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Microbial polyketide synthases: More and more prolific

Microorganisms make a wealth of unusual metabolites that have a secondary role in the organism’s ontogeny, such as self-defense, aggression, or even communication as the need arises. These compounds often have biological activity valuable to humankind (1). Nevertheless, as valuable as antibiotics an... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 30 March 1999, Vol.96(7), p.3336
Main Author: C. Richard Hutchinson
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490
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recordid: pnas_s96_7_3336
title: Microbial polyketide synthases: More and more prolific
format: Article
creator:
  • C. Richard Hutchinson
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 30 March 1999, Vol.96(7), p.3336
description: Microorganisms make a wealth of unusual metabolites that have a secondary role in the organism’s ontogeny, such as self-defense, aggression, or even communication as the need arises. These compounds often have biological activity valuable to humankind (1). Nevertheless, as valuable as antibiotics and other naturally occurring drugs have been over the past 60 years, their future use is threatened by now widespread resistance to antibiotics among human, animal, and agricultural pathogens. Despite the fact that microbial metabolites are being found continually by pharmaceutical companies through targeted screening programs, fewer and fewer fundamentally new types of drugs have been found in this way during the past two decades (2).
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490
fulltext: fulltext_linktorsrc
issn:
  • 0027-8424
  • 00278424
  • 1091-6490
  • 10916490
url: Link


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descriptionMicroorganisms make a wealth of unusual metabolites that have a secondary role in the organism’s ontogeny, such as self-defense, aggression, or even communication as the need arises. These compounds often have biological activity valuable to humankind (1). Nevertheless, as valuable as antibiotics and other naturally occurring drugs have been over the past 60 years, their future use is threatened by now widespread resistance to antibiotics among human, animal, and agricultural pathogens. Despite the fact that microbial metabolites are being found continually by pharmaceutical companies through targeted screening programs, fewer and fewer fundamentally new types of drugs have been found in this way during the past two decades (2).
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