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Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding.

The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use th... Full description

Journal Title: Nature April 15, 2012, Vol.484(7395), pp.542-545
Main Author: Marinari, Eliana
Other Authors: Mehonic, Aida , Curran, Scott , Gale, Jonathan , Duke, Thomas , Baum, Buzz
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1476-4687 ; DOI: 10.1038/nature10984
Link: http://search.proquest.com/docview/1010231867/?pq-origsite=primo
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recordid: proquest1010231867
title: Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding.
format: Article
creator:
  • Marinari, Eliana
  • Mehonic, Aida
  • Curran, Scott
  • Gale, Jonathan
  • Duke, Thomas
  • Baum, Buzz
subjects:
  • Animals–Cytology
  • Apoptosis–Cytology
  • Cell Communication–Pathology
  • Cell Count–Pathology
  • Cell Death–Pathology
  • Cell Growth Processes–Pathology
  • Cell Survival–Pathology
  • Drosophila Melanogaster–Pathology
  • Epithelial Cells–Pathology
  • Female–Pathology
  • Male–Pathology
  • Models, Biological–Pathology
  • Neoplasms–Pathology
  • Stochastic Processes–Pathology
ispartof: Nature, April 15, 2012, Vol.484(7395), pp.542-545
description: The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a model system to identify a novel process of crowding-induced cell delamination that balances growth to ensure the development of well-ordered cell packing. In crowded regions of the tissue, a proportion of cells undergo a serial loss of cell-cell junctions and a progressive loss of apical area, before being squeezed out by their neighbours. This path of delamination is recapitulated by a simple computational model of epithelial mechanics, in which stochastic cell loss relieves overcrowding as the system tends towards equilibrium. We show that this process of delamination is mechanistically distinct from apoptosis-mediated cell extrusion and precedes the first signs of cell death....
language: eng
source:
identifier: E-ISSN: 1476-4687 ; DOI: 10.1038/nature10984
fulltext: fulltext
issn:
  • 14764687
  • 1476-4687
url: Link


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titleLive-cell delamination counterbalances epithelial growth to limit tissue overcrowding.
creatorMarinari, Eliana ; Mehonic, Aida ; Curran, Scott ; Gale, Jonathan ; Duke, Thomas ; Baum, Buzz
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ispartofNature, April 15, 2012, Vol.484(7395), pp.542-545
identifierE-ISSN: 1476-4687 ; DOI: 10.1038/nature10984
subjectAnimals–Cytology ; Apoptosis–Cytology ; Cell Communication–Pathology ; Cell Count–Pathology ; Cell Death–Pathology ; Cell Growth Processes–Pathology ; Cell Survival–Pathology ; Drosophila Melanogaster–Pathology ; Epithelial Cells–Pathology ; Female–Pathology ; Male–Pathology ; Models, Biological–Pathology ; Neoplasms–Pathology ; Stochastic Processes–Pathology
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descriptionThe development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a model system to identify a novel process of crowding-induced cell delamination that balances growth to ensure the development of well-ordered cell packing. In crowded regions of the tissue, a proportion of cells undergo a serial loss of cell-cell junctions and a progressive loss of apical area, before being squeezed out by their neighbours. This path of delamination is recapitulated by a simple computational model of epithelial mechanics, in which stochastic cell loss relieves overcrowding as the system tends towards equilibrium. We show that this process of delamination is mechanistically distinct from apoptosis-mediated cell extrusion and precedes the first signs of cell death....
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