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HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages (HDAC6 Regulates Macrophage Activation)

Activated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this study, we identify... Full description

Journal Title: 2014 Vol.9(10), p.e110718
Main Author: Yan, Bing
Other Authors: Xie, Songbo , Liu, Zhu , Ran, Jie , Li, Yuanyuan , Wang, Jian , Yang, Yang , Zhou, Jun , Li, Dengwen , Liu, Min
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0110718
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recordid: plos10.1371/journal.pone.0110718
title: HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages (HDAC6 Regulates Macrophage Activation)
format: Article
creator:
  • Yan, Bing
  • Xie, Songbo
  • Liu, Zhu
  • Ran, Jie
  • Li, Yuanyuan
  • Wang, Jian
  • Yang, Yang
  • Zhou, Jun
  • Li, Dengwen
  • Liu, Min
subjects:
  • Research Article
  • Biology And Life Sciences
ispartof: 2014, Vol.9(10), p.e110718
description: Activated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this study, we identify a novel role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation. Our data show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines. Further study reveals that the regulation of macrophage activation by HDAC6 is independent of F-actin polymerization and filopodium formation; instead, it is mediated by the effects of HDAC6 on cell adhesion and microtubule acetylation. These data thus suggest that HDAC6 is an important regulator of LPS-induced macrophage activation and might be a potential target for the management of inflammatory disorders.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0110718
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleHDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages (HDAC6 Regulates Macrophage Activation)
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descriptionActivated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this study, we identify a novel role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation. Our data show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines. Further study reveals that the regulation of macrophage activation by HDAC6 is independent of F-actin polymerization and filopodium formation; instead, it is mediated by the effects of HDAC6 on cell adhesion and microtubule acetylation. These data thus suggest that HDAC6 is an important regulator of LPS-induced macrophage activation and might be a potential target for the management of inflammatory disorders.
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titleHDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages (HDAC6 Regulates Macrophage Activation)
descriptionActivated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this study, we identify a novel role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation. Our data show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines. Further study reveals that the regulation of macrophage activation by HDAC6 is independent of F-actin polymerization and filopodium formation; instead, it is mediated by the effects of HDAC6 on cell adhesion and microtubule acetylation. These data thus suggest that HDAC6 is an important regulator of LPS-induced macrophage activation and might be a potential target for the management of inflammatory disorders.
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abstractActivated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this study, we identify a novel role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation. Our data show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines. Further study reveals that the regulation of macrophage activation by HDAC6 is independent of F-actin polymerization and filopodium formation; instead, it is mediated by the effects of HDAC6 on cell adhesion and microtubule acetylation. These data thus suggest that HDAC6 is an important regulator of LPS-induced macrophage activation and might be a potential target for the management of inflammatory disorders.
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doi10.1371/journal.pone.0110718
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date2014-10-16