schliessen

Filtern

 

Bibliotheken

An Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster (The Relationships between Homologous/Clustered miRNAs)

The study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23∼27∼24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically s... Full description

Journal Title: 2014 Vol.9(8), p.e106223
Main Author: Liang, Tingming
Other Authors: Yu, JiaFeng , Liu, Chang , Guo, Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0106223
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: plos10.1371/journal.pone.0106223
title: An Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster (The Relationships between Homologous/Clustered miRNAs)
format: Article
creator:
  • Liang, Tingming
  • Yu, JiaFeng
  • Liu, Chang
  • Guo, Li
subjects:
  • Research Article
  • Biology And Life Sciences
ispartof: 2014, Vol.9(8), p.e106223
description: The study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23∼27∼24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically selected as an example. These related miRNAs show similar evolutionary patterns and various expression patterns. Most of them show consistent isomiR expression pattern, and the “switching” phenomenon can be found between different abundant isomiR species. These findings suggest that these sequence or location related miRNAs show the similar miRNA processing and maturation processes, and the robust selection of the most dominant isomiR exists in specific tissues. Functional analysis show that these miRNAs show similar distributions of enriched gene categories, suggesting the close functional prelateships via direct or indirect coordinate regulation in biological processes. The study reveals the close evolutionary, expression and functional relationships between related homologous/clustered miRNAs, which will further enrich miRNA studies and understand direct or indirect interactions between miRNAs.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0106223
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID505774858
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1371/journal.pone.0106223
sourceidplos
recordidTN_plos10.1371/journal.pone.0106223
sourcesystemPC
pqid1556306582
galeid417793573
display
typearticle
titleAn Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster (The Relationships between Homologous/Clustered miRNAs)
creatorLiang, Tingming ; Yu, JiaFeng ; Liu, Chang ; Guo, Li
contributorXue, Yu (Editor)
ispartof2014, Vol.9(8), p.e106223
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0106223
subjectResearch Article ; Biology And Life Sciences
descriptionThe study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23∼27∼24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically selected as an example. These related miRNAs show similar evolutionary patterns and various expression patterns. Most of them show consistent isomiR expression pattern, and the “switching” phenomenon can be found between different abundant isomiR species. These findings suggest that these sequence or location related miRNAs show the similar miRNA processing and maturation processes, and the robust selection of the most dominant isomiR exists in specific tissues. Functional analysis show that these miRNAs show similar distributions of enriched gene categories, suggesting the close functional prelateships via direct or indirect coordinate regulation in biological processes. The study reveals the close evolutionary, expression and functional relationships between related homologous/clustered miRNAs, which will further enrich miRNA studies and understand direct or indirect interactions between miRNAs.
languageeng
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Liang, Tingming
1Yu, JiaFeng
2Liu, Chang
3Guo, Li
4Xue, Yu (Editor)
titleAn Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster (The Relationships between Homologous/Clustered miRNAs)
descriptionThe study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23∼27∼24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically selected as an example. These related miRNAs show similar evolutionary patterns and various expression patterns. Most of them show consistent isomiR expression pattern, and the “switching” phenomenon can be found between different abundant isomiR species. These findings suggest that these sequence or location related miRNAs show the similar miRNA processing and maturation processes, and the robust selection of the most dominant isomiR exists in specific tissues. Functional analysis show that these miRNAs show similar distributions of enriched gene categories, suggesting the close functional prelateships via direct or indirect coordinate regulation in biological processes. The study reveals the close evolutionary, expression and functional relationships between related homologous/clustered miRNAs, which will further enrich miRNA studies and understand direct or indirect interactions between miRNAs.
subject
0Research Article
1Biology And Life Sciences
general
010.1371/journal.pone.0106223
1English
sourceidplos
recordidplos10.1371/journal.pone.0106223
issn
01932-6203
119326203
rsrctypearticle
creationdate2014
recordtypearticle
addtitleThe Relationships between Homologous/Clustered miRNAs
searchscopeplos
scopeplos
lsr30VSR-Enriched:[galeid, pqid]
sort
titleAn Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster (The Relationships between Homologous/Clustered miRNAs)
authorLiang, Tingming ; Yu, JiaFeng ; Liu, Chang ; Guo, Li
creationdate20140826
facets
frbrgroupid3315547800780437918
frbrtype5
languageeng
creationdate2014
topic
0Research Article
1Biology And Life Sciences
collectionPLoS
prefilterarticles
rsrctypearticles
creatorcontrib
0Liang, Tingming
1Yu, JiaFeng
2Liu, Chang
3Guo, Li
4Xue, Yu
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Liang
1Yu
2Liu
3Guo
4Xue
aufirst
0Tingming
1JiaFeng
2Chang
3Li
4Yu
au
0Liang, Tingming
1Yu, JiaFeng
2Liu, Chang
3Guo, Li
addauXue, Yu
atitleAn Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster (The Relationships between Homologous/Clustered miRNAs)
risdate20140826
volume9
issue8
spagee106223
pagese106223
eissn1932-6203
genrearticle
ristypeJOUR
abstractThe study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23∼27∼24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically selected as an example. These related miRNAs show similar evolutionary patterns and various expression patterns. Most of them show consistent isomiR expression pattern, and the “switching” phenomenon can be found between different abundant isomiR species. These findings suggest that these sequence or location related miRNAs show the similar miRNA processing and maturation processes, and the robust selection of the most dominant isomiR exists in specific tissues. Functional analysis show that these miRNAs show similar distributions of enriched gene categories, suggesting the close functional prelateships via direct or indirect coordinate regulation in biological processes. The study reveals the close evolutionary, expression and functional relationships between related homologous/clustered miRNAs, which will further enrich miRNA studies and understand direct or indirect interactions between miRNAs.
copSan Francisco, USA
pubPublic Library of Science
doi10.1371/journal.pone.0106223
oafree_for_read
date2014-08-26