schliessen

Filtern

 

Bibliotheken

Overexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma (Overexpression of TRIM24 in Human HCC)

The survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors. TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which was associated with cellular proliferation and was an oncogene in tumor... Full description

Journal Title: 2014 Vol.9(1), p.e85462
Main Author: Liu, Xiao
Other Authors: Huang, Yu , Yang, Dinghua , Li, Xianghong , Liang, Jiankun , Lin, Liang , Zhang, Meng , Zhong, Kebo , Liang, Bo , Li, Jialu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0085462
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0085462
title: Overexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma (Overexpression of TRIM24 in Human HCC)
format: Article
creator:
  • Liu, Xiao
  • Huang, Yu
  • Yang, Dinghua
  • Li, Xianghong
  • Liang, Jiankun
  • Lin, Liang
  • Zhang, Meng
  • Zhong, Kebo
  • Liang, Bo
  • Li, Jialu
subjects:
  • Research Article
  • Biology
  • Medicine
ispartof: 2014, Vol.9(1), p.e85462
description: The survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors. TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which was associated with cellular proliferation and was an oncogene in tumor development. Here we provide the first evidence of the expression profile and clinicopathological significance of TRIM24 in patients with hepatocellular carcinoma (HCC). Immunohistochemistry was employed to determine the expression level of TRIM24 in HCC tissues and noncancerous liver tissues. Elevated TRIM24 level was found in 61.4% HCC samples (51/83) correlating with AFP (P = 0.036), poor differentiation (P = 0.004), intrahepatic metastasis (P = 0.004), recurrence (P = 0.000006), and shorter tumor-free survival time (P = 0.002). Small interfering RNA induced down-regulation of TRIM24 promoted apoptosis in HCC cell line HepG2. Moreover, western blotting analysis revealed that knockdown of TRIM24 increased the protein levels of p53, Bax, and Caspase-8, and decreased Bcl-2, Survivin, Cyclin D1, and CDK4. Depletion of TRIM24 decreased Snail, Slug, β-catenin, and Vimentin, and increased E-cadherin expression, which suggested the involvement of TRIM24 in EMT. These results indicated that TRIM24 plays an important role in the pathogenesis of human HCC.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0085462
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID546640957
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0085462
sourceidplos
recordidTN_plos10.1371/journal.pone.0085462
sourcesystemPC
pqid1475119957
galeid478874599
display
typearticle
titleOverexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma (Overexpression of TRIM24 in Human HCC)
creatorLiu, Xiao ; Huang, Yu ; Yang, Dinghua ; Li, Xianghong ; Liang, Jiankun ; Lin, Liang ; Zhang, Meng ; Zhong, Kebo ; Liang, Bo ; Li, Jialu
contributorWen, Zilong (Editor)
ispartof2014, Vol.9(1), p.e85462
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0085462
subjectResearch Article ; Biology ; Medicine
descriptionThe survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors. TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which was associated with cellular proliferation and was an oncogene in tumor development. Here we provide the first evidence of the expression profile and clinicopathological significance of TRIM24 in patients with hepatocellular carcinoma (HCC). Immunohistochemistry was employed to determine the expression level of TRIM24 in HCC tissues and noncancerous liver tissues. Elevated TRIM24 level was found in 61.4% HCC samples (51/83) correlating with AFP (P = 0.036), poor differentiation (P = 0.004), intrahepatic metastasis (P = 0.004), recurrence (P = 0.000006), and shorter tumor-free survival time (P = 0.002). Small interfering RNA induced down-regulation of TRIM24 promoted apoptosis in HCC cell line HepG2. Moreover, western blotting analysis revealed that knockdown of TRIM24 increased the protein levels of p53, Bax, and Caspase-8, and decreased Bcl-2, Survivin, Cyclin D1, and CDK4. Depletion of TRIM24 decreased Snail, Slug, β-catenin, and Vimentin, and increased E-cadherin expression, which suggested the involvement of TRIM24 in EMT. These results indicated that TRIM24 plays an important role in the pathogenesis of human HCC.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Liu, Xiao
1Huang, Yu
2Yang, Dinghua
3Li, Xianghong
4Liang, Jiankun
5Lin, Liang
6Zhang, Meng
7Zhong, Kebo
8Liang, Bo
9Li, Jialu
10Wen, Zilong (Editor)
titleOverexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma (Overexpression of TRIM24 in Human HCC)
descriptionThe survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors. TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which was associated with cellular proliferation and was an oncogene in tumor development. Here we provide the first evidence of the expression profile and clinicopathological significance of TRIM24 in patients with hepatocellular carcinoma (HCC). Immunohistochemistry was employed to determine the expression level of TRIM24 in HCC tissues and noncancerous liver tissues. Elevated TRIM24 level was found in 61.4% HCC samples (51/83) correlating with AFP (P = 0.036), poor differentiation (P = 0.004), intrahepatic metastasis (P = 0.004), recurrence (P = 0.000006), and shorter tumor-free survival time (P = 0.002). Small interfering RNA induced down-regulation of TRIM24 promoted apoptosis in HCC cell line HepG2. Moreover, western blotting analysis revealed that knockdown of TRIM24 increased the protein levels of p53, Bax, and Caspase-8, and decreased Bcl-2, Survivin, Cyclin D1, and CDK4. Depletion of TRIM24 decreased Snail, Slug, β-catenin, and Vimentin, and increased E-cadherin expression, which suggested the involvement of TRIM24 in EMT. These results indicated that TRIM24 plays an important role in the pathogenesis of human HCC.
subject
0Research Article
1Biology
2Medicine
general
010.1371/journal.pone.0085462
1English
sourceidplos
recordidplos10.1371/journal.pone.0085462
issn
01932-6203
119326203
rsrctypearticle
creationdate2014
recordtypearticle
addtitleOverexpression of TRIM24 in Human HCC
searchscopeplos
scopeplos
lsr30VSR-Enriched:[galeid, pqid]
sort
titleOverexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma (Overexpression of TRIM24 in Human HCC)
authorLiu, Xiao ; Huang, Yu ; Yang, Dinghua ; Li, Xianghong ; Liang, Jiankun ; Lin, Liang ; Zhang, Meng ; Zhong, Kebo ; Liang, Bo ; Li, Jialu
creationdate20140107
facets
frbrgroupid4724155868923736495
frbrtype5
languageeng
creationdate2014
topic
0Research Article
1Biology
2Medicine
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Liu, Xiao
1Huang, Yu
2Yang, Dinghua
3Li, Xianghong
4Liang, Jiankun
5Lin, Liang
6Zhang, Meng
7Zhong, Kebo
8Liang, Bo
9Li, Jialu
10Wen, Zilong
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Liu
1Huang
2Yang
3Li
4Liang
5Lin
6Zhang
7Zhong
8Wen
aufirst
0Xiao
1Yu
2Dinghua
3Xianghong
4Jiankun
5Liang
6Meng
7Kebo
8Bo
9Jialu
10Zilong
au
0Liu, Xiao
1Huang, Yu
2Yang, Dinghua
3Li, Xianghong
4Liang, Jiankun
5Lin, Liang
6Zhang, Meng
7Zhong, Kebo
8Liang, Bo
9Li, Jialu
addauWen, Zilong
atitleOverexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma (Overexpression of TRIM24 in Human HCC)
risdate20140107
volume9
issue1
spagee85462
pagese85462
eissn1932-6203
ristypeJOUR
abstractThe survival and colonization of tumor cells at new locations involve a variety of complex genetic, epigenetic, and microenvironmental factors. TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which was associated with cellular proliferation and was an oncogene in tumor development. Here we provide the first evidence of the expression profile and clinicopathological significance of TRIM24 in patients with hepatocellular carcinoma (HCC). Immunohistochemistry was employed to determine the expression level of TRIM24 in HCC tissues and noncancerous liver tissues. Elevated TRIM24 level was found in 61.4% HCC samples (51/83) correlating with AFP (P = 0.036), poor differentiation (P = 0.004), intrahepatic metastasis (P = 0.004), recurrence (P = 0.000006), and shorter tumor-free survival time (P = 0.002). Small interfering RNA induced down-regulation of TRIM24 promoted apoptosis in HCC cell line HepG2. Moreover, western blotting analysis revealed that knockdown of TRIM24 increased the protein levels of p53, Bax, and Caspase-8, and decreased Bcl-2, Survivin, Cyclin D1, and CDK4. Depletion of TRIM24 decreased Snail, Slug, β-catenin, and Vimentin, and increased E-cadherin expression, which suggested the involvement of TRIM24 in EMT. These results indicated that TRIM24 plays an important role in the pathogenesis of human HCC.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0085462
oafree_for_read
date2014-01-07