schliessen

Filtern

 

Bibliotheken

Breast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression (BRMS1 Regulates HCC Cell Apoptosis via OPN)

Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellula... Full description

Journal Title: 2012 Vol.7(8), p.e42976
Main Author: Wu, Yanhua
Other Authors: Jiang, Wenjun , Wang, Yingming , Wu, Jun , Saiyin, Hexige , Qiao, Xiaojing , Mei, Xinyu , Guo, Bin , Fang, Xiao , Zhang, Lu , Lou, Huiling , Wu, Chaoqun , Qiao, Shouyi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0042976
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0042976
title: Breast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression (BRMS1 Regulates HCC Cell Apoptosis via OPN)
format: Article
creator:
  • Wu, Yanhua
  • Jiang, Wenjun
  • Wang, Yingming
  • Wu, Jun
  • Saiyin, Hexige
  • Qiao, Xiaojing
  • Mei, Xinyu
  • Guo, Bin
  • Fang, Xiao
  • Zhang, Lu
  • Lou, Huiling
  • Wu, Chaoqun
  • Qiao, Shouyi
subjects:
  • Research Article
  • Biology
  • Medicine
  • Genetics And Genomics
  • Cell Biology
  • Oncology
ispartof: 2012, Vol.7(8), p.e42976
description: Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that the expression level of BRMS1 was significantly down-regulated in HCC tissues. Expression of BRMS1 in SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized cells to apoptosis induced by serum deprivation or anoikis. Consistently, knockdown of endogenous BRMS1 expression in Hep3B cells suppressed cell apoptosis. We identified that BRMS1 suppresses osteopontin (OPN) expression in HCC cells and that there is a negative correlation between BRMS1 and OPN mRNA expression in HCC tissues. Moreover, knockdown of endogenous OPN expression reversed the anti-apoptosis effect achieved by knockdown of BRMS1. Taken together, our results show that BRMS1 sensitizes HCC cells to apoptosis through suppressing OPN expression, suggesting a potential role of BRMS1 in regulating HCC apoptosis and metastasis.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0042976
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID983277691
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0042976
sourceidplos
recordidTN_plos10.1371/journal.pone.0042976
sourcesystemOther
pqid1036879224
galeid498257773
display
typearticle
titleBreast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression (BRMS1 Regulates HCC Cell Apoptosis via OPN)
creatorWu, Yanhua ; Jiang, Wenjun ; Wang, Yingming ; Wu, Jun ; Saiyin, Hexige ; Qiao, Xiaojing ; Mei, Xinyu ; Guo, Bin ; Fang, Xiao ; Zhang, Lu ; Lou, Huiling ; Wu, Chaoqun ; Qiao, Shouyi
contributorWong, Chun-ming (Editor)
ispartof2012, Vol.7(8), p.e42976
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0042976
subjectResearch Article ; Biology ; Medicine ; Genetics And Genomics ; Cell Biology ; Oncology
descriptionBreast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that the expression level of BRMS1 was significantly down-regulated in HCC tissues. Expression of BRMS1 in SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized cells to apoptosis induced by serum deprivation or anoikis. Consistently, knockdown of endogenous BRMS1 expression in Hep3B cells suppressed cell apoptosis. We identified that BRMS1 suppresses osteopontin (OPN) expression in HCC cells and that there is a negative correlation between BRMS1 and OPN mRNA expression in HCC tissues. Moreover, knockdown of endogenous OPN expression reversed the anti-apoptosis effect achieved by knockdown of BRMS1. Taken together, our results show that BRMS1 sensitizes HCC cells to apoptosis through suppressing OPN expression, suggesting a potential role of BRMS1 in regulating HCC apoptosis and metastasis.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Wu, Yanhua
1Jiang, Wenjun
2Wang, Yingming
3Wu, Jun
4Saiyin, Hexige
5Qiao, Xiaojing
6Mei, Xinyu
7Guo, Bin
8Fang, Xiao
9Zhang, Lu
10Lou, Huiling
11Wu, Chaoqun
12Qiao, Shouyi
13Wong, Chun-ming (Editor)
titleBreast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression (BRMS1 Regulates HCC Cell Apoptosis via OPN)
descriptionBreast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that the expression level of BRMS1 was significantly down-regulated in HCC tissues. Expression of BRMS1 in SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized cells to apoptosis induced by serum deprivation or anoikis. Consistently, knockdown of endogenous BRMS1 expression in Hep3B cells suppressed cell apoptosis. We identified that BRMS1 suppresses osteopontin (OPN) expression in HCC cells and that there is a negative correlation between BRMS1 and OPN mRNA expression in HCC tissues. Moreover, knockdown of endogenous OPN expression reversed the anti-apoptosis effect achieved by knockdown of BRMS1. Taken together, our results show that BRMS1 sensitizes HCC cells to apoptosis through suppressing OPN expression, suggesting a potential role of BRMS1 in regulating HCC apoptosis and metastasis.
subject
0Research Article
1Biology
2Medicine
3Genetics And Genomics
4Cell Biology
5Oncology
general
010.1371/journal.pone.0042976
1English
sourceidplos
recordidplos10.1371/journal.pone.0042976
issn
01932-6203
119326203
rsrctypearticle
creationdate2012
recordtypearticle
addtitleBRMS1 Regulates HCC Cell Apoptosis via OPN
searchscopeplos
scopeplos
lsr30VSR-Enriched:[galeid, pqid]
sort
titleBreast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression (BRMS1 Regulates HCC Cell Apoptosis via OPN)
authorWu, Yanhua ; Jiang, Wenjun ; Wang, Yingming ; Wu, Jun ; Saiyin, Hexige ; Qiao, Xiaojing ; Mei, Xinyu ; Guo, Bin ; Fang, Xiao ; Zhang, Lu ; Lou, Huiling ; Wu, Chaoqun ; Qiao, Shouyi
creationdate20120821
facets
frbrgroupid8296512995867052502
frbrtype5
languageeng
creationdate2012
topic
0Research Article
1Biology
2Medicine
3Genetics And Genomics
4Cell Biology
5Oncology
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Wu, Yanhua
1Jiang, Wenjun
2Wang, Yingming
3Wu, Jun
4Saiyin, Hexige
5Qiao, Xiaojing
6Mei, Xinyu
7Guo, Bin
8Fang, Xiao
9Zhang, Lu
10Lou, Huiling
11Wu, Chaoqun
12Qiao, Shouyi
13Wong, Chun-ming
toplevelpeer_reviewed
frbr
t2
k12012
k219326203
k310.1371/journal.pone.0042976
k47
k58
k642976
k8breast cancer metastasis suppressor 1 regulates hepatocellular carcinoma cell apoptosis via suppressing osteopontin expression
k9breastcancermetastasssion
k12breastcancermetastasissup
k15yanhuawu
k16wuyanhua
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typepublisher
addata
aulast
0Wu
1Jiang
2Wang
3Saiyin
4Qiao
5Mei
6Guo
7Fang
8Zhang
9Lou
10Wong
aufirst
0Yanhua
1Wenjun
2Yingming
3Jun
4Hexige
5Xiaojing
6Xinyu
7Bin
8Xiao
9Lu
10Huiling
11Chaoqun
12Shouyi
13Chun-Ming
au
0Wu, Yanhua
1Jiang, Wenjun
2Wang, Yingming
3Wu, Jun
4Saiyin, Hexige
5Qiao, Xiaojing
6Mei, Xinyu
7Guo, Bin
8Fang, Xiao
9Zhang, Lu
10Lou, Huiling
11Wu, Chaoqun
12Qiao, Shouyi
addauWong, Chun-ming
atitleBreast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression (BRMS1 Regulates HCC Cell Apoptosis via OPN)
risdate20120821
volume7
issue8
spagee42976
pagese42976
eissn1932-6203
genrearticle
ristypeJOUR
abstractBreast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that the expression level of BRMS1 was significantly down-regulated in HCC tissues. Expression of BRMS1 in SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized cells to apoptosis induced by serum deprivation or anoikis. Consistently, knockdown of endogenous BRMS1 expression in Hep3B cells suppressed cell apoptosis. We identified that BRMS1 suppresses osteopontin (OPN) expression in HCC cells and that there is a negative correlation between BRMS1 and OPN mRNA expression in HCC tissues. Moreover, knockdown of endogenous OPN expression reversed the anti-apoptosis effect achieved by knockdown of BRMS1. Taken together, our results show that BRMS1 sensitizes HCC cells to apoptosis through suppressing OPN expression, suggesting a potential role of BRMS1 in regulating HCC apoptosis and metastasis.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0042976
oafree_for_read
date2012-08-21