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Ume6 transcription factor is part of a signaling cascade that regulates autophagy

Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8... Full description

Journal Title: Proceedings of the National Academy of Sciences 10 July 2012, Vol.109(28), p.11206
Main Author: Clinton R. Bartholomew
Other Authors: Tsukasa Suzuki , Zhou Du , Steven K. Backues , Meiyan Jin , Melinda A. Lynch-Day , Midori Umekawa , Avani Kamath , Mantong Zhao , Zhiping Xie , Ken Inoki , Daniel J. Klionsky
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1200313109
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recordid: pnas_s109_28_11206
title: Ume6 transcription factor is part of a signaling cascade that regulates autophagy
format: Article
creator:
  • Clinton R. Bartholomew
  • Tsukasa Suzuki
  • Zhou Du
  • Steven K. Backues
  • Meiyan Jin
  • Melinda A. Lynch-Day
  • Midori Umekawa
  • Avani Kamath
  • Mantong Zhao
  • Zhiping Xie
  • Ken Inoki
  • Daniel J. Klionsky
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences, 10 July 2012, Vol.109(28), p.11206
description: Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved.
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1200313109
fulltext: fulltext_linktorsrc
issn:
  • 0027-8424
  • 00278424
  • 1091-6490
  • 10916490
url: Link


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titleUme6 transcription factor is part of a signaling cascade that regulates autophagy
creatorClinton R. Bartholomew ; Tsukasa Suzuki ; Zhou Du ; Steven K. Backues ; Meiyan Jin ; Melinda A. Lynch-Day ; Midori Umekawa ; Avani Kamath ; Mantong Zhao ; Zhiping Xie ; Ken Inoki ; Daniel J. Klionsky
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descriptionAutophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved.
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titleUme6 transcription factor is part of a signaling cascade that regulates autophagy
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Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved.

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Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved.

pubNational Acad Sciences
doi10.1073/pnas.1200313109
urlhttp://www.pnas.org/content/109/28/11206.abstract
lad01Proceedings of the National Academy of Sciences
pages11206-11210
date2012-07-10