schliessen

Filtern

 

Bibliotheken

Aging Kit Mutant Mice Develop Cardiomyopathy (Kit Mutant and Myocyte Turnover)

Both bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit + cells counts and ii. the stability of left ventricular (LV) contractile function and structure during... Full description

Journal Title: PLoS ONE 2012, Vol.7(3), p.e33407
Main Author: Ye, Lei
Other Authors: Zhang, Eric Yang , Xiong, Qiang , Astle, Clinton M , Zhang, Pengyuan , Li, Qinglu , From, Arthur H. L , Harrison, David E , Zhang, Jianyi Jay
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0033407
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0033407
title: Aging Kit Mutant Mice Develop Cardiomyopathy (Kit Mutant and Myocyte Turnover)
format: Article
creator:
  • Ye, Lei
  • Zhang, Eric Yang
  • Xiong, Qiang
  • Astle, Clinton M
  • Zhang, Pengyuan
  • Li, Qinglu
  • From, Arthur H. L
  • Harrison, David E
  • Zhang, Jianyi Jay
subjects:
  • Research Article
  • Biology
  • Medicine
  • Physiology
  • Cell Biology
ispartof: PLoS ONE, 2012, Vol.7(3), p.e33407
description: Both bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit + cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv and W41/W42) and in wild type (WT) mice at 4 and 12 months of age and the effects of the mutations on LV mass, vascular density and the numbers of proliferating cells were also determined. In 4 month old Kit mutant and WT mice, LV ejection fractions (EF) and LV fractional shortening rates (FS) were comparable. At 12 months of age EF and FS were significantly decreased and LV mass was significantly increased only in W41/W42 mice. Myocardial vascular densities and c-Kit + cell numbers were significantly reduced in both mutant groups when compared to WT hearts. Replacement of mutant BM with WT BM at 4 months of age did not prevent these abnormalities in either mutant group although they were somewhat attenuated in the W/Wv group. Notably BM transplantation did not prevent the development of cardiomyopathy in 12 month W41/W42 mice. The data suggest that decreased numbers and functional capacities of c-Kit + cardiac resident progenitor cells may be the basis of the cardiomyopathy in W41/W42 mice and although defects in mutant BM progenitor cells may prove to be contributory, they are not causal.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0033407
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID106338524
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0033407
sourceidplos
recordidTN_plos10.1371/journal.pone.0033407
sourcesystemPC
pqid929121843
display
typearticle
titleAging Kit Mutant Mice Develop Cardiomyopathy (Kit Mutant and Myocyte Turnover)
creatorYe, Lei ; Zhang, Eric Yang ; Xiong, Qiang ; Astle, Clinton M ; Zhang, Pengyuan ; Li, Qinglu ; From, Arthur H. L ; Harrison, David E ; Zhang, Jianyi Jay
contributorQin, Gangjian (Editor)
ispartofPLoS ONE, 2012, Vol.7(3), p.e33407
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0033407
subjectResearch Article ; Biology ; Medicine ; Physiology ; Cell Biology
descriptionBoth bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit + cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv and W41/W42) and in wild type (WT) mice at 4 and 12 months of age and the effects of the mutations on LV mass, vascular density and the numbers of proliferating cells were also determined. In 4 month old Kit mutant and WT mice, LV ejection fractions (EF) and LV fractional shortening rates (FS) were comparable. At 12 months of age EF and FS were significantly decreased and LV mass was significantly increased only in W41/W42 mice. Myocardial vascular densities and c-Kit + cell numbers were significantly reduced in both mutant groups when compared to WT hearts. Replacement of mutant BM with WT BM at 4 months of age did not prevent these abnormalities in either mutant group although they were somewhat attenuated in the W/Wv group. Notably BM transplantation did not prevent the development of cardiomyopathy in 12 month W41/W42 mice. The data suggest that decreased numbers and functional capacities of c-Kit + cardiac resident progenitor cells may be the basis of the cardiomyopathy in W41/W42 mice and although defects in mutant BM progenitor cells may prove to be contributory, they are not causal.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Ye, Lei
1Zhang, Eric Yang
2Xiong, Qiang
3Astle, Clinton M
4Zhang, Pengyuan
5Li, Qinglu
6From, Arthur H. L
7Harrison, David E
8Zhang, Jianyi Jay
9Qin, Gangjian (Editor)
titleAging Kit Mutant Mice Develop Cardiomyopathy (Kit Mutant and Myocyte Turnover)
descriptionBoth bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit + cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv and W41/W42) and in wild type (WT) mice at 4 and 12 months of age and the effects of the mutations on LV mass, vascular density and the numbers of proliferating cells were also determined. In 4 month old Kit mutant and WT mice, LV ejection fractions (EF) and LV fractional shortening rates (FS) were comparable. At 12 months of age EF and FS were significantly decreased and LV mass was significantly increased only in W41/W42 mice. Myocardial vascular densities and c-Kit + cell numbers were significantly reduced in both mutant groups when compared to WT hearts. Replacement of mutant BM with WT BM at 4 months of age did not prevent these abnormalities in either mutant group although they were somewhat attenuated in the W/Wv group. Notably BM transplantation did not prevent the development of cardiomyopathy in 12 month W41/W42 mice. The data suggest that decreased numbers and functional capacities of c-Kit + cardiac resident progenitor cells may be the basis of the cardiomyopathy in W41/W42 mice and although defects in mutant BM progenitor cells may prove to be contributory, they are not causal.
subject
0Research Article
1Biology
2Medicine
3Physiology
4Cell Biology
general
010.1371/journal.pone.0033407
1English
sourceidplos
recordidplos10.1371/journal.pone.0033407
issn
01932-6203
119326203
rsrctypearticle
creationdate2012
recordtypearticle
addtitle
0PLoS ONE
1Kit Mutant and Myocyte Turnover
searchscopeplos
scopeplos
lsr30VSR-Enriched:[pqid]
sort
titleAging Kit Mutant Mice Develop Cardiomyopathy (Kit Mutant and Myocyte Turnover)
authorYe, Lei ; Zhang, Eric Yang ; Xiong, Qiang ; Astle, Clinton M ; Zhang, Pengyuan ; Li, Qinglu ; From, Arthur H. L ; Harrison, David E ; Zhang, Jianyi Jay
creationdate20120313
facets
frbrgroupid5054166490178940450
frbrtype5
languageeng
creationdate2012
topic
0Research Article
1Biology
2Medicine
3Physiology
4Cell Biology
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Ye, Lei
1Zhang, Eric Yang
2Xiong, Qiang
3Astle, Clinton M
4Zhang, Pengyuan
5Li, Qinglu
6From, Arthur H. L
7Harrison, David E
8Zhang, Jianyi Jay
9Qin, Gangjian
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12012
k219326203
k310.1371/journal.pone.0033407
k47
k53
k633407
k7plos one
k8aging kit mutant mice develop cardiomyopathy
k9agingkitmutantmicedepathy
k12agingkitmutantmicedevelop
k15leiye
k16yelei
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Ye
1Zhang
2Xiong
3Astle
4Li
5From
6Harrison
7Qin
aufirst
0Lei
1Eric Yang
2Qiang
3Clinton M.
4Pengyuan
5Qinglu
6Arthur H. L.
7David E.
8Jianyi Jay
9Gangjian
au
0Ye, Lei
1Zhang, Eric Yang
2Xiong, Qiang
3Astle, Clinton M
4Zhang, Pengyuan
5Li, Qinglu
6From, Arthur H. L
7Harrison, David E
8Zhang, Jianyi Jay
addauQin, Gangjian
atitleAging Kit Mutant Mice Develop Cardiomyopathy (Kit Mutant and Myocyte Turnover)
jtitlePLoS ONE
risdate20120313
volume7
issue3
spagee33407
pagese33407
eissn1932-6203
genrearticle
ristypeJOUR
abstractBoth bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit + cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv and W41/W42) and in wild type (WT) mice at 4 and 12 months of age and the effects of the mutations on LV mass, vascular density and the numbers of proliferating cells were also determined. In 4 month old Kit mutant and WT mice, LV ejection fractions (EF) and LV fractional shortening rates (FS) were comparable. At 12 months of age EF and FS were significantly decreased and LV mass was significantly increased only in W41/W42 mice. Myocardial vascular densities and c-Kit + cell numbers were significantly reduced in both mutant groups when compared to WT hearts. Replacement of mutant BM with WT BM at 4 months of age did not prevent these abnormalities in either mutant group although they were somewhat attenuated in the W/Wv group. Notably BM transplantation did not prevent the development of cardiomyopathy in 12 month W41/W42 mice. The data suggest that decreased numbers and functional capacities of c-Kit + cardiac resident progenitor cells may be the basis of the cardiomyopathy in W41/W42 mice and although defects in mutant BM progenitor cells may prove to be contributory, they are not causal.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0033407
oafree_for_read
date2012-03-13