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Active targeting strategies for anticancer drug nanocarriers.

Chemotherapy at present remains the main form of treatment for cancer, though there is no clinically available antineoplastic drug that acts selectively on the tumor mass. For this reason, the scientific research is focused towards the development of novel cancer therapies and drug delivery strategi... Full description

Journal Title: Current drug delivery May 2012, Vol.9(3), pp.255-268
Main Author: Basile, Livia
Other Authors: Pignatello, Rosario , Passirani, Catherine
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1875-5704
Link: http://search.proquest.com/docview/1011190582/?pq-origsite=primo
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recordid: proquest1011190582
title: Active targeting strategies for anticancer drug nanocarriers.
format: Article
creator:
  • Basile, Livia
  • Pignatello, Rosario
  • Passirani, Catherine
subjects:
  • Animals–Administration & Dosage
  • Antineoplastic Agents–Administration & Dosage
  • Drug Carriers–Administration & Dosage
  • Drug Delivery Systems–Drug Therapy
  • Humans–Drug Therapy
  • Liposomes–Drug Therapy
  • Micelles–Drug Therapy
  • Nanoparticles–Drug Therapy
  • Neoplasms–Drug Therapy
  • Antineoplastic Agents
  • Drug Carriers
  • Liposomes
  • Micelles
ispartof: Current drug delivery, May 2012, Vol.9(3), pp.255-268
description: Chemotherapy at present remains the main form of treatment for cancer, though there is no clinically available antineoplastic drug that acts selectively on the tumor mass. For this reason, the scientific research is focused towards the development of novel cancer therapies and drug delivery strategies, like drug targeting, that would enhance the therapeutic efficacy of drugs while reducing their side toxicity. This review describes tree types of nanoparticles used in active targeting for cancer treatment: liposomes, lipid and polymer nanoparticles, and micelles. The opportunities and challenges achieved by the proposed strategies of active targeting have been highlighted, as well as the necessity to conciliate the targeting efficiency of drug nanocarriers with their longevity in the bloodstream.
language: eng
source:
identifier: E-ISSN: 1875-5704
fulltext: fulltext
issn:
  • 18755704
  • 1875-5704
url: Link


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identifierE-ISSN: 1875-5704
subjectAnimals–Administration & Dosage ; Antineoplastic Agents–Administration & Dosage ; Drug Carriers–Administration & Dosage ; Drug Delivery Systems–Drug Therapy ; Humans–Drug Therapy ; Liposomes–Drug Therapy ; Micelles–Drug Therapy ; Nanoparticles–Drug Therapy ; Neoplasms–Drug Therapy ; Antineoplastic Agents ; Drug Carriers ; Liposomes ; Micelles
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descriptionChemotherapy at present remains the main form of treatment for cancer, though there is no clinically available antineoplastic drug that acts selectively on the tumor mass. For this reason, the scientific research is focused towards the development of novel cancer therapies and drug delivery strategies, like drug targeting, that would enhance the therapeutic efficacy of drugs while reducing their side toxicity. This review describes tree types of nanoparticles used in active targeting for cancer treatment: liposomes, lipid and polymer nanoparticles, and micelles. The opportunities and challenges achieved by the proposed strategies of active targeting have been highlighted, as well as the necessity to conciliate the targeting efficiency of drug nanocarriers with their longevity in the bloodstream.
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