schliessen

Filtern

 

Bibliotheken

Acute Response of Peripheral Blood Cell to Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetic Patient (Acute Response in PBMC after HSCT in T1D patients)

Autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approach that can improve β cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved. ; We applied AHST to nine T1D patients diagnosed... Full description

Journal Title: PLoS ONE 2012, Vol.7(2), p.e31887
Main Author: Zhang, Xiaofang
Other Authors: Ye, Lei , Hu, Jiong , Tang, Wei , Liu, Ruixin , Yang, Minglan , Hong, Jie , Wang, Weiqing , Ning, Guang , Gu, Weiqiong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0031887
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0031887
title: Acute Response of Peripheral Blood Cell to Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetic Patient (Acute Response in PBMC after HSCT in T1D patients)
format: Article
creator:
  • Zhang, Xiaofang
  • Ye, Lei
  • Hu, Jiong
  • Tang, Wei
  • Liu, Ruixin
  • Yang, Minglan
  • Hong, Jie
  • Wang, Weiqing
  • Ning, Guang
  • Gu, Weiqiong
subjects:
  • Research Article
  • Biology
  • Medicine
  • Immunology
  • Diabetes And Endocrinology
  • Hematology
ispartof: PLoS ONE, 2012, Vol.7(2), p.e31887
description: Autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approach that can improve β cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved. ; We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute responses in peripheral blood for lymphocyte subpopulation as well as for genomic expression profiling at the six-month follow-up. ; We found six patients obtained insulin free (IF group) and three remained insulin dependent (ID group); C-peptide production was significantly higher in IF group compared to ID group. The acute responses in lymphocytes at six-month follow-up include declined CD3CD4, CD3CD8 T cell population and recovered B cell, NK cell population in both groups but with no significant differences between the two groups; most immune-related genes and pathways were up-regulated in peripheral blood mononuclear cell (PBMC) of both groups while none of transcription factors for immune regulatory component were significantly changed; the IF group demonstrated more AHST-modified genetic events than the ID group and distinct pattern of top pathways, co-expression network as well as ‘hub’ genes (eg, TCF7 and GZMA) were associated with each group. ; AHST could improve the islet function in newly diagnosed T1D patients and elimination of the islet specific autoreactive T cells might be one of the mechanisms involved; T1D patients responded differently to AHST possibly due to the distinct transcriptional events occurring in PBMC. ; ClinicalTrials.gov
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0031887
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID1140961258
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0031887
sourceidplos
recordidTN_plos10.1371/journal.pone.0031887
sourcesystemPC
pqid1323859230
galeid477052124
display
typearticle
titleAcute Response of Peripheral Blood Cell to Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetic Patient (Acute Response in PBMC after HSCT in T1D patients)
creatorZhang, Xiaofang ; Ye, Lei ; Hu, Jiong ; Tang, Wei ; Liu, Ruixin ; Yang, Minglan ; Hong, Jie ; Wang, Weiqing ; Ning, Guang ; Gu, Weiqiong
contributorChung, Sookja (Editor)
ispartofPLoS ONE, 2012, Vol.7(2), p.e31887
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0031887
subjectResearch Article ; Biology ; Medicine ; Immunology ; Diabetes And Endocrinology ; Hematology
descriptionAutologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approach that can improve β cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved. ; We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute responses in peripheral blood for lymphocyte subpopulation as well as for genomic expression profiling at the six-month follow-up. ; We found six patients obtained insulin free (IF group) and three remained insulin dependent (ID group); C-peptide production was significantly higher in IF group compared to ID group. The acute responses in lymphocytes at six-month follow-up include declined CD3CD4, CD3CD8 T cell population and recovered B cell, NK cell population in both groups but with no significant differences between the two groups; most immune-related genes and pathways were up-regulated in peripheral blood mononuclear cell (PBMC) of both groups while none of transcription factors for immune regulatory component were significantly changed; the IF group demonstrated more AHST-modified genetic events than the ID group and distinct pattern of top pathways, co-expression network as well as ‘hub’ genes (eg, TCF7 and GZMA) were associated with each group. ; AHST could improve the islet function in newly diagnosed T1D patients and elimination of the islet specific autoreactive T cells might be one of the mechanisms involved; T1D patients responded differently to AHST possibly due to the distinct transcriptional events occurring in PBMC. ; ClinicalTrials.gov
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Zhang, Xiaofang
1Ye, Lei
2Hu, Jiong
3Tang, Wei
4Liu, Ruixin
5Yang, Minglan
6Hong, Jie
7Wang, Weiqing
8Ning, Guang
9Gu, Weiqiong
10Chung, Sookja (Editor)
titleAcute Response of Peripheral Blood Cell to Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetic Patient (Acute Response in PBMC after HSCT in T1D patients)
descriptionAutologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approach that can improve β cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved. ; We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute responses in peripheral blood for lymphocyte subpopulation as well as for genomic expression profiling at the six-month follow-up. ; We found six patients obtained insulin free (IF group) and three remained insulin dependent (ID group); C-peptide production was significantly higher in IF group compared to ID group. The acute responses in lymphocytes at six-month follow-up include declined CD3CD4, CD3CD8 T cell population and recovered B cell, NK cell population in both groups but with no significant differences between the two groups; most immune-related genes and pathways were up-regulated in peripheral blood mononuclear cell (PBMC) of both groups while none of transcription factors for immune regulatory component were significantly changed; the IF group demonstrated more AHST-modified genetic events than the ID group and distinct pattern of top pathways, co-expression network as well as ‘hub’ genes (eg, TCF7 and GZMA) were associated with each group. ; AHST could improve the islet function in newly diagnosed T1D patients and elimination of the islet specific autoreactive T cells might be one of the mechanisms involved; T1D patients responded differently to AHST possibly due to the distinct transcriptional events occurring in PBMC. ; ClinicalTrials.gov
subject
0Research Article
1Biology
2Medicine
3Immunology
4Diabetes And Endocrinology
5Hematology
general
010.1371/journal.pone.0031887
1English
sourceidplos
recordidplos10.1371/journal.pone.0031887
issn
01932-6203
119326203
rsrctypearticle
creationdate2012
recordtypearticle
addtitle
0PLoS ONE
1Acute Response in PBMC after HSCT in T1D patients
searchscopeplos
scopeplos
lsr30VSR-Enriched:[galeid, pqid]
sort
titleAcute Response of Peripheral Blood Cell to Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetic Patient (Acute Response in PBMC after HSCT in T1D patients)
authorZhang, Xiaofang ; Ye, Lei ; Hu, Jiong ; Tang, Wei ; Liu, Ruixin ; Yang, Minglan ; Hong, Jie ; Wang, Weiqing ; Ning, Guang ; Gu, Weiqiong
creationdate20120222
facets
frbrgroupid5209022159256662316
frbrtype5
languageeng
creationdate2012
topic
0Research Article
1Biology
2Medicine
3Immunology
4Diabetes And Endocrinology
5Hematology
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhang, Xiaofang
1Ye, Lei
2Hu, Jiong
3Tang, Wei
4Liu, Ruixin
5Yang, Minglan
6Hong, Jie
7Wang, Weiqing
8Ning, Guang
9Gu, Weiqiong
10Chung, Sookja
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12012
k219326203
k310.1371/journal.pone.0031887
k47
k52
k631887
k7plos one
k8acute response of peripheral blood cell to autologous hematopoietic stem cell transplantation in type 1 diabetic patient
k9acuteresponseofperiptient
k12acuteresponseofperipheral
k15xiaofangzhang
k16zhangxiaofang
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Zhang
1Ye
2Hu
3Tang
4Liu
5Yang
6Hong
7Wang
8Ning
9Gu
10Chung
aufirst
0Xiaofang
1Lei
2Jiong
3Wei
4Ruixin
5Minglan
6Jie
7Weiqing
8Guang
9Weiqiong
10Sookja
au
0Zhang, Xiaofang
1Ye, Lei
2Hu, Jiong
3Tang, Wei
4Liu, Ruixin
5Yang, Minglan
6Hong, Jie
7Wang, Weiqing
8Ning, Guang
9Gu, Weiqiong
addauChung, Sookja
atitleAcute Response of Peripheral Blood Cell to Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetic Patient (Acute Response in PBMC after HSCT in T1D patients)
jtitlePLoS ONE
risdate20120222
volume7
issue2
spagee31887
pagese31887
eissn1932-6203
genrearticle
ristypeJOUR
abstractAutologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approach that can improve β cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved. ; We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute responses in peripheral blood for lymphocyte subpopulation as well as for genomic expression profiling at the six-month follow-up. ; We found six patients obtained insulin free (IF group) and three remained insulin dependent (ID group); C-peptide production was significantly higher in IF group compared to ID group. The acute responses in lymphocytes at six-month follow-up include declined CD3CD4, CD3CD8 T cell population and recovered B cell, NK cell population in both groups but with no significant differences between the two groups; most immune-related genes and pathways were up-regulated in peripheral blood mononuclear cell (PBMC) of both groups while none of transcription factors for immune regulatory component were significantly changed; the IF group demonstrated more AHST-modified genetic events than the ID group and distinct pattern of top pathways, co-expression network as well as ‘hub’ genes (eg, TCF7 and GZMA) were associated with each group. ; AHST could improve the islet function in newly diagnosed T1D patients and elimination of the islet specific autoreactive T cells might be one of the mechanisms involved; T1D patients responded differently to AHST possibly due to the distinct transcriptional events occurring in PBMC. ; ClinicalTrials.gov
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0031887
oafree_for_read
date2012-02-22