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A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

A recently identified variant within the fat mass and obesity-associated ( FTO ) gene is carried by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, in adults and an ~1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons world... Full description

Journal Title: Proceedings of the National Academy of Sciences 04 May 2010, Vol.107(18), p.8404
Main Author: April J. Ho
Other Authors: Jason L. Stein , Xue Hua , Suh Lee , Derrek P. Hibar , Alex D. Leow , Ivo D. Dinov , Arthur W. Toga , Andrew J. Saykin , Li Shen , Tatiana Foroud , Nathan Pankratz , Matthew J. Huentelman , David W. Craig , Jill D. Gerber , April N. Allen , Jason J. Corneveaux , Dietrich A. Stephan , Charles S. Decarli , Bryan M. Dechairo , Steven G. Potkin , Clifford R. Jack, Jr , Michael W. Weiner , Cyrus A. Raji , Oscar L. Lopez , James T. Becker , Owen T. Carmichael , Paul M. Thompson , the Alzheimer'S Disease Neuroimaging Initiative , Michael Weiner , Leon Thal , Ronald Petersen , William Jagust , John Trojanowki , Laurel Beckett , Robert C. Green , Anthony Gamst , William Z. Potter , Tom Montine , Dale Anders , Matthew Bernstein , Joel Felmlee , Nick Fox , Paul Thompson , Norbert Schuff , Gene Alexander , Dan Bandy , Robert A. Koeppe , Norm Foster , Eric M. Reiman , Kewei Chen , Les Shaw , Virginia M.-Y. Lee , Magdalena Korecka , Karen Crawford , Scott Neu , Danielle Harvey , John Kornak , Zaven Kachaturian , Richard Frank , Peter J. Snyder , Susan Molchan , Jeffrey Kaye , Remi Vorobik , Joseph Quinn , Lon Schneider , Sonia Pawluczyk , Bryan Spann , Adam S. Fleisher , Helen Vanderswag , Judith L. Heidebrink , Joanne L. Lord , Kris Johnson , Rachelle S. Doody , Javier Villanueva-Meyer , Munir Chowdhury , Yaakov Stern , Lawrence S. Honig , Karen L. Bell , John C. Morris , Mark A. Mintun , Stacy Schneider , Daniel Marson , Randall Griffith , Beverly Badger , Hillel Grossman , Cheuk Tang , Jessica Stern , Leyla Detoledo-Morrell , Raj C. Shah , Julie Bach , Ranjan Duara , Richard Isaacson , Silvia Strauman , Marilyn S. Albert , Julia Pedroso , Jaimie Toroney , Henry Rusinek , Mony J de Leon , Susan M De Santi , P. Murali Doraiswamy , Jeffrey R. Petrella , Marilyn Aiello , Christopher M. Clark , Cassie Pham , Jessica Nunez , Charles D. Smith , Curtis A. Given II , Peter Hardy , Steven T. Dekosky , Maryann Oakley , Donna M. Simpson , M. Saleem Ismail , Anton Porsteinsson , Colleen Mccallum , Steven C. Cramer , Ruth A. Mulnard , Catherine Mcadams-Ortiz , Ramon Diaz-Arrastia , Kristen Martin-Cook , Michael Devous , Allan I. Levey , James J. Lah , Janet S. Cellar , Jeffrey M. Burns , Heather S. Anderson , Mary M. Laubinger , George Bartzokis , Daniel H.S. Silverman , Po H. Lu , Rita Fletcher , Francine Parfitt , Heather Johnson , Martin Farlow , Scott Herring , Ann M. Hake , Christopher H. van Dyck , Martha G. Macavoy , Laurel A. Bifano , Howard Chertkow , Howard Bergman , Chris Hosein , Sandra Black , Simon Graham , Curtis Caldwell , Howard Feldman , Michele Assaly , Ging-Yuek R. Hsiung , Andrew Kertesz , John Rogers , Dick Trost , Charles Bernick , Darren Gitelman , Nancy Johnson , Marsel Mesulam , Carl Sadowsky , Teresa Villena , Scott Mesner , Paul S. Aisen , Kathleen B. Johnson , Kelly E. Behan , Reisa A. Sperling , Dorene M. Rentz , Keith A. Johnson , Allyson Rosen , Jared Tinklenberg , Wes Ashford , Marwan Sabbagh , Donald Connor , Sanja Obradov , Ron Killiany , Alex Norbash , Thomas O. Obisesan , Annapurni Jayam-Trouth , Paul Wang , Alexander P. Auchus , Juebin Huang , Robert P. Friedland , Charles Decarli , Evan Fletcher , Owen Carmichael , Smita Kittur , Seema Mirje , Sterling C. Johnson , Michael Borrie , T-Y Lee , Sanjay Asthana , Cynthia M. Carlsson , Diane Highum , Adrian Preda , Dana Nguyen , Pierre N. Tariot , Barry A. Hendin , Douglas W. Scharre , Maria Kataki , David Q. Beversdorf , Earl A. Zimmerman , Dzintra Celmins , Alice D. Brown , Sam Gandy , Marjorie E. Marenberg , Barry W. Rovner , Godfrey Pearlson , Karen Blank , Karen Anderson , Robert B. Santulli , Nadia Pare , Jeff D. Williamson , Kaycee M. Sink , Huntington Potter , B. Ashok Raj , Amy Giordano , Brian R. Ott , Chuang-Kuo Wu , Ronald Cohen , Kerri L. Wilks
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.0910878107
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recordid: pnas_s107_18_8404
title: A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
format: Article
creator:
  • April J. Ho
  • Jason L. Stein
  • Xue Hua
  • Suh Lee
  • Derrek P. Hibar
  • Alex D. Leow
  • Ivo D. Dinov
  • Arthur W. Toga
  • Andrew J. Saykin
  • Li Shen
  • Tatiana Foroud
  • Nathan Pankratz
  • Matthew J. Huentelman
  • David W. Craig
  • Jill D. Gerber
  • April N. Allen
  • Jason J. Corneveaux
  • Dietrich A. Stephan
  • Charles S. Decarli
  • Bryan M. Dechairo
  • Steven G. Potkin
  • Clifford R. Jack, Jr
  • Michael W. Weiner
  • Cyrus A. Raji
  • Oscar L. Lopez
  • James T. Becker
  • Owen T. Carmichael
  • Paul M. Thompson
  • the Alzheimer'S Disease Neuroimaging Initiative
  • Michael Weiner
  • Leon Thal
  • Ronald Petersen
  • William Jagust
  • John Trojanowki
  • Laurel Beckett
  • Robert C. Green
  • Anthony Gamst
  • William Z. Potter
  • Tom Montine
  • Dale Anders
  • Matthew Bernstein
  • Joel Felmlee
  • Nick Fox
  • Paul Thompson
  • Norbert Schuff
  • Gene Alexander
  • Dan Bandy
  • Robert A. Koeppe
  • Norm Foster
  • Eric M. Reiman
  • Kewei Chen
  • Les Shaw
  • Virginia M.-Y. Lee
  • Magdalena Korecka
  • Karen Crawford
  • Scott Neu
  • Danielle Harvey
  • John Kornak
  • Zaven Kachaturian
  • Richard Frank
  • Peter J. Snyder
  • Susan Molchan
  • Jeffrey Kaye
  • Remi Vorobik
  • Joseph Quinn
  • Lon Schneider
  • Sonia Pawluczyk
  • Bryan Spann
  • Adam S. Fleisher
  • Helen Vanderswag
  • Judith L. Heidebrink
  • Joanne L. Lord
  • Kris Johnson
  • Rachelle S. Doody
  • Javier Villanueva-Meyer
  • Munir Chowdhury
  • Yaakov Stern
  • Lawrence S. Honig
  • Karen L. Bell
  • John C. Morris
  • Mark A. Mintun
  • Stacy Schneider
  • Daniel Marson
  • Randall Griffith
  • Beverly Badger
  • Hillel Grossman
  • Cheuk Tang
  • Jessica Stern
  • Leyla Detoledo-Morrell
  • Raj C. Shah
  • Julie Bach
  • Ranjan Duara
  • Richard Isaacson
  • Silvia Strauman
  • Marilyn S. Albert
  • Julia Pedroso
  • Jaimie Toroney
  • Henry Rusinek
  • Mony J de Leon
  • Susan M De Santi
  • P. Murali Doraiswamy
  • Jeffrey R. Petrella
  • Marilyn Aiello
  • Christopher M. Clark
  • Cassie Pham
  • Jessica Nunez
  • Charles D. Smith
  • Curtis A. Given II
  • Peter Hardy
  • Steven T. Dekosky
  • Maryann Oakley
  • Donna M. Simpson
  • M. Saleem Ismail
  • Anton Porsteinsson
  • Colleen Mccallum
  • Steven C. Cramer
  • Ruth A. Mulnard
  • Catherine Mcadams-Ortiz
  • Ramon Diaz-Arrastia
  • Kristen Martin-Cook
  • Michael Devous
  • Allan I. Levey
  • James J. Lah
  • Janet S. Cellar
  • Jeffrey M. Burns
  • Heather S. Anderson
  • Mary M. Laubinger
  • George Bartzokis
  • Daniel H.S. Silverman
  • Po H. Lu
  • Rita Fletcher
  • Francine Parfitt
  • Heather Johnson
  • Martin Farlow
  • Scott Herring
  • Ann M. Hake
  • Christopher H. van Dyck
  • Martha G. Macavoy
  • Laurel A. Bifano
  • Howard Chertkow
  • Howard Bergman
  • Chris Hosein
  • Sandra Black
  • Simon Graham
  • Curtis Caldwell
  • Howard Feldman
  • Michele Assaly
  • Ging-Yuek R. Hsiung
  • Andrew Kertesz
  • John Rogers
  • Dick Trost
  • Charles Bernick
  • Darren Gitelman
  • Nancy Johnson
  • Marsel Mesulam
  • Carl Sadowsky
  • Teresa Villena
  • Scott Mesner
  • Paul S. Aisen
  • Kathleen B. Johnson
  • Kelly E. Behan
  • Reisa A. Sperling
  • Dorene M. Rentz
  • Keith A. Johnson
  • Allyson Rosen
  • Jared Tinklenberg
  • Wes Ashford
  • Marwan Sabbagh
  • Donald Connor
  • Sanja Obradov
  • Ron Killiany
  • Alex Norbash
  • Thomas O. Obisesan
  • Annapurni Jayam-Trouth
  • Paul Wang
  • Alexander P. Auchus
  • Juebin Huang
  • Robert P. Friedland
  • Charles Decarli
  • Evan Fletcher
  • Owen Carmichael
  • Smita Kittur
  • Seema Mirje
  • Sterling C. Johnson
  • Michael Borrie
  • T-Y Lee
  • Sanjay Asthana
  • Cynthia M. Carlsson
  • Diane Highum
  • Adrian Preda
  • Dana Nguyen
  • Pierre N. Tariot
  • Barry A. Hendin
  • Douglas W. Scharre
  • Maria Kataki
  • David Q. Beversdorf
  • Earl A. Zimmerman
  • Dzintra Celmins
  • Alice D. Brown
  • Sam Gandy
  • Marjorie E. Marenberg
  • Barry W. Rovner
  • Godfrey Pearlson
  • Karen Blank
  • Karen Anderson
  • Robert B. Santulli
  • Nadia Pare
  • Jeff D. Williamson
  • Kaycee M. Sink
  • Huntington Potter
  • B. Ashok Raj
  • Amy Giordano
  • Brian R. Ott
  • Chuang-Kuo Wu
  • Ronald Cohen
  • Kerri L. Wilks
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences, 04 May 2010, Vol.107(18), p.8404
description: A recently identified variant within the fat mass and obesity-associated ( FTO ) gene is carried by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, in adults and an ~1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of ~8% in the frontal lobes and 12% in the occipital lobes—these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.0910878107
fulltext: fulltext_linktorsrc
issn:
  • 0027-8424
  • 00278424
  • 1091-6490
  • 10916490
url: Link


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titleA commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
creatorApril J. Ho ; Jason L. Stein ; Xue Hua ; Suh Lee ; Derrek P. Hibar ; Alex D. Leow ; Ivo D. Dinov ; Arthur W. Toga ; Andrew J. Saykin ; Li Shen ; Tatiana Foroud ; Nathan Pankratz ; Matthew J. Huentelman ; David W. Craig ; Jill D. Gerber ; April N. Allen ; Jason J. Corneveaux ; Dietrich A. Stephan ; Charles S. Decarli ; Bryan M. Dechairo ; Steven G. Potkin ; Clifford R. Jack, Jr ; Michael W. Weiner ; Cyrus A. Raji ; Oscar L. Lopez ; James T. Becker ; Owen T. Carmichael ; Paul M. Thompson ; the Alzheimer'S Disease Neuroimaging Initiative ; Michael Weiner ; Leon Thal ; Ronald Petersen ; William Jagust ; John Trojanowki ; Laurel Beckett ; Robert C. Green ; Anthony Gamst ; William Z. Potter ; Tom Montine ; Dale Anders ; Matthew Bernstein ; Joel Felmlee ; Nick Fox ; Paul Thompson ; Norbert Schuff ; Gene Alexander ; Dan Bandy ; Robert A. Koeppe ; Norm Foster ; Eric M. Reiman ; Kewei Chen ; Les Shaw ; Virginia M.-Y. Lee ; Magdalena Korecka ; Karen Crawford ; Scott Neu ; Danielle Harvey ; John Kornak ; Zaven Kachaturian ; Richard Frank ; Peter J. Snyder ; Susan Molchan ; Jeffrey Kaye ; Remi Vorobik ; Joseph Quinn ; Lon Schneider ; Sonia Pawluczyk ; Bryan Spann ; Adam S. Fleisher ; Helen Vanderswag ; Judith L. Heidebrink ; Joanne L. Lord ; Kris Johnson ; Rachelle S. Doody ; Javier Villanueva-Meyer ; Munir Chowdhury ; Yaakov Stern ; Lawrence S. Honig ; Karen L. Bell ; John C. Morris ; Mark A. Mintun ; Stacy Schneider ; Daniel Marson ; Randall Griffith ; Beverly Badger ; Hillel Grossman ; Cheuk Tang ; Jessica Stern ; Leyla Detoledo-Morrell ; Raj C. Shah ; Julie Bach ; Ranjan Duara ; Richard Isaacson ; Silvia Strauman ; Marilyn S. Albert ; Julia Pedroso ; Jaimie Toroney ; Henry Rusinek ; Mony J de Leon ; Susan M De Santi ; P. Murali Doraiswamy ; Jeffrey R. Petrella ; Marilyn Aiello ; Christopher M. Clark ; Cassie Pham ; Jessica Nunez ; Charles D. Smith ; Curtis A. Given II ; Peter Hardy ; Steven T. Dekosky ; Maryann Oakley ; Donna M. Simpson ; M. Saleem Ismail ; Anton Porsteinsson ; Colleen Mccallum ; Steven C. Cramer ; Ruth A. Mulnard ; Catherine Mcadams-Ortiz ; Ramon Diaz-Arrastia ; Kristen Martin-Cook ; Michael Devous ; Allan I. Levey ; James J. Lah ; Janet S. Cellar ; Jeffrey M. Burns ; Heather S. Anderson ; Mary M. Laubinger ; George Bartzokis ; Daniel H.S. Silverman ; Po H. Lu ; Rita Fletcher ; Francine Parfitt ; Heather Johnson ; Martin Farlow ; Scott Herring ; Ann M. Hake ; Christopher H. van Dyck ; Martha G. Macavoy ; Laurel A. Bifano ; Howard Chertkow ; Howard Bergman ; Chris Hosein ; Sandra Black ; Simon Graham ; Curtis Caldwell ; Howard Feldman ; Michele Assaly ; Ging-Yuek R. Hsiung ; Andrew Kertesz ; John Rogers ; Dick Trost ; Charles Bernick ; Darren Gitelman ; Nancy Johnson ; Marsel Mesulam ; Carl Sadowsky ; Teresa Villena ; Scott Mesner ; Paul S. Aisen ; Kathleen B. Johnson ; Kelly E. Behan ; Reisa A. Sperling ; Dorene M. Rentz ; Keith A. Johnson ; Allyson Rosen ; Jared Tinklenberg ; Wes Ashford ; Marwan Sabbagh ; Donald Connor ; Sanja Obradov ; Ron Killiany ; Alex Norbash ; Thomas O. Obisesan ; Annapurni Jayam-Trouth ; Paul Wang ; Alexander P. Auchus ; Juebin Huang ; Robert P. Friedland ; Charles Decarli ; Evan Fletcher ; Owen Carmichael ; Smita Kittur ; Seema Mirje ; Sterling C. Johnson ; Michael Borrie ; T-Y Lee ; Sanjay Asthana ; Cynthia M. Carlsson ; Diane Highum ; Adrian Preda ; Dana Nguyen ; Pierre N. Tariot ; Barry A. Hendin ; Douglas W. Scharre ; Maria Kataki ; David Q. Beversdorf ; Earl A. Zimmerman ; Dzintra Celmins ; Alice D. Brown ; Sam Gandy ; Marjorie E. Marenberg ; Barry W. Rovner ; Godfrey Pearlson ; Karen Blank ; Karen Anderson ; Robert B. Santulli ; Nadia Pare ; Jeff D. Williamson ; Kaycee M. Sink ; Huntington Potter ; B. Ashok Raj ; Amy Giordano ; Brian R. Ott ; Chuang-Kuo Wu ; Ronald Cohen ; Kerri L. Wilks
ispartofProceedings of the National Academy of Sciences, 04 May 2010, Vol.107(18), p.8404
identifier
subjectSciences (General)
descriptionA recently identified variant within the fat mass and obesity-associated ( FTO ) gene is carried by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, in adults and an ~1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of ~8% in the frontal lobes and 12% in the occipital lobes—these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.
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8Andrew J. Saykin
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10Tatiana Foroud
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16Jason J. Corneveaux
17Dietrich A. Stephan
18Charles S. Decarli
19Bryan M. Dechairo
20Steven G. Potkin
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22Michael W. Weiner
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24Oscar L. Lopez
25James T. Becker
26Owen T. Carmichael
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60Peter J. Snyder
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82Daniel Marson
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93Silvia Strauman
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96Jaimie Toroney
97Henry Rusinek
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99Susan M De Santi
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titleA commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
description

A recently identified variant within the fat mass and obesity-associated ( FTO ) gene is carried by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, in adults and an ~1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of ~8% in the frontal lobes and 12% in the occipital lobes—these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.

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titleA commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
authorApril J. Ho ; Jason L. Stein ; Xue Hua ; Suh Lee ; Derrek P. Hibar ; Alex D. Leow ; Ivo D. Dinov ; Arthur W. Toga ; Andrew J. Saykin ; Li Shen ; Tatiana Foroud ; Nathan Pankratz ; Matthew J. Huentelman ; David W. Craig ; Jill D. Gerber ; April N. Allen ; Jason J. Corneveaux ; Dietrich A. Stephan ; Charles S. Decarli ; Bryan M. Dechairo ; Steven G. Potkin ; Clifford R. Jack, Jr ; Michael W. Weiner ; Cyrus A. Raji ; Oscar L. Lopez ; James T. Becker ; Owen T. Carmichael ; Paul M. Thompson ; the Alzheimer'S Disease Neuroimaging Initiative ; Michael Weiner ; Leon Thal ; Ronald Petersen ; William Jagust ; John Trojanowki ; Laurel Beckett ; Robert C. Green ; Anthony Gamst ; William Z. Potter ; Tom Montine ; Dale Anders ; Matthew Bernstein ; Joel Felmlee ; Nick Fox ; Paul Thompson ; Norbert Schuff ; Gene Alexander ; Dan Bandy ; Robert A. Koeppe ; Norm Foster ; Eric M. Reiman ; Kewei Chen ; Les Shaw ; Virginia M.-Y. Lee ; Magdalena Korecka ; Karen Crawford ; Scott Neu ; Danielle Harvey ; John Kornak ; Zaven Kachaturian ; Richard Frank ; Peter J. Snyder ; Susan Molchan ; Jeffrey Kaye ; Remi Vorobik ; Joseph Quinn ; Lon Schneider ; Sonia Pawluczyk ; Bryan Spann ; Adam S. Fleisher ; Helen Vanderswag ; Judith L. Heidebrink ; Joanne L. Lord ; Kris Johnson ; Rachelle S. Doody ; Javier Villanueva-Meyer ; Munir Chowdhury ; Yaakov Stern ; Lawrence S. Honig ; Karen L. Bell ; John C. Morris ; Mark A. Mintun ; Stacy Schneider ; Daniel Marson ; Randall Griffith ; Beverly Badger ; Hillel Grossman ; Cheuk Tang ; Jessica Stern ; Leyla Detoledo-Morrell ; Raj C. Shah ; Julie Bach ; Ranjan Duara ; Richard Isaacson ; Silvia Strauman ; Marilyn S. Albert ; Julia Pedroso ; Jaimie Toroney ; Henry Rusinek ; Mony J de Leon ; Susan M De Santi ; P. Murali Doraiswamy ; Jeffrey R. Petrella ; Marilyn Aiello ; Christopher M. Clark ; Cassie Pham ; Jessica Nunez ; Charles D. Smith ; Curtis A. Given II ; Peter Hardy ; Steven T. Dekosky ; Maryann Oakley ; Donna M. Simpson ; M. Saleem Ismail ; Anton Porsteinsson ; Colleen Mccallum ; Steven C. Cramer ; Ruth A. Mulnard ; Catherine Mcadams-Ortiz ; Ramon Diaz-Arrastia ; Kristen Martin-Cook ; Michael Devous ; Allan I. Levey ; James J. Lah ; Janet S. Cellar ; Jeffrey M. Burns ; Heather S. Anderson ; Mary M. Laubinger ; George Bartzokis ; Daniel H.S. Silverman ; Po H. Lu ; Rita Fletcher ; Francine Parfitt ; Heather Johnson ; Martin Farlow ; Scott Herring ; Ann M. Hake ; Christopher H. van Dyck ; Martha G. Macavoy ; Laurel A. Bifano ; Howard Chertkow ; Howard Bergman ; Chris Hosein ; Sandra Black ; Simon Graham ; Curtis Caldwell ; Howard Feldman ; Michele Assaly ; Ging-Yuek R. Hsiung ; Andrew Kertesz ; John Rogers ; Dick Trost ; Charles Bernick ; Darren Gitelman ; Nancy Johnson ; Marsel Mesulam ; Carl Sadowsky ; Teresa Villena ; Scott Mesner ; Paul S. Aisen ; Kathleen B. Johnson ; Kelly E. Behan ; Reisa A. Sperling ; Dorene M. Rentz ; Keith A. Johnson ; Allyson Rosen ; Jared Tinklenberg ; Wes Ashford ; Marwan Sabbagh ; Donald Connor ; Sanja Obradov ; Ron Killiany ; Alex Norbash ; Thomas O. Obisesan ; Annapurni Jayam-Trouth ; Paul Wang ; Alexander P. Auchus ; Juebin Huang ; Robert P. Friedland ; Charles Decarli ; Evan Fletcher ; Owen Carmichael ; Smita Kittur ; Seema Mirje ; Sterling C. Johnson ; Michael Borrie ; T-Y Lee ; Sanjay Asthana ; Cynthia M. Carlsson ; Diane Highum ; Adrian Preda ; Dana Nguyen ; Pierre N. Tariot ; Barry A. Hendin ; Douglas W. Scharre ; Maria Kataki ; David Q. Beversdorf ; Earl A. Zimmerman ; Dzintra Celmins ; Alice D. Brown ; Sam Gandy ; Marjorie E. Marenberg ; Barry W. Rovner ; Godfrey Pearlson ; Karen Blank ; Karen Anderson ; Robert B. Santulli ; Nadia Pare ; Jeff D. Williamson ; Kaycee M. Sink ; Huntington Potter ; B. Ashok Raj ; Amy Giordano ; Brian R. Ott ; Chuang-Kuo Wu ; Ronald Cohen ; Kerri L. Wilks
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creatorcontrib
0April J. Ho
1Jason L. Stein
2Xue Hua
3Suh Lee
4Derrek P. Hibar
5Alex D. Leow
6Ivo D. Dinov
7Arthur W. Toga
8Andrew J. Saykin
9Li Shen
10Tatiana Foroud
11Nathan Pankratz
12Matthew J. Huentelman
13David W. Craig
14Jill D. Gerber
15April N. Allen
16Jason J. Corneveaux
17Dietrich A. Stephan
18Charles S. Decarli
19Bryan M. Dechairo
20Steven G. Potkin
21Clifford R. Jack, Jr
22Michael W. Weiner
23Cyrus A. Raji
24Oscar L. Lopez
25James T. Becker
26Owen T. Carmichael
27Paul M. Thompson
28the Alzheimer'S Disease Neuroimaging Initiative
29Michael Weiner
30Leon Thal
31Ronald Petersen
32William Jagust
33John Trojanowki
34Laurel Beckett
35Robert C. Green
36Anthony Gamst
37William Z. Potter
38Tom Montine
39Dale Anders
40Matthew Bernstein
41Joel Felmlee
42Nick Fox
43Paul Thompson
44Norbert Schuff
45Gene Alexander
46Dan Bandy
47Robert A. Koeppe
48Norm Foster
49Eric M. Reiman
50Kewei Chen
51Les Shaw
52Virginia M.-Y. Lee
53Magdalena Korecka
54Karen Crawford
55Scott Neu
56Danielle Harvey
57John Kornak
58Zaven Kachaturian
59Richard Frank
60Peter J. Snyder
61Susan Molchan
62Jeffrey Kaye
63Remi Vorobik
64Joseph Quinn
65Lon Schneider
66Sonia Pawluczyk
67Bryan Spann
68Adam S. Fleisher
69Helen Vanderswag
70Judith L. Heidebrink
71Joanne L. Lord
72Kris Johnson
73Rachelle S. Doody
74Javier Villanueva-Meyer
75Munir Chowdhury
76Yaakov Stern
77Lawrence S. Honig
78Karen L. Bell
79John C. Morris
80Mark A. Mintun
81Stacy Schneider
82Daniel Marson
83Randall Griffith
84Beverly Badger
85Hillel Grossman
86Cheuk Tang
87Jessica Stern
88Leyla Detoledo-Morrell
89Raj C. Shah
90Julie Bach
91Ranjan Duara
92Richard Isaacson
93Silvia Strauman
94Marilyn S. Albert
95Julia Pedroso
96Jaimie Toroney
97Henry Rusinek
98Mony J de Leon
99Susan M De Santi
100...
jtitleProceedings of the National Academy of Sciences
creationdate2010
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
aulast
0April J. Ho
1Jason L. Stein
2Xue Hua
3Suh Lee
4Derrek P. Hibar
5Alex D. Leow
6Ivo D. Dinov
7Arthur W. Toga
8Andrew J. Saykin
9Li Shen
10Tatiana Foroud
11Nathan Pankratz
12Matthew J. Huentelman
13David W. Craig
14Jill D. Gerber
15April N. Allen
16Jason J. Corneveaux
17Dietrich A. Stephan
18Charles S. Decarli
19Bryan M. Dechairo
20Steven G. Potkin
21Clifford R. Jack
22Michael W. Weiner
23Cyrus A. Raji
24Oscar L. Lopez
25James T. Becker
26Owen T. Carmichael
27Paul M. Thompson
28the Alzheimer'S Disease Neuroimaging Initiative
29Michael Weiner
30Leon Thal
31Ronald Petersen
32William Jagust
33John Trojanowki
34Laurel Beckett
35Robert C. Green
36Anthony Gamst
37William Z. Potter
38Tom Montine
39Dale Anders
40Matthew Bernstein
41Joel Felmlee
42Nick Fox
43Paul Thompson
44Norbert Schuff
45Gene Alexander
46Dan Bandy
47Robert A. Koeppe
48Norm Foster
49Eric M. Reiman
50Kewei Chen
51Les Shaw
52Virginia M.-Y. Lee
53Magdalena Korecka
54Karen Crawford
55Scott Neu
56Danielle Harvey
57John Kornak
58Zaven Kachaturian
59Richard Frank
60Peter J. Snyder
61Susan Molchan
62Jeffrey Kaye
63Remi Vorobik
64Joseph Quinn
65Lon Schneider
66Sonia Pawluczyk
67Bryan Spann
68Adam S. Fleisher
69Helen Vanderswag
70Judith L. Heidebrink
71Joanne L. Lord
72Kris Johnson
73Rachelle S. Doody
74Javier Villanueva-Meyer
75Munir Chowdhury
76Yaakov Stern
77Lawrence S. Honig
78Karen L. Bell
79John C. Morris
80Mark A. Mintun
81Stacy Schneider
82Daniel Marson
83Randall Griffith
84Beverly Badger
85Hillel Grossman
86Cheuk Tang
87Jessica Stern
88Leyla Detoledo-Morrell
89Raj C. Shah
90Julie Bach
91Ranjan Duara
92Richard Isaacson
93Silvia Strauman
94Marilyn S. Albert
95Julia Pedroso
96Jaimie Toroney
97Henry Rusinek
98Mony J de Leon
99Susan M De Santi
100...
aufirstJr
auinitJ
auinit1J
au
0April J. Ho
1Jason L. Stein
2Xue Hua
3Suh Lee
4Derrek P. Hibar
5Alex D. Leow
6Ivo D. Dinov
7Arthur W. Toga
8Andrew J. Saykin
9Li Shen
10Tatiana Foroud
11Nathan Pankratz
12Matthew J. Huentelman
13David W. Craig
14Jill D. Gerber
15April N. Allen
16Jason J. Corneveaux
17Dietrich A. Stephan
18Charles S. Decarli
19Bryan M. Dechairo
20Steven G. Potkin
21Clifford R. Jack, Jr
22Michael W. Weiner
23Cyrus A. Raji
24Oscar L. Lopez
25James T. Becker
26Owen T. Carmichael
27Paul M. Thompson
28the Alzheimer'S Disease Neuroimaging Initiative
29Michael Weiner
30Leon Thal
31Ronald Petersen
32William Jagust
33John Trojanowki
34Laurel Beckett
35Robert C. Green
36Anthony Gamst
37William Z. Potter
38Tom Montine
39Dale Anders
40Matthew Bernstein
41Joel Felmlee
42Nick Fox
43Paul Thompson
44Norbert Schuff
45Gene Alexander
46Dan Bandy
47Robert A. Koeppe
48Norm Foster
49Eric M. Reiman
50Kewei Chen
51Les Shaw
52Virginia M.-Y. Lee
53Magdalena Korecka
54Karen Crawford
55Scott Neu
56Danielle Harvey
57John Kornak
58Zaven Kachaturian
59Richard Frank
60Peter J. Snyder
61Susan Molchan
62Jeffrey Kaye
63Remi Vorobik
64Joseph Quinn
65Lon Schneider
66Sonia Pawluczyk
67Bryan Spann
68Adam S. Fleisher
69Helen Vanderswag
70Judith L. Heidebrink
71Joanne L. Lord
72Kris Johnson
73Rachelle S. Doody
74Javier Villanueva-Meyer
75Munir Chowdhury
76Yaakov Stern
77Lawrence S. Honig
78Karen L. Bell
79John C. Morris
80Mark A. Mintun
81Stacy Schneider
82Daniel Marson
83Randall Griffith
84Beverly Badger
85Hillel Grossman
86Cheuk Tang
87Jessica Stern
88Leyla Detoledo-Morrell
89Raj C. Shah
90Julie Bach
91Ranjan Duara
92Richard Isaacson
93Silvia Strauman
94Marilyn S. Albert
95Julia Pedroso
96Jaimie Toroney
97Henry Rusinek
98Mony J de Leon
99Susan M De Santi
100...
atitleA commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
jtitleProceedings of the National Academy of Sciences
risdate20100504
volume107
issue18
spage8404
issn0027-8424
eissn1091-6490
formatjournal
genrearticle
ristypeJOUR
abstract

A recently identified variant within the fat mass and obesity-associated ( FTO ) gene is carried by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, in adults and an ~1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of ~8% in the frontal lobes and 12% in the occipital lobes—these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.

pubNational Acad Sciences
doi10.1073/pnas.0910878107
urlhttp://www.pnas.org/content/107/18/8404.abstract
lad01Proceedings of the National Academy of Sciences
pages8404-8409
date2010-05-04