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Abnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication (White Matter in Obsessive-Compulsive Disorder)

Abnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. ; To investigate whether the abno... Full description

Journal Title: PLoS ONE 2012, Vol.7(4), p.e35889
Main Author: Fan, Qing
Other Authors: Yan, Xu , Wang, Jijun , Chen, Ying , Wang, Xuemei , Li, Chunbo , Tan, Ling , You, Chao , Zhang, Tianhong , Zuo, Sai , Xu, Dongrong , Chen, Kemin , Finlayson-Burden, Jodie Marie , Xiao, Zeping
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0035889
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recordid: plos10.1371/journal.pone.0035889
title: Abnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication (White Matter in Obsessive-Compulsive Disorder)
format: Article
creator:
  • Fan, Qing
  • Yan, Xu
  • Wang, Jijun
  • Chen, Ying
  • Wang, Xuemei
  • Li, Chunbo
  • Tan, Ling
  • You, Chao
  • Zhang, Tianhong
  • Zuo, Sai
  • Xu, Dongrong
  • Chen, Kemin
  • Finlayson-Burden, Jodie Marie
  • Xiao, Zeping
subjects:
  • Research Article
  • Biology
  • Medicine
  • Social And Behavioral Sciences
  • Mental Health
  • Physiology
  • Neuroscience
ispartof: PLoS ONE, 2012, Vol.7(4), p.e35889
description: Abnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. ; To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. ; Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were acquired from 27 unmedicated OCD patients (including 13 drug-naïve individuals) and 23 healthy controls. Voxel-based analysis was then performed to detect regions with significant group difference. We compared the DTI-derived parameters of 15 patients before and after 12-week Selective Serotonin Reuptake Inhibitor (SSRI) therapies. Significant differences of DTI-derived parameters were observed between OCD and healthy groups in multiple structures, mainly within the fronto-striato-thalamo-cortical loop. An increased RD in combination with no change in AD among OCD patients was found in the left medial superior frontal gyrus, temporo-parietal lobe, occipital lobe, striatum, insula and right midbrain. There was no statistical difference in DTI-derived parameters between drug-naive and previously medicated OCD patients. After being medicated, OCD patients showed a reduction in RD of the left striatum and right midbrain, and in MD of the right midbrain. ; Our preliminary findings suggest that abnormalities of white matter microstructure, particularly in terms of myelin integrity, are primari ly located within the fronto-striato-thalamo-cortical circuit of individuals with OCD. Some abnormalities may be partly reversed by SSRI treatment.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0035889
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleAbnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication (White Matter in Obsessive-Compulsive Disorder)
creatorFan, Qing ; Yan, Xu ; Wang, Jijun ; Chen, Ying ; Wang, Xuemei ; Li, Chunbo ; Tan, Ling ; You, Chao ; Zhang, Tianhong ; Zuo, Sai ; Xu, Dongrong ; Chen, Kemin ; Finlayson-Burden, Jodie Marie ; Xiao, Zeping
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0035889
subjectResearch Article ; Biology ; Medicine ; Social And Behavioral Sciences ; Mental Health ; Physiology ; Neuroscience
descriptionAbnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. ; To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. ; Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were acquired from 27 unmedicated OCD patients (including 13 drug-naïve individuals) and 23 healthy controls. Voxel-based analysis was then performed to detect regions with significant group difference. We compared the DTI-derived parameters of 15 patients before and after 12-week Selective Serotonin Reuptake Inhibitor (SSRI) therapies. Significant differences of DTI-derived parameters were observed between OCD and healthy groups in multiple structures, mainly within the fronto-striato-thalamo-cortical loop. An increased RD in combination with no change in AD among OCD patients was found in the left medial superior frontal gyrus, temporo-parietal lobe, occipital lobe, striatum, insula and right midbrain. There was no statistical difference in DTI-derived parameters between drug-naive and previously medicated OCD patients. After being medicated, OCD patients showed a reduction in RD of the left striatum and right midbrain, and in MD of the right midbrain. ; Our preliminary findings suggest that abnormalities of white matter microstructure, particularly in terms of myelin integrity, are primari ly located within the fronto-striato-thalamo-cortical circuit of individuals with OCD. Some abnormalities may be partly reversed by SSRI treatment.
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titleAbnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication (White Matter in Obsessive-Compulsive Disorder)
descriptionAbnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. ; To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. ; Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were acquired from 27 unmedicated OCD patients (including 13 drug-naïve individuals) and 23 healthy controls. Voxel-based analysis was then performed to detect regions with significant group difference. We compared the DTI-derived parameters of 15 patients before and after 12-week Selective Serotonin Reuptake Inhibitor (SSRI) therapies. Significant differences of DTI-derived parameters were observed between OCD and healthy groups in multiple structures, mainly within the fronto-striato-thalamo-cortical loop. An increased RD in combination with no change in AD among OCD patients was found in the left medial superior frontal gyrus, temporo-parietal lobe, occipital lobe, striatum, insula and right midbrain. There was no statistical difference in DTI-derived parameters between drug-naive and previously medicated OCD patients. After being medicated, OCD patients showed a reduction in RD of the left striatum and right midbrain, and in MD of the right midbrain. ; Our preliminary findings suggest that abnormalities of white matter microstructure, particularly in terms of myelin integrity, are primari ly located within the fronto-striato-thalamo-cortical circuit of individuals with OCD. Some abnormalities may be partly reversed by SSRI treatment.
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abstractAbnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi-parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. ; To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. ; Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were acquired from 27 unmedicated OCD patients (including 13 drug-naïve individuals) and 23 healthy controls. Voxel-based analysis was then performed to detect regions with significant group difference. We compared the DTI-derived parameters of 15 patients before and after 12-week Selective Serotonin Reuptake Inhibitor (SSRI) therapies. Significant differences of DTI-derived parameters were observed between OCD and healthy groups in multiple structures, mainly within the fronto-striato-thalamo-cortical loop. An increased RD in combination with no change in AD among OCD patients was found in the left medial superior frontal gyrus, temporo-parietal lobe, occipital lobe, striatum, insula and right midbrain. There was no statistical difference in DTI-derived parameters between drug-naive and previously medicated OCD patients. After being medicated, OCD patients showed a reduction in RD of the left striatum and right midbrain, and in MD of the right midbrain. ; Our preliminary findings suggest that abnormalities of white matter microstructure, particularly in terms of myelin integrity, are primari ly located within the fronto-striato-thalamo-cortical circuit of individuals with OCD. Some abnormalities may be partly reversed by SSRI treatment.
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