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Evaluation of Microbubbles as Contrast Agents for Ultrasonography and Magnetic Resonance Imaging (Microbubbles: A Dual-Modality Contrast Agent)

Microbubbles (MBs) can serve as an ultrasound contrast agent, and has the potential for magnetic resonance imaging (MRI). Due to the relatively low effect of MBs on MRI, it is necessary to develop new MBs that are more suitable for MRI. In this study, we evaluate the properties of SonoVue® and custo... Full description

Journal Title: PLoS ONE 2012, Vol.7(4), p.e34644
Main Author: Li, Ling
Other Authors: Wei, Qiang , Li, Hong-Bo , Wen, Song , Teng, Gao-Jun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0034644
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recordid: plos10.1371/journal.pone.0034644
title: Evaluation of Microbubbles as Contrast Agents for Ultrasonography and Magnetic Resonance Imaging (Microbubbles: A Dual-Modality Contrast Agent)
format: Article
creator:
  • Li, Ling
  • Wei, Qiang
  • Li, Hong-Bo
  • Wen, Song
  • Teng, Gao-Jun
subjects:
  • Research Article
  • Biology
  • Medicine
  • Oncology
  • Neuroscience
  • Gastroenterology And Hepatology
  • Radiology And Medical Imaging
ispartof: PLoS ONE, 2012, Vol.7(4), p.e34644
description: Microbubbles (MBs) can serve as an ultrasound contrast agent, and has the potential for magnetic resonance imaging (MRI). Due to the relatively low effect of MBs on MRI, it is necessary to develop new MBs that are more suitable for MRI. In this study, we evaluate the properties of SonoVue® and custom-made Fe 3 O 4 -nanoparticle-embedded microbubbles (Fe 3 O 4 -MBs) in terms of contrast agents for ultrsonography (US) and MRI. ; A total of 20 HepG2 subcutaneous-tumor-bearing nude mice were randomly assigned to 2 groups (i.e., n = 10 mice each group), one for US test and the other for MRI test. Within each group, two tests were performed for each mouse. The contrast agent for the first test is SonoVue®, and the second is FeO-MBs. US was performed using a Technos US system (Esaote, Italy) with a contrast-tuned imaging (CnTI™) mode. MRI was performed using a 7.0T Micro-MRI (PharmaScan, Bruker Biospin GmbH, Germany) with an EPI-T* sequence. The data of signal-to-noise ratio (SNR) from the region-of-interest of each US and MR image was calculated by ImageJ (National Institute of Health, USA). In group 1, enhancement of SonoVue® was significantly higher than FeO-MBs on US (P0.05). The SNR analysis of the enhancement process reveals a strong negative correlation in both cases (i.e., SonoVue® r = −0.733, FeO-MBs r = −0.903, with P
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0034644
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
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descriptionMicrobubbles (MBs) can serve as an ultrasound contrast agent, and has the potential for magnetic resonance imaging (MRI). Due to the relatively low effect of MBs on MRI, it is necessary to develop new MBs that are more suitable for MRI. In this study, we evaluate the properties of SonoVue® and custom-made Fe 3 O 4 -nanoparticle-embedded microbubbles (Fe 3 O 4 -MBs) in terms of contrast agents for ultrsonography (US) and MRI. ; A total of 20 HepG2 subcutaneous-tumor-bearing nude mice were randomly assigned to 2 groups (i.e., n = 10 mice each group), one for US test and the other for MRI test. Within each group, two tests were performed for each mouse. The contrast agent for the first test is SonoVue®, and the second is FeO-MBs. US was performed using a Technos US system (Esaote, Italy) with a contrast-tuned imaging (CnTI™) mode. MRI was performed using a 7.0T Micro-MRI (PharmaScan, Bruker Biospin GmbH, Germany) with an EPI-T* sequence. The data of signal-to-noise ratio (SNR) from the region-of-interest of each US and MR image was calculated by ImageJ (National Institute of Health, USA). In group 1, enhancement of SonoVue® was significantly higher than FeO-MBs on US (P0.05). The SNR analysis of the enhancement process reveals a strong negative correlation in both cases (i.e., SonoVue® r = −0.733, FeO-MBs r = −0.903, with P<0.05). ; It might be important to change the FeO-MBs' shell structure and/or the imagining strategy of US to improve the imaging quality of FeO-MBs on US. As an intriguing prospect that can be detected by US and MRI, MBs are worthy of further study.
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descriptionMicrobubbles (MBs) can serve as an ultrasound contrast agent, and has the potential for magnetic resonance imaging (MRI). Due to the relatively low effect of MBs on MRI, it is necessary to develop new MBs that are more suitable for MRI. In this study, we evaluate the properties of SonoVue® and custom-made Fe 3 O 4 -nanoparticle-embedded microbubbles (Fe 3 O 4 -MBs) in terms of contrast agents for ultrsonography (US) and MRI. ; A total of 20 HepG2 subcutaneous-tumor-bearing nude mice were randomly assigned to 2 groups (i.e., n = 10 mice each group), one for US test and the other for MRI test. Within each group, two tests were performed for each mouse. The contrast agent for the first test is SonoVue®, and the second is FeO-MBs. US was performed using a Technos US system (Esaote, Italy) with a contrast-tuned imaging (CnTI™) mode. MRI was performed using a 7.0T Micro-MRI (PharmaScan, Bruker Biospin GmbH, Germany) with an EPI-T* sequence. The data of signal-to-noise ratio (SNR) from the region-of-interest of each US and MR image was calculated by ImageJ (National Institute of Health, USA). In group 1, enhancement of SonoVue® was significantly higher than FeO-MBs on US (P0.05). The SNR analysis of the enhancement process reveals a strong negative correlation in both cases (i.e., SonoVue® r = −0.733, FeO-MBs r = −0.903, with P<0.05). ; It might be important to change the FeO-MBs' shell structure and/or the imagining strategy of US to improve the imaging quality of FeO-MBs on US. As an intriguing prospect that can be detected by US and MRI, MBs are worthy of further study.
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abstractMicrobubbles (MBs) can serve as an ultrasound contrast agent, and has the potential for magnetic resonance imaging (MRI). Due to the relatively low effect of MBs on MRI, it is necessary to develop new MBs that are more suitable for MRI. In this study, we evaluate the properties of SonoVue® and custom-made Fe 3 O 4 -nanoparticle-embedded microbubbles (Fe 3 O 4 -MBs) in terms of contrast agents for ultrsonography (US) and MRI. ; A total of 20 HepG2 subcutaneous-tumor-bearing nude mice were randomly assigned to 2 groups (i.e., n = 10 mice each group), one for US test and the other for MRI test. Within each group, two tests were performed for each mouse. The contrast agent for the first test is SonoVue®, and the second is FeO-MBs. US was performed using a Technos US system (Esaote, Italy) with a contrast-tuned imaging (CnTI™) mode. MRI was performed using a 7.0T Micro-MRI (PharmaScan, Bruker Biospin GmbH, Germany) with an EPI-T* sequence. The data of signal-to-noise ratio (SNR) from the region-of-interest of each US and MR image was calculated by ImageJ (National Institute of Health, USA). In group 1, enhancement of SonoVue® was significantly higher than FeO-MBs on US (P0.05). The SNR analysis of the enhancement process reveals a strong negative correlation in both cases (i.e., SonoVue® r = −0.733, FeO-MBs r = −0.903, with P<0.05). ; It might be important to change the FeO-MBs' shell structure and/or the imagining strategy of US to improve the imaging quality of FeO-MBs on US. As an intriguing prospect that can be detected by US and MRI, MBs are worthy of further study.
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doi10.1371/journal.pone.0034644
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date2012-04-10