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Hydrogen Sulfide in Paraventricular Nucleus Enhances Sympathetic Activity and Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats (Hydrogen Sulfide in Paraventricular Nucleus)

Intracerebroventricular infusion of NaHS, a hydrogen sulfide (H 2 S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles of H 2 S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chroni... Full description

Journal Title: 2012 Vol.7(11), p.e50102
Main Author: Gan, Xian-Bing
Other Authors: Liu, Tong-Yan , Xiong, Xiao-Qing , Chen, Wei-Wei , Zhou, Ye-Bo , Zhu, Guo-Qing
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050102
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recordid: plos10.1371/journal.pone.0050102
title: Hydrogen Sulfide in Paraventricular Nucleus Enhances Sympathetic Activity and Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats (Hydrogen Sulfide in Paraventricular Nucleus)
format: Article
creator:
  • Gan, Xian-Bing
  • Liu, Tong-Yan
  • Xiong, Xiao-Qing
  • Chen, Wei-Wei
  • Zhou, Ye-Bo
  • Zhu, Guo-Qing
subjects:
  • Research Article
  • Biology
  • Medicine
  • Physiology
ispartof: 2012, Vol.7(11), p.e50102
description: Intracerebroventricular infusion of NaHS, a hydrogen sulfide (H 2 S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles of H 2 S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chronic heart failure (CHF). ; CHF was induced by left descending coronary artery ligation in rats. Renal sympathetic nerve activity (RSNA) and MAP were recorded under anesthesia. CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. PVN microinjection of low doses of a HS donor, GYY4137 (0.01 and 0.1 nmol), had no significant effects on RSNA, MAP and CSAR. High doses of GYY4137 (1, 2 and 4 nmol) increased baseline RSNA, MAP and heart rate (HR), and enhanced CSAR. The effects were greater in CHF rats than sham-operated rats. A cystathionine-β-synthase (CBS) inhibitor, hydroxylamine (HA) in PVN had no significant effect on the RSNA, MAP and CSAR. CBS activity and HS level in the PVN were decreased in CHF rats. No significant difference in CBS level in PVN was found between sham-operated rats and CHF rats. Stimulation of cardiac sympathetic afferents with capsaicin decreased CBS activity and HS level in the PVN in both sham-operated rats and CHF rats. ; Exogenous HS in PVN increases RSNA, MAP and HR, and enhances CSAR. The effects are greater in CHF rats than those in sham-operated rats. Endogenous HS in PVN is not responsible for the sympathetic activation and enhanced CSAR in CHF rats.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050102
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
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titleHydrogen Sulfide in Paraventricular Nucleus Enhances Sympathetic Activity and Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats (Hydrogen Sulfide in Paraventricular Nucleus)
creatorGan, Xian-Bing ; Liu, Tong-Yan ; Xiong, Xiao-Qing ; Chen, Wei-Wei ; Zhou, Ye-Bo ; Zhu, Guo-Qing
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descriptionIntracerebroventricular infusion of NaHS, a hydrogen sulfide (H 2 S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles of H 2 S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chronic heart failure (CHF). ; CHF was induced by left descending coronary artery ligation in rats. Renal sympathetic nerve activity (RSNA) and MAP were recorded under anesthesia. CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. PVN microinjection of low doses of a HS donor, GYY4137 (0.01 and 0.1 nmol), had no significant effects on RSNA, MAP and CSAR. High doses of GYY4137 (1, 2 and 4 nmol) increased baseline RSNA, MAP and heart rate (HR), and enhanced CSAR. The effects were greater in CHF rats than sham-operated rats. A cystathionine-β-synthase (CBS) inhibitor, hydroxylamine (HA) in PVN had no significant effect on the RSNA, MAP and CSAR. CBS activity and HS level in the PVN were decreased in CHF rats. No significant difference in CBS level in PVN was found between sham-operated rats and CHF rats. Stimulation of cardiac sympathetic afferents with capsaicin decreased CBS activity and HS level in the PVN in both sham-operated rats and CHF rats. ; Exogenous HS in PVN increases RSNA, MAP and HR, and enhances CSAR. The effects are greater in CHF rats than those in sham-operated rats. Endogenous HS in PVN is not responsible for the sympathetic activation and enhanced CSAR in CHF rats.
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titleHydrogen Sulfide in Paraventricular Nucleus Enhances Sympathetic Activity and Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats (Hydrogen Sulfide in Paraventricular Nucleus)
descriptionIntracerebroventricular infusion of NaHS, a hydrogen sulfide (H 2 S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles of H 2 S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chronic heart failure (CHF). ; CHF was induced by left descending coronary artery ligation in rats. Renal sympathetic nerve activity (RSNA) and MAP were recorded under anesthesia. CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. PVN microinjection of low doses of a HS donor, GYY4137 (0.01 and 0.1 nmol), had no significant effects on RSNA, MAP and CSAR. High doses of GYY4137 (1, 2 and 4 nmol) increased baseline RSNA, MAP and heart rate (HR), and enhanced CSAR. The effects were greater in CHF rats than sham-operated rats. A cystathionine-β-synthase (CBS) inhibitor, hydroxylamine (HA) in PVN had no significant effect on the RSNA, MAP and CSAR. CBS activity and HS level in the PVN were decreased in CHF rats. No significant difference in CBS level in PVN was found between sham-operated rats and CHF rats. Stimulation of cardiac sympathetic afferents with capsaicin decreased CBS activity and HS level in the PVN in both sham-operated rats and CHF rats. ; Exogenous HS in PVN increases RSNA, MAP and HR, and enhances CSAR. The effects are greater in CHF rats than those in sham-operated rats. Endogenous HS in PVN is not responsible for the sympathetic activation and enhanced CSAR in CHF rats.
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abstractIntracerebroventricular infusion of NaHS, a hydrogen sulfide (H 2 S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles of H 2 S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chronic heart failure (CHF). ; CHF was induced by left descending coronary artery ligation in rats. Renal sympathetic nerve activity (RSNA) and MAP were recorded under anesthesia. CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. PVN microinjection of low doses of a HS donor, GYY4137 (0.01 and 0.1 nmol), had no significant effects on RSNA, MAP and CSAR. High doses of GYY4137 (1, 2 and 4 nmol) increased baseline RSNA, MAP and heart rate (HR), and enhanced CSAR. The effects were greater in CHF rats than sham-operated rats. A cystathionine-β-synthase (CBS) inhibitor, hydroxylamine (HA) in PVN had no significant effect on the RSNA, MAP and CSAR. CBS activity and HS level in the PVN were decreased in CHF rats. No significant difference in CBS level in PVN was found between sham-operated rats and CHF rats. Stimulation of cardiac sympathetic afferents with capsaicin decreased CBS activity and HS level in the PVN in both sham-operated rats and CHF rats. ; Exogenous HS in PVN increases RSNA, MAP and HR, and enhances CSAR. The effects are greater in CHF rats than those in sham-operated rats. Endogenous HS in PVN is not responsible for the sympathetic activation and enhanced CSAR in CHF rats.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0050102
oafree_for_read
date2012-11-15