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Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma (IL6 Predicts Poor Prognosis in Male OSCC)

Interleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender diffe... Full description

Journal Title: 2012 Vol.7(11), p.e50104
Main Author: Chen, Chih-Jung
Other Authors: Sung, Wen-Wei , Lin, Yueh-Min , Chen, Mu-Kuan , Lee, Ching-Hsiao , Lee, Huei , Yeh, Kun-Tu , Ko, Jiunn-Liang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050104
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recordid: plos10.1371/journal.pone.0050104
title: Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma (IL6 Predicts Poor Prognosis in Male OSCC)
format: Article
creator:
  • Chen, Chih-Jung
  • Sung, Wen-Wei
  • Lin, Yueh-Min
  • Chen, Mu-Kuan
  • Lee, Ching-Hsiao
  • Lee, Huei
  • Yeh, Kun-Tu
  • Ko, Jiunn-Liang
subjects:
  • Research Article
  • Medicine
  • Physiology
  • Oncology
  • Pathology
  • Otolaryngology
ispartof: 2012, Vol.7(11), p.e50104
description: Interleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. ; In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. ; High IL6 expression in tumor cells was significantly associated OSCC patient characteristics including female gender (P
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0050104
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleGender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma (IL6 Predicts Poor Prognosis in Male OSCC)
creatorChen, Chih-Jung ; Sung, Wen-Wei ; Lin, Yueh-Min ; Chen, Mu-Kuan ; Lee, Ching-Hsiao ; Lee, Huei ; Yeh, Kun-Tu ; Ko, Jiunn-Liang
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descriptionInterleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. ; In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. ; High IL6 expression in tumor cells was significantly associated OSCC patient characteristics including female gender (P<0.001), high lymph node metastatic rate (P = 0.007), and poor tumor differentiation (P = 0.008). Tumor-expressed IL6 had prognostic role in male OSCC patients as defined by the log-rank test (P = 0.014), but not in female patients (P = 0.959). In male OSCC patients, high IL6 expression in tumor cells was associated with poor prognosis (P = 0.025) and a 1.454-fold higher death risk, as determined by Cox regression. ; High IL6 expression in tumor cells was therefore significantly associated with aggressive clinical manifestations and might be an independent survival predictor, particularly in male OSCC patients.
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titleGender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma (IL6 Predicts Poor Prognosis in Male OSCC)
descriptionInterleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. ; In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. ; High IL6 expression in tumor cells was significantly associated OSCC patient characteristics including female gender (P<0.001), high lymph node metastatic rate (P = 0.007), and poor tumor differentiation (P = 0.008). Tumor-expressed IL6 had prognostic role in male OSCC patients as defined by the log-rank test (P = 0.014), but not in female patients (P = 0.959). In male OSCC patients, high IL6 expression in tumor cells was associated with poor prognosis (P = 0.025) and a 1.454-fold higher death risk, as determined by Cox regression. ; High IL6 expression in tumor cells was therefore significantly associated with aggressive clinical manifestations and might be an independent survival predictor, particularly in male OSCC patients.
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abstractInterleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. ; In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. ; High IL6 expression in tumor cells was significantly associated OSCC patient characteristics including female gender (P<0.001), high lymph node metastatic rate (P = 0.007), and poor tumor differentiation (P = 0.008). Tumor-expressed IL6 had prognostic role in male OSCC patients as defined by the log-rank test (P = 0.014), but not in female patients (P = 0.959). In male OSCC patients, high IL6 expression in tumor cells was associated with poor prognosis (P = 0.025) and a 1.454-fold higher death risk, as determined by Cox regression. ; High IL6 expression in tumor cells was therefore significantly associated with aggressive clinical manifestations and might be an independent survival predictor, particularly in male OSCC patients.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0050104
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date2012-11-21