schliessen

Filtern

 

Bibliotheken

Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor

In utero exposure to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Δ 9 -THC-induced cognitive impairments, the neuronal basis of Δ 9 -THC-related develo... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 27 December 2005, Vol.102(52), p.19115
Main Author: Paul Berghuis
Other Authors: Marton B. Dobszay , Xinyu Wang , Sabrina Spano , Fernanda Ledda , Kyle M. Sousa , Gunnar Schulte , Patrik Ernfors , Ken Mackie , Gustavo Paratcha , Yasmin L. Hurd , Tibor Harkany
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.0509494102
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: pnas_s102_52_19115
title: Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
format: Article
creator:
  • Paul Berghuis
  • Marton B. Dobszay
  • Xinyu Wang
  • Sabrina Spano
  • Fernanda Ledda
  • Kyle M. Sousa
  • Gunnar Schulte
  • Patrik Ernfors
  • Ken Mackie
  • Gustavo Paratcha
  • Yasmin L. Hurd
  • Tibor Harkany
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 27 December 2005, Vol.102(52), p.19115
description: In utero exposure to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Δ 9 -THC-induced cognitive impairments, the neuronal basis of Δ 9 -THC-related developmental deficits remains unknown. Using a Boyden chamber assay, we show that agonist stimulation of the CB 1 cannabinoid receptor (CB 1 R) on cholecystokinin-expressing interneurons induces chemotaxis that is additive with brain-derived neurotrophic factor (BDNF)-induced interneuron migration. We find that Src kinase-dependent TrkB receptor transactivation mediates endocannabinoid (eCB)-induced chemotaxis in the absence of BDNF. Simultaneously, eCBs suppress the BDNF-dependent morphogenesis of interneurons, and this suppression is abolished by Src kinase inhibition in vitro . Because sustained prenatal Δ 9 -THC stimulation of CB 1 Rs selectively increases the density of cholecystokinin-expressing interneurons in the hippocampus in vivo , we conclude that prenatal CB 1 R activity governs proper interneuron placement and integration during corticogenesis. Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification. corticogenesis drug abuse neurotrophin
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.0509494102
fulltext: fulltext_linktorsrc
issn:
  • 0027-8424
  • 00278424
  • 1091-6490
  • 10916490
url: Link


@attributes
ID881996094
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid102_52_19115
sourceidpnas_s
recordidTN_pnas_s102_52_19115
sourcesystemOther
dbid
0PNE
1RNA
pqid69045305
galeid140955296
display
typearticle
titleEndocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
creatorPaul Berghuis ; Marton B. Dobszay ; Xinyu Wang ; Sabrina Spano ; Fernanda Ledda ; Kyle M. Sousa ; Gunnar Schulte ; Patrik Ernfors ; Ken Mackie ; Gustavo Paratcha ; Yasmin L. Hurd ; Tibor Harkany
ispartofProceedings of the National Academy of Sciences of the United States of America, 27 December 2005, Vol.102(52), p.19115
identifier
subjectSciences (General)
descriptionIn utero exposure to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Δ 9 -THC-induced cognitive impairments, the neuronal basis of Δ 9 -THC-related developmental deficits remains unknown. Using a Boyden chamber assay, we show that agonist stimulation of the CB 1 cannabinoid receptor (CB 1 R) on cholecystokinin-expressing interneurons induces chemotaxis that is additive with brain-derived neurotrophic factor (BDNF)-induced interneuron migration. We find that Src kinase-dependent TrkB receptor transactivation mediates endocannabinoid (eCB)-induced chemotaxis in the absence of BDNF. Simultaneously, eCBs suppress the BDNF-dependent morphogenesis of interneurons, and this suppression is abolished by Src kinase inhibition in vitro . Because sustained prenatal Δ 9 -THC stimulation of CB 1 Rs selectively increases the density of cholecystokinin-expressing interneurons in the hippocampus in vivo , we conclude that prenatal CB 1 R activity governs proper interneuron placement and integration during corticogenesis. Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification. corticogenesis drug abuse neurotrophin
languageeng
source
version10
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttp://www.pnas.org/content/102/52/19115.abstract$$EView_full_text_in_National_Academy_of_Sciences_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Paul Berghuis
1Marton B. Dobszay
2Xinyu Wang
3Sabrina Spano
4Fernanda Ledda
5Kyle M. Sousa
6Gunnar Schulte
7Patrik Ernfors
8Ken Mackie
9Gustavo Paratcha
10Yasmin L. Hurd
11Tibor Harkany
titleEndocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
description

In utero exposure to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Δ 9 -THC-induced cognitive impairments, the neuronal basis of Δ 9 -THC-related developmental deficits remains unknown. Using a Boyden chamber assay, we show that agonist stimulation of the CB 1 cannabinoid receptor (CB 1 R) on cholecystokinin-expressing interneurons induces chemotaxis that is additive with brain-derived neurotrophic factor (BDNF)-induced interneuron migration. We find that Src kinase-dependent TrkB receptor transactivation mediates endocannabinoid (eCB)-induced chemotaxis in the absence of BDNF. Simultaneously, eCBs suppress the BDNF-dependent morphogenesis of interneurons, and this suppression is abolished by Src kinase inhibition in vitro . Because sustained prenatal Δ 9 -THC stimulation of CB 1 Rs selectively increases the density of cholecystokinin-expressing interneurons in the hippocampus in vivo , we conclude that prenatal CB 1 R activity governs proper interneuron placement and integration during corticogenesis. Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification. corticogenesis drug abuse neurotrophin

subjectSciences (General)
general
0English
1National Acad Sciences
210.1073/pnas.0509494102
3PNAS (National Academy of Sciences)
4National Academy of Sciences (U.S.)
sourceidpnas_s
recordidpnas_s102_52_19115
issn
00027-8424
100278424
21091-6490
310916490
rsrctypearticle
creationdate2005
addtitleProceedings of the National Academy of Sciences of the United States of America
searchscope
0pnas_full
1pnas4
2pnas5
scope
0pnas_full
1pnas4
2pnas5
lsr45$$EView_full_text_in_National_Academy_of_Sciences_(Access_to_full_text_may_be_restricted)
tmp01
0PNAS (National Academy of Sciences)
1National Academy of Sciences (U.S.)
tmp02
0PNE
1RNA
startdate20051227
enddate20051227
lsr40Proceedings of the National Academy of Sciences of the United States of America, 27 December 2005, Vol.102 (52), p.19115
doi10.1073/pnas.0509494102
citationpf 19115 vol 102 issue 52
lsr30VSR-Enriched:[pqid, galeid, pages]
sort
titleEndocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
authorPaul Berghuis ; Marton B. Dobszay ; Xinyu Wang ; Sabrina Spano ; Fernanda Ledda ; Kyle M. Sousa ; Gunnar Schulte ; Patrik Ernfors ; Ken Mackie ; Gustavo Paratcha ; Yasmin L. Hurd ; Tibor Harkany
creationdate20051227
lso0120051227
facets
frbrgroupid2705852745944575607
frbrtype5
newrecords20190724
languageeng
topicSciences (General)
collection
0PNAS (National Academy of Sciences)
1National Academy of Sciences (U.S.)
prefilterarticles
rsrctypearticles
creatorcontrib
0Paul Berghuis
1Marton B. Dobszay
2Xinyu Wang
3Sabrina Spano
4Fernanda Ledda
5Kyle M. Sousa
6Gunnar Schulte
7Patrik Ernfors
8Ken Mackie
9Gustavo Paratcha
10Yasmin L. Hurd
11Tibor Harkany
jtitleProceedings of the National Academy of Sciences of the United States of America
creationdate2005
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
au
0Paul Berghuis
1Marton B. Dobszay
2Xinyu Wang
3Sabrina Spano
4Fernanda Ledda
5Kyle M. Sousa
6Gunnar Schulte
7Patrik Ernfors
8Ken Mackie
9Gustavo Paratcha
10Yasmin L. Hurd
11Tibor Harkany
atitleEndocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
jtitleProceedings of the National Academy of Sciences of the United States of America
risdate20051227
volume102
issue52
spage19115
issn0027-8424
eissn1091-6490
formatjournal
genrearticle
ristypeJOUR
abstract

In utero exposure to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Δ 9 -THC-induced cognitive impairments, the neuronal basis of Δ 9 -THC-related developmental deficits remains unknown. Using a Boyden chamber assay, we show that agonist stimulation of the CB 1 cannabinoid receptor (CB 1 R) on cholecystokinin-expressing interneurons induces chemotaxis that is additive with brain-derived neurotrophic factor (BDNF)-induced interneuron migration. We find that Src kinase-dependent TrkB receptor transactivation mediates endocannabinoid (eCB)-induced chemotaxis in the absence of BDNF. Simultaneously, eCBs suppress the BDNF-dependent morphogenesis of interneurons, and this suppression is abolished by Src kinase inhibition in vitro . Because sustained prenatal Δ 9 -THC stimulation of CB 1 Rs selectively increases the density of cholecystokinin-expressing interneurons in the hippocampus in vivo , we conclude that prenatal CB 1 R activity governs proper interneuron placement and integration during corticogenesis. Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification. corticogenesis drug abuse neurotrophin

pubNational Acad Sciences
doi10.1073/pnas.0509494102
urlhttp://www.pnas.org/content/102/52/19115.abstract
lad01Proceedings of the National Academy of Sciences of the United States of America
pages19115-19120
date2005-12-27