schliessen

Filtern

 

Bibliotheken

Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (Cdk5, Synaptic Plasticity, and Behavior)

Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of... Full description

Journal Title: PLoS ONE 2011, Vol.6(9), p.e25735
Main Author: Guan, Ji-Song
Other Authors: Su, Susan C , Gao, Jun , Joseph, Nadine , Xie, Zhigang , Zhou, Ying , Durak, Omer , Zhang, Lei , Zhu, J. Julius , Clauser, Karl R , Carr, Steven A , Tsai, Li-Huei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0025735
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0025735
title: Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (Cdk5, Synaptic Plasticity, and Behavior)
format: Article
creator:
  • Guan, Ji-Song
  • Su, Susan C
  • Gao, Jun
  • Joseph, Nadine
  • Xie, Zhigang
  • Zhou, Ying
  • Durak, Omer
  • Zhang, Lei
  • Zhu, J. Julius
  • Clauser, Karl R
  • Carr, Steven A
  • Tsai, Li-Huei
subjects:
  • Research Article
  • Biology
  • Medicine
  • Social And Behavioral Sciences
  • Molecular Biology
  • Mental Health
  • Physiology
  • Neuroscience
ispartof: PLoS ONE, 2011, Vol.6(9), p.e25735
description: Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of synaptic plasticity in cultured neurons. Surprisingly, we found that Cdk5 loss of function in hippocampal circuits results in severe impairments in memory formation and retrieval. Moreover, Cdk5 loss of function in the hippocampus disrupts cAMP signaling due to an aberrant increase in phosphodiesterase (PDE) proteins. Dysregulation of cAMP is associated with defective CREB phosphorylation and disrupted composition of synaptic proteins in Cdk5-deficient mice. Rolipram, a PDE4 inhibitor that prevents cAMP depletion, restores synaptic plasticity and memory formation in Cdk5-deficient mice. Collectively, our results demonstrate a critical role for Cdk5 in the regulation of cAMP-mediated hippocampal functions essential for synaptic plasticity and memory formation.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0025735
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID228419700
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0025735
sourceidplos
recordidTN_plos10.1371/journal.pone.0025735
sourcesystemOther
pqid1308928004
galeid476877782
display
typearticle
titleCdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (Cdk5, Synaptic Plasticity, and Behavior)
creatorGuan, Ji-Song ; Su, Susan C ; Gao, Jun ; Joseph, Nadine ; Xie, Zhigang ; Zhou, Ying ; Durak, Omer ; Zhang, Lei ; Zhu, J. Julius ; Clauser, Karl R ; Carr, Steven A ; Tsai, Li-Huei
contributorNait-oumesmar, Brahim (Editor)
ispartofPLoS ONE, 2011, Vol.6(9), p.e25735
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0025735
subjectResearch Article ; Biology ; Medicine ; Social And Behavioral Sciences ; Molecular Biology ; Mental Health ; Physiology ; Neuroscience
descriptionMemory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of synaptic plasticity in cultured neurons. Surprisingly, we found that Cdk5 loss of function in hippocampal circuits results in severe impairments in memory formation and retrieval. Moreover, Cdk5 loss of function in the hippocampus disrupts cAMP signaling due to an aberrant increase in phosphodiesterase (PDE) proteins. Dysregulation of cAMP is associated with defective CREB phosphorylation and disrupted composition of synaptic proteins in Cdk5-deficient mice. Rolipram, a PDE4 inhibitor that prevents cAMP depletion, restores synaptic plasticity and memory formation in Cdk5-deficient mice. Collectively, our results demonstrate a critical role for Cdk5 in the regulation of cAMP-mediated hippocampal functions essential for synaptic plasticity and memory formation.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Guan, Ji-Song
1Su, Susan C
2Gao, Jun
3Joseph, Nadine
4Xie, Zhigang
5Zhou, Ying
6Durak, Omer
7Zhang, Lei
8Zhu, J. Julius
9Clauser, Karl R
10Carr, Steven A
11Tsai, Li-Huei
12Nait-oumesmar, Brahim (Editor)
titleCdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (Cdk5, Synaptic Plasticity, and Behavior)
descriptionMemory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of synaptic plasticity in cultured neurons. Surprisingly, we found that Cdk5 loss of function in hippocampal circuits results in severe impairments in memory formation and retrieval. Moreover, Cdk5 loss of function in the hippocampus disrupts cAMP signaling due to an aberrant increase in phosphodiesterase (PDE) proteins. Dysregulation of cAMP is associated with defective CREB phosphorylation and disrupted composition of synaptic proteins in Cdk5-deficient mice. Rolipram, a PDE4 inhibitor that prevents cAMP depletion, restores synaptic plasticity and memory formation in Cdk5-deficient mice. Collectively, our results demonstrate a critical role for Cdk5 in the regulation of cAMP-mediated hippocampal functions essential for synaptic plasticity and memory formation.
subject
0Research Article
1Biology
2Medicine
3Social And Behavioral Sciences
4Molecular Biology
5Mental Health
6Physiology
7Neuroscience
general
010.1371/journal.pone.0025735
1English
sourceidplos
recordidplos10.1371/journal.pone.0025735
issn
01932-6203
119326203
rsrctypearticle
creationdate2011
recordtypearticle
addtitle
0PLoS ONE
1Cdk5, Synaptic Plasticity, and Behavior
searchscopeplos
scopeplos
lsr30VSR-Enriched:[pqid, galeid]
sort
titleCdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (Cdk5, Synaptic Plasticity, and Behavior)
authorGuan, Ji-Song ; Su, Susan C ; Gao, Jun ; Joseph, Nadine ; Xie, Zhigang ; Zhou, Ying ; Durak, Omer ; Zhang, Lei ; Zhu, J. Julius ; Clauser, Karl R ; Carr, Steven A ; Tsai, Li-Huei
creationdate20110930
facets
frbrgroupid9139699794569883958
frbrtype5
languageeng
creationdate2011
topic
0Research Article
1Biology
2Medicine
3Social And Behavioral Sciences
4Molecular Biology
5Mental Health
6Physiology
7Neuroscience
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Guan, Ji-Song
1Su, Susan C
2Gao, Jun
3Joseph, Nadine
4Xie, Zhigang
5Zhou, Ying
6Durak, Omer
7Zhang, Lei
8Zhu, J. Julius
9Clauser, Karl R
10Carr, Steven A
11Tsai, Li-Huei
12Nait-oumesmar, Brahim
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12011
k219326203
k310.1371/journal.pone.0025735
k46
k59
k625735
k7plos one
k8cdk5 is required for memory function hippocampal plasticity via the camp signaling pathway
k9cdk5isrequiredformemthway
k12cdk5isrequiredformemoryfu
k15jisongguan
k16guanjisong
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Guan
1Su
2Gao
3Joseph
4Xie
5Zhou
6Durak
7Zhang
8Zhu
9Clauser
10Carr
11Tsai
12Nait-Oumesmar
aufirst
0Ji-Song
1Susan C.
2Jun
3Nadine
4Zhigang
5Ying
6Omer
7Lei
8J. Julius
9Karl R.
10Steven A.
11Li-Huei
12Brahim
au
0Guan, Ji-Song
1Su, Susan C
2Gao, Jun
3Joseph, Nadine
4Xie, Zhigang
5Zhou, Ying
6Durak, Omer
7Zhang, Lei
8Zhu, J. Julius
9Clauser, Karl R
10Carr, Steven A
11Tsai, Li-Huei
addauNait-oumesmar, Brahim
atitleCdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (Cdk5, Synaptic Plasticity, and Behavior)
jtitlePLoS ONE
risdate20110930
volume6
issue9
spagee25735
pagese25735
eissn1932-6203
genrearticle
ristypeJOUR
abstractMemory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of synaptic plasticity in cultured neurons. Surprisingly, we found that Cdk5 loss of function in hippocampal circuits results in severe impairments in memory formation and retrieval. Moreover, Cdk5 loss of function in the hippocampus disrupts cAMP signaling due to an aberrant increase in phosphodiesterase (PDE) proteins. Dysregulation of cAMP is associated with defective CREB phosphorylation and disrupted composition of synaptic proteins in Cdk5-deficient mice. Rolipram, a PDE4 inhibitor that prevents cAMP depletion, restores synaptic plasticity and memory formation in Cdk5-deficient mice. Collectively, our results demonstrate a critical role for Cdk5 in the regulation of cAMP-mediated hippocampal functions essential for synaptic plasticity and memory formation.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0025735
oafree_for_read
date2011-09-30