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Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation

Much remains unknown regarding speciation. Host-pathogen interactions are a major driving force for diversification, but the genomic basis for speciation and host shifting remains unclear. The fungal genus Metarhizium contains species ranging from specialists with very narrow host ranges to generali... Full description

Journal Title: Proceedings of the National Academy of Sciences 25 November 2014, Vol.111(47), p.16796
Main Author: Xiao Hu
Other Authors: Guohua Xiao , Peng Zheng , Yanfang Shang , Yao Su , Xinyu Zhang , Xingzhong Liu , Shuai Zhan , Raymond J. St. Leger , Chengshu Wang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1412662111
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recordid: pnas_s111_47_16796
title: Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation
format: Article
creator:
  • Xiao Hu
  • Guohua Xiao
  • Peng Zheng
  • Yanfang Shang
  • Yao Su
  • Xinyu Zhang
  • Xingzhong Liu
  • Shuai Zhan
  • Raymond J. St. Leger
  • Chengshu Wang
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences, 25 November 2014, Vol.111(47), p.16796
description: Much remains unknown regarding speciation. Host-pathogen interactions are a major driving force for diversification, but the genomic basis for speciation and host shifting remains unclear. The fungal genus Metarhizium contains species ranging from specialists with very narrow host ranges to generalists that attack a wide range of insects. By genomic analyses of seven species, we demonstrated that generalists evolved from specialists via transitional species with intermediate host ranges and that this shift paralleled insect evolution. We found that specialization was associated with retention of sexuality and rapid evolution of existing protein sequences whereas generalization was associated with protein-family expansion, loss of genome-defense mechanisms, genome restructuring, horizontal gene transfer, and positive selection that accelerated after reinforcement of reproductive isolation. These results advance understanding of speciation and genomic signatures that underlie pathogen adaptation to hosts. Metarhizium | speciation | transitional species | host specificity | genomic features www.pnas.org/cgi/doi/10.1073/pnas.1412662111
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1412662111
fulltext: fulltext_linktorsrc
issn:
  • 0027-8424
  • 00278424
  • 1091-6490
  • 10916490
url: Link


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descriptionMuch remains unknown regarding speciation. Host-pathogen interactions are a major driving force for diversification, but the genomic basis for speciation and host shifting remains unclear. The fungal genus Metarhizium contains species ranging from specialists with very narrow host ranges to generalists that attack a wide range of insects. By genomic analyses of seven species, we demonstrated that generalists evolved from specialists via transitional species with intermediate host ranges and that this shift paralleled insect evolution. We found that specialization was associated with retention of sexuality and rapid evolution of existing protein sequences whereas generalization was associated with protein-family expansion, loss of genome-defense mechanisms, genome restructuring, horizontal gene transfer, and positive selection that accelerated after reinforcement of reproductive isolation. These results advance understanding of speciation and genomic signatures that underlie pathogen adaptation to hosts. Metarhizium | speciation | transitional species | host specificity | genomic features www.pnas.org/cgi/doi/10.1073/pnas.1412662111
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