion or recurrent otitis media
k9evaluationof15functimedia
k12evaluationof15functionalc
k15michèlemsale
k16salemichèlem
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Sale
1Chen
2Weeks
3Mychaleckyj
4Hou
5Marion
6Segade
7Casselbrant
8Mandel
9Ferrell
10Rich
11Daly
12Toland
aufirst
0Michèle M.
1Wei-Min
2Daniel E.
3Josyf C.
4Xuanlin
5Miranda
6Fernando
7Margaretha L.
8Ellen M.
9Robert E.
10Stephen S.
11Kathleen A.
12Amanda Ewart
au
0Sale, Michèle M
1Chen, Wei-Min
2Weeks, Daniel E
3Mychaleckyj, Josyf C
4Hou, Xuanlin
5Marion, Miranda
6Segade, Fernando
7Casselbrant, Margaretha L
8Mandel, Ellen M
9Ferrell, Robert E
10Rich, Stephen S
11Daly, Kathleen A
addauToland, Amanda Ewart
atitleEvaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM) (COME/ROM Candidate Gene Analyses)
jtitlePLoS ONE
risdate20110816
volume6
issue8
spagee22297
pagese22297
eissn1932-6203
genrearticle
ristypeJOUR
abstractDNA sequence variants in genes involved in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). We evaluated single nucleotide polymorphisms (SNPs) in 15 functional candidate genes. A total of 99 SNPs were successfully genotyped on the Sequenom platform in 142 families (618 subjects) from the Minnesota COME/ROM Family Study. Data were analyzed for association with COME/ROM using the Generalized Disequilibrium Test (GDT). Sex and age at exam were adjusted as covariates, relatedness was accounted for, and genotype differences from all phenotypically discordant relative pairs were utilized to measure the evidence of association between COME/ROM and each SNP. SNP rs2735733 in the region of the mucin 5, subtypes A/C gene ( MUC5AC ) exhibited nominal evidence for association with COME/ROM (P = 0.002). Two additional SNPs from this region had P values<0.05. Other variants exhibiting associations with COME/ROM at P<0.05 included the SCN1B SNP rs8100085 (P = 0.013), SFTPD SNP rs1051246 (P = 0.039) and TLR4 SNP rs2770146 (P = 0.038). However, none of these associations replicated in an independent sample of COME/ROM families. The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0022297
oafree_for_read
date2011-08-16