schliessen

Filtern

 

Bibliotheken

Aberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters (Aberrant Protein Expression in Lung Cancer)

Because cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures... Full description

Journal Title: PLoS ONE 2012, Vol.7(2), p.e31087
Main Author: He, Yong
Other Authors: Zhou, Zhen , Hofstetter, Wayne L , Zhou, Yanbin , Hu, Wenxian , Guo, Chengcheng , Wang, Li , Guo, Wei , Pataer, Apar , Correa, Arlene M , Lu, Yiling , Wang, Jing , Diao, Lixia , Byers, Lauren Averett , Wistuba, Ignacio I , Roth, Jack A , Swisher, Stephen G , Heymach, John V , Fang, Bingliang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0031087
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0031087
title: Aberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters (Aberrant Protein Expression in Lung Cancer)
format: Article
creator:
  • He, Yong
  • Zhou, Zhen
  • Hofstetter, Wayne L
  • Zhou, Yanbin
  • Hu, Wenxian
  • Guo, Chengcheng
  • Wang, Li
  • Guo, Wei
  • Pataer, Apar
  • Correa, Arlene M
  • Lu, Yiling
  • Wang, Jing
  • Diao, Lixia
  • Byers, Lauren Averett
  • Wistuba, Ignacio I
  • Roth, Jack A
  • Swisher, Stephen G
  • Heymach, John V
  • Fang, Bingliang
subjects:
  • Research Article
  • Biology
  • Medicine
  • Genetics And Genomics
  • Molecular Biology
  • Oncology
  • Pathology
ispartof: PLoS ONE, 2012, Vol.7(2), p.e31087
description: Because cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures in primary lung cancer tissues. ; We analyzed 126 proteins and/or protein phosphorylation sites in case-matched normal and tumor samples from 101 lung cancer patients with reverse-phase protein array (RPPA) assay. The results showed that 18 molecules were significantly different (
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0031087
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID1607756382
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0031087
sourceidplos
recordidTN_plos10.1371/journal.pone.0031087
sourcesystemPC
pqid922758277
display
typearticle
titleAberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters (Aberrant Protein Expression in Lung Cancer)
creatorHe, Yong ; Zhou, Zhen ; Hofstetter, Wayne L ; Zhou, Yanbin ; Hu, Wenxian ; Guo, Chengcheng ; Wang, Li ; Guo, Wei ; Pataer, Apar ; Correa, Arlene M ; Lu, Yiling ; Wang, Jing ; Diao, Lixia ; Byers, Lauren Averett ; Wistuba, Ignacio I ; Roth, Jack A ; Swisher, Stephen G ; Heymach, John V ; Fang, Bingliang
contributorDeb, Sumitra (Editor)
ispartofPLoS ONE, 2012, Vol.7(2), p.e31087
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0031087
subjectResearch Article ; Biology ; Medicine ; Genetics And Genomics ; Molecular Biology ; Oncology ; Pathology
descriptionBecause cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures in primary lung cancer tissues. ; We analyzed 126 proteins and/or protein phosphorylation sites in case-matched normal and tumor samples from 101 lung cancer patients with reverse-phase protein array (RPPA) assay. The results showed that 18 molecules were significantly different (<0.05) by at least 30% between normal and tumor tissues. Most of those molecules play roles in cell proliferation, DNA repair, signal transduction and lipid metabolism, or function as cell surface/matrix proteins. We also validated RPPA results by Western blot and/or immunohistochemical analyses for some of those molecules. Statistical analyses showed that Ku80 levels were significantly higher in tumors of nonsmokers than in those of smokers. Cyclin B1 levels were significantly overexpressed in poorly differentiated tumors while Cox2 levels were significantly overexpressed in neuroendocrinal tumors. A high level of Stat5 is associated with favorable survival outcome for patients treated with surgery. ; Our results revealed that some molecules involved in DNA damage/repair, signal transductions, lipid metabolism, and cell proliferation were drastically aberrant in lung cancer tissues, and Stat5 may serve a molecular marker for prognosis of lung cancers.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0He, Yong
1Zhou, Zhen
2Hofstetter, Wayne L
3Zhou, Yanbin
4Hu, Wenxian
5Guo, Chengcheng
6Wang, Li
7Guo, Wei
8Pataer, Apar
9Correa, Arlene M
10Lu, Yiling
11Wang, Jing
12Diao, Lixia
13Byers, Lauren Averett
14Wistuba, Ignacio I
15Roth, Jack A
16Swisher, Stephen G
17Heymach, John V
18Fang, Bingliang
19Deb, Sumitra (Editor)
titleAberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters (Aberrant Protein Expression in Lung Cancer)
descriptionBecause cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures in primary lung cancer tissues. ; We analyzed 126 proteins and/or protein phosphorylation sites in case-matched normal and tumor samples from 101 lung cancer patients with reverse-phase protein array (RPPA) assay. The results showed that 18 molecules were significantly different (<0.05) by at least 30% between normal and tumor tissues. Most of those molecules play roles in cell proliferation, DNA repair, signal transduction and lipid metabolism, or function as cell surface/matrix proteins. We also validated RPPA results by Western blot and/or immunohistochemical analyses for some of those molecules. Statistical analyses showed that Ku80 levels were significantly higher in tumors of nonsmokers than in those of smokers. Cyclin B1 levels were significantly overexpressed in poorly differentiated tumors while Cox2 levels were significantly overexpressed in neuroendocrinal tumors. A high level of Stat5 is associated with favorable survival outcome for patients treated with surgery. ; Our results revealed that some molecules involved in DNA damage/repair, signal transductions, lipid metabolism, and cell proliferation were drastically aberrant in lung cancer tissues, and Stat5 may serve a molecular marker for prognosis of lung cancers.
subject
0Research Article
1Biology
2Medicine
3Genetics And Genomics
4Molecular Biology
5Oncology
6Pathology
general
010.1371/journal.pone.0031087
1English
sourceidplos
recordidplos10.1371/journal.pone.0031087
issn
01932-6203
119326203
rsrctypearticle
creationdate2012
recordtypearticle
addtitle
0PLoS ONE
1Aberrant Protein Expression in Lung Cancer
searchscopeplos
scopeplos
lsr30VSR-Enriched:[pqid]
sort
titleAberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters (Aberrant Protein Expression in Lung Cancer)
authorHe, Yong ; Zhou, Zhen ; Hofstetter, Wayne L ; Zhou, Yanbin ; Hu, Wenxian ; Guo, Chengcheng ; Wang, Li ; Guo, Wei ; Pataer, Apar ; Correa, Arlene M ; Lu, Yiling ; Wang, Jing ; Diao, Lixia ; Byers, Lauren Averett ; Wistuba, Ignacio I ; Roth, Jack A ; Swisher, Stephen G ; Heymach, John V ; Fang, Bingliang
creationdate20120210
facets
frbrgroupid8007079413112270850
frbrtype5
languageeng
creationdate2012
topic
0Research Article
1Biology
2Medicine
3Genetics And Genomics
4Molecular Biology
5Oncology
6Pathology
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0He, Yong
1Zhou, Zhen
2Hofstetter, Wayne L
3Zhou, Yanbin
4Hu, Wenxian
5Guo, Chengcheng
6Wang, Li
7Guo, Wei
8Pataer, Apar
9Correa, Arlene M
10Lu, Yiling
11Wang, Jing
12Diao, Lixia
13Byers, Lauren Averett
14Wistuba, Ignacio I
15Roth, Jack A
16Swisher, Stephen G
17Heymach, John V
18Fang, Bingliang
19Deb, Sumitra
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12012
k219326203
k310.1371/journal.pone.0031087
k47
k52
k631087
k7plos one
k8aberrant expression of proteins involved in signal transduction dna repair pathways in lung cancer their association with clinical parameters
k9aberrantexpressionofeters
k12aberrantexpressionofprote
k15yonghe
k16heyong
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0He
1Zhou
2Hofstetter
3Hu
4Guo
5Wang
6Pataer
7Correa
8Lu
9Diao
10Byers
11Wistuba
12Roth
13Swisher
14Heymach
15Fang
16Deb
aufirst
0Yong
1Zhen
2Wayne L.
3Yanbin
4Wenxian
5Chengcheng
6Li
7Wei
8Apar
9Arlene M.
10Yiling
11Jing
12Lixia
13Lauren Averett
14Ignacio I.
15Jack A.
16Stephen G.
17John V.
18Bingliang
19Sumitra
au
0He, Yong
1Zhou, Zhen
2Hofstetter, Wayne L
3Zhou, Yanbin
4Hu, Wenxian
5Guo, Chengcheng
6Wang, Li
7Guo, Wei
8Pataer, Apar
9Correa, Arlene M
10Lu, Yiling
11Wang, Jing
12Diao, Lixia
13Byers, Lauren Averett
14Wistuba, Ignacio I
15Roth, Jack A
16Swisher, Stephen G
17Heymach, John V
18Fang, Bingliang
addauDeb, Sumitra
atitleAberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters (Aberrant Protein Expression in Lung Cancer)
jtitlePLoS ONE
risdate20120210
volume7
issue2
spagee31087
pagese31087
eissn1932-6203
genrearticle
ristypeJOUR
abstractBecause cell signaling and cell metabolic pathways are executed through proteins, protein signatures in primary tumors are useful for identifying key nodes in signaling networks whose alteration is associated with malignancy and/or clinical outcomes. This study aimed to determine protein signatures in primary lung cancer tissues. ; We analyzed 126 proteins and/or protein phosphorylation sites in case-matched normal and tumor samples from 101 lung cancer patients with reverse-phase protein array (RPPA) assay. The results showed that 18 molecules were significantly different (<0.05) by at least 30% between normal and tumor tissues. Most of those molecules play roles in cell proliferation, DNA repair, signal transduction and lipid metabolism, or function as cell surface/matrix proteins. We also validated RPPA results by Western blot and/or immunohistochemical analyses for some of those molecules. Statistical analyses showed that Ku80 levels were significantly higher in tumors of nonsmokers than in those of smokers. Cyclin B1 levels were significantly overexpressed in poorly differentiated tumors while Cox2 levels were significantly overexpressed in neuroendocrinal tumors. A high level of Stat5 is associated with favorable survival outcome for patients treated with surgery. ; Our results revealed that some molecules involved in DNA damage/repair, signal transductions, lipid metabolism, and cell proliferation were drastically aberrant in lung cancer tissues, and Stat5 may serve a molecular marker for prognosis of lung cancers.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0031087
oafree_for_read
date2012-02-10