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Continuous Regional Arterial Infusion with Fluorouracil and Octreotide Attenuates Severe Acute Pancreatitis in a Canine Model (CRAI Attenuates Severe Acute Pancreatitis)

To investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). ; The animals were divided into five groups; group A (Sham), group B (SAP),... Full description

Journal Title: PLoS ONE 2012, Vol.7(5), p.e37347
Main Author: Zhou, Meng Tao
Other Authors: Chen, Bi Cheng , Sun, Hong Wei , Jin, Yue Peng , Yang, Fa Jing , Zhang, Xing , Andersson, Roland , Zhang, Qi Yu
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0037347
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recordid: plos10.1371/journal.pone.0037347
title: Continuous Regional Arterial Infusion with Fluorouracil and Octreotide Attenuates Severe Acute Pancreatitis in a Canine Model (CRAI Attenuates Severe Acute Pancreatitis)
format: Article
creator:
  • Zhou, Meng Tao
  • Chen, Bi Cheng
  • Sun, Hong Wei
  • Jin, Yue Peng
  • Yang, Fa Jing
  • Zhang, Xing
  • Andersson, Roland
  • Zhang, Qi Yu
subjects:
  • Research Article
  • Biology
  • Medicine
  • Surgery
  • Pharmacology
  • Gastroenterology And Hepatology
ispartof: PLoS ONE, 2012, Vol.7(5), p.e37347
description: To investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). ; The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu + Oct). Levels of amylase, α-tumor necrosis factor (TNF-α), blood urea nitrogen (BUN), creatinine, thromboxane B2 and 6-keto- prostaglandin F1α were measured both before and after the induction of SAP. Pathologic examination of the pancreas and kidneys was performed after termination of the study. ; Pathologic changes noted in the pancreas in SAP significantly improved following CRAI with either single or combined administration of 5-Fu and Oct, where combination therapy demonstrated the lowest injury score. All treatment groups had significantly lower levels of serum TNF-α and amylase activity (
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0037347
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleContinuous Regional Arterial Infusion with Fluorouracil and Octreotide Attenuates Severe Acute Pancreatitis in a Canine Model (CRAI Attenuates Severe Acute Pancreatitis)
creatorZhou, Meng Tao ; Chen, Bi Cheng ; Sun, Hong Wei ; Jin, Yue Peng ; Yang, Fa Jing ; Zhang, Xing ; Andersson, Roland ; Zhang, Qi Yu
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0037347
subjectResearch Article ; Biology ; Medicine ; Surgery ; Pharmacology ; Gastroenterology And Hepatology
descriptionTo investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). ; The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu + Oct). Levels of amylase, α-tumor necrosis factor (TNF-α), blood urea nitrogen (BUN), creatinine, thromboxane B2 and 6-keto- prostaglandin F1α were measured both before and after the induction of SAP. Pathologic examination of the pancreas and kidneys was performed after termination of the study. ; Pathologic changes noted in the pancreas in SAP significantly improved following CRAI with either single or combined administration of 5-Fu and Oct, where combination therapy demonstrated the lowest injury score. All treatment groups had significantly lower levels of serum TNF-α and amylase activity (<0.05), though only groups D and E had a lower BUN level as compared to group B. The plasma thromboxane B level increased in SAP, but the ratio of thromboxane B/6-keto- prostaglandin F decreased in the treatment groups, with the combination therapy (group E) demonstrating the lowest ratio as compared to the other 3 experimental groups (<0.05). ; The findings in the present study demonstrate an attenuation of SAP in a canine model following CRAI administration with 5-Fu or Oct, alone or in combination.
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descriptionTo investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). ; The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu + Oct). Levels of amylase, α-tumor necrosis factor (TNF-α), blood urea nitrogen (BUN), creatinine, thromboxane B2 and 6-keto- prostaglandin F1α were measured both before and after the induction of SAP. Pathologic examination of the pancreas and kidneys was performed after termination of the study. ; Pathologic changes noted in the pancreas in SAP significantly improved following CRAI with either single or combined administration of 5-Fu and Oct, where combination therapy demonstrated the lowest injury score. All treatment groups had significantly lower levels of serum TNF-α and amylase activity (<0.05), though only groups D and E had a lower BUN level as compared to group B. The plasma thromboxane B level increased in SAP, but the ratio of thromboxane B/6-keto- prostaglandin F decreased in the treatment groups, with the combination therapy (group E) demonstrating the lowest ratio as compared to the other 3 experimental groups (<0.05). ; The findings in the present study demonstrate an attenuation of SAP in a canine model following CRAI administration with 5-Fu or Oct, alone or in combination.
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abstractTo investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). ; The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu + Oct). Levels of amylase, α-tumor necrosis factor (TNF-α), blood urea nitrogen (BUN), creatinine, thromboxane B2 and 6-keto- prostaglandin F1α were measured both before and after the induction of SAP. Pathologic examination of the pancreas and kidneys was performed after termination of the study. ; Pathologic changes noted in the pancreas in SAP significantly improved following CRAI with either single or combined administration of 5-Fu and Oct, where combination therapy demonstrated the lowest injury score. All treatment groups had significantly lower levels of serum TNF-α and amylase activity (<0.05), though only groups D and E had a lower BUN level as compared to group B. The plasma thromboxane B level increased in SAP, but the ratio of thromboxane B/6-keto- prostaglandin F decreased in the treatment groups, with the combination therapy (group E) demonstrating the lowest ratio as compared to the other 3 experimental groups (<0.05). ; The findings in the present study demonstrate an attenuation of SAP in a canine model following CRAI administration with 5-Fu or Oct, alone or in combination.
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date2012-05-24