schliessen

Filtern

 

Bibliotheken

Biodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts (Anti-Tumor Effect of Controlled Drug Delivery)

OSCC is one of the most common malignancies and numerous clinical agents currently applied in combinative chemotherapy. Here we reported a novel therapeutic strategy, SAHA and DDP-loaded PECE (SAHA-DDP/PECE), can improve the therapeutic effects of intratumorally chemotherapy on OSCC cell xenografts.... Full description

Journal Title: PLoS ONE 2012, Vol.7(4), p.e33860
Main Author: Li, Jing
Other Authors: Gong, Changyang , Feng, Xiaodong , Zhou, Xikun , Xu, Xiaoping , Xie, Liang , Wang, Ruinan , Zhang, Dunfang , Wang, Hui , Deng, Peng , Zhou, Min , Ji, Ning , Zhou, Yu , Wang, Yun , Wang, Zhiyong , Liao, Ga , Geng, Ning , Chu, Liangyin , Qian, Zhiyong , Wang, Zhi , Chen, Qianming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0033860
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0033860
title: Biodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts (Anti-Tumor Effect of Controlled Drug Delivery)
format: Article
creator:
  • Li, Jing
  • Gong, Changyang
  • Feng, Xiaodong
  • Zhou, Xikun
  • Xu, Xiaoping
  • Xie, Liang
  • Wang, Ruinan
  • Zhang, Dunfang
  • Wang, Hui
  • Deng, Peng
  • Zhou, Min
  • Ji, Ning
  • Zhou, Yu
  • Wang, Yun
  • Wang, Zhiyong
  • Liao, Ga
  • Geng, Ning
  • Chu, Liangyin
  • Qian, Zhiyong
  • Wang, Zhi
  • Chen, Qianming
subjects:
  • Research Article
  • Biology
  • Materials Science
  • Medicine
  • Biotechnology
  • Oncology
  • Pharmacology
  • Dermatology
ispartof: PLoS ONE, 2012, Vol.7(4), p.e33860
description: OSCC is one of the most common malignancies and numerous clinical agents currently applied in combinative chemotherapy. Here we reported a novel therapeutic strategy, SAHA and DDP-loaded PECE (SAHA-DDP/PECE), can improve the therapeutic effects of intratumorally chemotherapy on OSCC cell xenografts. ; The objective of this study was to evaluate the therapeutic efficacy of the SAHA-DDP/PECE in situ controlled drug delivery system on OSCC cell xenografts. ; A biodegradable and thermosensitive hydrogel was successfully developed to load SAHA and DDP. Tumor-beared mice were intratumorally administered with SAHA-DDP/PECE at 50 mg/kg (SAHA) +2 mg/kg (DDP) in 100 ul PECE hydrogel every two weeks, SAHA-DDP at 50 mg/kg(SAHA) +2 mg/kg(DDP) in NS, 2 mg/kg DDP solution, 50 mg/kg SAHA solution, equal volume of PECE hydrogel, or equal volume of NS on the same schedule, respectively. The antineoplastic actions of SAHA and DDP alone and in combination were evaluated using the determination of tumor volume, immunohistochemistry, western blot, and TUNEL analysis. ; The hydrogel system was a free-flowing sol at 10°C, become gel at body temperature, and could sustain more than 14 days in situ. SAHA-DDP/PECE was subsequently injected into tumor OSCC tumor-beared mice. The results demonstrated that such a strategy as this allows the carrier system to show a sustained release of SAHA and DDP in vivo, and could improved therapeutic effects compared with a simple additive therapeutic effect of SAHA and DDP on mouse model. ; Our research indicated that the novel SAHA-DDP/PECE system based on biodegradable PECE copolymer enhanced the therapeutic effects and could diminished the side effects of SAHA/DDP. The present work might be of great importance to the further exploration of the potential application of SAHA/DDP-hydrogel controlled drug release system in the treatment of OSCC.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0033860
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID1310152806
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0033860
sourceidplos
recordidTN_plos10.1371/journal.pone.0033860
sourcesystemOther
pqid1324558154
galeid477074625
display
typearticle
titleBiodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts (Anti-Tumor Effect of Controlled Drug Delivery)
creatorLi, Jing ; Gong, Changyang ; Feng, Xiaodong ; Zhou, Xikun ; Xu, Xiaoping ; Xie, Liang ; Wang, Ruinan ; Zhang, Dunfang ; Wang, Hui ; Deng, Peng ; Zhou, Min ; Ji, Ning ; Zhou, Yu ; Wang, Yun ; Wang, Zhiyong ; Liao, Ga ; Geng, Ning ; Chu, Liangyin ; Qian, Zhiyong ; Wang, Zhi ; Chen, Qianming
contributorXie, Jingwu (Editor)
ispartofPLoS ONE, 2012, Vol.7(4), p.e33860
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0033860
subjectResearch Article ; Biology ; Materials Science ; Medicine ; Biotechnology ; Oncology ; Pharmacology ; Dermatology
descriptionOSCC is one of the most common malignancies and numerous clinical agents currently applied in combinative chemotherapy. Here we reported a novel therapeutic strategy, SAHA and DDP-loaded PECE (SAHA-DDP/PECE), can improve the therapeutic effects of intratumorally chemotherapy on OSCC cell xenografts. ; The objective of this study was to evaluate the therapeutic efficacy of the SAHA-DDP/PECE in situ controlled drug delivery system on OSCC cell xenografts. ; A biodegradable and thermosensitive hydrogel was successfully developed to load SAHA and DDP. Tumor-beared mice were intratumorally administered with SAHA-DDP/PECE at 50 mg/kg (SAHA) +2 mg/kg (DDP) in 100 ul PECE hydrogel every two weeks, SAHA-DDP at 50 mg/kg(SAHA) +2 mg/kg(DDP) in NS, 2 mg/kg DDP solution, 50 mg/kg SAHA solution, equal volume of PECE hydrogel, or equal volume of NS on the same schedule, respectively. The antineoplastic actions of SAHA and DDP alone and in combination were evaluated using the determination of tumor volume, immunohistochemistry, western blot, and TUNEL analysis. ; The hydrogel system was a free-flowing sol at 10°C, become gel at body temperature, and could sustain more than 14 days in situ. SAHA-DDP/PECE was subsequently injected into tumor OSCC tumor-beared mice. The results demonstrated that such a strategy as this allows the carrier system to show a sustained release of SAHA and DDP in vivo, and could improved therapeutic effects compared with a simple additive therapeutic effect of SAHA and DDP on mouse model. ; Our research indicated that the novel SAHA-DDP/PECE system based on biodegradable PECE copolymer enhanced the therapeutic effects and could diminished the side effects of SAHA/DDP. The present work might be of great importance to the further exploration of the potential application of SAHA/DDP-hydrogel controlled drug release system in the treatment of OSCC.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Li, Jing
1Gong, Changyang
2Feng, Xiaodong
3Zhou, Xikun
4Xu, Xiaoping
5Xie, Liang
6Wang, Ruinan
7Zhang, Dunfang
8Wang, Hui
9Deng, Peng
10Zhou, Min
11Ji, Ning
12Zhou, Yu
13Wang, Yun
14Wang, Zhiyong
15Liao, Ga
16Geng, Ning
17Chu, Liangyin
18Qian, Zhiyong
19Wang, Zhi
20Chen, Qianming
21Xie, Jingwu (Editor)
titleBiodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts (Anti-Tumor Effect of Controlled Drug Delivery)
descriptionOSCC is one of the most common malignancies and numerous clinical agents currently applied in combinative chemotherapy. Here we reported a novel therapeutic strategy, SAHA and DDP-loaded PECE (SAHA-DDP/PECE), can improve the therapeutic effects of intratumorally chemotherapy on OSCC cell xenografts. ; The objective of this study was to evaluate the therapeutic efficacy of the SAHA-DDP/PECE in situ controlled drug delivery system on OSCC cell xenografts. ; A biodegradable and thermosensitive hydrogel was successfully developed to load SAHA and DDP. Tumor-beared mice were intratumorally administered with SAHA-DDP/PECE at 50 mg/kg (SAHA) +2 mg/kg (DDP) in 100 ul PECE hydrogel every two weeks, SAHA-DDP at 50 mg/kg(SAHA) +2 mg/kg(DDP) in NS, 2 mg/kg DDP solution, 50 mg/kg SAHA solution, equal volume of PECE hydrogel, or equal volume of NS on the same schedule, respectively. The antineoplastic actions of SAHA and DDP alone and in combination were evaluated using the determination of tumor volume, immunohistochemistry, western blot, and TUNEL analysis. ; The hydrogel system was a free-flowing sol at 10°C, become gel at body temperature, and could sustain more than 14 days in situ. SAHA-DDP/PECE was subsequently injected into tumor OSCC tumor-beared mice. The results demonstrated that such a strategy as this allows the carrier system to show a sustained release of SAHA and DDP in vivo, and could improved therapeutic effects compared with a simple additive therapeutic effect of SAHA and DDP on mouse model. ; Our research indicated that the novel SAHA-DDP/PECE system based on biodegradable PECE copolymer enhanced the therapeutic effects and could diminished the side effects of SAHA/DDP. The present work might be of great importance to the further exploration of the potential application of SAHA/DDP-hydrogel controlled drug release system in the treatment of OSCC.
subject
0Research Article
1Biology
2Materials Science
3Medicine
4Biotechnology
5Oncology
6Pharmacology
7Dermatology
general
010.1371/journal.pone.0033860
1English
sourceidplos
recordidplos10.1371/journal.pone.0033860
issn
01932-6203
119326203
rsrctypearticle
creationdate2012
recordtypearticle
addtitle
0PLoS ONE
1Anti-Tumor Effect of Controlled Drug Delivery
searchscopeplos
scopeplos
lsr30VSR-Enriched:[galeid, pqid]
sort
titleBiodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts (Anti-Tumor Effect of Controlled Drug Delivery)
authorLi, Jing ; Gong, Changyang ; Feng, Xiaodong ; Zhou, Xikun ; Xu, Xiaoping ; Xie, Liang ; Wang, Ruinan ; Zhang, Dunfang ; Wang, Hui ; Deng, Peng ; Zhou, Min ; Ji, Ning ; Zhou, Yu ; Wang, Yun ; Wang, Zhiyong ; Liao, Ga ; Geng, Ning ; Chu, Liangyin ; Qian, Zhiyong ; Wang, Zhi ; Chen, Qianming
creationdate20120418
facets
frbrgroupid4471296765038781281
frbrtype5
languageeng
creationdate2012
topic
0Research Article
1Biology
2Materials Science
3Medicine
4Biotechnology
5Oncology
6Pharmacology
7Dermatology
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Li, Jing
1Gong, Changyang
2Feng, Xiaodong
3Zhou, Xikun
4Xu, Xiaoping
5Xie, Liang
6Wang, Ruinan
7Zhang, Dunfang
8Wang, Hui
9Deng, Peng
10Zhou, Min
11Ji, Ning
12Zhou, Yu
13Wang, Yun
14Wang, Zhiyong
15Liao, Ga
16Geng, Ning
17Chu, Liangyin
18Qian, Zhiyong
19Wang, Zhi
20Chen, Qianming
21Xie, Jingwu
jtitlePLoS ONE
toplevelpeer_reviewed
frbr
t2
k12012
k219326203
k310.1371/journal.pone.0033860
k47
k54
k633860
k7plos one
k8biodegradable thermosensitive hydrogel for saha ddp delivery therapeutic effects on oral squamous cell carcinoma xenografts
k9biodegradablethermosrafts
k12biodegradablethermosensit
k15jingli
k16lijing
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Li
1Gong
2Feng
3Zhou
4Xu
5Xie
6Wang
7Zhang
8Deng
9Ji
10Liao
11Geng
12Chu
13Qian
14Chen
aufirst
0Jing
1Changyang
2Xiaodong
3Xikun
4Xiaoping
5Liang
6Ruinan
7Dunfang
8Hui
9Peng
10Min
11Ning
12Yu
13Yun
14Zhiyong
15Ga
16Liangyin
17Zhi
18Qianming
19Jingwu
au
0Li, Jing
1Gong, Changyang
2Feng, Xiaodong
3Zhou, Xikun
4Xu, Xiaoping
5Xie, Liang
6Wang, Ruinan
7Zhang, Dunfang
8Wang, Hui
9Deng, Peng
10Zhou, Min
11Ji, Ning
12Zhou, Yu
13Wang, Yun
14Wang, Zhiyong
15Liao, Ga
16Geng, Ning
17Chu, Liangyin
18Qian, Zhiyong
19Wang, Zhi
20Chen, Qianming
addauXie, Jingwu
atitleBiodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts (Anti-Tumor Effect of Controlled Drug Delivery)
jtitlePLoS ONE
risdate20120418
volume7
issue4
spagee33860
pagese33860
eissn1932-6203
genrearticle
ristypeJOUR
abstractOSCC is one of the most common malignancies and numerous clinical agents currently applied in combinative chemotherapy. Here we reported a novel therapeutic strategy, SAHA and DDP-loaded PECE (SAHA-DDP/PECE), can improve the therapeutic effects of intratumorally chemotherapy on OSCC cell xenografts. ; The objective of this study was to evaluate the therapeutic efficacy of the SAHA-DDP/PECE in situ controlled drug delivery system on OSCC cell xenografts. ; A biodegradable and thermosensitive hydrogel was successfully developed to load SAHA and DDP. Tumor-beared mice were intratumorally administered with SAHA-DDP/PECE at 50 mg/kg (SAHA) +2 mg/kg (DDP) in 100 ul PECE hydrogel every two weeks, SAHA-DDP at 50 mg/kg(SAHA) +2 mg/kg(DDP) in NS, 2 mg/kg DDP solution, 50 mg/kg SAHA solution, equal volume of PECE hydrogel, or equal volume of NS on the same schedule, respectively. The antineoplastic actions of SAHA and DDP alone and in combination were evaluated using the determination of tumor volume, immunohistochemistry, western blot, and TUNEL analysis. ; The hydrogel system was a free-flowing sol at 10°C, become gel at body temperature, and could sustain more than 14 days in situ. SAHA-DDP/PECE was subsequently injected into tumor OSCC tumor-beared mice. The results demonstrated that such a strategy as this allows the carrier system to show a sustained release of SAHA and DDP in vivo, and could improved therapeutic effects compared with a simple additive therapeutic effect of SAHA and DDP on mouse model. ; Our research indicated that the novel SAHA-DDP/PECE system based on biodegradable PECE copolymer enhanced the therapeutic effects and could diminished the side effects of SAHA/DDP. The present work might be of great importance to the further exploration of the potential application of SAHA/DDP-hydrogel controlled drug release system in the treatment of OSCC.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0033860
oafree_for_read
date2012-04-18