schliessen

Filtern

 

Bibliotheken

The common marmoset: A new world primate species with limited Mhc class II variability

The common marmoset ( Callithrix jacchus ) is a New World primate species that is highly susceptible to fatal infections caused by various strains of bacteria. We present here a first step in the molecular characterization of the common marmoset’s Mhc class II genes by nucleotide sequence analysis o... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 29 September 1998, Vol.95(20), p.11745
Main Author: Susana G. Antunes
Other Authors: Natasja G. de Groot , Herbert Brok , Gaby Doxiadis , Alexandre A. L. Menezes , Nel Otting , Ronald E. Bontrop
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: pnas_s95_20_11745
title: The common marmoset: A new world primate species with limited Mhc class II variability
format: Article
creator:
  • Susana G. Antunes
  • Natasja G. de Groot
  • Herbert Brok
  • Gaby Doxiadis
  • Alexandre A. L. Menezes
  • Nel Otting
  • Ronald E. Bontrop
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 29 September 1998, Vol.95(20), p.11745
description: The common marmoset ( Callithrix jacchus ) is a New World primate species that is highly susceptible to fatal infections caused by various strains of bacteria. We present here a first step in the molecular characterization of the common marmoset’s Mhc class II genes by nucleotide sequence analysis of the polymorphic exon 2 segments. For this study, genetic material was obtained from animals bred in captivity as well as in the wild. The results demonstrate that the common marmoset has, like other primates, apparently functional Mhc - DR and - DQ regions, but the Mhc - DP region has been inactivated. At the - DR and - DQ loci, only a limited number of lineages were detected. On the basis of the number of alleles found, the - DQA and - B loci appear to be oligomorphic, whereas only a moderate degree of polymorphism was observed for two of three Mhc - DRB loci. The contact residues in the peptide-binding site of the Caja-DRB1*03 lineage members are highly conserved, whereas the -DRB*W16 lineage members show more divergence in that respect. The latter locus encodes five oligomorphic lineages whose members are not observed in any other primate species studied, suggesting rapid evolution, as illustrated by frequent exchange of polymorphic motifs. All common marmosets tested were found to share one monomorphic type of Caja - DRB*W12 allele probably encoded by a separate locus. Common marmosets apparently lack haplotype polymorphism because the number of Caja - DRB loci present per haplotype appears to be constant. Despite this, however, an unexpectedly high number of allelic combinations are observed at the haplotypic level, suggesting that Caja - DRB alleles are exchanged frequently between chromosomes by recombination, promoting an optimal distribution of limited Mhc polymorphisms among individuals of a given population. This peculiar genetic make up, in combination with the limited variability of the major histocompatability complex class II repertoire, may contribute to the common marmoset’s susceptibility to particular bacterial infections.
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490
fulltext: fulltext_linktorsrc
issn:
  • 0027-8424
  • 00278424
  • 1091-6490
  • 10916490
url: Link


@attributes
ID446907035
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid95_20_11745
sourceidpnas_s
recordidTN_pnas_s95_20_11745
sourcesystemPC
dbid
0PNE
1RNA
pqid201332078
galeid21232076
display
typearticle
titleThe common marmoset: A new world primate species with limited Mhc class II variability
creatorSusana G. Antunes ; Natasja G. de Groot ; Herbert Brok ; Gaby Doxiadis ; Alexandre A. L. Menezes ; Nel Otting ; Ronald E. Bontrop
ispartofProceedings of the National Academy of Sciences of the United States of America, 29 September 1998, Vol.95(20), p.11745
identifierISSN: 0027-8424 ; E-ISSN: 1091-6490
subjectSciences (General)
descriptionThe common marmoset ( Callithrix jacchus ) is a New World primate species that is highly susceptible to fatal infections caused by various strains of bacteria. We present here a first step in the molecular characterization of the common marmoset’s Mhc class II genes by nucleotide sequence analysis of the polymorphic exon 2 segments. For this study, genetic material was obtained from animals bred in captivity as well as in the wild. The results demonstrate that the common marmoset has, like other primates, apparently functional Mhc - DR and - DQ regions, but the Mhc - DP region has been inactivated. At the - DR and - DQ loci, only a limited number of lineages were detected. On the basis of the number of alleles found, the - DQA and - B loci appear to be oligomorphic, whereas only a moderate degree of polymorphism was observed for two of three Mhc - DRB loci. The contact residues in the peptide-binding site of the Caja-DRB1*03 lineage members are highly conserved, whereas the -DRB*W16 lineage members show more divergence in that respect. The latter locus encodes five oligomorphic lineages whose members are not observed in any other primate species studied, suggesting rapid evolution, as illustrated by frequent exchange of polymorphic motifs. All common marmosets tested were found to share one monomorphic type of Caja - DRB*W12 allele probably encoded by a separate locus. Common marmosets apparently lack haplotype polymorphism because the number of Caja - DRB loci present per haplotype appears to be constant. Despite this, however, an unexpectedly high number of allelic combinations are observed at the haplotypic level, suggesting that Caja - DRB alleles are exchanged frequently between chromosomes by recombination, promoting an optimal distribution of limited Mhc polymorphisms among individuals of a given population. This peculiar genetic make up, in combination with the limited variability of the major histocompatability complex class II repertoire, may contribute to the common marmoset’s susceptibility to particular bacterial infections.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttp://www.pnas.org/content/95/20/11745.abstract$$EView_full_text_in_National_Academy_of_Sciences_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Susana G. Antunes
1Natasja G. de Groot
2Herbert Brok
3Gaby Doxiadis
4Alexandre A. L. Menezes
5Nel Otting
6Ronald E. Bontrop
titleThe common marmoset: A new world primate species with limited Mhc class II variability
description

The common marmoset ( Callithrix jacchus ) is a New World primate species that is highly susceptible to fatal infections caused by various strains of bacteria. We present here a first step in the molecular characterization of the common marmoset’s Mhc class II genes by nucleotide sequence analysis of the polymorphic exon 2 segments. For this study, genetic material was obtained from animals bred in captivity as well as in the wild. The results demonstrate that the common marmoset has, like other primates, apparently functional Mhc - DR and - DQ regions, but the Mhc - DP region has been inactivated. At the - DR and - DQ loci, only a limited number of lineages were detected. On the basis of the number of alleles found, the - DQA and - B loci appear to be oligomorphic, whereas only a moderate degree of polymorphism was observed for two of three Mhc - DRB loci. The contact residues in the peptide-binding site of the Caja-DRB1*03 lineage members are highly conserved, whereas the -DRB*W16 lineage members show more divergence in that respect. The latter locus encodes five oligomorphic lineages whose members are not observed in any other primate species studied, suggesting rapid evolution, as illustrated by frequent exchange of polymorphic motifs. All common marmosets tested were found to share one monomorphic type of Caja - DRB*W12 allele probably encoded by a separate locus. Common marmosets apparently lack haplotype polymorphism because the number of Caja - DRB loci present per haplotype appears to be constant. Despite this, however, an unexpectedly high number of allelic combinations are observed at the haplotypic level, suggesting that Caja - DRB alleles are exchanged frequently between chromosomes by recombination, promoting an optimal distribution of limited Mhc polymorphisms among individuals of a given population. This peculiar genetic make up, in combination with the limited variability of the major histocompatability complex class II repertoire, may contribute to the common marmoset’s susceptibility to particular bacterial infections.

subjectSciences (General)
general
0English
1National Acad Sciences
2PNAS (National Academy of Sciences)
3National Academy of Sciences (U.S.)
sourceidpnas_s
recordidpnas_s95_20_11745
issn
00027-8424
100278424
21091-6490
310916490
rsrctypearticle
creationdate1998
addtitleProceedings of the National Academy of Sciences of the United States of America
searchscope
0pnas_full
1pnas4
2pnas5
scope
0pnas_full
1pnas4
2pnas5
lsr45$$EView_full_text_in_National_Academy_of_Sciences_(Access_to_full_text_may_be_restricted)
tmp01
0PNAS (National Academy of Sciences)
1National Academy of Sciences (U.S.)
tmp02
0PNE
1RNA
startdate19980929
enddate19980929
lsr40Proceedings of the National Academy of Sciences of the United States of America, 29 September 1998, Vol.95 (20), p.11745
citationpf 11745 vol 95 issue 20
lsr30VSR-Enriched:[doi, pages, pqid, galeid]
sort
titleThe common marmoset: A new world primate species with limited Mhc class II variability
authorSusana G. Antunes ; Natasja G. de Groot ; Herbert Brok ; Gaby Doxiadis ; Alexandre A. L. Menezes ; Nel Otting ; Ronald E. Bontrop
creationdate19980929
lso0119980929
facets
frbrgroupid8884814531044237046
frbrtype5
newrecords20190724
languageeng
topicSciences (General)
collection
0PNAS (National Academy of Sciences)
1National Academy of Sciences (U.S.)
prefilterarticles
rsrctypearticles
creatorcontrib
0Susana G. Antunes
1Natasja G. de Groot
2Herbert Brok
3Gaby Doxiadis
4Alexandre A. L. Menezes
5Nel Otting
6Ronald E. Bontrop
jtitleProceedings of the National Academy of Sciences of the United States of America
creationdate1998
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
au
0Susana G. Antunes
1Natasja G. de Groot
2Herbert Brok
3Gaby Doxiadis
4Alexandre A. L. Menezes
5Nel Otting
6Ronald E. Bontrop
atitleThe common marmoset: A new world primate species with limited Mhc class II variability
jtitleProceedings of the National Academy of Sciences of the United States of America
risdate19980929
volume95
issue20
spage11745
issn0027-8424
eissn1091-6490
formatjournal
genrearticle
ristypeJOUR
abstract

The common marmoset ( Callithrix jacchus ) is a New World primate species that is highly susceptible to fatal infections caused by various strains of bacteria. We present here a first step in the molecular characterization of the common marmoset’s Mhc class II genes by nucleotide sequence analysis of the polymorphic exon 2 segments. For this study, genetic material was obtained from animals bred in captivity as well as in the wild. The results demonstrate that the common marmoset has, like other primates, apparently functional Mhc - DR and - DQ regions, but the Mhc - DP region has been inactivated. At the - DR and - DQ loci, only a limited number of lineages were detected. On the basis of the number of alleles found, the - DQA and - B loci appear to be oligomorphic, whereas only a moderate degree of polymorphism was observed for two of three Mhc - DRB loci. The contact residues in the peptide-binding site of the Caja-DRB1*03 lineage members are highly conserved, whereas the -DRB*W16 lineage members show more divergence in that respect. The latter locus encodes five oligomorphic lineages whose members are not observed in any other primate species studied, suggesting rapid evolution, as illustrated by frequent exchange of polymorphic motifs. All common marmosets tested were found to share one monomorphic type of Caja - DRB*W12 allele probably encoded by a separate locus. Common marmosets apparently lack haplotype polymorphism because the number of Caja - DRB loci present per haplotype appears to be constant. Despite this, however, an unexpectedly high number of allelic combinations are observed at the haplotypic level, suggesting that Caja - DRB alleles are exchanged frequently between chromosomes by recombination, promoting an optimal distribution of limited Mhc polymorphisms among individuals of a given population. This peculiar genetic make up, in combination with the limited variability of the major histocompatability complex class II repertoire, may contribute to the common marmoset’s susceptibility to particular bacterial infections.

pubNational Acad Sciences
urlhttp://www.pnas.org/content/95/20/11745.abstract
lad01Proceedings of the National Academy of Sciences of the United States of America
doi10.1073/pnas.95.20.11745
pages11745-11750
date1998-09-29