schliessen

Filtern

 

Bibliotheken

Free radicals and antioxidants: updating a personal view

This article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen radicals and other reactive oxygen species (ROS) in the origin or progression of most human diseases remains... Full description

Journal Title: Nutrition Reviews Vol.70(5), p.257
Main Author: Halliwell, Barry
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Oxford University Press, UK
Created: May 2012
ID: ISSN: 00296643
Link: http://search.proquest.com/docview/1010042250/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1010042250
title: Free radicals and antioxidants: updating a personal view
format: Article
creator:
  • Halliwell, Barry
subjects:
  • Free Radicals
  • Antioxidants
  • Disease
  • Diet
  • Nutrition
ispartof: Nutrition Reviews, Vol.70(5), p.257
description: This article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen radicals and other reactive oxygen species (ROS) in the origin or progression of most human diseases remains uncertain, with cancer and neurodegenerative disease being likely exceptions. Even in diseases in which ROS are involved there has been little progress in developing effective antioxidant treatments. Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in vivo (as revealed by robust biomarkers). However, some strategies that are known to delay disease onset may act, at least in part, by decreasing oxidative damage levels. Nevertheless, far more is known today about endogenous antioxidant defenses and how they are regulated, which has led to a deeper understanding of how some ROS can act as signaling molecules. Increasing endogenous antioxidant levels (e.g., by supplying "pro-oxidants") may be a better approach to therapeutics and disease prevention than consuming large doses of "dietary antioxidants." [PUBLICATION ]
language: eng
source:
identifier: ISSN: 00296643
fulltext: fulltext
issn:
  • 00296643
  • 0029-6643
url: Link


@attributes
ID1400212554
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1010042250
sourceidproquest
recordidTN_proquest1010042250
sourcesystemOther
pqid1010042250
galeid290733843
display
typearticle
titleFree radicals and antioxidants: updating a personal view
creatorHalliwell, Barry
publisherOxford University Press, UK
creationdateMay 2012
ispartofNutrition Reviews, Vol.70(5), p.257
identifierISSN: 00296643
subjectFree Radicals ; Antioxidants ; Disease ; Diet ; Nutrition
descriptionThis article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen radicals and other reactive oxygen species (ROS) in the origin or progression of most human diseases remains uncertain, with cancer and neurodegenerative disease being likely exceptions. Even in diseases in which ROS are involved there has been little progress in developing effective antioxidant treatments. Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in vivo (as revealed by robust biomarkers). However, some strategies that are known to delay disease onset may act, at least in part, by decreasing oxidative damage levels. Nevertheless, far more is known today about endogenous antioxidant defenses and how they are regulated, which has led to a deeper understanding of how some ROS can act as signaling molecules. Increasing endogenous antioxidant levels (e.g., by supplying "pro-oxidants") may be a better approach to therapeutics and disease prevention than consuming large doses of "dietary antioxidants." [PUBLICATION ]
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1010042250/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontribHalliwell, Barry
titleFree radicals and antioxidants: updating a personal view
descriptionThis article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen radicals and other reactive oxygen species (ROS) in the origin or progression of most human diseases remains uncertain, with cancer and neurodegenerative disease being likely exceptions. Even in diseases in which ROS are involved there has been little progress in developing effective antioxidant treatments. Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in vivo (as revealed by robust biomarkers). However, some strategies that are known to delay disease onset may act, at least in part, by decreasing oxidative damage levels. Nevertheless, far more is known today about endogenous antioxidant defenses and how they are regulated, which has led to a deeper understanding of how some ROS can act as signaling molecules. Increasing endogenous antioxidant levels (e.g., by supplying "pro-oxidants") may be a better approach to therapeutics and disease prevention than consuming large doses of "dietary antioxidants." [PUBLICATION ]
subject
0Free Radicals
1Antioxidants
2Disease
3Diet
4Nutrition
general
0English
1Oxford University Press, UK
2Medical Database
3ProQuest Science Journals
4Consumer Health Database
5Health & Medical Collection (Alumni edition)
6Medical Database (Alumni edition)
7Nursing & Allied Health Database (Alumni edition)
8Science Database (Alumni edition)
9ProQuest Pharma Collection
10Health & Medical Collection
11Nursing & Allied Health Database
12ProQuest Agriculture Journals
13ProQuest Public Health
14Family Health Database (Alumni edition)
15Research Library China
16ProQuest Nursing & Allied Health Source
17ProQuest Research Library
18ProQuest Discovery
19ProQuest Agricultural Science Collection
20ProQuest Central
21ProQuest Hospital Collection
22ProQuest Natural Science Collection
23Research Library (Alumni edition)
24Hospital Premium Collection (Alumni edition)
25ProQuest SciTech Collection
26ProQuest Health & Medical Complete
27ProQuest Medical Library
28Agricultural & Environmental Science Database
29Natural Science Collection
30ProQuest Central (new)
31ProQuest Central K-12
32ProQuest Central Korea
33Research Library Prep
34SciTech Premium Collection
35Health Research Premium Collection
36Health Research Premium Collection (Alumni edition)
37ProQuest Central Essentials
38eLibrary
39ProQuest Central China
sourceidproquest
recordidproquest1010042250
issn
000296643
10029-6643
rsrctypereview
creationdate2012
searchscope
01000273
11000283
21005660
31006454
41006520
51006759
61006761
71006762
81006763
91006765
101006815
111006993
121007015
131007067
141007107
151007160
161007617
171007899
181007906
191007945
201008005
211008174
221008886
231009127
241009191
251009384
2610000020
2710000025
2810000027
2910000034
3010000035
3110000039
3210000047
3310000050
3410000064
3510000117
3610000118
3710000119
3810000120
3910000155
4010000156
4110000157
4210000158
4310000164
4410000234
4510000253
4610000255
4710000256
4810000257
4910000258
5010000259
5110000260
5210000270
5310000271
5410000281
5510000293
5610000300
57proquest
scope
01000273
11000283
21005660
31006454
41006520
51006759
61006761
71006762
81006763
91006765
101006815
111006993
121007015
131007067
141007107
151007160
161007617
171007899
181007906
191007945
201008005
211008174
221008886
231009127
241009191
251009384
2610000020
2710000025
2810000027
2910000034
3010000035
3110000039
3210000047
3310000050
3410000064
3510000117
3610000118
3710000119
3810000120
3910000155
4010000156
4110000157
4210000158
4310000164
4410000234
4510000253
4610000255
4710000256
4810000257
4910000258
5010000259
5110000260
5210000270
5310000271
5410000281
5510000293
5610000300
57proquest
alttitleNutrition Reviews
lsr43
01000273false
11000283false
21005660false
31006454false
41006520false
51006759false
61006761false
71006762false
81006763false
91006765false
101006815false
111006993false
121007015false
131007067false
141007107false
151007160false
161007617false
171007899false
181007906false
191007945false
201008005false
211008174false
221008886false
231009127false
241009191false
251009384false
2610000020false
2710000025false
2810000027false
2910000034false
3010000035false
3110000039false
3210000047false
3310000050false
3410000064false
3510000117false
3610000118false
3710000119false
3810000120false
3910000155false
4010000156false
4110000157false
4210000158false
4310000164false
4410000234false
4510000253false
4610000255false
4710000256false
4810000257false
4910000258false
5010000259false
5110000260false
5210000270false
5310000271false
5410000281false
5510000293false
5610000300false
startdate20120501
enddate20120501
citationpf 257 vol 70 issue 5
lsr30VSR-Enriched:[eissn, doi, pqid, pages, galeid]
sort
titleFree radicals and antioxidants: updating a personal view
authorHalliwell, Barry
creationdate20120501
lso0120120501
facets
frbrgroupid5901935098102698575
frbrtype5
newrecords20180321
languageeng
creationdate2012
topic
0Free Radicals
1Antioxidants
2Disease
3Diet
4Nutrition
collection
0Medical Database
1ProQuest Science Journals
2Consumer Health Database
3Health & Medical Collection (Alumni edition)
4Medical Database (Alumni edition)
5Nursing & Allied Health Database (Alumni edition)
6Science Database (Alumni edition)
7ProQuest Pharma Collection
8Health & Medical Collection
9Nursing & Allied Health Database
10ProQuest Agriculture Journals
11ProQuest Public Health
12Family Health Database (Alumni edition)
13Research Library China
14ProQuest Nursing & Allied Health Source
15ProQuest Research Library
16ProQuest Discovery
17ProQuest Agricultural Science Collection
18ProQuest Central
19ProQuest Hospital Collection
20ProQuest Natural Science Collection
21Research Library (Alumni edition)
22Hospital Premium Collection (Alumni edition)
23ProQuest SciTech Collection
24ProQuest Health & Medical Complete
25ProQuest Medical Library
26Agricultural & Environmental Science Database
27Natural Science Collection
28ProQuest Central (new)
29ProQuest Central K-12
30ProQuest Central Korea
31Research Library Prep
32SciTech Premium Collection
33Health Research Premium Collection
34Health Research Premium Collection (Alumni edition)
35ProQuest Central Essentials
36eLibrary
37ProQuest Central China
prefilterreviews
rsrctypereviews
creatorcontribHalliwell, Barry
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulastHalliwell
aufirstBarry
auinit1B.
auHalliwell, Barry
atitleFree radicals and antioxidants: updating a personal view
jtitleNutrition Reviews
risdate20120501
volume70
issue5
spage257
issn00296643
abstractThis article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen radicals and other reactive oxygen species (ROS) in the origin or progression of most human diseases remains uncertain, with cancer and neurodegenerative disease being likely exceptions. Even in diseases in which ROS are involved there has been little progress in developing effective antioxidant treatments. Mega-doses of dietary antioxidants have also generally failed to prevent human disease, in part because they do not decrease oxidative damage in vivo (as revealed by robust biomarkers). However, some strategies that are known to delay disease onset may act, at least in part, by decreasing oxidative damage levels. Nevertheless, far more is known today about endogenous antioxidant defenses and how they are regulated, which has led to a deeper understanding of how some ROS can act as signaling molecules. Increasing endogenous antioxidant levels (e.g., by supplying "pro-oxidants") may be a better approach to therapeutics and disease prevention than consuming large doses of "dietary antioxidants." [PUBLICATION ABSTRACT]
copOxford
pubOxford University Press, UK
urlhttp://search.proquest.com/docview/1010042250/
doi10.1111/j.1753-4887.2012.00476.x
pages257-25765
eissn17534887
date2012-05-01
genrearticle
formatjournal
ristypeJOUR