schliessen

Filtern

 

Bibliotheken

Bile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus (Bile Acids in Metabolic Syndrome)

Bile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as well as the biosynthetic precursor 7α-hydroxy-4-cholesten-3-one (C4) and their associations, respectively, with coron... Full description

Journal Title: PLoS ONE 2011, Vol.6(11), p.e25006
Main Author: Steiner, Carine
Other Authors: Othman, Alaa , Saely, Christoph H , Rein, Philipp , Drexel, Heinz , von Eckardstein, Arnold , Rentsch, Katharina M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0025006
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0025006
title: Bile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus (Bile Acids in Metabolic Syndrome)
format: Article
creator:
  • Steiner, Carine
  • Othman, Alaa
  • Saely, Christoph H
  • Rein, Philipp
  • Drexel, Heinz
  • von Eckardstein, Arnold
  • Rentsch, Katharina M
subjects:
  • Research Article
  • Biology
  • Mathematics
  • Medicine
  • Genetics And Genomics
  • Gastroenterology And Hepatology
  • Biochemistry
  • Mathematics
ispartof: PLoS ONE, 2011, Vol.6(11), p.e25006
description: Bile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as well as the biosynthetic precursor 7α-hydroxy-4-cholesten-3-one (C4) and their associations, respectively, with coronary artery disease (CAD), diabetes mellitus type 2 (T2DM), and non-diabetic metabolic syndrome (MetS). In hourly taken blood samples of four healthy probands, the intraindividual 24 h variation of C4, conjugated and unconjugated BAs ranged from 42% to 72%, from 23% to 91%, and from 49% to 90%, respectively. Conjugated BA concentrations mainly increased following food intake. Serum levels of C4 and unconjugated BAs changed with daytime with maxima varying interindividually between 20h00 and 1h00 and between 3h00 and 8h00, respectively. Comparisons of data from 75 CAD patients with 75 CAD-free controls revealed no statistically significant association of CAD with BAs or C4. Comparisons of data from 50 controls free of T2DM or MetS, 50 MetS patients, and 50 T2DM patients revealed significantly increased fasting serum levels of C4 in patients with MetS and T2DM. Multiple regression analysis revealed body mass index (BMI) and plasma levels of triglycerides (TG) as independent determinants of C4 levels. Upon multivariate and principle component analyses the association of C4 with T2DM and/or MetS was not independent of or superior to the canonical MetS components. In conclusion, despite large intra- and interindividual variation, serum levels of C4,are significantly increased in patients with MetS and T2DM but confounded with BMI and TG.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0025006
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID176232038
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0025006
sourceidplos
recordidTN_plos10.1371/journal.pone.0025006
sourcesystemPC
pqid905966376
galeid476863053
display
typearticle
titleBile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus (Bile Acids in Metabolic Syndrome)
creatorSteiner, Carine ; Othman, Alaa ; Saely, Christoph H ; Rein, Philipp ; Drexel, Heinz ; von Eckardstein, Arnold ; Rentsch, Katharina M
contributorOresic, Matej (Editor)
ispartofPLoS ONE, 2011, Vol.6(11), p.e25006
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0025006
subjectResearch Article ; Biology ; Mathematics ; Medicine ; Genetics And Genomics ; Gastroenterology And Hepatology ; Biochemistry ; Mathematics
descriptionBile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as well as the biosynthetic precursor 7α-hydroxy-4-cholesten-3-one (C4) and their associations, respectively, with coronary artery disease (CAD), diabetes mellitus type 2 (T2DM), and non-diabetic metabolic syndrome (MetS). In hourly taken blood samples of four healthy probands, the intraindividual 24 h variation of C4, conjugated and unconjugated BAs ranged from 42% to 72%, from 23% to 91%, and from 49% to 90%, respectively. Conjugated BA concentrations mainly increased following food intake. Serum levels of C4 and unconjugated BAs changed with daytime with maxima varying interindividually between 20h00 and 1h00 and between 3h00 and 8h00, respectively. Comparisons of data from 75 CAD patients with 75 CAD-free controls revealed no statistically significant association of CAD with BAs or C4. Comparisons of data from 50 controls free of T2DM or MetS, 50 MetS patients, and 50 T2DM patients revealed significantly increased fasting serum levels of C4 in patients with MetS and T2DM. Multiple regression analysis revealed body mass index (BMI) and plasma levels of triglycerides (TG) as independent determinants of C4 levels. Upon multivariate and principle component analyses the association of C4 with T2DM and/or MetS was not independent of or superior to the canonical MetS components. In conclusion, despite large intra- and interindividual variation, serum levels of C4,are significantly increased in patients with MetS and T2DM but confounded with BMI and TG.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Steiner, Carine
1Othman, Alaa
2Saely, Christoph H
3Rein, Philipp
4Drexel, Heinz
5von Eckardstein, Arnold
6Rentsch, Katharina M
7Oresic, Matej (Editor)
titleBile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus (Bile Acids in Metabolic Syndrome)
descriptionBile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as well as the biosynthetic precursor 7α-hydroxy-4-cholesten-3-one (C4) and their associations, respectively, with coronary artery disease (CAD), diabetes mellitus type 2 (T2DM), and non-diabetic metabolic syndrome (MetS). In hourly taken blood samples of four healthy probands, the intraindividual 24 h variation of C4, conjugated and unconjugated BAs ranged from 42% to 72%, from 23% to 91%, and from 49% to 90%, respectively. Conjugated BA concentrations mainly increased following food intake. Serum levels of C4 and unconjugated BAs changed with daytime with maxima varying interindividually between 20h00 and 1h00 and between 3h00 and 8h00, respectively. Comparisons of data from 75 CAD patients with 75 CAD-free controls revealed no statistically significant association of CAD with BAs or C4. Comparisons of data from 50 controls free of T2DM or MetS, 50 MetS patients, and 50 T2DM patients revealed significantly increased fasting serum levels of C4 in patients with MetS and T2DM. Multiple regression analysis revealed body mass index (BMI) and plasma levels of triglycerides (TG) as independent determinants of C4 levels. Upon multivariate and principle component analyses the association of C4 with T2DM and/or MetS was not independent of or superior to the canonical MetS components. In conclusion, despite large intra- and interindividual variation, serum levels of C4,are significantly increased in patients with MetS and T2DM but confounded with BMI and TG.
subject
0Research Article
1Biology
2Mathematics
3Medicine
4Genetics And Genomics
5Gastroenterology And Hepatology
6Biochemistry
general
010.1371/journal.pone.0025006
1English
sourceidplos
recordidplos10.1371/journal.pone.0025006
issn
01932-6203
119326203
rsrctypearticle
creationdate2011
recordtypearticle
addtitle
0PLoS ONE
1Bile Acids in Metabolic Syndrome
searchscopeplos
scopeplos
lsr30VSR-Enriched:[pqid, galeid]
sort
titleBile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus (Bile Acids in Metabolic Syndrome)
authorSteiner, Carine ; Othman, Alaa ; Saely, Christoph H ; Rein, Philipp ; Drexel, Heinz ; von Eckardstein, Arnold ; Rentsch, Katharina M
creationdate20111114
facets
frbrgroupid9128377473771990243
frbrtype5
languageeng
creationdate2011
topic
0Research Article
1Biology
2Mathematics
3Medicine
4Genetics And Genomics
5Gastroenterology And Hepatology
6Biochemistry
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Steiner, Carine
1Othman, Alaa
2Saely, Christoph H
3Rein, Philipp
4Drexel, Heinz
5von Eckardstein, Arnold
6Rentsch, Katharina M
7Oresic, Matej
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12011
k219326203
k310.1371/journal.pone.0025006
k46
k511
k625006
k7plos one
k8bile acid metabolites in serum intraindividual variation associations with coronary heart disease metabolic syndrome diabetes mellitus
k9bileacidmetabolitesilitus
k12bileacidmetabolitesinseru
k15carinesteiner
k16steinercarine
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Steiner
1Othman
2Saely
3Rein
4Drexel
5von Eckardstein
6Rentsch
7Oresic
aufirst
0Carine
1Alaa
2Christoph H.
3Philipp
4Heinz
5Arnold
6Katharina M.
7Matej
au
0Steiner, Carine
1Othman, Alaa
2Saely, Christoph H
3Rein, Philipp
4Drexel, Heinz
5von Eckardstein, Arnold
6Rentsch, Katharina M
addauOresic, Matej
atitleBile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus (Bile Acids in Metabolic Syndrome)
jtitlePLoS ONE
risdate20111114
volume6
issue11
spagee25006
pagese25006
eissn1932-6203
genrearticle
ristypeJOUR
abstractBile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as well as the biosynthetic precursor 7α-hydroxy-4-cholesten-3-one (C4) and their associations, respectively, with coronary artery disease (CAD), diabetes mellitus type 2 (T2DM), and non-diabetic metabolic syndrome (MetS). In hourly taken blood samples of four healthy probands, the intraindividual 24 h variation of C4, conjugated and unconjugated BAs ranged from 42% to 72%, from 23% to 91%, and from 49% to 90%, respectively. Conjugated BA concentrations mainly increased following food intake. Serum levels of C4 and unconjugated BAs changed with daytime with maxima varying interindividually between 20h00 and 1h00 and between 3h00 and 8h00, respectively. Comparisons of data from 75 CAD patients with 75 CAD-free controls revealed no statistically significant association of CAD with BAs or C4. Comparisons of data from 50 controls free of T2DM or MetS, 50 MetS patients, and 50 T2DM patients revealed significantly increased fasting serum levels of C4 in patients with MetS and T2DM. Multiple regression analysis revealed body mass index (BMI) and plasma levels of triglycerides (TG) as independent determinants of C4 levels. Upon multivariate and principle component analyses the association of C4 with T2DM and/or MetS was not independent of or superior to the canonical MetS components. In conclusion, despite large intra- and interindividual variation, serum levels of C4,are significantly increased in patients with MetS and T2DM but confounded with BMI and TG.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0025006
oafree_for_read
date2011-11-14